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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20240331T010000
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DTSTART:20241027T010000
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DTSTART;VALUE=DATE:20240213
DTEND;VALUE=DATE:20240214
DTSTAMP:20260410T104304
CREATED:20231129T120836Z
LAST-MODIFIED:20231218T152541Z
UID:164866-1707782400-1707868799@www.bordeaux-neurocampus.fr
SUMMARY:Spatial Proteomic Day
DESCRIPTION:Lieu : Neurocentre Magendie – Salle de conférence \n\nDans le cadre des Spatial Omics Days :\n– 6 février : Spatial transcriptomic day\n– 13 février : Spatial proteomic day \nLes technologies omiques spatiales englobent diverses méthodes permettant de superposer des données -omiques sur des images de tissus. Au-delà de l’identification de sous-populations moléculaires de cellules\, ces approches fournissent également des informations sur la localisation spatiale de ces sous-populations au sein du tissu d’origine. Il existe différentes solutions de omiques spatiales\, chacune présentant des caractéristiques\, des résolutions et des débits variés. Afin de comprendre les divers aspects de ces technologies\, PUMA propose une rencontre avec des experts du domaine. \nProgramme du 13 février\n– 8h30 : Accueil café\n– 9h00 – 9h15 : mot d’accueil\n– 9h15 – 10h00 : Leica\n– 10h00 – 10h45 : Miltenyi Biotec\n– 10h45 – 11h00 : pause café\n– 11h00 – 11h45 : Lunaphore\n– 11h45 – 12h30 : Akoya Biosciences\n– 12h30 – 14h30 : Speed meeting autour d’un buffet offert par les sponsors \nSur inscription : https://framaforms.org/spatial-proteomic-day-1702634282 \nPlace limitées \n
URL:https://www.bordeaux-neurocampus.fr/en/event/spatial-proteomic-day/
CATEGORIES:For scientists,home-event,Symposium
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DTSTART;TZID=Europe/Paris:20240213T113000
DTEND;TZID=Europe/Paris:20240213T113000
DTSTAMP:20260410T104304
CREATED:20240116T204501Z
LAST-MODIFIED:20240116T213659Z
UID:166931-1707823800-1707823800@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Benoit Labonté
DESCRIPTION:Venue: Centre Broca \n\nBenoit Labonté\nAssociate Professor\nUniversité Laval – Canada \nInvited by Anna Beyeler (Magendie) \nTitle\nDissecting the functional and molecular deficits at the cortico tegmental pathway in stressed males and females. \nAbstract\nThe medial prefrontal cortex (mPFC) is a central hub region for the processing of emotional and stressful environmental information. Recent studies by us and others suggest that cortically driven dysregulation of subcortical circuits underlies the expression of depressive-like behaviors in humans and chronically stressed animals. More precisely\, our group showed that stress changes the excitatory/inhibitory balance at cortical neurons projecting to the nucleus accumbens ( and the ventral tegmental area (VTA) differently in males and females. Importantly\, these alterations are accompanied by an important reorganization of pathway specific gene programs in a sex dependent fashion. How do these stress driven changes occurring in the mPFC affect synaptic transmission in downstream output brain structures in males and females\, and which transcriptional changes underlie these effects?\nIn this talk\, I will introduce novel and previously unpublished data characterizing the role of the cortico tegmental mPFC VTA pathway in the expression of stress responses I will present results obtained by combining optogenetics with patch electrophysiology and pharmacological approaches to reveal the cellular mechanisms underlying the activity of this pathway at baseline and under stress conditions. These results come with a variety of assays combined with pharmacogenetic and optogenetic manipulations to define the behavioral contribution of this\npathway at baseline and in the context of stress. Finally\, I will show results from our transcriptional analyses highlighting targets that may be responsible for the functional and behavioral impact of stress in a sex specific fashion. Globally I will provide a multidisciplinary perspective on the molecular mechanisms underlying the functional impact of chronic stress on the activity of the cortico teg mental pathway in males and females. \nSelected publications\nMansouri S\, Pessoni AM\, Rivera AM\, Tamminga CA\, Parise E\, Turecki G\, Nestler EJ\, Chen TH\, Labonté B. Transcriptional dissection of symptomatic profiles across the brain of men and women with depression. Nat Commun. 2023 Oct 26;14(1):6835. doi: 10.1038/s41467-023-42686-5. \nBittar TP\, Labonté B. Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors. Front Behav Neurosci. 2021 Jun 21;15:699592. doi: 10.3389/fnbeh.2021.699592. \nBittar TP\, Pelaez MC\, Hernandez Silva JC\, Quessy F\, Lavigne AA\, Morency D\, Blanchette LJ\, Arsenault E\, Cherasse Y\, Seigneur J\, Timofeev I\, Sephton CF\, Proulx CD\, Labonté B. Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways. Biol Psychiatry. 2021 Aug 1;90(3):194-205. doi: 10.1016/j.biopsych.2021.02.014. \nQuessy F\, Bittar T\, Blanchette LJ\, Lévesque M\, Labonté B. Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways. Sci Rep. 2021 May 26;11(1):11000. doi: 10.1038/s41598-021-90521. \nScarpa JR*\, Fatma M*\, Loh YHE*\, Traore R\, Stefan T\, Chen TH\, Nestler EJ\, Labonté B. Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models\, Biol Psychiatry\, 2020. Jan 22: S0006-3223(20)30011-1. doi: 10.1016/j.biopsych.2019.12.029. \nLabonté B*\, Abdallah K\, Maussion G\, Yerko V\, Yang J\, Bittar T\, Quessy F\, Golden SA\, Navarro L\, Checknita D\, Gigek C\, Lopez JP\, Neve RL\, Russo SJ\, Tremblay RE\, Côté G\, Meaney MJ\, Mechawar N\, Nestler EJ\, Turecki G* Regulation of impulsive-aggressive behaviors by a novel lincRNA. Mol Psychiatry. 2020 Jan 6. doi: 10.1038/s41380-019-0637-4. * co-corresponding authors. \nLabonte B\, Engmann O\, Purushothaman I\, Ménard C\, Wang J\, Tan C\, Scarpa JR\, Moy G\, Loh YHE\, Cahill M\, Lorsh Z\, Hamilton PJ\, Calipari ES\, Hodes GE\, Issler O\, Kronman H\, Pfau M\, Obradovic A\, Dong Y\, Neve R\, Russo S\, Kazarskis A\, Tamminga C\, Mechawar N\, Turecki G\, Zhang B\, Shen L\, and Nestler E. Sex-specific transcriptional signatures in the brain of males and females with major depressive disorders. Nature Medicine. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-benoit-labonte/
CATEGORIES:For scientists,home-event,Impromptu seminar
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