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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20230326T010000
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DTSTART;TZID=Europe/Paris:20230911T110000
DTEND;TZID=Europe/Paris:20230911T110000
DTSTAMP:20260410T201352
CREATED:20230829T072210Z
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SUMMARY:Séminaire - Hélène Marie
DESCRIPTION:Venue : Centre Broca  \n\nHélène Marie\nInstitut de Pharmacologie Moléculaire et Cellulaire\, Valbonne\, France\nhttps://www.ipmc.cnrs.fr \nInvited by Olivier Nicole (IINS) \nTitle\nAPP fragments are master regulators of NMDA Receptor function \nAbstract\nNMDA receptors (NMDARs) are essential actors in a large array of brain functions. Historically\, they are described as ionotropic receptors\, but there is also compelling evidence identifying an ion-flux independent signaling mode. Here\, I will summarize our recent research providing compelling evidence that two fragments of the amyloid-b precursor protein (APP) are essential regulators of NMDAR function at excitatory synapses. I will highlight the importance of the C-terminal domain of APP in regulating the levels of the NMDAR GluN2B subunit at these synapses. I will also demonstrate that the recently identified APP fragment called AETA inhibits ionotropic signaling while promoting ion-flux independent NMDAR signaling. Beyond their well-known implication in Alzheimer’s disease\, we thus argue that APP and its fragments are master regulators of NMDAR function in physiological conditions with potential implications in different NMDAR-linked disorders. \nKey publications\nSpatiotemporal insights of APP function. Dunot J\, Ribera A\, Pousinha PA*\, Marie H*. Curr Opin Neurobiol. 2023 Aug 3;82:102754. doi: 10.1016/j.conb.2023.102754. Co-first authors; *Co-last authors \nRajão-Saraiva J\, Dunot J\, Ribera A\, Temido-Ferreira M\, Coelho JE\, König S\, Moreno S\, Enguita FJ\, Willem M\, Kins S\, Marie H\, Lopes LV*\, Pousinha PA* (2023) Age-dependent NMDA receptor function is regulated by the amyloid precursor protein. Aging Cell\, Mar;22(3):e13778 doi: 10.1111/acel.13778.    * Co-last \nMensch M\, Dunot J\, Yishan SM\, Harris SS\, Blistein A\, Avdiu A\, Pousinha PA\, Giudici C\, Busche MA\, Jedlicka P\, Willem M and Marie H. (2021) Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo. Alzheimer’s Research & Therapy 13:125. doi: 10.1186/s13195-021-00860-1  PMID: 34238366 \nVitale P\, Salgueiro-Pereira AR\, Lupascu CA\, Willem M\, Migliore R\, Migliore M* and Marie H*. (2021) Analysis of age-dependent alterations in excitability properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer’s disease. Front. Aging Neurosci. 13:668948. * co-last authors  PMID: 34177555 doi: 10.3389/fnagi.2021.668948. \nKartalou GI\, Salgueiro-Pereira AR\, Endres T\, Lesnikova A\, Casarotto P\, Pousinha P\, Delanoe K\, Edelmann E\, Castrén E\, Gottmann K*\, Marie H*\, Lessmann V*. (2020) Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model. Int J Mol Sci. 2020 Nov 25;21(23):8957. * co-last authors  PMID: 33255764  doi: 10.3390/ijms21238957 \nPousinha PA\, Mouska X\, Bianchi D\, Temido-Ferreira M\, Rajão-Saraiva J\, Gomes R\, Fernandez SP\, Salgueiro-Pereira AR\, Gandin C\, Raymond EF\, Barik J\, Goutagny R\, Bethus I\, Lopes LV\, Migliore M and Marie H. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing\, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Rep. 29(2):317-331.e5.  PMID: 31597094  doi: 10.1016/j.celrep.2019.08.103. \nKootar S\, Frandemiche ML\, Dhib G\, Mouska X\, Lorivel T\, Poupon-Silvestre G\, Hunt H\, Tronche F\, Bethus I\, Barik J\, Marie H. (2018)  Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses. Neurobiol Dis. 118:117-128.  PMID: 30003950. doi: 10.1016/j.nbd.2018.07.001. \nPousinha PA\, Mouska X\, Raymond EF\, Gwizdek C\, Dhib G\, Poupon G\, Zaragosi LE\, Giudici C\, Bethus I\, Pacary E\, Willem M\, Marie H. (2017) Physiological and pathophysiological control of synaptic GluN2B−NMDA receptors by the C−terminal domain of amyloid precursor protein. Elife. Jul 6;6. pii: e25659. doi: 10.7554/eLife.25659.   PMID: 28682239 \nWillem M\, Tahirovic S\, Busche MA\, Ovsepian SV\, Chafai M\, Kootar S\, Hornburg D\, Evans LDB\, Moore S\, Daria A\, Hampel H\, Müller V\, Giudici C\, Nuscher B\, Wenninger-Weinzierl A\, Kremmer E\, Heneka MT\, Thal DR\, Giedraitis V\, Lannfelt L\, Müller U\, Livesey FJ\, Meissner F\, Herms J\, Konnerth A\, Marie H\, Haass C. (2015) h-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature\, 526(7573):443-7.  PMID: 26322584 doi: 10.1038/nature14864. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminaire-helene-marie/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20230911T140000
DTEND;TZID=Europe/Paris:20230911T140000
DTSTAMP:20260410T201352
CREATED:20230711T135133Z
LAST-MODIFIED:20230829T095124Z
UID:161236-1694440800-1694440800@www.bordeaux-neurocampus.fr
SUMMARY:Soutenance d'HDR - Olivier Nicole
DESCRIPTION:Lieu : Centre Broca \n\nOlivier Nicole\nEquipe Groc\nIINS \nTitle\nNMDA receptor functions in brain physiology and diseases \nAbstract\nSince the discovery of NMDA-Rs four decades ago\, substantial efforts have been made to dissect their major contributions to neural physiology and pathologies. Indeed\, NMDA-R functions encompass the regulation of neuronal migration\, synaptogenesis\, and maturation during development\, as well as the initiation of long-term synaptic plasticity and fine-tuning of brain network activities and behaviors. Consequently\, impairments in NMDA-R signaling contribute to devastating neurological and psychiatric disorders such as stroke\, neurodegenerative diseases\, autism\, or schizophrenia\, and the underlying mechanisms of NMDA-R dysfunctions have been under close scrutiny. More recently\, an increasing corpus of studies highlights that NMDA-R physiology cannot be restricted to fluxing ions and involves additional facets controlling synaptic transmissions in health and disease (i.e.\, receptor channel properties\, total expression\, synaptic content\, and nanoscale organization\, extrasynaptic content\, and surface diffusion). After a summary of my past achievements\, I will develop my ongoing projects. The driving force of my project is to elucidate the functional role of new dimensions of NMDA-R physiology in brain development and in neural network remodeling underlying physiological and pathological processes. \nJury\nDr Héléne MARIE\, IPMC UMR-CNRS 7275\, Sophia Antipolis – Rapportrice\nDr Claire RAMPON\, CBI\, UMR-CNRS 5169\, Toulouse – Rapportrice\nPr Thomas FRERET\, UMRS-INSERM U1075\, Caen – Rapporteur\nDr Stephen TRAYNELIS\, Emory University\, Atlanta (USA) (Via zoom) – Examinateur\nDr Laurent GROC\, UMR-CNRS 5297\, Bordeaux – Examinateur \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-hdr-olivier-nicole/
CATEGORIES:For scientists,HDR,home-event
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