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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20260329T010000
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DTSTART;VALUE=DATE:20260929
DTEND;VALUE=DATE:20261016
DTSTAMP:20261006T132844
CREATED:20260303T224940Z
LAST-MODIFIED:20260923T223555Z
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SUMMARY:Cajal lectures - Neurovascular circuits
DESCRIPTION:Venue: CARF \n\nLectures are open to everyone \nThe Neurovascular Unit & Beyond – How CNS Border Sites Dynamically Regulate Brain Homeostasis\nTuesday\, September 29 \n9am – Robert Thorne (Denali University of Minnesota)\nIntroduction to the CNS barriers and related translational concepts. \nWednesday\, September 30 \n9am – Jerome Badaut (CNRS\, France)\nOut of the Cage: Wild Vertebrate Insights into CNS Borders and Neurovascular Biology. \nThursday\, October 1st \n9am – Nanna Macaulay (University of Copenhagen Denmark)\nChoroid plexus and CSF dynamics – the where\, which\, what\, and how of CSF secretion. \nSaturday\, October 3rd \n11am – Valentin Nagerl (Goettingen Germany)\nBarriers within: Imaging the extracellular space in the brain. \nMonday\, October 5 \n9am – Benoit Vanhollebeke (Université libre de Bruxelles Belgium)\nThe dynamic Blood-Brain Barrier: From Development to Modulation. \n11am – Jean-Francois Ghersi Egea (INSERM Lyon France)\nThe choroid plexus-CSF system in neurodevelopment and beyond: Relevance to CNS physiology\, pathology\, pharmaco-toxicology. \nTuesday\, October 6 (Venue: Centre Broca) \n9am – Brita Engelhardt (Theodor Kocher Institute University of Bern Switzerland)\nBrain barriers: the dynamic gatekeepers of CNS immune privilege and homeostasis. \n11am – Richard Daneman (University of California San Diego US)\nEvolution of the blood-brain barrier. \nThursday\, October 8 \n9am – Martin Lauritzen (University of Copenhagen Denmark)\nCerebral blood vessel physiology and the importance of the glycocalyx. \nMonday\, October 12 \n9am – Christer Betsholtz (Uppsala University / Karolinska Sweden)\nAn overview of the leptomeninges\, their physiology and their barrier properties. \n11am – Gou Young Koh (KAIST\, Korea Korea)\nMeningeal Lymphatics: A Novel Pathway for Brain Clearance. \nWednesday\, October 14 \n9am – Irena Loryan (Uppsala University Sweden)\nThe journey of small molecules to the brain: an introduction to neuro PK/PD Concepts and their applications. \n11am – Joy Zuchero (Denali Therapeutics\, US)\nUtilizing the Brain Vasculature for CNS Drug Delivery. \nThursday\, October 15 \n11am – Henrik Zetterberg (University of Gothenburg Sweden)\nUpdate on biofluid-based biomarkers for Alzheimer’s disease and other neurodegenerative dementias. \nFriday\, October 16 \n9am – Caroline Menard (University of Laval Canada)\nThe stressed blood-brain barrier: from resilience to depression. \n\n\nDetails about the course\nhttps://cajal-training.org/on-site/neurovascular-unit-beyond/ \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neurovascular-circuits/
CATEGORIES:Cajal Lectures,For scientists,home-event
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DTSTART;TZID=Europe/Paris:20261009T140000
DTEND;TZID=Europe/Paris:20261009T140000
DTSTAMP:20261006T132844
CREATED:20260901T075112Z
LAST-MODIFIED:20260911T145132Z
UID:205553-1791554400-1791554400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Mélie Talaron
DESCRIPTION:Venue: BBS \n\nMélie Talaron\nTeam: Decision and Adptation – INCIA \nSupervisors: Etienne Coutureau et Nathan Holmes (The University of New South Wales) \nTitle\nHow does the brain integrate sensory and emotional memories? A study of the role of the hippocampus in sensory preconditioning in rats \nAbstract\nAnimals and humans adapt to their environments by learning to predict motivationally significant events such as the presence of food or danger. These predictions are often based on direct experience of the contingencies between different stimuli and events (e.g.\, a sound followed by the attack of a predator) but can also be generated in the absence of such experience. For example\, by linking the sensory and emotional elements of distinct memories\, we can generate novel inferences about stimuli that have only ever been experienced as innocuous. This type of inference has implications for how memories are encoded and stored in the brain; and raises the question of how they are integrated to generate adaptive behavior. The encoding and integration of associative memories are known to be hippocampus-dependent. Yet\, the differential contributions of dorsal versus ventral hippocampus and their connectivity in these processes remains unclear. This thesis combines behavioral paradigms\, pharmacological inactivations\, fiber photometry recordings\, and chemogenetic manipulations to investigate the role of dorsal and ventral hippocampus in the encoding and integration of sensory and emotional memories in rats. In the first set of experiments\, we establish auditory-visual sensory preconditioning and show that integration operates via mediated learning: rats retrieve past information at the time of conditioning to form new associations between stimuli. In a second line of work\, we use pharmacological inactivation to investigate the causal role of dorsal and ventral hippocampus in the different stages of sensory preconditioning. We show that ventral\, but not dorsal\, hippocampus is required to form innocuous stimulus-stimulus associations\, and that both subregions are necessary for mediated learning. Critically\, we identify the signature of successful mediated learning by evidencing higher dorso-ventral hippocampus connectivity during stimulus presentations. We show that this connection is part of a broader network supporting mediated learning\, which includes the perirhinal cortex. Finally\, using chemogenetic manipulation in a gustatory sensory preconditioning protocol\, we demonstrate that the hippocampus is also critical to encode and integrate memories even when stimuli are unimodal. This work highlights the differential contributions of dorsal and ventral hippocampus in animals’ ability to infer outcomes in the absence of direct experience when facing novel situations. \nKeywords: sensory preconditioning\, hippocampus\, rat\, fear conditioning\, conditioned taste aversion \nJury\nM. JOHANSEN Joshua\, Professor\, Irvine University of California\, Rapporteur\nMme DOYERE Valérie\, Directrice de recherche\, Institut des Neurosciences Paris-Saclay\, Rapporteure\nMme BONARDI Charlotte\, Senior Lecturer\, University of Nottingham\, Examinatrice\nMme ROUX Lisa\, Directrice de recherche\, Université de Bordeaux\, Examinatrice\nM. COUTUREAU Etienne\, Directeur de recherche\, Université de Bordeaux\, Directeur de these\nM. HOLMES Nathan\, Associate Professor\, The University of New South Wales\, Co-directeur de these \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-melie-talaron/
CATEGORIES:Thesis
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