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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20251026T010000
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DTSTART;VALUE=DATE:20251124
DTEND;VALUE=DATE:20251206
DTSTAMP:20260530T083319
CREATED:20250221T135325Z
LAST-MODIFIED:20251205T164224Z
UID:181025-1763942400-1764979199@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: "Neuroimmunology in Physiology and Disease: From Fundamental Concepts to Hands-on Training"
DESCRIPTION:Venue : CARF \nOrganized by the Bordeaux School of Neuroscience. \nLectures are open to everyone. \n\nNovember 26 – 9:00am \nSonia Garel (Institut de Biologie de l’École Normale Supérieure\, France)\nMicroglia in early brain construction. \nNovember 26 – 11:00am\n Michael Heneka (Luxemburg University\, Luxemburg)\nTunneling nanotubes as rescue routes between microglia and neurons \nNovember 27 – 9:00am \nAndrew Greenhalgh (University of Manchester\, UK)\nNavigating a career in neuroimmunology. \nNovember 28 – 9:00am \n Renzo Mancuso  (VIB\, Antwerp\, Belgium)\nElucidating the role of human microglia in neurodegeneration \nNovember 28 – 11:00am \nArthur Liesz (Ludwig-Maximilians Munich University\, Germany)\nImmunological brain-body interaction after stroke. \nDecember 1 – 9:00am \nRejuane Rua (Centre d’Immunologie de Marseille Luminy\, France)\nBrain border macrophages : more than immune sentinels? \nDecember 3 – 9:00am \nMichal Schwartz (Weizmann Institute of Science\, Israel)\nTBA \nDecember 3 – 11:00am \nAleksandra Deczkowska (Institut Pasteur\, France)\nImmune regulation of brain physiology. \nDecember 5 – 9:00am \nLaurent Groc (University of Bordeaux\, CNRS\, France)\nDecrypting pathogenic brain autoantibody at the molecular level. \nDecember 4 – 5:00pm \nJonathan Kipnis (Washington University School of Medicine\, USA)\nWhat is CNS immune privilege? An update. \nCourse Directors \n\nRosa Chiara Paolicelli – University of Lausanne\, Switzerland\nAgnes Nadjar – Neurocentre Magendie\, University of Bordeaux\, France\nStefano Pluchino – University of Cambridge\, UK\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neuroimmunology-in-physiology-and-disease-from-fundamental-concepts-to-hands-on-training/
CATEGORIES:Cajal Lectures,For scientists
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20251126
DTEND;VALUE=DATE:20251129
DTSTAMP:20260530T083319
CREATED:20241213T113900Z
LAST-MODIFIED:20251128T160738Z
UID:178855-1764115200-1764374399@www.bordeaux-neurocampus.fr
SUMMARY:GDR NeuralNet - Annual Meeting
DESCRIPTION:Venue: Centre Broca \n\nProgramme\n\nhttps://neuralnet2025.sciencesconf.org/\n\nScientific committee\n\nJulien Courtin (Neurocentre Magendie)\nXavier Hinaut (IMN)\nFrédéric Lanore (IINS)\nCatherine Le Moine (INCIA)\n\n\nMore details\nhttps://neuralnet2025.sciencesconf.org/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/neuralnet-2025/
CATEGORIES:For scientists,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251128T140000
DTEND;TZID=Europe/Paris:20251128T140000
DTSTAMP:20260530T083319
CREATED:20251110T175206Z
LAST-MODIFIED:20251127T143303Z
UID:189598-1764338400-1764338400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - John Bickle
DESCRIPTION:Venue: BBS\, salle sud\n \nAvailable on Zoom: https://u-bordeaux-fr.zoom.us/j/87817347170?pwd=sUXG8z2zZPEjWP2bqIU7odY9JlYOre.1 \n\nJohn Bickle\nProfessor of Philosophy and Shackouls Honors College Faculty\, Mississippi State University and Scientist-Educator\, Department of Advanced Biomedical Education\,\nUniversity of Mississippi Medical Center\, USA \nTitle\nAssessing Neurophilosophy and the Philosophy of Neuroscience\, circa 2026 \nAbstract\nRemarkably (at least to those of us who were there when it happened) next April 29 marks the fortieth anniversary of the publication of Patricia Churchland’s seminal book\, Neurophilosophy: Toward a Unified Science of the Mind-Brain (MIT Press/Bradford\, 1986). The fields of both neurophilosophy and the philosophy of neuroscience have expanded extensively since that landmark cornerstone. My Stanford Encyclopedia of Philosophy entry\, “The Philosophy of Neuroscience” (Bickle\, Mandik\, Landreth\, https://plato.stanford.edu/entries/neuroscience/) has tracked the twists and turns these fields have taken\, with numerous updates over the quarter-century since it was first published in 1999. Every past revision added a new section detailing topics and publications that had gained prominence since the previous one. So while the most recent revision (last updated August 2019) presents a detailed history of these two fields\, much of that history is now by and large forgotten\, and only marginally relevant for scholars who want an introduction to current research foci. It is thus time to start again from scratch\, and Gualtiero Piccinni has graciously agreed to join Tony Landreth and me to do this necessary overhaul. \nWhich episodes in the histories of these two fields are worth mentioning in a greatly condensed historical first section? The initial focus on intertheoretic reduction and its competitors as providing resources to reformulate philosophy’s mind-body problem? The rise of connectionism? The initial sketches\, the early impacts and the subsequent dominance of the “new mechanist” account of explanation? The impact of the science-in-practice movement from the broader philosophy of science over the past two decades\, with its emphasis on detailed case studies and on extra-theory aspects of science\, such as experimentation\, modeling and research tools? \nWhat now are the defining issues of neurophilosophy and the philosophy of neuroscience\, and which published works best reflect current debates? Candidate topics are numerous: recent challenges to mechanism as the correct account of explanation in neuroscience\, even of causal explanation; experimental practices in both “wetlab” neurobiology and in systems/cognitive/affective neuroscience; recent accounts of ‘representation’ and ‘computation’ in the nervous system; neurocognitive architectures and “ontologies”; the neuroscience of senses other than vision and pain (for example\, olfaction)\, and ultimately of consciousness; the rise and development of neuro-axiology\, i.e.\, neuroethics\, neurolaw\, neuroaesthetics. Are there other “hot” or emerging topics? Whose publications are the canonical ones for these current concerns? \nMy aim in this talk/seminar is twofold. First\, to report on the progress Piccinini\, Landreth and I have made on this project. Second\, to provoke a fruitful discussion with all participants to help us push this project onward. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-john-bickle/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20251128T143000
DTEND;TZID=Europe/Paris:20251128T143000
DTSTAMP:20260530T083319
CREATED:20250707T071223Z
LAST-MODIFIED:20251124T115808Z
UID:185890-1764340200-1764340200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Éloïse Daniel
DESCRIPTION:Venue : Centre Broca \n\nÉloïse Daniel\nTeam : Planar polarity and plasticity\nNeurocentre Magendie \nTitle\nIdentification and characterisation of new molecular tools to study the Planar Cell Polarity signalling and its role in cognitive processes \nAbstract\nA good memory is not just about correctly recalling learned information\, but also about encoding memories distinctly from one another and being able to retrieve a complete memory from partial information. These two cognitive processes are pattern separation – or memory discrimination – and pattern completion – or memory generalisation. Both rely on the hippocampus\, a brain structure that is crucial for learning\, consolidating\, and recalling memories.  To accomplish these complex tasks\, the hippocampus relies on the trisynaptic circuit composed of the entorhinal cortex\, the dentate gyrus\, and the CA3 region of the hippocampus. These structures can be compromised by alterations in intra- and intercellular signalling\, either in adulthood or during normal and pathological ageing\, or during the maturation of neural circuits. Numerous studies have shown that receptors\, adhesion molecules\, or scaffolding proteins may play a role in these memory processes. \nAmong these genes and proteins are members of the planar cell polarity (PCP) signalling pathway. This signalling pathway is conserved and known to shape tissues during development by regulating adhesion complexes and cytoskeletal dynamics. In this project\, we are testing the hypothesis that modulation of PCP signalling disrupts the structural organisation of neurons in the dentate gyrus\, which regulates specific cognitive processes such as pattern separation and pattern completion. We propose to characterise the role of C-Daam1 truncation – the C-terminal domain of the endogenous Daam1 protein belonging to PCP signalling – in specific brain functions. To do this\, we combined molecular and cellular biology approaches with complex hippocampus-dependent behavioural tasks designed to capture the properties and elementary components of declarative memory in animals. \nOur results show that overexpression of C-Daam1 in adult mice reduces the dendritic complexity of granule cells in the dentate gyrus and neuronal activation in both the dentate gyrus and CA3. Behaviourally\, this translates into enhanced mnemonic discrimination (pattern separation) but impaired memory generalisation (pattern completion). In addition\, PCP signalling dependent on Daam1 has recently been associated with synaptic dysfunction induced by β-amyloid accumulation\, a protein directly involved in Alzheimer’s disease. We therefore evaluated the potential effect of C-Daam1 in transgenic mice modelling this pathology. Strikingly\, C-Daam1 enables long-term memory maintenance in the early stages of the disease. \nThis project provides new insights into the mechanisms supporting functional memory and opens up new therapeutic avenues for maintaining mnemonic abilities during pathological ageing. \nKeywords: Hippocampus\, Memory\, Planar Cell Polarity \nPublications\nNon publié \nDaniel E.L.J.\, Moreau M.\, Houguet A.\, Isch C.\, Poirault-chassac S.\, Depret N.\, Montcouquiol M.\, Desmedt A.\, Marighetto A.\, Sans N.\n‘Modulation of the PCP signaling pathway regulates mnemonic discrimination and pattern completion processes in mice’. (in preparation) \nSélection \nBenjamin J. A. Robert and others\, ‘Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion’\, Cell Reports\, 31.10 (2020)\, p. 107743\, doi:10.1016/j.celrep.2020.107743. \nHabas et al.\, ‘Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1’\, Cell 107\, no. 7 (2001): 843–54\, https://doi.org/10.1016/s0092-8674(01)00614-6. \nKatherine J. Sellers et al.\, ‘Amyloid β Synaptotoxicity Is Wnt-PCP Dependent and Blocked by Fasudil’\, Alzheimer’s & Dementia 14\, no. 3 (2018): 306–17\, https://doi.org/10.1016/j.jalz.2017.09.008. \nJury\n\nDr RAMPON Claire – Université de Toulouse – Rapportrice\nDr POIRIER Roseline – Université de Paris-Saclay    Rapportrice\nDr PIETROPAOLO Susanna – Université de Bordeaux         Examinatrice\nDr WOLFF Mathieu – Université de Bordeaux – Examinateur\nDr SANS Nathalie – Université de Bordeaux – Directrice de thèse (membre invité)\nDr MARIGHETTO Aline – Université de Bordeaux – Membre invité\n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-eloise-daniel/
CATEGORIES:Magendie,Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251128T143000
DTEND;TZID=Europe/Paris:20251128T143000
DTSTAMP:20260530T083319
CREATED:20250904T080244Z
LAST-MODIFIED:20251113T091541Z
UID:187892-1764340200-1764340200@www.bordeaux-neurocampus.fr
SUMMARY:Thsesis defense - Simon Lecomte
DESCRIPTION:Venue: BBS \n\nSimon Lecomte\nTeam: Synapses et circuits neuronaux \nThesis supervisor: Christophe Mulle \nTitle\n“Impact of FMRP deletion on presynaptic mechanisms at mf-CA3 synapse” \nAbstract\nFragile X syndrome (FXS)\, the most common inherited form of intellectual disability and a major cause of autism spectrum disorder\, results from silencing of the Fmr1 gene encoding the RNA-binding protein\, FMRP. While most research has focused on dendritic and postsynaptic mechanisms\, emerging evidence suggests a presynaptic role of FMRP\, particularly through cAMP-dependent signaling pathways. This project investigates how loss of FMRP affects presynaptic mechanisms in the CA3 region of the hippocampus\, with a specific emphasis on cAMP–protein kinase A (PKA) signaling. Using patch-clamp electrophysiology and imaging in acute and fixed mouse hippocampal slices with targeted genetic mutations in dentate gyrus cells\, I show that presynaptic loss of FMRP disrupts mossy fiber–CA3 synaptic transmission. My results indicate a deregulation of cAMP–PKA signaling and altered presynaptic calcium-dependent mechanisms\, providing new insights into the presynaptic contribution of FMRP to synaptic function in FXS. \nKeywords: FMRP\, hippocampus\, mossy fiber\, presynapse\, patch-clamp \nPublication\nMarneffe\, C.\, Moreira-de-Sá\, A.\, Lecomte\, S.\, Erhardt\, A.\, & Mulle\, C. (2025). Short term plasticity at hippocampal mossy fiber synapses. Neuroscience\, 578\, 105-117. (ainsi que diverses publications dans le journal étudiant brainstorm\, et podcast “Thèse et vous”)\nJury\n\nAndreas Frick (Neurocentre Magendie\, Bordeaux\, président du jury\, examinateur)\nIngrid Bureau (INMED\, Marseille\, rapportrice)\nPierre Vincent (IGF\, Montpellier\, rapporteur)\nJoana Lourenço (ICM\, Paris\, examinatrice)\nYann Humeau (FMI\, Bâle\, invité)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thsesis-defense-simon-lecomte/
CATEGORIES:Thesis
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