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PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260928
DTEND;VALUE=DATE:20260930
DTSTAMP:20261002T011823
CREATED:20260129T085649Z
LAST-MODIFIED:20260624T191608Z
UID:191968-1790553600-1790726399@www.bordeaux-neurocampus.fr
SUMMARY:France Volume-EM first event
DESCRIPTION:Venue: Centre Broca \n\nConferences & Workshops \nMore details\nhttps://frvem2026.sciencesconf.org \nOrganizing Committee\n\nFanny Decoeur (BIC)\nRemi Le Borgne (Univ. Paris Cité)\nEsthel Pénard (Inst. Pasteur)\nMelina Petrel (BIC)\nBénédicte Salin (IBGC)\nSandra Sara (Synchrotron Soleil)\nFranceVolumeEM board\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/france-volume-em-first-event/
CATEGORIES:BIC,For scientists,home-event,Symposium,Trainings
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260928T080000
DTEND;TZID=Europe/Paris:20260928T170000
DTSTAMP:20261002T011823
CREATED:20260928T193245Z
LAST-MODIFIED:20260928T193245Z
UID:206659-1790582400-1790614800@www.bordeaux-neurocampus.fr
SUMMARY:Spark Seminar - Edouard Lhomme
DESCRIPTION:In person: Amphithéâtre\, Bât. BBS\, Campus Carreire\, Université de Bordeaux\nOnline: Zoom (link sent after registration) \nSeminar in french. \n\nRegister now \nFrom lab result to first patient: how to set up a clinical trial in Bordeaux \nYou have a promising result in the lab. What comes next? \nFor most health researchers\, setting up a clinical trial is the hardest part to picture. Which steps come first? Who do you talk to? How long does each one take? Guess wrong and you lose months. \nYou don’t have to figure it out alone. With the University of Bordeaux and CHU de Bordeaux in the same city\, you can run your trial here\, close to your lab and your clinical partners. \nDr Edouard Lhomme\, Associate Professor at the University of Bordeaux and head of EUCLID\, the academic platform that supports clinical trials\, will show you the way from start to finish:\n– What to do\n– When to do it\n– How to get it done \nThe talk runs for about 45 minutes\, and then we open the floor for Q&A. If you join us in person\, stay for the networking drinks from 18:30 and meet other researchers working on the same questions. \nAbout the speaker\nDr Edouard LHOMME\, MD\, PhD\nMaître de Conférences des Universités – Praticien Hospitalier \nEdouard Lhomme\, MD\, PhD\, is a public health physician and clinical epidemiologist specialized in infectious diseases and vaccine trials. He is Associate Professor at the University of Bordeaux and heads EUCLID\, an academic platform that supports international clinical trials. His research at Inserm Bordeaux Population Health focuses on methods to improve the design and evaluation of vaccine trials. He co-chairs the ANRS-MIE Coordinated Action on Respiratory Viruses and\, since 2026\, sits on the Technical Committee for Vaccinations (CTV) of the French National Authority for Health (HAS). \n
URL:https://www.bordeaux-neurocampus.fr/en/event/spark-seminar-edouard-lhomme/
CATEGORIES:For scientists,home-event,Impromptu seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260928T140000
DTEND;TZID=Europe/Paris:20260928T140000
DTSTAMP:20261002T011823
CREATED:20260907T085436Z
LAST-MODIFIED:20260910T120817Z
UID:205775-1790604000-1790604000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Ioana Carcea
DESCRIPTION:Venue: CARF – Conference room  \n\nIoana Carcea\nAssociate Professor at Department of Pharmacology\, Physiology and Neuroscience\nRutgers\, New Jersey Medical School\, USA \nInvited by Tessa Scarabello (IINS) \nTitle\nBiological mechanisms linking social support and health \nAbstract\nSocial support strongly associates with mental and physical health\, yet it remains unclear whether changes in social behavior are a cause or an early symptom of disease. We find that disrupting the function of peripheral systems (e.g.\, immune activation by bacterial toxins) leads to specific alterations in social behavior. These effects are mediated\, in part\, by changes in oxytocin neuropeptide signaling. Conversely\, depriving mice of social interactions impairs hypothalamic regulation of glucose homeostasis in a sex-specific manner\, an outcome that depends on oxytocin modulation of sympathetic output. Together\, these findings reveal a bidirectional causal relationship between social behavior and physiological health\, in which changes in bodily state reshape social function\, while the social environment itself feeds back to regulate core physiological processes. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-ioana-carcea/
CATEGORIES:For scientists,home-event,Impromptu seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260929
DTEND;VALUE=DATE:20261016
DTSTAMP:20261002T011823
CREATED:20260303T224940Z
LAST-MODIFIED:20260923T223555Z
UID:196423-1790640000-1792108799@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures - Neurovascular circuits
DESCRIPTION:Venue: CARF \n\nLectures are open to everyone \nThe Neurovascular Unit & Beyond – How CNS Border Sites Dynamically Regulate Brain Homeostasis\nTuesday\, September 29 \n9am – Robert Thorne (Denali University of Minnesota)\nIntroduction to the CNS barriers and related translational concepts. \nWednesday\, September 30 \n9am – Jerome Badaut (CNRS\, France)\nOut of the Cage: Wild Vertebrate Insights into CNS Borders and Neurovascular Biology. \nThursday\, October 1st \n9am – Nanna Macaulay (University of Copenhagen Denmark)\nChoroid plexus and CSF dynamics – the where\, which\, what\, and how of CSF secretion. \nSaturday\, October 3rd \n11am – Valentin Nagerl (Goettingen Germany)\nBarriers within: Imaging the extracellular space in the brain. \nMonday\, October 5 \n9am – Benoit Vanhollebeke (Université libre de Bruxelles Belgium)\nThe dynamic Blood-Brain Barrier: From Development to Modulation. \n11am – Jean-Francois Ghersi Egea (INSERM Lyon France)\nThe choroid plexus-CSF system in neurodevelopment and beyond: Relevance to CNS physiology\, pathology\, pharmaco-toxicology. \nTuesday\, October 6 (Venue: Centre Broca) \n9am – Brita Engelhardt (Theodor Kocher Institute University of Bern Switzerland)\nBrain barriers: the dynamic gatekeepers of CNS immune privilege and homeostasis. \n11am – Richard Daneman (University of California San Diego US)\nEvolution of the blood-brain barrier. \nThursday\, October 8 \n9am – Martin Lauritzen (University of Copenhagen Denmark)\nCerebral blood vessel physiology and the importance of the glycocalyx. \nMonday\, October 12 \n9am – Christer Betsholtz (Uppsala University / Karolinska Sweden)\nAn overview of the leptomeninges\, their physiology and their barrier properties. \n11am – Gou Young Koh (KAIST\, Korea Korea)\nMeningeal Lymphatics: A Novel Pathway for Brain Clearance. \nWednesday\, October 14 \n9am – Irena Loryan (Uppsala University Sweden)\nThe journey of small molecules to the brain: an introduction to neuro PK/PD Concepts and their applications. \n11am – Joy Zuchero (Denali Therapeutics\, US)\nUtilizing the Brain Vasculature for CNS Drug Delivery. \nThursday\, October 15 \n11am – Henrik Zetterberg (University of Gothenburg Sweden)\nUpdate on biofluid-based biomarkers for Alzheimer’s disease and other neurodegenerative dementias. \nFriday\, October 16 \n9am – Caroline Menard (University of Laval Canada)\nThe stressed blood-brain barrier: from resilience to depression. \n\n\nDetails about the course\nhttps://cajal-training.org/on-site/neurovascular-unit-beyond/ \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neurovascular-circuits/
CATEGORIES:Cajal Lectures,For scientists,home-event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T140000
DTSTAMP:20261002T011823
CREATED:20260826T151049Z
LAST-MODIFIED:20260826T151635Z
UID:205194-1790690400-1790690400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Camille Ruffier
DESCRIPTION:Venue: CARF \nDefense in french \n\nCamille Ruffier\nNutriNeuro \nTitle\nDevelopment of photoactivable polymersomes for temporal et spatial control of molecular delivery into the brain \nAbstract\nMany neurological and neuropsychiatric diseases remain poorly treated and constitute a major cause of disability worldwide. Several of these pathologies are localized to a specific area of the brain\, and their treatment remains inadequate: systemically administered drugs reach the affected areas only in limited concentrations and without precise spatiotemporal control. While the blood-brain barrier and the structural heterogeneity of the brain severely limit the targeted delivery of drugs\, alternative approaches such as intracranial pharmacology offer promising prospects. However\, these methods remain passive: drug diffusion is neither dose-dependent nor controllable over time\, which limits their clinical efficacy. Meanwhile\, nanotechnologies offer stable and versatile vectors capable of efficiently encapsulating and transporting various therapeutic agents\, but they do not\, on their own\, allow for localized and on-demand delivery. Our approach addresses these limitations by developing photoactivatable polymersomes capable of releasing their contents in a localized manner under the influence of light.\nMy work is based on three main axes: (i) the design of photoactivable and biocompatible polymersomes; (ii) the evaluation of their safety in order to ensure safe and effective use at the level of brain tissue; (iii) the demonstration of an efficient photorelease of bioactive molecules in neuronal circuits.\nOur work confirmed that the emulsion-centrifugation process is a suitable method for obtaining a high yield of photoactivable micrometer-sized polymersomes (mean diameter of 8.27 ± 0.14 µm)\, capable of rapid and localized release of their contents\, with a mean release time of 6.39 ± 0.90 s. The biocompatibility and release capacity of these polymersomes were evaluated in vitro on primary murine cortical cultures. Neither illumination at 470 nm (optical fiber Ø 400 µm\, NA 0.5\, 20 s)\, nor incubation with polymersomes at increasing concentrations (600 to 9000 polymersomes/well)\, nor the combination of the two affected cell viability. In vivo tolerance was confirmed by injecting polymersomes into the brains of mice and analyzing glial reactivity by immunolabeling IBA-1 and GFAP proteins 48 hours and 3 weeks post-injection. The polymersomes did not elicit any glial response beyond the effect of the stereotaxic injection itself\, demonstrating that the polymersomes and their photoactivation are well tolerated by brain cells and tissues. To demonstrate the efficacy of photorelease in brain tissue and to quantify its ability to modulate neuronal processes\, we developed a protocol based on measuring neuronal activity. Electrophysiological recordings were performed on mouse brain sections preserving the synaptic connection between the CA3 and CA1 regions of the hippocampus\, a key area involved in memory processes. Thanks to the encapsulation and then photorelease of CNQX (100 µM)\, a competitive antagonist of AMPA/kainate receptors\, we have demonstrated that polymersomes act as on-demand reservoirs\, allowing prolonged and localized drug administration around the injection site.\nIn conclusion\, photoactivable polymersomes represent a promising tool for studying brain mechanisms and developing innovative therapeutic strategies. Their potential is currently being evaluated in vivo in a murine model of glioblastoma for the targeted release of CNQX to limit tumor invasion. \nKeywords: polymersomes\, targeted molecular delivery\, photostimulation\, brain \nPublication\nhttps://doi.org/10.21203/rs.3.rs-9232875/v1 \nJury\n\nMme BOSCH-BOUJU Clémentine – Maître de conférences\, Nutrineuro (Bordeaux) – Directrice de thèse\nMme NADJAR Agnès – Professeure\, IMN (Bordeaux) – Présidente du jury\nMme MURA Simona – Professeure\, Institut Galien Paris-Saclay (Paris) – Rapporteur\nM. VENANCE Laurent – Directeur de recherche\, Collège de France (Paris) – Rapporteur\nMme MUTSCHLER Angela – Maître de conférences\, LCPO (Bordeaux) – Examinateur\nM. CAZORLA Maxime – Chargé de recherche\, INT (Marseille) – Examinateur\nMembres invités :\n– M. LECOMMANDOUX Sébastien – Professeur\, LCPO (Bordeaux)\n– M. MCCLENAGHAN Nathan – Directeur de recherche\, ISM (Bordeaux)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-camille-ruffier/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T143000
DTEND;TZID=Europe/Paris:20260929T143000
DTSTAMP:20261002T011823
CREATED:20260601T135933Z
LAST-MODIFIED:20260831T091128Z
UID:202797-1790692200-1790692200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Tessa Scarabello
DESCRIPTION:Venue: Centre Broca \nLanguage of the defense: english \n\nTessa Scarabello\nIINS \nThesis director: Lisa Roux \nTitle\nOlfaction and Oxytocin in female alloparental behaviors \nAbstract\nAlloparental behaviors define the set of actions undertaken by adults to insure the survival of other individuals’ progeny such as crouching over the young\, retrieval\, or parental nesting. The very first encounter with a pup can trigger the emergence of these behaviors in naive virgin mice who had never expressed these behaviors before\, and their performances is known to improve upon repeated exposures to pups. Yet\, the neurobiological substrates of this phenomenon are still unclear. Previous work highlighted the importance of auditory cues and oxytocin (OT) release in the auditory cortex of virgin females for the establishment of retrieval behavior. In contrast\, the role played by olfaction in the transition of mice from naive to efficient caretakers remains so far little explored. \nThe goal of this work has been to assess the impact of olfaction in the establishment of alloparental behaviors in naive female mice\, as well as the influence of oxytocinergic neuromodulation in the main part of the olfactory cortex\, the piriform cortex (PIR). \nWe found that within just a few minutes\, naive C57Bl6/J female mice exposed to pups start building a nest to host the pup. However\, when the odor of the pup is masked\, the onset of nesting in these mice is delayed despite comparable pup investigation times compared to controls. In addition\, mice display non-adapted behaviors when they are unable to smell the natural odor of the pup: they favor failed pup retrievals over nest building. Altogether\, these first observations suggest that olfaction plays a role in triggering adapted alloparental behaviors upon first pup exposure. \nGiven the role of OT in social behaviors\, we hypothesized that oxytocinergic transmission in the PIR could play a role in alloparental behavior emergence. Using immunochemistry in the Oxtr-3xHA-T2A-iCreERT2 mouse line\, we showed that oxytocin receptors (OTR) are mostly expressed in the deep layer III of the PIR\, unlike in previous works based on OTR-targeted antibodies. To assess the dynamics of OT signaling in the PIR during our task\, and in particular during pup olfactory investigation preceding the start of nesting\, we monitored mice with fiber photometry using an OT GRAB sensor expressed in the PIR. This method did not reveal any significant OT level change at the time of pup investigation but we found a slow build-up of OT in the PIR spanning the whole task time course. In contrast\, using GCaMP8m expressed in OTR-positive cells\, we found that OTR-positive neurons are consistently activated across all pup olfactory investigation events\, even though they represent only a small percentage of PIR cells. Altogether\, these results indicate that OTR and OT are present in the PIR upon pup exposure\, and that they could exert a slow influence on neuronal responses in PIR circuits. \nTo selectively suppress the expression of OTR in the PIR and test the impact on pup care strategy\, we adopted a viral approach to express the cre-recombinase locally in the PIR of Oxtr[flox] mice. Similar to previous experiments with pup odor masking\, this local knock-out of the OTR in the PIR impaired pup care strategy\, compared to mice injected with a control virus. \nTo identify the brain-wide circuits involved in this behavioral effect\, we used brain-wide activity mapping combined with brain clearing (iDISCO) to compare the brains of naive females exposed for the first time to a pup\, with or without a local knock-out of OTR in the PIR. We found striking differences in the activation of the Orbito Frontal Cortex\, a region known to participate to sensory processing and decision-making in social contexts. These results suggest that OT in the PIR contributes to gate the neuronal circuits recruited during pup odor exposure\, leading to the selection of appropriate behaviors. Altogether\, this work paves the way for future research to understand how olfaction and its modulation by OT shapes pup-directed behavioral changes in naive female mice. \n  \nKey words: Alloparental behaviors; Oxytocin ; Olfaction \nJury\n\nMrs BUONVISO Nathalie\, DR\, CRNL\, Lyon – Spokesperson\nMrs CARCEA Ioana\, AP\, Rutgers Brain Health Institute\, N.J – Spokesperson\nMrs MUSCATELLI Françoise\, DR\, INMED\, Marseille – Examinator\nMr  RENIER Nicolas\, DR\, ICM\, Paris – Examinator\nMrs ROUX Lisa\, DR\, IINS\, Bordeaux – Thesis director\nMr FERREIRA Guillaume\, DR\, INRAE\, Bordeaux – Invited\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-tessa-scarabello/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260930T140000
DTEND;TZID=Europe/Paris:20260930T140000
DTSTAMP:20261002T011823
CREATED:20260604T203431Z
LAST-MODIFIED:20260924T095333Z
UID:202796-1790776800-1790776800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Victor Jouque
DESCRIPTION:Venue: Centre Broca \n\nVictor Jouque \nTeams: Energy balance and obesity \nDaniela cota \nNeurocentre Magendie \nTitre\nBeyond satiety: deciphering the role of hypothalamic POMC neurons in the consumption of Hypercaloric food. \nRésumé\nEating is a process essential for life. Therefore\, powerful brain mechanisms have evolved to allow not only the matching of the organism’s energy needs with energy intake\, but also the recognition of food rich in calories so as to guarantee survival under variable environmental food sources. In this context\, neuronal circuits classically aiming at integrating information about the organism’s energy status must interact with networks regulating the rewarding aspect of food intake. Although exposure to calorie-rich diets is well known to promote overeating and consequent obesity in today’s modern societies\, little is known about how such communication is set in place and the neuronal substrates underlying this phenomenon. Hypothalamic pro-opiomelanocortin (POMC) neurons are classically viewed as the mediators of satiety via the release of the neuropeptide a-MSH in response to metabolic and hormonal cues. However\, recent evidence demonstrates that POMC neurons are highly heterogeneous\, can become active before food consumption and stimulate feeding under specific conditions. In addition\, POMC neurons release the u-opioid receptor (MOR) agonist β-endorphin\, known to stimulate the intake of energy-dense food\, therefore challenging the traditional view of their satietogenic function. \nObjectives: The general aim of this thesis was to study the role of hypothalamic POMC neurons in the consumption of energy-dense palatable food. The specific objectives were the following: \n(1) Define the mechanism engaged by POMC neurons in the hyperphagia toward hypercaloric food; \n(2) Unravel the neuronal circuit implicated \nBy combining neuroanatomical\, electrophysiological and in vivo calcium imaging approaches at single cell resolution\, we demonstrate that POMC neurons are rapidly activated by consumption of high-fat diet (HFD) through orosensory processes. \nActivation of hypothalamic POMC neurons is specific to HFD exposure and it drives hyperphagia in both sexes\, as chemogenetic inhibition of POMC neurons reduces HFD intake. These effects seem to require the synthesis and release of the POMC-derived peptide β-endorphin\, as its levels increase in POMC terminals upon HFD exposure\, while HFD-driven hyperphagia can be selectively inhibited by MOR antagonism. Single nucleus RNA sequencing (SnRNAseq) data further show that POMC neurons activated in response to HFD have increased expression of molecular mechanisms controlling the synthesis\, addressing and release of β-endorphin. \nUsing anterograde tracing of POMC neuronal projections\, we then reveal that POMC neurons project to several structures implicated in food reward\, especially the lateral septum. Using patch clamp recording coupled with optogenetics\, we demonstrate that POMC neurons are electrically connected with LS neurons through an inhibitory neurocircuit. Pharmacological inhibition of MOR activity specifically in the LS\, but not in other brain structures receiving POMC neuron projections\, recapitulates the hypophagic effects induced by general MOR blockade. Finally\, in vivo optogenetic inhibition of the POMC-LS neurocircuit reduces HFD intake\, demonstrating that the lateral septum acts as a downstream brain region mediating HFD-driven hyperphagia by integrating POMC-derived β-endorphin. \nOur work suggests that\, contrary to established dogma\, certain POMC neurons subpopulations drive the intake of hypercaloric and palatable food through a previously uncharacterized neurocircuit involving the release of b-endorphin in the lateral septum. These set of findings\, altogether provide novel information on the complex role played by hypothalamic POMC neurons in the regulation of feeding beyond satiety. \n  \n– Keywords : POMC neurons\, feeding behavior\, Hypothalamus\, Neuronal circuits \n– Mes publications :  \nLópez-Gambero AJ\, Jouque V\, Cota D. A sympathetic brake on gut GLP-1 release. Neuron. 2024 Mar 20. Doi : 10.1016/j.neuron.2024.02.015. PMID :38513615 \nJouque V\, Miralpeix C\, López-Gambero AJ\, Nicolas JC\, Quarta C\, Cota D. Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism. Rev Endocr Metab Disord. 2025 Sep 19. Doi: 10.1007/s11154-025-09993-2. PMID: 40971005 \nJury\nAmandine Gautier-Stein\, DR \nGangarossa Guiseppe\, Pr \nSerge Luquet\, DR\nRovere Carole\, CR \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-victor-jouque/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261002
DTEND;VALUE=DATE:20261003
DTSTAMP:20261002T011823
CREATED:20260129T172653Z
LAST-MODIFIED:20261001T100023Z
UID:191969-1790899200-1790985599@www.bordeaux-neurocampus.fr
SUMMARY:2026 Synapse and Network Day
DESCRIPTION:The next Synapse and Network Day will take place on 2 October 2026 at the auditorium of the Centre Broca. \nThis year’s edition will feature talks from colleagues across local institutions\, as well as two exceptional invited speakers: Dr. Cécile Charrier (IBENS\, Paris) and Prof. Kate Jeffery (University of Glasgow). \nRegistration\nRegistration is free\, but mandatory for all participants. This will allow the organizers to plan the day properly! \nDeadline: September 20th. \nPlease register using the following link: \nhttps://framaforms.org/synapse-and-network-day-2026-1785752129 \nPoster presentations\nPhD students and postdoctoral researchers are also encouraged to present their work as a poster. \nPoster registration is mandatory through the registration link (30 slots currently available). We may be able to accommodate additional posters depending on demand. \nProgram\n9:15 – Welcoming words \n9:30 – Anna Brachet (IINS)\nUnraveling the organization and mechanosensitivity of the neuronal membrane periodic\nskeleton \n10:00 – Risa Iguchi (INCIA)\nFunctional analysis of vIOFC interneurons during decision-making under expected\nuncertainty \n10:20 – Estelle Cartier (Neurocentre Magendie)\nInfluence of temporal origin of dentate granule neurons on their synaptic inputs \n10:40 Coffee break \n11:10 – Emma Perrot (IMN)\nFunctional characterization of VIP neurons of the dorsal raphe nucleus in Vigilance and\nParkinson’s disease \n11:30 Cécile Charrier (IBENS\, Paris)\nHuman-specific and activity-dependent regulations of synapses\n(Talk in the frame of the 2026-2027 PhD seminar series) \n12:20 Lunch break \n14:00 Nicolas Mallet (IMN)\nWhen Network Dynamics go Wrong: Rate vs. Synchrony. What drives Parkinsonian Motor Deficits? \n14:30 – Camille Mergaux (IINS)\nExploring the interplay between the neuronal surfaceome and extracellular matrix in\nhippocampal networs \n14:50 – Tommaso Garavaldi (Neurocentre Magendie)\nAstroglial CB1 receptor in the external Globus Pallidus fine-tunes locomotor activity \n15:10 – Céline Nicolas (INCIA)\nHow ovarian hormones influence cocaine relapse: a focus on progesterone \n15:40 Coffee break \n16:10 – Nikolette Zsigri (Neurocentre Magendie)\nInvestigating the Role of Medial Prefrontal Cortex in Temporal Multisensory Integration \n16:30 – Margaux Saint-Martin (IINS)\nNeuroligin-1 in astrocyte-synapse crosstalk \n16:50 – Kate Jefferey (Univ. of Glasgow)\nTBD \n17:40 – Closing remarks \n17:45 – Wine and Cheese \n\nWe look forward to welcoming you all for what promises to be an exciting and stimulating day of scientific exchange! \nOrganising committee \nBruna Mira\nChiara Galizia\nGiulio Casali\nMarie Oulé \nScientific Committee \nElena Avignone\nMario Carta\nClémentine Bosch-Bouju\nFrédéric Lanore \n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/network-and-synapse-day-2026/
CATEGORIES:For scientists,home-event,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261002T093000
DTEND;TZID=Europe/Paris:20261002T093000
DTSTAMP:20261002T011823
CREATED:20260612T203209Z
LAST-MODIFIED:20260909T072019Z
UID:203275-1790933400-1790933400@www.bordeaux-neurocampus.fr
SUMMARY:HDR Defense - Olivier Rossier
DESCRIPTION:Venu: BBS \n\nOlivier Rossier\nIINS \nTitle\nFrom adhesion sites to neuronal synapses: architecture\, dynamics\, and functions of the canonical constituents of cell adhesion. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-hdr-olivier-rossier/
CATEGORIES:HDR
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261002T113000
DTEND;TZID=Europe/Paris:20261002T113000
DTSTAMP:20261002T011823
CREATED:20260122T092647Z
LAST-MODIFIED:20260923T222903Z
UID:191723-1790940600-1790940600@www.bordeaux-neurocampus.fr
SUMMARY:PhD Seminar - Cécile Charrier
DESCRIPTION:Venue: Centre Broca \n\nCécile Charrier\nIBENS\, Paris \nTitle\nHuman-specific and activity-dependent regulations of synapses \n\nThis PhD seminar is organized in the frame of the 2026-2027 PhD seminar series and the Synapse and Network Day \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-cecile-charrier/
CATEGORIES:For scientists,home-event,Monthly conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261002T140000
DTEND;TZID=Europe/Paris:20261002T140000
DTSTAMP:20261002T011823
CREATED:20260604T204930Z
LAST-MODIFIED:20260930T060501Z
UID:201303-1790949600-1790949600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Léa Peltier
DESCRIPTION:Venue: CARF \nLanguage of the defense: english \n\nLéa Peltier\nIINS \nThesis supervisor: Frédéric Gambino \nTitle\nCortico-cortical circuits of perceptual decision-making \nAbstract\nAnimals continuously use sensory information to guide actions toward their goals. A fundamental problem in this process is determining whether an intended action is physically attainable given both the geometry of the environment and the animal’s own biomechanical capabilities. In rodents\, the whisker-related primary somatosensory cortex (wS1\, barrel cortex) and secondary motor cortex (wM2) are key components of the sensorimotor network supporting whisker-guided active sensing. However\, much of our understanding of these regions comes from highly controlled tasks in head-restrained animals\, leaving their roles during continuous\, self-generated perceptual decisions poorly understood. In this thesis\, we combined freely moving gap-crossing behavior\, quantitative whole-body tracking\, cortical lesions\, and longitudinal electrophysiological recordings from wS1 and wM2 to investigate the behavioral and neural mechanisms underlying attainability judgments. \nWe first developed a gap-crossing paradigm in which freely moving mice actively explored a target platform before deciding whether to cross. Quantitative analysis of continuous behavior allowed us to decompose this process into distinct behavioral subprocesses and identify candidate perceptual and decisional windows as well as different perception-action categories. We next investigated the causal contribution of the barrel cortex by lesioning it either before or after animals learned the task. Mice were able to acquire the task without wS1 and recovered within a few days when the lesion was performed after learning\, demonstrating that barrel cortex is not strictly required for gap-crossing behavior. However\, its contribution depended on previous experience. Animals lesioned before learning favored perception-action strategies characterized by a greater reliance on integrated sensorimotor processes and fewer overt perceptual epochs. Conversely\, animals lesioned after learning exhibited an increased prevalence of overt perceptual epochs before committing to crossing. Thus\, wS1 contributes to the organization of perception-action coupling rather than simply determining whether the task can be performed\, with its role shaped by previous experience. Finally\, we recorded electrophysiological activity in wS1 and wM2 to examine the cortical dynamics accompanying these behavioral processes. Both regions showed task-related activity during sensory exploration and movement preparation\, but with distinct temporal profiles. Neither region exhibited a categorical activity pattern that distinguished trials in which the target platform was reachable\, detectable but unreachable\, or absent. Instead\, lesion experiments revealed interactions between the two cortical areas. Removal of wS1 altered the temporal organization of layer 5 wM2 activity associated with movement preparation\, whereas removal of wM2 increased and temporally broadened layer 5 wS1 activity beyond periods of likely tactile contact. Disrupting either region therefore reorganized task-related activity in the remaining cortex rather than abolishing it. \nTogether\, these findings show that gap-crossing decisions emerge from continuous\, embodied sensorimotor computations in which mice relate sensory estimates of environmental geometry to their own biomechanical capabilities. They identify wS1 not as an obligatory substrate for this behavior\, but as a contributor to the temporal organization of perception and action\, and reveal wS1 and wM2 as components of an interacting cortical network capable of functional reorganization following perturbation. More broadly\, this work demonstrates how studying self-generated and uninstructed behavior can reveal neural and behavioral mechanisms of perceptual decision-making that are difficult to capture in highly constrained experimental paradigms. \nKeywords: perceptual decision-making\, freely moving\, gap-crossing\, attainability judgment\, wS1-wM2 circuit\, in vivo electrophysiological recordings\, excitotoxic lesion. \nJury\n\nSami El-Boustani: spokesperson\nIsabelle Férézou: spokesperson\nMarion Rivalan: examinator\nMathieu Wolff: examinator\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-lea-peltier/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261002T140000
DTEND;TZID=Europe/Paris:20261002T173000
DTSTAMP:20261002T011824
CREATED:20260615T133507Z
LAST-MODIFIED:20260916T100654Z
UID:203314-1790949600-1790962200@www.bordeaux-neurocampus.fr
SUMMARY:Mini-symposium: Exploring the Forces\, Structures and Signals that Shape Life: From Molecules to Cellular Scales
DESCRIPTION:Venue: BBS \n\nIn the frame of Olivier Rossier’s HDR defense. \nProgram\n14h00 – 14h30 : Sophie BRASSELET (Institut Fresnel\, Marseille\, France) \n“Deciphering the organization of proteins at the nanoscale with polarized microscopy” \n14h30 – 15h00 : Benoit LADOUX (Friedrich-Alexander Universität Erlangen-Nürnberg ; Max Planck-Zentrum für Physik und Medizin\, Erlangen\, Germany & Institut Jacques Monod\, Paris\, France) \n“Epithelial Tissue Mechanics Through the Lens of Ion Transport and Pressure Regulation” \n15h00 – 15h30 : Patricia BASSEREAU (Institut Curie\, UMR168 CNRS\, Paris\, France) \n“Membrane-mediated attractive forces between membrane proteins” \n15h30 – 16h00 : Pere ROCA-CUSACHS (Institute for Bioengineering of Catalonia\, Barcelona\, Spain) \n“The forces shaping nucleocytoplasmic transport” \nCoffee break \n16h30 – 17h00 : Vesa HYTÖNEN (Tampere University\, Tampere\, Finland) \n“Insights into talin: Disease-associated variants and novel force reporter module” \n17h00 – 17h30 : Violaine MOREAU (Bordeaux Institute of Oncology INSERM\, Bordeaux\, France) \n“Geodesic actin networks in cancer cells” \n
URL:https://www.bordeaux-neurocampus.fr/en/event/mini-symposium-olivier-rossier/
CATEGORIES:For scientists,home-event,IINS,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261006T140000
DTEND;TZID=Europe/Paris:20261006T140000
DTSTAMP:20261002T011824
CREATED:20260910T140604Z
LAST-MODIFIED:20260914T085406Z
UID:205919-1791295200-1791295200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Clara-Fahia Toussaint
DESCRIPTION:Venue : BBS \n \nThesis defended in french \n\nIMN\nTeam: Physiopathology of proteinopathies \nThesis directed by Vincent Planche \nTitle\nIs Alzheimer’s disease unique to humans? \nAbstract\nAlzheimer’s disease (AD) is a major public health problem in our ageing Western societies. More than a century after it was first described\, there is still no consensus on the definition of AD. A purely biological view suggests that the mere presence of extracellular amyloid protein deposits and intracellular tau protein aggregates is sufficient to define the condition\, as these abnormalities are considered « causal» according to the amyloid cascade hypothesis. For other authors\, biological findings alone are insufficient for diagnosis and must be accompanied by clinical signs suggestive of progression towards dementia\, particularly as biological abnormalities may precede symptoms by 10 to 20 years\, and many healthy older people with amyloid deposits will never develop the disease. This nosological issue causes the estimated global prevalence to vary from 32 million (clinical-biological definition at the dementia stage) to 315 million people (biological definition)\, with major implications for future diagnostic and therapeutic strategies (plasma biomarkers\, anti-amyloid immunotherapies). \nThis issue is reflected in the representation of AD within the animal kingdom. Certain characteristic lesions have been reported in rodents\, cetaceans and elderly primates\, but these species do not develop all the characteristics of human tauopathy\, and the cognitive impact of these lesions remains uncertain. The very concept of dementia\, based on the loss of independence in everyday activities\, remains an anthropocentric definition with no equivalent in the animal kingdom. AD would therefore exist in animals according to a minimalist biological definition centred on amyloid\, but not according to a clinical-biological definition. \nThe first part of this thesis addresses this question through a systematic review of the literature on the presence of amyloid lesions and neurofibrillary tangles in non-human primates (38 articles\, 543 brains\, four species). Using logistic regression analyses\, this study shows that amyloid plaques follow an isometric pattern\, proportional to the lifespan of each species\, whilst neurofibrillary tangles (NFTs) follow a chronometric pattern\, appearing at a fixed time point (30 to 50 years) regardless of life expectancy. This dissociation challenges the hypothesis of the amyloid cascade as a universal mechanism and suggests that the full range of neuropathological lesions associated with AD is only present when a species’ lifespan allows these two independent processes to overlap. \nThe second part uses quantitative proteomics to compare the molecular signature of the human disease with that observed in macaques that have been injected with pathological tau proteins extracted from patients’ brains\, with or without co-injection of oligomeric Aβ. The human signature is not observed in macaques: there is no correlation between the two species\, as the model responds to the injection without replicating the molecular program of the human disease. \nThe third line of inquiry is based on the observation that longevity\, a necessary condition for the emergence of a clinically and biologically defined AD\, is not the sole factor influencing its manifestation at the population level. We developed an age-structured population model\, simulated on an individual-centred basis\, which combines demographic dynamics with the social allocation of care. This model shows that longevity alone is sufficient to cause the disease to emerge in a population\, and that healthcare does not trigger it but rather perpetuates it\, by prolonging the time lived with the disease. The evolutionary reconstruction further shows that the decline in adult mortality necessarily precedes the decline in the age at which people have children. \nKey words\nNon Human Primate\, Alzheimer\, care\, proteomic \nJury\nPresidente : Dr\, ABROUS Nora\nRapporteur : Dr\, POTIER Marie-Claude\nRapporteur : Pr\, KEUCK Lara\nExaminateur : MCF-PH\, VILLAIN Nicolas\nDirecteur de thèse : Pr\, LEMOINE Maël\nCo-Directeur : PU-PH\, PLANCHE Vincent\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-clara-fahia-toussaint/
CATEGORIES:IMN,Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261008T090000
DTEND;TZID=Europe/Paris:20261008T170000
DTSTAMP:20261002T011824
CREATED:20260128T134217Z
LAST-MODIFIED:20260924T132607Z
UID:191829-1791450000-1791478800@www.bordeaux-neurocampus.fr
SUMMARY:Imagination 2: conceptual and neural basis of higher-order mental processes
DESCRIPTION:Venue: Centre Broca \n\nScientific committee \n\nGuillaume Ferreira (NutriNeuro)\nGiovanni Marsicano (Neurocentre Magendie)\nEtienne Coutureau (INCIA)\nMélie Talaron (INCIA)\n\nAbout the symposium\nHuman abilities such as guessing\, imagining or being creative can lead after distortions to aberrant perceptions (hallucinations) and beliefs (delusions) characteristics of some psychiatric disorders such as schizophrenia or psychosis. Such abilities are all based on the capacity to form associations between different stimuli\, from perceptual learning to higher-order conditioning\, which is central to guide adaptive behaviour in humans and animals. < \n“Imagination 2” is a follow-up of our successful symposium “Imagination” held in Bordeaux in December 2023. It will draw together 9 researcherswith balanced gender (6 females and 3 males)\, career stage (PhD student\, post-docs\, young PIs and senior PIs) and geographical origins (3 french speakers and 6 foreign speakers\, of which 4 are coming from Europe\, 1 from North America and 1 from Oceania). Some of them will present in a first session the concept of higher-order mental processes as well as their ontogenetic and phylogenetic evidences (Dwyer\, Avargues-Weber\, Ducourneau\, Bonardi\, Mondino\,) while\, in a second session\, others researchers will provide evidence in animal models of the neurobiological basis of higher-order conditioning and mental sensory representations (Barrera-Conde\, Garcia-Manzanares\, Holmes and Johansen). \nThis meeting is perfectly inscribed in the philosophy of GPR Brain 2030 and in particular of the subproject ADAPSY\, by gathering experimental and clinical researchers allowing to form new translational links in the field of psychiatric and mental disorders. The formation of these new links is one of the highest priorities of our GPR. \nProgramme\nMorning session: Concepts\, ontogenetic and phylogenetic evidences of higher-order cognition\n9h00 – Welcome coffee \n9h30-10h05 – Dominic Dwyer (PI; Univ Cardiff\, UK)\n“Stimulus substitution and multiple response measures: A cautionary tale for studies of higher-order learning” \n10h05-10h40 – Aurore Avargues-Weber (PI; Univ Toulouse\, France)\n“Number bias and symbolic representation in honeybees”\n \n10h40-11h15 – Eva Ducourneau (NutriNeuro\, Bordeaux\, France)\n“Higher-order conditioning in newborn rabbits: behavioural characteristics and neuromodulatory systems” \n11h15-11h50 – Charlotte Bonardi (PI; Univ Nottingham\,UK)\n“A behavioural theory of recognition memory: Implications for Neuroscience” \n11h50-12h25 – Marine Mondino (PI; CRNL\, France)\n“Brain correlates of distinguishing imagination from reality: evidence from non-invasive brain stimulation studies in humans” \nAfternoon session: Neurobiological basis of higher-order conditioning\n14h00 – Afternoon coffee \n14h30-15h05 – Marta Barrera-Conde (Neurocentre Magendie\, Bordeaux\, France)\n“Cannabinoid modulation of incidental associations engrams across sensory modalities” \n15h05-15h40 – Irene Garcia Manzanares (IMIM Barcelona\, Spain)\n“Disentangling the link between cannabis and psychosis: from mediated learning to reality testing” \n15h40-16h15 – Nathan Holmes (PI; UNSW Sydney\, Australia)\n“Mediated associations and their implications for theories of information processing” \n16h15-16h50 – Joshua Johansen (PI; UC Irvine\, USA)\n“Prefrontal encoding of an internal model for emotional inference” \n\nWith the financial support of Bordeaux Neurocampus \n
URL:https://www.bordeaux-neurocampus.fr/en/event/imagination-2/
CATEGORIES:For scientists,home-event,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261009T140000
DTEND;TZID=Europe/Paris:20261009T140000
DTSTAMP:20261002T011824
CREATED:20260901T075112Z
LAST-MODIFIED:20260911T145132Z
UID:205553-1791554400-1791554400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Mélie Talaron
DESCRIPTION:Venue: BBS \n\nMélie Talaron\nTeam: Decision and Adptation – INCIA \nSupervisors: Etienne Coutureau et Nathan Holmes (The University of New South Wales) \nTitle\nHow does the brain integrate sensory and emotional memories? A study of the role of the hippocampus in sensory preconditioning in rats \nAbstract\nAnimals and humans adapt to their environments by learning to predict motivationally significant events such as the presence of food or danger. These predictions are often based on direct experience of the contingencies between different stimuli and events (e.g.\, a sound followed by the attack of a predator) but can also be generated in the absence of such experience. For example\, by linking the sensory and emotional elements of distinct memories\, we can generate novel inferences about stimuli that have only ever been experienced as innocuous. This type of inference has implications for how memories are encoded and stored in the brain; and raises the question of how they are integrated to generate adaptive behavior. The encoding and integration of associative memories are known to be hippocampus-dependent. Yet\, the differential contributions of dorsal versus ventral hippocampus and their connectivity in these processes remains unclear. This thesis combines behavioral paradigms\, pharmacological inactivations\, fiber photometry recordings\, and chemogenetic manipulations to investigate the role of dorsal and ventral hippocampus in the encoding and integration of sensory and emotional memories in rats. In the first set of experiments\, we establish auditory-visual sensory preconditioning and show that integration operates via mediated learning: rats retrieve past information at the time of conditioning to form new associations between stimuli. In a second line of work\, we use pharmacological inactivation to investigate the causal role of dorsal and ventral hippocampus in the different stages of sensory preconditioning. We show that ventral\, but not dorsal\, hippocampus is required to form innocuous stimulus-stimulus associations\, and that both subregions are necessary for mediated learning. Critically\, we identify the signature of successful mediated learning by evidencing higher dorso-ventral hippocampus connectivity during stimulus presentations. We show that this connection is part of a broader network supporting mediated learning\, which includes the perirhinal cortex. Finally\, using chemogenetic manipulation in a gustatory sensory preconditioning protocol\, we demonstrate that the hippocampus is also critical to encode and integrate memories even when stimuli are unimodal. This work highlights the differential contributions of dorsal and ventral hippocampus in animals’ ability to infer outcomes in the absence of direct experience when facing novel situations. \nKeywords: sensory preconditioning\, hippocampus\, rat\, fear conditioning\, conditioned taste aversion \nJury\nM. JOHANSEN Joshua\, Professor\, Irvine University of California\, Rapporteur\nMme DOYERE Valérie\, Directrice de recherche\, Institut des Neurosciences Paris-Saclay\, Rapporteure\nMme BONARDI Charlotte\, Senior Lecturer\, University of Nottingham\, Examinatrice\nMme ROUX Lisa\, Directrice de recherche\, Université de Bordeaux\, Examinatrice\nM. COUTUREAU Etienne\, Directeur de recherche\, Université de Bordeaux\, Directeur de these\nM. HOLMES Nathan\, Associate Professor\, The University of New South Wales\, Co-directeur de these \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-melie-talaron/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261010
DTEND;VALUE=DATE:20261012
DTSTAMP:20261002T011824
CREATED:20260922T143318Z
LAST-MODIFIED:20260922T145937Z
UID:206411-1791590400-1791763199@www.bordeaux-neurocampus.fr
SUMMARY:Village des Sciences : "Saveurs savantes"
DESCRIPTION:Lieu : Cap Sciences \n\nEmbarquez pour un voyage culinaire afin d’explorer l’alimentation\, du champ à l’assiette\, et ses interactions avec notre santé et celle des écosystèmes. \nBordeaux Neurocampus sera présent avec 3 stands tenus par des personnels de l’INCIA\, de NutriNeuro et du Neurocentre Magendie \nEn savoir plus \n
URL:https://www.bordeaux-neurocampus.fr/en/event/village-des-sciences-2026/
CATEGORIES:Events for all,pour tous homepage
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261012T113000
DTEND;TZID=Europe/Paris:20261012T123000
DTSTAMP:20261002T011824
CREATED:20260925T121734Z
LAST-MODIFIED:20260925T121802Z
UID:206599-1791804600-1791808200@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Yi Zuo
DESCRIPTION:Venu: Centre Broca \n\nYi Zuo\, MCD Biology\, UC Santa Cruz \nInvited by Daniel Choquet (IINS). \nYi Zuo is a Professor of Neuroscience at the University of California\, Santa Cruz. Her laboratory studies how experience shapes neural circuits through synaptic remodeling and how these processes are altered in neurological and psychiatric disorders. Her research combines in vivo structural and functional imaging\, mouse genetics\, circuit manipulation\, and behavioral analysis. \nZuo received her B.S. from Tsinghua University and Ph.D. in Neuroscience from Northwestern University\, followed by postdoctoral training at New York University and the University of Texas at Austin. She joined UC Santa Cruz in 2007. Her honors include a Sloan Research Fellowship\, an Ellison Medical Foundation New Scholar Award\, recognition as a finalist for the Blavatnik National Award for Young Scientists\, and a Max Planck Fellowship. She has also taught and co-directed advanced neuroscience imaging courses at MBL\, MPFI\, and CSHA. \nTitle\nThe dynamic brain: Understanding the synaptic basis of behavior \nAbstract\nThe ability to learn new skills and to adapt to an ever-changing environment is vital for survival.  My lab aims to understand the neural basis of such abilities from the molecular to the circuit level\, centering on the synaptic circuit. The synapse\, a specialized site for connection between neurons\, is the elemental structural and functional unit of the brain. Modifications of synaptic structure and function provide a cellular mechanism for learning and memory\, while abnormal synaptic connections are hallmarks of many neurological and psychiatric disorders. My lab focuses on how experience affects neuronal circuitry through synaptic modifications\, and explores cellular mechanisms underlying the structural changes of synapses under both physiological and pathological conditions. \n  \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-yi-zuo/
LOCATION:Amphi Centre Broca Nouvelle Aquitaine\, Université de Bordeaux\, 146 Rue Léo Saignat\, Bordeaux\, France\, France
CATEGORIES:For scientists,IINS,Impromptu seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261013T173000
DTEND;TZID=Europe/Paris:20261013T203000
DTSTAMP:20261002T011824
CREATED:20260129T174011Z
LAST-MODIFIED:20260923T143409Z
UID:193542-1791912600-1791923400@www.bordeaux-neurocampus.fr
SUMMARY:Cerveaux en surchauffe. Le stress des jeunes et des étudiants : comprendre\, prévenir\, agir
DESCRIPTION:Lieu : Station Marne\n16-22\, Cours de la Marne\, Bordeaux \n\nUne soirée pour mieux comprendre le stress… et reprendre le contrôle ! \nStress\, pression\, examens\, avenir…
 Pourquoi notre cerveau s’emballe-t-il ? Comment mieux gérer le stress ? Et quelles solutions pour préserver son bien-être ? \nMardi 13 octobre de 17h30 à 20h30\, venez comprendre\, échanger et découvrir des solutions concrètes avec des chercheurs\, des professionnels et des associations. \nSoirée animée par Claire Guyot (Soyez curieux) \nInscription recommandée. \n17h30 – 20h30 : Village des associations\n– Association des Psychologues Étudiants de Bordeaux (APE)\n– Association Bordelaise des Étudiant.e.s en Psychomotricité (ABEP)\n– Espace Santé étudiants\n– Maison du cerveau NEURIKARE \n18h-18h45 : Conférence « Méditation : une révolution dans le cerveau »\nIntervenants :\n– Dr Emmanuel Mellet\, psychiatre\nService de médecine palliative et d’accompagnement\, CHU de Bordeaux\n– Pr François Tison\, neurologue\nCHU de Bordeaux\, Université de Bordeaux \n19h-20h – Table ronde : “Le stress des jeunes et des étudiants”\nIntervenants :\n– Dr Emmanuel Mellet\, psychiatre\nService de médecine palliative et d’accompagnement\, CHU de Bordeaux\n– Anne Moreau\, directrice de l’Espace Santé Etudiants\nUniversité de Bordeaux\n– Pr François Tison\, neurologue\,\nCHU de Bordeaux\, Université de Bordeaux\n– Pr Marie Tournier\, psychiatre\nCentre hospitalier Charles Perrens\, Université de Bordeaux\n– Pr Christophe Tzourio\, épidémiologiste\nCHU de Bordeaux\, Université de Bordeaux \nInscription\nhttps://framaforms.org/cerveaux-en-surchauffe-1789558555 \nVotre inscription nous permettra d’organiser l’événement et de vous prévenir en cas de changement. Vos données seront supprimées le lendemain de l’événement. \nVous bénéficiez un droit de modification et de suppression de ces données personnelles. Contact : bordeaux.neurocampus@u-bordeaux.fr \n\nÉvénement pour tout public organisé dans le cadre du congrès scientifique BrainStress \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cerveaux-en-surchauffe/
CATEGORIES:Events for all,home-event,pour tous homepage
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261014
DTEND;VALUE=DATE:20261017
DTSTAMP:20261002T011824
CREATED:20250505T115703Z
LAST-MODIFIED:20260710T094132Z
UID:183881-1791936000-1792195199@www.bordeaux-neurocampus.fr
SUMMARY:Bordeaux Neurocampus International Conference: BrainStress
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine\n \n\nThe brain under stress: from molecular processes to clinical perspectives\n  \nEarly bird registration and abstract submission deadlines: July 1st \nSessions\n\nStress and brain : the Developmental Origins of Health and Disease (Dohad) perspective\nStress and brain aging\nLife’s Stressors: Psychosocial\, Nutritional and Environmental Challenges to the Brain\nImpact of Stress on the Brain and Beyond: From Physiology to Pathology\nFight the stress- from pharmacology to Mindfulness meditation\n\nSpeakers\n\nTallie Z. Baram\nAnna Beyeler\nGael Chetelat\nDiego Candia-Rivera\nAna Luisa Carvalho\nNils Gassen\nAlex Kwan\nHailan Hu\nFreddy Jeanneteau\nPierre Gressens\nAnthi Krontira\nAndreas Meyer-Lindenberg\nCarmine Pariante\nSébastien Parnaudeau\nRui S. Rodrigues\nEleni Siopi\nNim Tottenham\n\nScientific Committee\n\nMuriel Darnaudery – University of Bordeaux – NutriNeuro\nMuriel Koehl – Inserm – Neurocentre Magendie\nAnna Beyeler – Inserm – Neurocentre Magendie\nJoeri Bordes – Neurocentre Magendie\nJulien Dupuis – Inserm – IINS\nEmmanuel Mellet – CNRS – IMN\nMarie-Pierre Moisan – Inrae – NutriNeuro\nFrançois Tison – CHU de Bordeaux / University of Bordeaux – IMN\n\nMore details / registration\nhttps://brainconf.u-bordeaux.fr/en/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/brainstress/
CATEGORIES:For scientists,home-event,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261014
DTEND;VALUE=DATE:20261017
DTSTAMP:20261002T011824
CREATED:20260122T095837Z
LAST-MODIFIED:20260203T141757Z
UID:191858-1791936000-1792195199@www.bordeaux-neurocampus.fr
SUMMARY:Sino-French BioImaging Workshop
DESCRIPTION:\n\n\nThe Sino-French BioImaging Symposium\, that will take place at the Centre Broca Nouvelle-Aquitaine in October 2026\, will also include an advanced workshop. \n\n\n\nFrom 14 to 16 October 2026\, this workshop is designed for young researchers who wish to deepen their knowledge in state-of-the-art super-resolution imaging techniques. \n\n\n\nIn the framework of an International Research Network (IRN) between France and China\, this international event will be dedicated to cutting-edge imaging technologies for life sciences\, with a special focus on Super Resolution and advanced microscopy methods. \nFor more information\nhttps://france-bioimaging.org/news-events/our-events/sfbs-sino-french-bioimaging-symposium-2026/ \n  \n  \n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/sino-french-bioimaging-thematic-school/
LOCATION:Centre Broca Nouvelle-Aquitaine\, 38 Rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:For scientists,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T120000
DTEND;TZID=Europe/Paris:20261016T120000
DTSTAMP:20261002T011824
CREATED:20260911T133629Z
LAST-MODIFIED:20260922T123544Z
UID:206374-1792152000-1792152000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Paolo Bartolomeo
DESCRIPTION:Venue: IBIO (Ground floor) \n\nPaolo Bartolomeo\,\nMD\, PhD\nParis Brain Institute / PICNIC Team \nInvited by Marc Joliot (IMN) \nTitle\nThe Neural Architecture of Visual Mental Imagery \nAbstract\nPaolo Bartolomeo\, MD\, PhD\, trained as a clinical neurologist and neuroscientist. He is internationally recognized for his expertise in the cognitive neuroscience of subjective experience and consciousness. He leads the PICNIC laboratory at the Paris Brain Institute. His research has made a significant contribution to our understanding of the structural and functional neuroanatomy of attention\, perception\, and mental imagery. His work adopts a multidisciplinary approach combining state-of-the-art behavioral assessments\, advanced neuroimaging\, and neurostimulation techniques. His research\, conducted with both healthy individuals and patients with brain lesions\, has provided valuable insights into the neural foundations of conscious experience\, cognitive recovery after stroke\, and the dynamic interactions between perception and attention. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-paolo-bartolomeo/
CATEGORIES:For scientists,home-event,IMN,Impromptu seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T143000
DTEND;TZID=Europe/Paris:20261016T143000
DTSTAMP:20261002T011824
CREATED:20260723T065927Z
LAST-MODIFIED:20260907T092233Z
UID:205608-1792161000-1792161000@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Achille Gillig
DESCRIPTION:Venue: Bâtiment A29\, Amphithéâtre A\, Campus Peixotto \n \nDefense in french \n\nAchille Gillig \nNeurofunctional imaging group\,\nInstitut des Maladies Neurodégénératives \nSupervisor: Marc Joliot \nTitle\nFunctional neuroimaging of the resting state in humans: characterization of the individual brain organization in networks \nAbstract\nOver the past three decades\, functional neuroimaging has profoundly changed how the relationship between brain organization and cognition is studied. While classical approaches sought to localize cognitive functions in circumscribed regions\, accumulating evidence has shifted the field toward a network-based understanding of brain function. Resting-state functional MRI has been central to this shift by showing that\, even without an explicit task\, the brain remains intrinsically organized into coherent resting-state networks. Because these networks partly resemble systems recruited during perception\, action\, cognition\, and emotion\, they have often been interpreted as a possible intrinsic architecture supporting mental processes. \nHowever\, the exact functional meaning of this intrinsic architecture remains unsettled. In particular\, it is still unclear whether resting-state networks should be understood as fundamental cognitive modules involved in the offline maintenance of specific cognitive processes. This thesis addressed this question by investigating the relevance of intrinsic brain organization into resting-state networks for cognition\, interindividual differences in behavior\, and dementia-related cognitive decline. \nThe first contribution was to provide a more precise framework for interpreting the cognitive relevance of resting-state networks. To this aim\, we introduced a 33-network resting-state atlas and characterized each network using meta-analytic decoding and consensus-derived cognitive labeling. This aimed to move beyond informal cognitive labels commonly assigned to resting-state networks\, by providing empirically grounded associations between intrinsic networks and task-related cognitive processes. It therefore offered a framework in which the proposed cognitive relevance of resting-state networks can be tested. \nThe second contribution challenged the assumption that resting-state networks correspond to strictly specific cognitive modules. Using resting-state functional connectivity prediction of multiple behavioral measures\, we showed that connectivity predictive of behavior did not primarily organize at the level of fine-grained cognitive processes\, but around broader latent dimensions including Cognition\, Positive Affect\, and Negative Affect. Crucially\, only connectivity predictive of Cognition was associated with a segregated intrinsic architecture\, characterized by stronger within-network connectivity and reduced between-network connectivity. This pattern was particularly expressed in networks previously associated with higher-level cognitive processes. These results suggest that cognition relates to a flexible modular intrinsic architecture expressed across multiple networks. \nThe third contribution extended this framework to dementia-related cognitive decline. In memory-clinic patients\, we showed that dementia-related steep cognitive decline was associated with global network dedifferentiation\, together with a more selective loss of within-networks connectivity. This strengthens the association between network segregation and efficient cognition\, while suggesting that dementia alters cognition through two complementary network-level mechanisms\, with a global dedifferentiation of large-scale systems and a more selective disruption of the internal cohesiveness of specific networks. \nTaken together\, these studies support a nuanced view of the cognitive relevance of resting-state networks. The intrinsic architecture of the brain does not appear to map onto cognition as a set of fixed\, process-specific modules. Rather\, resting-state networks appear to constitute a behaviorally meaningful large-scale architecture whose segregated organization supports cognition and whose dedifferentiation accompanies cognitive decline. \nKey words\nResting-state fMRI; functional connectivity; resting-state networks; cognition; predictive modeling; dementia. \nJury\n\nM. JOLIOT Marc Directeur de recherche\, IMN\, Université de Bordeaux\, CNRS\, CEA\, Bordeaux – Directeur de thèse\nM. WASSERMANN Demian Directeur de recherche\, Centre Inria de Saclay\, Université Paris-Saclay\, Inria\, CEA\, Palaiseau – Rapporteur\nM. BARTOLOMEO Paolo Directeur de recherche\, Paris Brain Institute\, Sorbonne Université\, Inserm\, CNRS\, Paris – Rapporteur\nMme LOPEZ-PERSEM Alizée Chargée de recherche\, Sorbonne Université\, Institut du Cerveau – Paris Brain Institute – ICM\, Inserm\, CNRS\, AP-HP\, Hôpital de la Pitié Salpêtrière\, Paris – Examinatrice\nMme CHANRAUD Sandra Maîtresse de conférences\, INCIA\, CNRS\, Université de Bordeaux\, Bordeaux – Examinatrice\nM. JOBARD Gaël Maître de conférence\, IMN\, Université de Bordeaux\, CNRS\, CEA\, Bordeaux – Invité\n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-achille-gillig/
CATEGORIES:IMN,Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261019
DTEND;VALUE=DATE:20261022
DTSTAMP:20261002T011824
CREATED:20260121T100222Z
LAST-MODIFIED:20260723T100015Z
UID:191596-1792368000-1792627199@www.bordeaux-neurocampus.fr
SUMMARY:Sino-French BioImaging Symposium
DESCRIPTION:Venue: Centre Broca \n\nOrganized by Rémi Galland and Jean-Baptiste Sibarita (IINS) \nIn the framework of an International Research Network (IRN) between France and China\, this international event will be dedicated to cutting-edge imaging technologies for life sciences\, with a special focus on Super Resolution and advanced microscopy methods. \nThis three-day symposium will be featuring keynote lectures\, invited talks\, selected short communications\, posters\, and industrial sessions.\n \nMore details \nhttps://france-bioimaging.org/news-events/our-events/sfbs-sino-french-bioimaging-symposium-2026/ \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/sino-french-bioimaging-symposium/
CATEGORIES:For scientists,Symposium
ATTACH;FMTTYPE=image/png:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2026/01/Fichier-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261020T123000
DTEND;TZID=Europe/Paris:20261020T133000
DTSTAMP:20261002T011824
CREATED:20261001T160045Z
LAST-MODIFIED:20261001T161043Z
UID:206785-1792499400-1792503000@www.bordeaux-neurocampus.fr
SUMMARY:Webinaire Research connect
DESCRIPTION:Webinaire sur Zoom. \nCliquez ici pour vous inscrire \n\nCe webinaire a pour objectif de présenter les fonctionnalités de l’Outil de veille des financements pour la Recherche “Research Connect” et de faciliter une prise en main rapide pour vous créer des alertes personnalisées. \nQu’est-ce que Research Connect ?\nPour vous aider à structurer une activité de veille et d’identification des  financements adaptés à vos projets de recherche\, l’université de Bordeaux met à votre disposition l’outil ResearchConnect. \nResearchConnect est une base de données\, actualisée en temps réel\, qui vous permet de cibler\, selon votre profil et vos besoins\, des opportunités de  financements au niveau national\, européen et international (partenariats industriels\, projets collaboratifs\, individuels\, bourses\, mobilité\, formation\, etc.). \nL’accès se fait depuis la page d’accueil du site ResearchConnect via la création d’un compte avec une adresse mail “u-bordeaux.fr“.  \nInscription au webinaire\nCliquez ici pour vous inscrire \nCe webinaire est ouvert à tous les chercheurs/enseignants-chercheurs\, ainsi qu’aux  personnels en appui à la recherche au niveau des laboratoires et des services centraux (adresse mail “u-bordeaux.fr“. requise). \nIl sera animé par Mylène Joubin\, senior manager chez Idox\, opérateur de l’outil ResearchConnect. \nContact\nPour toute question \nLionel Clémençon\nT. 05 40 00 87 27\nChargé de développement formation – Europe Academy\nOSE – Offre de Service Europe\nSite universitaire de Bordeaux \n
URL:https://www.bordeaux-neurocampus.fr/en/event/webinaire-research-connect/
CATEGORIES:For scientists,home-event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261020T140000
DTEND;TZID=Europe/Paris:20261020T140000
DTSTAMP:20261002T011824
CREATED:20260922T091427Z
LAST-MODIFIED:20260923T070142Z
UID:206357-1792504800-1792504800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Adrien Denizet
DESCRIPTION:Venue : BBS \nThesis defended in french \n \n\nIMN\nTeam: Purinergic mediated neuroinflammation and brain disorders\nThesis directed by Philippe Peixoto (ISM).\nCo-directed by Sandrine Bertrand (INCIA) and Eric Boué-Grabot (IMN) \nTitle\nTotal syntheses of Securinega alkaloids and study of their biological activities \nAbstract\nSecurinega alkaloids constitute a family of tetracyclic metabolites isolated from subtropical plants of the Phyllanthaceae family. Since the identification of the first members of this class in the mid-XXth century\, more than 170 compounds have been described to date. Over the years\, these molecules have attracted increasing interest because of their diverse biological activities. Among them\, the activity at GABAA receptors of (–)-securinine\, the first isolated entity of this family\, was demonstrated approximately forty years ago\, paving the way for the study of these alkaloids in the context of central nervous system disorders. Despite these initial observations\, the molecular mechanisms underlying their neurobiological effects remain largely unknown\, leaving unresolved their pharmacological positioning among currently available GABAA receptor ligands. Limited access to these compounds from natural sources has long hindered their investigation. However\, advances in organic synthesis now make it possible to explore them in greater depth using modern neurobiological tools. In this context\, the main objective of this thesis was to characterize the activity of several Securinega alkaloids at GABAA receptors and to determine which structural features of both the natural products and the receptor influence their activity. \nThe first stage of this work consisted in producing several members of this family in sufficient quantities through total synthesis\, relying on expertise developed and mastered within my research group. Electrophysiological studies performed on Xenopus laevis oocytes and mouse brain slices revealed structure–activity relationships within this series of alkaloids\, as well as an influence of GABAA receptor subunit composition on their activity. These results were further supported by molecular modeling studies\, providing a rationale for the observed selectivity profiles. Beyond the central nervous system\, the potential application of these compounds was also explored in the field of phytopathology through the evaluation of their activity against grapevine downy mildew\, a major socio-economic challenge in the Bordeaux region. Finally\, a second component of this thesis\, developed in parallel with the main project\, led to the first asymmetric total synthesis of (+)- and (–)-myrioneurinols through the combination of two transformations developed within the laboratory: a chlorinative alkynyl-Prins reaction and a late-stage resolution strategy based on the Barton–McCombie reaction. \nKey words\nOrganic chemistry\, Neurobiology\, Securinega alkaloids\, Natural products\, GABAA receptors\, Total synthesis\, Myrioneurinol \nJury\n\nThomas GRUTTER\, Directeur de recherche\, CNRS-UMR 7199\, Strasbourg – Rapporteur\nYung-Sing WONG\, Directeur de recherche\, CNRS-UMR 5063\, Grenoble – Rapporteur\nMme Stéphanie CLUZET\, Professeure\, CNRS-UMR 1366\, Bordeaux – Examinatrice\nYannick LANDAIS\, Professeur\, CNRS-UMR 5255\, Bordeaux – Examinateur\nAntoine TALY\, Directeur de recherche\, CNRS-UPR 9080\, Paris – Examinateur\nPhilippe A. PEIXOTO\, Chargé de recherche\, CNRS-UMR 5255\, Bordeaux – Directeur de thèse\nMme Sandrine BERTRAND\, Directrice de recherche\, CNRS-UMR 5287\, Bordeaux – Co-encadrante\nM. Éric BOUÉ-GRABOT\, Directeur de recherche\, CNRS-UMR 5293\, Bordeaux – Co-encadrant\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-adrien-denizet/
CATEGORIES:IMN,Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261021T140000
DTEND;TZID=Europe/Paris:20261021T140000
DTSTAMP:20261002T011824
CREATED:20260924T130026Z
LAST-MODIFIED:20260924T141750Z
UID:206552-1792591200-1792591200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Emma Marillat
DESCRIPTION:Venue: BBS \nSoutenance en français \n\nEmma Marillat \nSupervisors: Mathieu Wolff (INCIA) and Frédéric Gambino (IINS) \nTitle\nThalamocortical base of decision making in uncertain environments \nAbstract\nDecision-making in uncertain environments relies on a dynamic balance between exploring new options and exploiting choices already known to be advantageous. Understanding the neural substrates of this balance is a major challenge in cognitive neuroscience. The orbitofrontal cortex (OFC) and the mediodorsal thalamic nucleus (MD) appear to be key players in adaptive decision-making\, but the functional interactions between these regions remain poorly characterized. \nTo investigate this question\, we used a “three-armed bandit” instrumental task in which the most favorable option (one lever among three) varies over time\, forcing animals to alternate between exploration and exploitation strategies. We first established that lesioning the OFC or the MD produces a specific deficit in this task\, reflected as a difficulty in recovering optimal performance when the most favorable option is switched. Importantly\, we also established that lesioning the submedius thalamus\, the other major thalamic afferent to the OFC\, has no effect. In addition\, a viral neuroanatomical tracing strategy allowed us to establish that although the thalamocortical pathways originating from the MD and the Sub both converge onto the OFC\, they predominantly contact different cortical neuronal populations. Taken together\, these data suggest the existence of two anatomically and functionally distinct thalamocortical circuits within the OFC. \nTo further clarify the functional role of the OFC-MD circuit\, we then assessed the functional contribution of each region using a fiber photometry approach in animals performing the task. We observed that OFC activity increases both at the time of choice and when a reward is obtained\, indicating that the choice and its reinforcement appear to be represented at the cortical level. In contrast\, thalamic activity is modulated neither by the choice nor by the reward\, as the MD shows increased activity only when the animal evaluates the consequences of its choice. Interestingly\, this thalamic activation appears to result from learning\, since the MD is essentially silent in naive animals. This dynamic thus suggests that the MD does not directly encode reward value\, but rather contributes to the maintenance and consolidation of optimal choice strategies by potentially influencing prefrontal regions at the moment when the current value representation of the choice may be called into question. Taken together\, these data indicate a distinct and complementary specific functional contribution of the OFC and the MD\, ensuring the implementation of adaptive strategies when an abrupt change occurs in the environment. \nThese results obtained in rodents converge with earlier work conducted in human and non-human primates\, suggesting broad conservation of the functional organizational principles of thalamocortical circuits across the phylum. Alterations in thalamocortical connectivity are a recurrent symptom in numerous psychiatric disorders\, such as addictive disorders\, schizophrenia\, or obsessive-compulsive disorder. Better understanding the functional organizational principles of thalamocortical circuits could therefore pave the way toward improved management of the alterations in behavioral flexibility and decision-making seen in these mental disorders. \n  \nKey-words: Decision\, Adaptative behavior\, Thalamocortical circuits\, Chemogenetic\, Fiber photometry \nJury\n\nEmmanuelle Courtiol\, CR (Université de Lyon) : rapporteure\nRomain Goutagny\, DR (Université de Strasbourg) : rapporteur\nAgnès Nadjar\, Pr (Université de Bordeaux) : examinatrice\nMathieu Wolff\, DR (Université de Bordeaux) : directeur de thèse\nFrédéric Gambino\, CR (Université de Bordeaux): codirecteur de thèse\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-emma-marillat/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261022T093000
DTEND;TZID=Europe/Paris:20261022T123000
DTSTAMP:20261002T011824
CREATED:20260831T100207Z
LAST-MODIFIED:20260925T112942Z
UID:205518-1792661400-1792672200@www.bordeaux-neurocampus.fr
SUMMARY:Mini-symposium: The Cellular Biology of the Neuron
DESCRIPTION:Venue: Centre Broca \n\nIn the frame of Léa Sarzynski’s thesis defense. \n9:30 – Jose Esteban (CBM Severo Ochoa\, Madrid) – Interplay between synaptic plasticity and cellular metabolism via PI3K signaling \n10:00 – Marina Mikhaylova (AG Optobiology\, Berlin) – A Neuron’s Disposal System: Autophagy and Unconventional Clearance Pathways \n10:30-10:50 – Coffee break \n10:50 – Christophe Leterrier (INP\, Marseille) – The axonal cytoskeleton down to the nanoscale \n11:20 – Flavie Lavoie-Cardinal (CERVO\, Laval) – Decoding synaptic diversity with AI-assisted nanoscopy \n
URL:https://www.bordeaux-neurocampus.fr/en/event/mini-symposium-2/
LOCATION:Amphi Centre Broca Nouvelle Aquitaine\, Université de Bordeaux\, 146 Rue Léo Saignat\, Bordeaux\, France\, France
CATEGORIES:For scientists,home-event,IINS,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261022T133000
DTEND;TZID=Europe/Paris:20261022T133000
DTSTAMP:20261002T011824
CREATED:20260902T194023Z
LAST-MODIFIED:20260902T194023Z
UID:205695-1792675800-1792675800@www.bordeaux-neurocampus.fr
SUMMARY:Soutenance d'HDR - Quentin Leyrolle
DESCRIPTION:Lieu : CARF \nSoutenance en français \n\nImpact du dialogue nutrition-microbiote intestinal sur la santé mentale : le rôle des métabolites bactériens. \nRésumé\nLes troubles de la santé mentale constituent un enjeu majeur de santé publique\, avec un impact humain\, sociétal et économique considérable. Ils sont caractérisés par une forte hétérogénéité clinique et une efficacité variable des traitements. L’identification de nouvelles cibles biologiques et le développement d’approches personnalisées constituent donc des priorités. Dans une approche transdiagnostique\, l’inflammation apparaît comme un mécanisme commun impliqué dans l’apparition et la persistance de nombreux symptômes psychiatriques et cognitifs. Le microbiote intestinal joue un rôle majeur dans l’axe intestin-cerveau\, notamment via la régulation des réponses immunitaires et de l’inflammation cérébrale. Ses métabolites constituent des médiateurs essentiels de cette communication. Parmi eux\, les indoles\, issus du métabolisme bactérien du tryptophane\, possèdent des propriétés immunomodulatrices et peuvent agir sur des mécanismes impliqués dans la neuroinflammation\, la neurotransmission et le comportement. Contrairement aux stratégies ciblant directement le microbiote\, dont l’efficacité varie selon la composition microbienne individuelle\, l’utilisation de ces molécules sous forme de postbiotiques permettrait une meilleure standardisation\, un contrôle précis des doses et une plus grande reproductibilité des effets biologiques. \nCe projet vise à établir les bases scientifiques et translationnelles nécessaires au développement de ces nouvelles interventions. Il s’articule autour de trois axes complémentaires : (1) développer une intervention postbiotique ciblée avec les indoles et caractériser leurs mécanismes d’action jusqu’à une première évaluation chez l’Homme ; (2) identifier de nouveaux métabolites bactériens pouvant servir de biomarqueurs de maladie\, de sous-types cliniques ou de réponse aux traitements\, ainsi que de futurs candidats postbiotiques\, dans différentes populations incluant la dépression\, le trouble déficit de l’attention avec ou sans hyperactivité (TDAH)\, le trouble dysphorique prémenstruel (TDPM) et les troubles cognitifs liés au vieillissement  ; et (3) évaluer des interventions nutritionnelles innovantes visant à stimuler la production endogène de métabolites bactériens protecteurs. \nÀ terme\, ce projet ambitionne de faire émerger une nouvelle génération d’approches ciblant l’axe intestin-cerveau via les métabolites microbiens\, afin de contribuer au développement d’interventions plus précises et personnalisées en santé mentale\, de l’enfance au vieillissement. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-dhdr-quentin-leyrolle/
CATEGORIES:HDR
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261022T143000
DTEND;TZID=Europe/Paris:20261022T143000
DTSTAMP:20261002T011824
CREATED:20260604T203618Z
LAST-MODIFIED:20260831T101121Z
UID:201275-1792679400-1792679400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Léa Sarzynski
DESCRIPTION:Venue: Centre Broca \nLanguage of defense:  english \n\nLéa Sarzynski \nIINS \nThesis director: Anna Brachet \nTitle\nDeciphering βII and βIII spectrins organisation and function in the dendritic cytoskeleton \nAbstract\nSpectrins are membrane skeletal proteins ubiquitously expressed in metazoans where they play key roles in regulating cell shape and organisation. As a consequence\, spectrin mutations are associated with a wide range of diseases affecting nearly every organ system\, including cancer\, osteoporosis\, and neurodevelopmental disorders. \nSpectrins typically assemble as α-β tetramers. In mammalian neurons\, αII-spectrin associates with one of three β-spectrins: βII\, βIII\, or βIV. These tetramers bind actin rings to form a periodic lattice repeated every ~190 nm known as the membrane periodic skeleton (MPS)\, a structure unique to neurons and very robust in the axon and its initial segment. \nWhile β-spectrin paralogues are generally segregated into distinct cellular compartments across cell types\, the somatodendritic compartment of neurons presents a notable exception: two paralogues\, βII- and βIII-spectrin\, are co-expressed there. βII-spectrin is conserved across all vertebrates\, whereas βIII-spectrin is evolutionarily more recent and is restricted to mammals. \nMy thesis aimed at investigating the organisation and function of βII and βIII spectrins in dendritic shafts and spines\, both in baseline and during synaptic plasticity. \nUsing advanced super-resolution microscopy techniques\, we showed that the dendritic MPS is built from a dual β-spectrin system in which βII and βIII spectrins are co-expressed and interleaved at the nanoscale within shafts and spine necks. Our results suggest that these paralogues form both homotypic (βII or βIII only) and heterotypic (βII/βIII) tetramers\, with an approximately 100 nm radial periodicity. While either paralogue alone is sufficient to maintain MPS lattice architecture\, their combined loss disrupts MPS integrity altogether. Using targeted mutagenesis\, we further demonstrated that actin binding is required to stabilise both paralogues within the MPS\, whereas βIII-spectrin anchoring additionally depends on phosphoinositide lipids. \nRegarding their role in dendritic spines\, combining imaging and electrophysiology\, we found that although βII- and βIII-spectrin are functionally redundant for MPS integrity\, both are independently required to maintain a correct number of spines and synapses. Detailed characterisation of the remaining spines revealed no effect of spectrin loss on spine morphology or glutamate receptor content (AMPA and NMDA)\, but uncovered a deficit in spine motility\, associated with reduced levels of non-muscle myosin II. \nRegarding synaptic plasticity\, loss of either β-spectrin alone\, or both in combination\, had no effect on long-term depression (LTD)\, but completely abolished long-term potentiation (LTP). To understand this phenotype\, we examined AMPAR molecular behaviour in detail. Using FRAP imaging and super-resolution microscopy\, we found that\, at baseline\, spectrin loss leaves GluA1 quantity unaffected but strongly increases its mobility and disrupts its nanoscale organisation\, revealing a key role for spectrins in constraining AMPAR diffusion and clustering. This disorganisation doesn’t impact basal synaptic transmission but impairs LTP induction and maintenance. \nAltogether\, our findings reveal that\, unlike the axonal MPS\, the dendritic MPS is a composite scaffold in which structural redundancy coexists with paralogue-specific regulatory mechanisms\, mainly identified for lipid binding so far. Despite this redundancy\, both spectrins are individually required for proper spine number and for LTP\, highlighting distinct layers of structural and functional control within a single membrane skeletal system. \nKey words: spectrin ; cytoskeleton ; dendrite \nJury\n\nFlavie Lavoie-Cardinal (CERVO\, Université Laval\, Canada):  Spokesperson\nJosé A. Esteban (CBM Severo Ochoa\, Madrid\, Espagne):  Spokesperson\nMarina Mikhaylova (AG Optogenetics\, Université de Berlin\, Allemagne): Examinator\nChristophe Leterrier (INP\, Université Aix-Marseille): Examinator\nNathalie Sans (Neurocentre Magendie\, Université de Bordeaux): Examinator\n\n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-lea-sarzynski/
LOCATION:Amphi Centre Broca Nouvelle Aquitaine\, Université de Bordeaux\, 146 Rue Léo Saignat\, Bordeaux\, France\, France
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261023T113000
DTEND;TZID=Europe/Paris:20261023T113000
DTSTAMP:20261002T011824
CREATED:20260326T171015Z
LAST-MODIFIED:20260327T123942Z
UID:196687-1792755000-1792755000@www.bordeaux-neurocampus.fr
SUMMARY:Friday seminar - Hanna Pickard
DESCRIPTION:Venue: Centre Broca \n\nHanna Pickard\nBloomberg Distinguished Professor of Philosophy and Bioethics and Krieger-Eisenhower Professor\nJohn Hopkins University\nhttps://philosophy.jhu.edu/directory/hanna-pickard/\nhttps://www.hannapickard.com/ \nAuthor of “What Would You Do Alone in a Cage with Nothing but Cocaine? A Philosophy of Addiction” \nInvited by Serge Ahmed (INCIA) \nTitle\nAddiction and the Good \n
URL:https://www.bordeaux-neurocampus.fr/en/event/friday-seminar-hanna-pickard/
CATEGORIES:For scientists,home-event,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261029
DTEND;VALUE=DATE:20261030
DTSTAMP:20261002T011824
CREATED:20260911T100628Z
LAST-MODIFIED:20260911T100746Z
UID:205933-1793232000-1793318399@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Abderrahman Fettah
DESCRIPTION:Venue: Centre Broca \n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-abderrahman-fettah/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR