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X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20260329T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260626T110000
DTEND;TZID=Europe/Paris:20260626T110000
DTSTAMP:20260624T121407
CREATED:20260617T160623Z
LAST-MODIFIED:20260617T161110Z
UID:203398-1782471600-1782471600@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire « L'IA à l'université de Bordeaux »
DESCRIPTION:Lieu : Salle de conférence de l’IBGC (dans la limite des places disponibles) ou sur Zoom \nParticipation à distance (Zoom) :\nLien de connexion : https://u-bordeaux-fr.zoom.us/j/83262492410 \nOrganisé par le département SBM \n\nIntervenant : \nXavier Blanc\, vice-président en charge de l’intelligence artificielle \nRésumé\nDepuis plusieurs mois\, l’université de Bordeaux a engagé une réflexion collective sur la place de l’intelligence artificielle dans ses différentes missions. L’objectif de cette présentation est de proposer un panorama\, nécessairement non exhaustif\, des nombreuses initiatives déjà menées au sein de l’établissement dans les domaines de la recherche\, de la formation\, de l’innovation et des services. \nL’intelligence artificielle (IA) constitue aujourd’hui une opportunité majeure pour accélérer la production de connaissances\, enrichir les pratiques pédagogiques\, améliorer certains processus administratifs et renforcer les liens avec le monde socio-économique. Elle représente également un enjeu stratégique pour l’attractivité et le rayonnement de l’université. \nCette transformation s’accompagne toutefois de défis importants : intégrité académique\, protection des données\, maîtrise des biais\, souveraineté numérique\, conformité réglementaire et développement d’usages responsables. L’université a ainsi un rôle essentiel à jouer pour accompagner ces évolutions de manière éclairée et maîtrisée. \nCette présentation permettra de revenir sur les premiers travaux conduits dans le cadre de la vice-présidence IA : cartographie des initiatives existantes\, échanges avec les composantes\, les laboratoires et les services\, coordination des acteurs\, identification des besoins et définition des premiers axes de travail visant à construire une stratégie IA cohérente à l’échelle de l’établissement. \nSource : https://sbm.u-bordeaux.fr/evenements/seminaire-lia-luniversite-de-bordeaux \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminaire-lia-a-luniversite-de-bordeaux/
CATEGORIES:Evénement Université,For scientists,home-event,Other events
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260626T130000
DTEND;TZID=Europe/Paris:20260626T130000
DTSTAMP:20260624T121407
CREATED:20260408T150849Z
LAST-MODIFIED:20260604T092433Z
UID:198589-1782478800-1782478800@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Ibukun Akinrinade
DESCRIPTION:Venue: Institut Magendie (conference room) \n\nIbukun Akinrinade\nBains lab\nHotchkiss brain Institute (HBI)\, University of Calgary\, Canada\nhttps://www.ibukunakinrinade.com/ \nInvited by Giovanni Marsicano (Neurocentre Magendie) \nTitle\nDecoding the Social World: Neural Mechanisms of Social Information Processing \nAbstract\nSocial interactions are fundamental to survival\, yet they require animals to continuously acquire\, interpret\, and evaluate information about others to guide appropriate behavioural responses. Despite the importance of these processes\, the neural mechanisms that transform social information into adaptive behaviour remain poorly understood. \nIn this seminar\, I will present research examining how the brain processes socially relevant information across multiple stages of social interaction. Using zebrafish and mouse models\, I identify evolutionarily conserved neural mechanisms that enable animals to detect socially transmitted cues\, recognize the affective states of others\, and rapidly evaluate unfamiliar conspecifics during direct encounters. Combining behavioural analysis\, neural activity recordings\, genetics\, and circuit manipulations\, I show that oxytocin-dependent circuits regulate the detection and interpretation of socially derived information\, and the hypothalamic corticotropin-releasing hormone neurons of the paraventricular nucleus are necessary for rapid social appraisal during uncertain social encounters. \nTogether\, these findings reveal conserved neural systems that allow animals to extract information from others and transform it into adaptive behavioural responses\, providing new insights into the neural basis of social behaviour and its disruption in neuropsychiatric disorders. \nSelected publications\nAkinrinade I\, Kareklas K\, Teles MC\, Reis TK\, Gliksberg M\, Levkowitz G\, Oliveira RF. (2023). Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish. Science (New York\, N.Y.). 379(6638): 1232-1237. DOI: 10.1126/science.abq5158 \nAkinrinade ID\, Varela SAM\, Oliveira RF (2023). Sex differences in social buffering and social contagion of alarm responses in zebrafish. Animal cognition. (accepted). \nScaia MF\, Akinrinade I\, Petri G\, Oliveira RF (2022). Sex Differences in Aggression Are Paralleled by Differential Activation of the Brain Social Decision-Making Network in Zebrafish. Frontiers in behavioural neuroscience. 16: 784835. https://doi.org/10.3389/fnbeh.2022.784835 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-ibukun-akinrinade/
CATEGORIES:For scientists,home-event,Impromptu seminar,Magendie
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260626T140000
DTEND;TZID=Europe/Paris:20260626T140000
DTSTAMP:20260624T121407
CREATED:20260604T083823Z
LAST-MODIFIED:20260612T163140Z
UID:198588-1782482400-1782482400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Meera Chandra
DESCRIPTION:Venue: Centre Broca \nDefense in english \n\nMeera Chandra\nIINS \nSupervisor: Eric Hosy \nTitle\nNanoscale organization and plasticity-dependent remodeling of glutamate receptors in striatal synapses and its implications in Shank3- associated ASD \nAbstract\nAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by deficits in social communication\, repetitive behaviours\, and restricted interests. Large-scale exome and genome sequencing have converged with high confidence to identify risk genes that encode proteins associated with synaptic assembly\, maturation\, and functions. Among the most prominent are scaffolding proteins of the Shank family (Shank1-3)\, neuroligins\, neurexins\, and SYNGAP1. These genes regulate the nanoscale architecture of excitatory postsynapses by anchoring glutamate receptors\, controlling actin dynamics\, and influencing overall synaptic transmission. Shank3 is a highly penetrant monogenic cause of ASD. Despite strong genetic and behavioural evidence\, the direct understanding of nanoscale-level alterations in Shank3-haploinsufficiency remain incompletely understood. On the other hand\, while AMPA-R nanodomain organisation has been observed in the hippocampus\, it has not been systematically examined in the striatum. \nThis thesis investigates region-specific differences in AMPA-R nanoscale clustering between the hippocampus and striatum and characterized the consequences of Shank3 deficiency in these two brain regions\, which are critically implicated in ASD behavioural phenotypes. \nWe found that AMPA-Rs display distinct nanodomain organization in hippocampal versus striatal synapses. The differential expression of Shank family proteins in the hippocampus and striatum regulates the dependency of synapses on Shank3 for the organization and anchoring of receptors.  Shank3 deficiency caused more pronounced surface alterations in AMPA-R levels in the hippocampus but had subtler effects on nanodomain structure in the striatum. Nevertheless\, electrophysiological studies have revealed robust deficits in AMPA-R-mediated synaptic transmission in Shank3-KO mice. Complete Shank3 deletion also led to upregulation of the surface expression of NMDA-R in dendritic spines in both brain regions. Finally\, Shank3 deletion impaired mGluR-dependent long-term depression (LTD)\, causing no alteration in surface AMPA-R levels upon mGluR-LTD\, followed by defective LTD-induced spine loss\, as revealed by super-resolution and confocal imaging. Preliminary data also revealed differential synaptic responses to inflammatory cues in Shank3 heterozygous and knockout mice. \nTogether\, with electrophysiology\, super resolution microscopy and confocal imaging\, this study provides the first nanoscale characterization of AMPA-R organization in the striatum and establishes a mechanistic link between Shank3 deficiency and region-specific iGluR clustering dysregulation and plasticity deficits. These findings offer new insights into well-established LTD-mechanisms using super-resolution imaging combined with the pathophysiology of ASD. \nKey words : Autism\, Shank3\, Nanoscale organization\, AMPA-R\, Long term depression\, Striatum \nJury\n\nCécile Charrier (ENS Paris)\nJulie Perroy (IGF\, Montpellier)\nLaurent Venance (CIRB\, College de France\, Paris)\nJérôme Baufreton (IMN\, Bordeaux)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-meera-chandra/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20260626T140000
DTEND;TZID=Europe/Paris:20260626T140000
DTSTAMP:20260624T121407
CREATED:20260610T121221Z
LAST-MODIFIED:20260610T121221Z
UID:202939-1782482400-1782482400@www.bordeaux-neurocampus.fr
SUMMARY:BIC Webinar: Image Deconvolution\, Restoration and Analysis with Huygens
DESCRIPTION:\nZoom link: https://us02web.zoom.us/j/89210143160?pwd=WB3PyrSgUl31JmnaQHddmIHYF8DCGD.1 \n\nJoin this webinar to explore the fundamentals of Huygens deconvolution and gain a deeper understanding of the theoretical principles underlying this image analysis method. \nThrough practical demonstrations\, you will discover how image deconvolution and restoration techniques can improve image quality and contribute to obtaining reproducible analysis results. \nThe session will also cover the main benefits and limitations of these approaches\, as well as essential quality control strategies for ensuring accurate\, reliable\, and reproducible results. \nYour images may be used as examples during the webinar. You can submit them via the upload page on our website: https://svi.nl/upload \nThe images will be used solely for the purposes of this webinar. \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/bic-webinar-image-deconvolution-restoration-and-analysis-with-huygens/
CATEGORIES:BIC,For scientists,home-event,Trainings
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