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PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
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METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260928
DTEND;VALUE=DATE:20260930
DTSTAMP:20261006T132840
CREATED:20260129T085649Z
LAST-MODIFIED:20260624T191608Z
UID:191968-1790553600-1790726399@www.bordeaux-neurocampus.fr
SUMMARY:France Volume-EM first event
DESCRIPTION:Venue: Centre Broca \n\nConferences & Workshops \nMore details\nhttps://frvem2026.sciencesconf.org \nOrganizing Committee\n\nFanny Decoeur (BIC)\nRemi Le Borgne (Univ. Paris Cité)\nEsthel Pénard (Inst. Pasteur)\nMelina Petrel (BIC)\nBénédicte Salin (IBGC)\nSandra Sara (Synchrotron Soleil)\nFranceVolumeEM board\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/france-volume-em-first-event/
CATEGORIES:BIC,For scientists,home-event,Symposium,Trainings
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260929
DTEND;VALUE=DATE:20261016
DTSTAMP:20261006T132840
CREATED:20260303T224940Z
LAST-MODIFIED:20260923T223555Z
UID:196423-1790640000-1792108799@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures - Neurovascular circuits
DESCRIPTION:Venue: CARF \n\nLectures are open to everyone \nThe Neurovascular Unit & Beyond – How CNS Border Sites Dynamically Regulate Brain Homeostasis\nTuesday\, September 29 \n9am – Robert Thorne (Denali University of Minnesota)\nIntroduction to the CNS barriers and related translational concepts. \nWednesday\, September 30 \n9am – Jerome Badaut (CNRS\, France)\nOut of the Cage: Wild Vertebrate Insights into CNS Borders and Neurovascular Biology. \nThursday\, October 1st \n9am – Nanna Macaulay (University of Copenhagen Denmark)\nChoroid plexus and CSF dynamics – the where\, which\, what\, and how of CSF secretion. \nSaturday\, October 3rd \n11am – Valentin Nagerl (Goettingen Germany)\nBarriers within: Imaging the extracellular space in the brain. \nMonday\, October 5 \n9am – Benoit Vanhollebeke (Université libre de Bruxelles Belgium)\nThe dynamic Blood-Brain Barrier: From Development to Modulation. \n11am – Jean-Francois Ghersi Egea (INSERM Lyon France)\nThe choroid plexus-CSF system in neurodevelopment and beyond: Relevance to CNS physiology\, pathology\, pharmaco-toxicology. \nTuesday\, October 6 (Venue: Centre Broca) \n9am – Brita Engelhardt (Theodor Kocher Institute University of Bern Switzerland)\nBrain barriers: the dynamic gatekeepers of CNS immune privilege and homeostasis. \n11am – Richard Daneman (University of California San Diego US)\nEvolution of the blood-brain barrier. \nThursday\, October 8 \n9am – Martin Lauritzen (University of Copenhagen Denmark)\nCerebral blood vessel physiology and the importance of the glycocalyx. \nMonday\, October 12 \n9am – Christer Betsholtz (Uppsala University / Karolinska Sweden)\nAn overview of the leptomeninges\, their physiology and their barrier properties. \n11am – Gou Young Koh (KAIST\, Korea Korea)\nMeningeal Lymphatics: A Novel Pathway for Brain Clearance. \nWednesday\, October 14 \n9am – Irena Loryan (Uppsala University Sweden)\nThe journey of small molecules to the brain: an introduction to neuro PK/PD Concepts and their applications. \n11am – Joy Zuchero (Denali Therapeutics\, US)\nUtilizing the Brain Vasculature for CNS Drug Delivery. \nThursday\, October 15 \n11am – Henrik Zetterberg (University of Gothenburg Sweden)\nUpdate on biofluid-based biomarkers for Alzheimer’s disease and other neurodegenerative dementias. \nFriday\, October 16 \n9am – Caroline Menard (University of Laval Canada)\nThe stressed blood-brain barrier: from resilience to depression. \n\n\nDetails about the course\nhttps://cajal-training.org/on-site/neurovascular-unit-beyond/ \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neurovascular-circuits/
CATEGORIES:Cajal Lectures,For scientists,home-event
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DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T140000
DTSTAMP:20261006T132840
CREATED:20260826T151049Z
LAST-MODIFIED:20260826T151635Z
UID:205194-1790690400-1790690400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Camille Ruffier
DESCRIPTION:Venue: CARF \nDefense in french \n\nCamille Ruffier\nNutriNeuro \nTitle\nDevelopment of photoactivable polymersomes for temporal et spatial control of molecular delivery into the brain \nAbstract\nMany neurological and neuropsychiatric diseases remain poorly treated and constitute a major cause of disability worldwide. Several of these pathologies are localized to a specific area of the brain\, and their treatment remains inadequate: systemically administered drugs reach the affected areas only in limited concentrations and without precise spatiotemporal control. While the blood-brain barrier and the structural heterogeneity of the brain severely limit the targeted delivery of drugs\, alternative approaches such as intracranial pharmacology offer promising prospects. However\, these methods remain passive: drug diffusion is neither dose-dependent nor controllable over time\, which limits their clinical efficacy. Meanwhile\, nanotechnologies offer stable and versatile vectors capable of efficiently encapsulating and transporting various therapeutic agents\, but they do not\, on their own\, allow for localized and on-demand delivery. Our approach addresses these limitations by developing photoactivatable polymersomes capable of releasing their contents in a localized manner under the influence of light.\nMy work is based on three main axes: (i) the design of photoactivable and biocompatible polymersomes; (ii) the evaluation of their safety in order to ensure safe and effective use at the level of brain tissue; (iii) the demonstration of an efficient photorelease of bioactive molecules in neuronal circuits.\nOur work confirmed that the emulsion-centrifugation process is a suitable method for obtaining a high yield of photoactivable micrometer-sized polymersomes (mean diameter of 8.27 ± 0.14 µm)\, capable of rapid and localized release of their contents\, with a mean release time of 6.39 ± 0.90 s. The biocompatibility and release capacity of these polymersomes were evaluated in vitro on primary murine cortical cultures. Neither illumination at 470 nm (optical fiber Ø 400 µm\, NA 0.5\, 20 s)\, nor incubation with polymersomes at increasing concentrations (600 to 9000 polymersomes/well)\, nor the combination of the two affected cell viability. In vivo tolerance was confirmed by injecting polymersomes into the brains of mice and analyzing glial reactivity by immunolabeling IBA-1 and GFAP proteins 48 hours and 3 weeks post-injection. The polymersomes did not elicit any glial response beyond the effect of the stereotaxic injection itself\, demonstrating that the polymersomes and their photoactivation are well tolerated by brain cells and tissues. To demonstrate the efficacy of photorelease in brain tissue and to quantify its ability to modulate neuronal processes\, we developed a protocol based on measuring neuronal activity. Electrophysiological recordings were performed on mouse brain sections preserving the synaptic connection between the CA3 and CA1 regions of the hippocampus\, a key area involved in memory processes. Thanks to the encapsulation and then photorelease of CNQX (100 µM)\, a competitive antagonist of AMPA/kainate receptors\, we have demonstrated that polymersomes act as on-demand reservoirs\, allowing prolonged and localized drug administration around the injection site.\nIn conclusion\, photoactivable polymersomes represent a promising tool for studying brain mechanisms and developing innovative therapeutic strategies. Their potential is currently being evaluated in vivo in a murine model of glioblastoma for the targeted release of CNQX to limit tumor invasion. \nKeywords: polymersomes\, targeted molecular delivery\, photostimulation\, brain \nPublication\nhttps://doi.org/10.21203/rs.3.rs-9232875/v1 \nJury\n\nMme BOSCH-BOUJU Clémentine – Maître de conférences\, Nutrineuro (Bordeaux) – Directrice de thèse\nMme NADJAR Agnès – Professeure\, IMN (Bordeaux) – Présidente du jury\nMme MURA Simona – Professeure\, Institut Galien Paris-Saclay (Paris) – Rapporteur\nM. VENANCE Laurent – Directeur de recherche\, Collège de France (Paris) – Rapporteur\nMme MUTSCHLER Angela – Maître de conférences\, LCPO (Bordeaux) – Examinateur\nM. CAZORLA Maxime – Chargé de recherche\, INT (Marseille) – Examinateur\nMembres invités :\n– M. LECOMMANDOUX Sébastien – Professeur\, LCPO (Bordeaux)\n– M. MCCLENAGHAN Nathan – Directeur de recherche\, ISM (Bordeaux)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-camille-ruffier/
CATEGORIES:Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T143000
DTEND;TZID=Europe/Paris:20260929T143000
DTSTAMP:20261006T132840
CREATED:20260601T135933Z
LAST-MODIFIED:20260831T091128Z
UID:202797-1790692200-1790692200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Tessa Scarabello
DESCRIPTION:Venue: Centre Broca \nLanguage of the defense: english \n\nTessa Scarabello\nIINS \nThesis director: Lisa Roux \nTitle\nOlfaction and Oxytocin in female alloparental behaviors \nAbstract\nAlloparental behaviors define the set of actions undertaken by adults to insure the survival of other individuals’ progeny such as crouching over the young\, retrieval\, or parental nesting. The very first encounter with a pup can trigger the emergence of these behaviors in naive virgin mice who had never expressed these behaviors before\, and their performances is known to improve upon repeated exposures to pups. Yet\, the neurobiological substrates of this phenomenon are still unclear. Previous work highlighted the importance of auditory cues and oxytocin (OT) release in the auditory cortex of virgin females for the establishment of retrieval behavior. In contrast\, the role played by olfaction in the transition of mice from naive to efficient caretakers remains so far little explored. \nThe goal of this work has been to assess the impact of olfaction in the establishment of alloparental behaviors in naive female mice\, as well as the influence of oxytocinergic neuromodulation in the main part of the olfactory cortex\, the piriform cortex (PIR). \nWe found that within just a few minutes\, naive C57Bl6/J female mice exposed to pups start building a nest to host the pup. However\, when the odor of the pup is masked\, the onset of nesting in these mice is delayed despite comparable pup investigation times compared to controls. In addition\, mice display non-adapted behaviors when they are unable to smell the natural odor of the pup: they favor failed pup retrievals over nest building. Altogether\, these first observations suggest that olfaction plays a role in triggering adapted alloparental behaviors upon first pup exposure. \nGiven the role of OT in social behaviors\, we hypothesized that oxytocinergic transmission in the PIR could play a role in alloparental behavior emergence. Using immunochemistry in the Oxtr-3xHA-T2A-iCreERT2 mouse line\, we showed that oxytocin receptors (OTR) are mostly expressed in the deep layer III of the PIR\, unlike in previous works based on OTR-targeted antibodies. To assess the dynamics of OT signaling in the PIR during our task\, and in particular during pup olfactory investigation preceding the start of nesting\, we monitored mice with fiber photometry using an OT GRAB sensor expressed in the PIR. This method did not reveal any significant OT level change at the time of pup investigation but we found a slow build-up of OT in the PIR spanning the whole task time course. In contrast\, using GCaMP8m expressed in OTR-positive cells\, we found that OTR-positive neurons are consistently activated across all pup olfactory investigation events\, even though they represent only a small percentage of PIR cells. Altogether\, these results indicate that OTR and OT are present in the PIR upon pup exposure\, and that they could exert a slow influence on neuronal responses in PIR circuits. \nTo selectively suppress the expression of OTR in the PIR and test the impact on pup care strategy\, we adopted a viral approach to express the cre-recombinase locally in the PIR of Oxtr[flox] mice. Similar to previous experiments with pup odor masking\, this local knock-out of the OTR in the PIR impaired pup care strategy\, compared to mice injected with a control virus. \nTo identify the brain-wide circuits involved in this behavioral effect\, we used brain-wide activity mapping combined with brain clearing (iDISCO) to compare the brains of naive females exposed for the first time to a pup\, with or without a local knock-out of OTR in the PIR. We found striking differences in the activation of the Orbito Frontal Cortex\, a region known to participate to sensory processing and decision-making in social contexts. These results suggest that OT in the PIR contributes to gate the neuronal circuits recruited during pup odor exposure\, leading to the selection of appropriate behaviors. Altogether\, this work paves the way for future research to understand how olfaction and its modulation by OT shapes pup-directed behavioral changes in naive female mice. \n  \nKey words: Alloparental behaviors; Oxytocin ; Olfaction \nJury\n\nMrs BUONVISO Nathalie\, DR\, CRNL\, Lyon – Spokesperson\nMrs CARCEA Ioana\, AP\, Rutgers Brain Health Institute\, N.J – Spokesperson\nMrs MUSCATELLI Françoise\, DR\, INMED\, Marseille – Examinator\nMr  RENIER Nicolas\, DR\, ICM\, Paris – Examinator\nMrs ROUX Lisa\, DR\, IINS\, Bordeaux – Thesis director\nMr FERREIRA Guillaume\, DR\, INRAE\, Bordeaux – Invited\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-tessa-scarabello/
CATEGORIES:Thesis
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