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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230320
DTEND;VALUE=DATE:20230408
DTSTAMP:20260411T055115
CREATED:20221118T145344Z
LAST-MODIFIED:20230315T102544Z
UID:152883-1679270400-1680911999@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: Neuro-vascular function in health and disease
DESCRIPTION:\nVenue: CGFB (except March 29th) \n\nMonday\, March 20th – 11:00am (Virtual talk)\nMalcolm MacLeod (University of Edinburgh\, UK)\nImproving preclinical stroke research. \nTuesday\, March 21st – 9:00am\nMartin Lauritzen (University of Copenhagen\, Denmark)\nHumoral Neurobiology: Brain blood vessels\, metabolism\, BBB and CSF dynamics. \nWednesday\, March 22nd – 9:00am\nDavid Attwell (University College London\, UK)\nRegulation of cerebral blood flow by capillary pericytes in stroke\, Alzheimer’s disease and Covid-19. \nWednesday\, March 22nd – 11:00am\nPierre Magistretti (EPFL\, Swiss)\nNeuron-Glia metabolic coupling mediated by lactate : role in neuroenergetics\, plasticity and pathologies. \nThursday\, March 23rd – 9:00am\nSerge Charpak (Vision Institute\, France)\nQuantification of neurovascular coupling and brain oxygenation dynamics. \nFriday\, March 24th – 9:00am\nAndy Shih (University of Washington\, USA)\nIn vivo optical dissection of brain capillary function. \nSaturday\, March 25th – 9:00am\nSusanne Van Veluw (Harvard Medical School\, USA)\nVasomotion-mediated perivascular clearance in cerebral amyloid angiopathy. \nWednesday\, March 29th – 9:00am\nFelipe Barros (Universidad San Sebastián\, Chile)\nVisualizing metabolic recruitment\, a partner for neurovascular coupling.\n⚠ This talk will take place at the Centre Broca \nThursday\, March 30th – 9:00am\nTurgay Dalkara (Hacettepe University Ankara\, Turkey)\nPost-ischemic CBF dysregulation in the brain and retina. \nFriday\, March 31st – 9:00am\nValentin Nagerl (University of Bordeaux\, France)\nShadow imaging of the micro-anatomy of living brain tissue. \nFriday\, March 31st – 11:00am\nPerimed : Presentation \nFriday\, March 31st – 11:45am\nBruker / Inscopix : Presentation \nMonday\, April 3rd – 9:00am\nRobert Thorne (University of Wisconsin-Madison\, USA)\nKey attributes of the CNS barriers and brain microenvironment: relevance for physiology and drug delivery \nMonday\, April 3rd – 11:00am\nJean-François Ghersi-Egea (CRNL\, France)\nThe choroid plexus-cerebrospinal fluid system in brain physiology\, pathology\,and pharmaco-toxicology. \nWednesday\, April 5th – 9:00am\nAndy Obenhaus (University of California Irvine\, USA)\nModification of the cerebrovasculature in neurodegenerative disease. \nThursday\, April 6th – 9:00am\nAnne Joutel (Institute of Psychiatry and Neurosciences of Paris\, France)\nDeciphering mechanisms of small vessel diseases of the brain. \n\n\n\n\n\n\n\n\n\n\n\nAbout the Cajal lectures\nThe Cajal lectures are organized in the frame of the Cajal courses\, located in the Bordeaux school of Neuroscience. They are open to everyone. \nMore details about this course:\nhttps://cajal-training.org/on-site/neuro-vascular/\n \n\n\nCourse directors\n\n\n\n\n\n\n\n\n\n\n\n\nNikolaus Plesnila\, Ludwig Maximilian University\, Germany \n\n\n\n\n\n\n\n\n\n\n\n\n\n\nJérôme Badaut\, Bordeaux University\, France \n\n\n\n\n\n\n\n\n\n\n\n\n\n\nCatherine Hall\,Sussex University\, UK \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neuro-vascular-function-in-health-and-disease/
CATEGORIES:Cajal Lectures,For scientists,home-event
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DTSTART;TZID=Europe/Paris:20230403T143000
DTEND;TZID=Europe/Paris:20230403T143000
DTSTAMP:20260411T055115
CREATED:20230327T140118Z
LAST-MODIFIED:20230327T140500Z
UID:157708-1680532200-1680532200@www.bordeaux-neurocampus.fr
SUMMARY:LP2i seminar - Chalermchai Pilapong
DESCRIPTION:Venue: CGFB Conference room \n\nChalermchai Pilapong\nAssoc. Prof.\, Department of Radiologic Technology\, Faculty of Associated Medical Science\, Chiang Mai University\, Thailand \nInvited by Richard Ortega\, LP2i \nTitle\nNon-Invasive Brain Imaging and Modulation of Brain Clearance Pathways with Ferric-Tannic Nanocomplexes \nAbstract\nCurrently\, several diseases found in elderly people such as dementia cannot easily be cured because the treatments are usually performed in the late stage of the diseases. Much effort has made to explore new strategies for diagnosis\, prevention\, and treatment of the disease. We present herein a new technology to non-invasively image and modulate the cellular and molecular function of the brain. To develop such technology\, we engineer molecular nanoparticle of ferric-tannic (FT) complexes to produce contrast change in T1 weighted MR imaging and to boost cellular clearance function and related pathways in the rat brain. Once intravenously administered into healthy Wistar rats\, the maximum enhancement of the T1-weighted MRI signal was observed at 0.5 h post injection\, corresponding to their maximum accumulation in the brain. After that time\, FT was rapidly cleared by the brain\, which was possibly modulated by organic anion transporters present at the blood-brain barrier. This result describes the ‘come-and-run’ concept of FT\, which could be utilised as brain-targeting agent for various proposes. Although the ‘come-and-run’ mechanism allows them to have a short half-life in the brain\, they remain long enough to activate brain clearance markers such as autophagic flux and LC3B. Moreover\, experiments in primary cell cultures support that FT was capable of attenuating a potentially dangerous molecules (e.g. Aβ1–42) via activation of autophagy\, lysosomal activity\, and clearance. Concerning about toxicity of FT\, FT was biodegradable and was found to have low acute toxicity\, and have no sub-acute toxicity in Wistar rat without any abnormalities or lesions the cerebrum\, cerebellum. Overall\, our study might lead to the development of new clinically translatable pharmaceuticals for brain MRI imaging and controlling the function of cells inside the brain. \nReferences\nKittilukkana A\, Phatruengdet T\, Intakhad J\, Chariyakornkul A\, Wongpoomchai R\, Pilapong C. Molecular\nNanoparticles of Ferric-Tannic Complexes Enhance Brain Magnetic Resonance Imaging and Activate Brain Clearance Pathways. Anal Chem. 2022 \nPhiwchai I\, Chariyarangsitham W\, Phatruengdet T\, Pilapong C*.\nFerric-Tannic Nanoparticles Increase Neuronal Cellular Clearance. ACS Chemical Neuroscience. 2019;10(9):4136-44. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/lp2i-seminar-chalermchai-pilapong/
CATEGORIES:For scientists,home-event,Impromptu seminar,Other events
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