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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
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DTSTART:20221030T010000
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DTSTART;VALUE=DATE:20220502
DTEND;VALUE=DATE:20220521
DTSTAMP:20260427T134538
CREATED:20211029T152925Z
LAST-MODIFIED:20220428T130232Z
UID:140640-1651449600-1653091199@www.bordeaux-neurocampus.fr
SUMMARY:Cajal course "Neural circuit basis of computation and behaviour"
DESCRIPTION:Bordeaux School of Neuroscience\, Bordeaux. \nProgram of lectures up to date on:\nhttp://www.bordeaux-school-of-neuroscience.eu/trainings/cajal/cajal-2022/ncbcb-2022/ \n\n\n\n\n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-course-neural-circuit-basis-of-computation-and-behaviour-2022/
CATEGORIES:Cajal Lectures,For scientists,home-event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20220511T110000
DTEND;TZID=Europe/Paris:20220511T110000
DTSTAMP:20260427T134538
CREATED:20220503T083208Z
LAST-MODIFIED:20220503T162037Z
UID:147502-1652266800-1652266800@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu Seminar - Frank Schnorrer
DESCRIPTION:Venue: Centre Broca \n\nDo titins rule sarcomeres of insect muscles? \nAbstract\nSarcomeres have a stereotypic architecture across animal species. In mammalian muscles\, sarcomere length is controlled by the large sarcomere ruler titin spanning from the Z-disc to the M-band. Similarly\, non-chordate species such as insects and worms do contain sarcomeres of defined length\, varying only between fiber types. However\, these species do not contain a large titin molecule spanning across a half sarcomere\, hence a simple ruler model cannot generally apply. To investigate how sarcomere length is controlled in non-chordates\, we have manipulated the length and elasticity of the Drosophila titin homolog Sallimus (Sls). In Drosophila larval muscles Sls contains a long PEVK spring domain and extends over 2 µm across the I-band linking the Z-disc to the I-band. Surprisingly\, we find that genetically reducing the spring domain length of Sls not only changes the I-band length\, as expected\, but also reduces the A-band and hence myosin filament length. Hence\, we hypothesize that a biomechanical feedback mechanism controls sarcomere length in non-chordate species. In support of this mechanism\, we have quantified the mechanical forces across Sls in different Drosophila muscle types and find high forces across Sls in sarcomeres with long I-bands\, and lower forces in sarcomeres with shorter I-bands. \n\nFrank Schnorrer\nInstitute for Developmental Biology Marseille \nhttp://muscledynamics.org/ \nInvited by Gregory Giannone \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-frank-schnorrer/
CATEGORIES:For scientists,home-event,Impromptu seminar
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