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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Paris:20250327T110000
DTEND;TZID=Europe/Paris:20250327T110000
DTSTAMP:20260407T105740
CREATED:20250304T121556Z
LAST-MODIFIED:20250313T111514Z
UID:181481-1743073200-1743073200@www.bordeaux-neurocampus.fr
SUMMARY:Conférence IBIO/RRI IMPACT - Michel Thiebaut de Schotten
DESCRIPTION:Venue: IBIO \nAlso on zoom :  <https://u-bordeaux-fr.zoom.us/j/83115534343?pwd=lF0rKLx94A9FOZcA2PTL1YIiW4EgSQ.1 \n\nMichel Thiebaut de Schotten\nTeam leader – IMN \nTitle\nA Human Brain Map of Mitochondrial Respiratory Capacity and Diversity \nAbstract\nMitochondrial oxidative phosphorylation (OxPhos) powers brain activity1\,2\, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders3\,4\, underscoring the need to define the brain’s molecular energetic landscape5–10. To bridge the cognitive neuroscience and cell biology scale gap\, we developed a physical voxelization approach to partition a frozen human coronal hemisphere section into 703 voxels comparable to neuroimaging resolution (3×3×3 mm). In each cortical and subcortical brain voxel\, we profiled mitochondrial phenotypes including OxPhos enzyme activities\, mitochondrial DNA and volume density\, and mitochondria-specific respiratory capacity. We show that the human brain contains a diversity of mitochondrial phenotypes driven by both topology and cell types. Compared to white matter\, grey matter contains >50% more mitochondria. We show that the more abundant grey matter mitochondria also are biochemically optimized for energy transformation\, particularly among recently evolved cortical brain regions. Scaling these data to the whole brain\, we created a backward linear regression model integrating several neuroimaging modalities11\, thereby generating a brain-wide map of mitochondrial distribution and specialization that predicts mitochondrial characteristics in an independent brain region of the same donor brain. This new approach and the resulting MitoBrainMap of mitochondrial phenotypes provide a foundation for exploring the molecular energetic landscape that enables normal brain functions\, relating it to neuroimaging data\, and defining the subcellular basis for regionalized brain processes relevant to neuropsychiatric and neurodegenerative disorders. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/conference-ibio-rri-impact-michel-thiebaut-de-schotten/
CATEGORIES:For scientists,home-event,IMN,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20250327T170000
DTEND;TZID=Europe/Paris:20250327T170000
DTSTAMP:20260407T105740
CREATED:20250227T143436Z
LAST-MODIFIED:20250318T132623Z
UID:181335-1743094800-1743094800@www.bordeaux-neurocampus.fr
SUMMARY:Reproducibilitea session
DESCRIPTION:Venue: Centre Broca (salle basal ganglia) \n\nThe rise and fall of peer review \n
URL:https://www.bordeaux-neurocampus.fr/en/event/reproducibilitea-session-march2025/
CATEGORIES:For scientists,home-event
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