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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20230426T140000
DTEND;TZID=Europe/Paris:20230426T140000
DTSTAMP:20260411T055108
CREATED:20230420T132752Z
LAST-MODIFIED:20230421T131821Z
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SUMMARY:Seminar - Roger Thompson
DESCRIPTION:Venue: CGFB \n\nSpeaker\nRoger Thompson\nHotchkiss Brain Institute at the University of Calgary \nInvited by Valentin Nägerl (IINS) and Jérôme Badaut \nTitle\nMetabotropic NMDA receptors and pannexin-1 in neuronal pathology and plasticity \nAbstract\nRecent advances in understanding NMDA receptor signalling have revealed that these prototypical ionotropic receptors can initiate signalling independently of their ion conductance. This ‘metabotropic’ (also called non-ionotropic) function has roles in plasticity and pathology. Our group has identified that a metabotropic NMDAR pathway involving Src kinase and activation of pannexin-1 (Panx1) channels is activated during stroke\, which causes neuronal death. In this seminar I will provide an overview of this pathway and its role in stroke. I will then discuss how metabotropic NMDARs / Panx1 are involved in synaptic plasticity. Briefly\, Panx1 regulates extracellular levels of anandamide (AEA) and controls presynaptic TRPV1. Structural insights into how Panx1 transports AEA suggests this channel is a long-sought endocannabinoid membrane transporter. \nAbout the speaker\nDr. Thompson is a Professor at the Hotchkiss Brain Institute at the University of Calgary. His research focuses on pannexin-1 biology as it relates to stroke\, cognitive decline and physiological brain functions. He has Bachelors (Queen’s University)\, PhD (McMaster University) and postdoctoral (University of Colorado Health Sciences Center\, University of British Columbia) experience and has been researching brain pathologies for over 20 years. His active research program focuses on identifying new molecular pathways and designing custom molecules to protect brain cells during disease. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-roger-thompson/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20230426T160000
DTEND;TZID=Europe/Paris:20230426T160000
DTSTAMP:20260411T055108
CREATED:20230421T134129Z
LAST-MODIFIED:20230426T123923Z
UID:158514-1682524800-1682524800@www.bordeaux-neurocampus.fr
SUMMARY:POSTPONED // Clinical Neuroanatomy Seminar - Mallar Chakravarty
DESCRIPTION:On zoom and YouTube \n \n\nAbstract\nIn the last decade\, biological psychiatry has witnessed the increased availability of large multi-modal datasets that seek to capture biological variation across the lifespan\, in prodromes of major mental illness\, and in individuals suffering from major neuropsychiatric disorders. Our group\, and several others\, have been leveraging these incredible datasets to gain insight into how variation in brain structure and function\, detectable via neuroimaging\, may relate to other disease-related factors observed in genetics and transcriptomics. However\, the outcomes of these studies rely on disparate datasets that were not collected to be analyzed in a single analytic framework. Thus\, many of the exciting findings that result from the creative multivariate data fusion techniques employed are somewhat observational. To move beyond these limitations\, our group has been working on examining phenotypic variation in model systems exposed to risk factors for neuropsychiatric disorders. Using longitudinal neuroimaging strategies and borrowing many of the magnificent techniques developed in the well-established human literature\, we are able to demonstrate meaningful multi-modal integration across behavioural\, imaging\, cellular\, and transcriptomic phenotypes. We believe that well-designed experiments that yield tremendous amounts of data from individual animal models are a critical way to better inform our understanding of the basis of human neuropsychiatric illness.  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/clinical-neuroanatomy-seminar-mallar-chakravarty/
CATEGORIES:For scientists,home-event,Impromptu seminar
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