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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20250330T010000
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DTSTART:20251026T010000
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DTSTART;VALUE=DATE:20251124
DTEND;VALUE=DATE:20251206
DTSTAMP:20260421T151620
CREATED:20250221T135325Z
LAST-MODIFIED:20251205T164224Z
UID:181025-1763942400-1764979199@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: "Neuroimmunology in Physiology and Disease: From Fundamental Concepts to Hands-on Training"
DESCRIPTION:Venue : CARF \nOrganized by the Bordeaux School of Neuroscience. \nLectures are open to everyone. \n\nNovember 26 – 9:00am \nSonia Garel (Institut de Biologie de l’École Normale Supérieure\, France)\nMicroglia in early brain construction. \nNovember 26 – 11:00am\n Michael Heneka (Luxemburg University\, Luxemburg)\nTunneling nanotubes as rescue routes between microglia and neurons \nNovember 27 – 9:00am \nAndrew Greenhalgh (University of Manchester\, UK)\nNavigating a career in neuroimmunology. \nNovember 28 – 9:00am \n Renzo Mancuso  (VIB\, Antwerp\, Belgium)\nElucidating the role of human microglia in neurodegeneration \nNovember 28 – 11:00am \nArthur Liesz (Ludwig-Maximilians Munich University\, Germany)\nImmunological brain-body interaction after stroke. \nDecember 1 – 9:00am \nRejuane Rua (Centre d’Immunologie de Marseille Luminy\, France)\nBrain border macrophages : more than immune sentinels? \nDecember 3 – 9:00am \nMichal Schwartz (Weizmann Institute of Science\, Israel)\nTBA \nDecember 3 – 11:00am \nAleksandra Deczkowska (Institut Pasteur\, France)\nImmune regulation of brain physiology. \nDecember 5 – 9:00am \nLaurent Groc (University of Bordeaux\, CNRS\, France)\nDecrypting pathogenic brain autoantibody at the molecular level. \nDecember 4 – 5:00pm \nJonathan Kipnis (Washington University School of Medicine\, USA)\nWhat is CNS immune privilege? An update. \nCourse Directors \n\nRosa Chiara Paolicelli – University of Lausanne\, Switzerland\nAgnes Nadjar – Neurocentre Magendie\, University of Bordeaux\, France\nStefano Pluchino – University of Cambridge\, UK\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neuroimmunology-in-physiology-and-disease-from-fundamental-concepts-to-hands-on-training/
CATEGORIES:Cajal Lectures,For scientists
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20251124
DTEND;VALUE=DATE:20251126
DTSTAMP:20260421T151620
CREATED:20251110T170249Z
LAST-MODIFIED:20251113T132722Z
UID:189697-1763942400-1764115199@www.bordeaux-neurocampus.fr
SUMMARY:Symposium: The Impact of philosophical thinking on today’s neuroscience
DESCRIPTION:Venue: IBGC – Campus Carreire\n \nOn registration (see link below) \n\nSpeakers\n\nSerge Ahmed (CNRS Research Director in neuroscience\, Incia\, Bordeaux\, FR)\nHéloïse Athea (Postdoctoral researcher in philosophy\, Gustave Roussy\, Villejuif\, FR)\,\nJohn Bickle (Professor\, Philosophy and History of Neuroscience\, Mississippi State University\, USA)\nElodie Boissard (Postdoctoral researcher in philosophy\, Incia\, Bordeaux & IHPST\, Paris\, FR)\nThomas Boraud (CNRS Research Director in neuroscience & Director of Institute of Neurodegenerative Diseases\, Bordeaux\, FR)\, with Cédric Brun\nThomas Pradeu (CNRS Research Director in Philosophy of Science\, ImmunoConcept\, Bordeaux\, FR)\nChristopher Stevens (Postdoctoral researcher in philosophy and neuroscience\, ImmunoConcept\, Bordeaux\, FR)\nPaul Thagard (Distinguished Professor Emeritus of Philosophy at the University of Waterloo\, CA)\nMarco Viola (Assistant Professor\, University of Roma 3\, Italy)\n\nAbstracts\nSee https://philinbiomed.cnrs.fr/event/philosophy-impact-neuroscience/ \nScientific program\nDay 1\, Monday 24th\n10.00-10.30 Welcome coffee \n10.30 – Marco Viola\nFrom dotted to continuous line: Scientometric evidence for a strengthened (though not flat) relationship between philosophy and neuroscience \n11.30 – Thomas Pradeu\nFrom philosophy in science to philosophy in neuroscience \n12.30 Lunch (buffet open to all participants) \n14.00 – Héloise Athéa\nWhat is cellular memory? From bench to philosophical side and back again \n15.00 – Lisa Roux\nTBA \n16.00 Coffee break \n16.30 – John Bickle\nExploratory research in neurobiology: a case study \n17.30-18.30 – Panel discussion.\nChair: Aline Desmedt. \nDay 2\, Tuesday 25th\n10.00-10.30 Welcome coffee \n10.30 – Christopher Stevens\nPhilosophical Thinking in Neuroscience: Zones of Impact \n11.30 – Serge Ahmed\nPhilosophers and the neurosciences of addiction \n12.30 Lunch (buffet open to all participants) \n14.00 – Elodie Boissard\nBrentano’s thesis of intentionality as the mark of the mental and the birth of experimental and clinical psychology \n15.00 – Thomas Boraud & Cédric Brun\nOne Decision\, Two concepts: A call for Philosophical Clarification \n16.00 Coffee break \n16.30 – Paul Thagard\nPhilosophical Contributions to Theoretical Neuroscience \n17.30-18.30 – Panel discussion.\nChair: Cédric Brun \nRegistration\nFree but mandatory. \nPlease register here:\nhttps://framadate.org/PoEN4TkULIrJCoe8 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/symposium-the-impact-of-philosophical-thinking-on-todays-neuroscience/
CATEGORIES:For scientists,home-event,IMN,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251124T090000
DTEND;TZID=Europe/Paris:20251124T170000
DTSTAMP:20260421T151620
CREATED:20251024T152832Z
LAST-MODIFIED:20251107T162352Z
UID:189099-1763974800-1764003600@www.bordeaux-neurocampus.fr
SUMMARY:Symposium IBGC
DESCRIPTION:Symposium for the Chair for Emergence\, Science\, and Society  of the Région Nouvelle-Aquitaine \n\nVenue: Centre Broca Nouvelle-Aquitaine\n9:00 – 9:20 : Welcome and coffee \n9:20 – 9:30 : Introduction\,\nDr. Isabelle Sagot \n9:30 – 10:30 : Scientific seminar\nPr. Peter Thorpe\, Queen Mary University\, London\, UK\nCell cycle control via protein associations – it’s all about who you know \n10:30 – 10:45 : Coffee break \n10:45 – 11:00 : Presentation\, Région Nouvelle Aquitaine\nM. Philippe Nauche\nVice-Président en charge de la Santé et Silver économie\nConseil Régional de Nouvelle Aquitaine \n11:00 – 11:10:\nPresentation of the Chair\, integration of the teams \n11:10 – 11:35\nDr. Pei-Yun Jenny Wu\, Genome Dynamics and Maintenance team \n11:35 – 12:00 \nDr. Damien Coudreuse\, SyntheCell team \n12:00 pm – 1:30 : Lunch and poster session \n13:30 – 2:30 pm: Break \nVenue: Amphitheater 12\n2:30 pm – 3:30 pm: Scientific seminar\nPr. Snezhana Oliferenko\, King’s College\, London\, UK\nExploring divergent biology of two fission yeast to understand membrane function \n3:30 pm – 3:45 pm: Break \n3:45 – 4:45 pm: Scientific seminar\nDr. David Santamaria\, Center for Cancer Research\, Salamanca\, Spain\nIdentifying novel vulnerabilities in KRAS-driven cancer \n4:45 pm – 5:00 pm: Closing remarks \n
URL:https://www.bordeaux-neurocampus.fr/en/event/symposium-ibgc/
CATEGORIES:For scientists,home-event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251124T140000
DTEND;TZID=Europe/Paris:20251124T140000
DTSTAMP:20260421T151620
CREATED:20250417T100316Z
LAST-MODIFIED:20251106T104828Z
UID:183128-1763992800-1763992800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Rémi Kinet
DESCRIPTION:Venue : Centre Broca \n\nRémi Kinet \nTeam : Pathophysiology of proteinopathies\nIMN \nThesis directed by Benjamin Dehay \nTitle\nStudy of Nanovectors for lysosome-based therapeutic strategies against neurodegenerative diseases \nAbstract\nMy PhD project was multifactorial and interdisciplinary\, focusing on the characterization\, modeling\, and treatment of neurodegenerative diseases linked to the autophagic mechanism. Neurodegenerative diseases share the common feature of progressive death of specific neuronal populations in different regions of the nervous system. Most neurodegenerative diseases are classified within the family of proteinopathies\, as they are characterized by the aggregation of pathological proteins that play a major role in the pathogenic process. Although the pathogenic mechanisms underlying these diseases are not yet fully understood\, numerous studies have shown that the autophagic pathway and its final organelle\, the lysosome\, are impaired and thus contribute to the pathogenic process by failing to degrade the protein aggregates that mark these diseases. This cellular clearance pathway has therefore emerged as a promising therapeutic target in the search for treatments for proteinopathies. To enable the development of a treatment applicable to animal models\, my work focused on three main axes: (i) in vivo modelling of Parkinson’s disease through the ATP13A2 gene\, which is linked to the autophagic mechanism; (ii) characterization of non-human primate models of neurodegenerative diseases to better understand and evaluate the different pathophysiological alterations in proteinopathies; and (iii) targeting the lysosome for therapeutic purposes in Parkinson’s disease. \nOur studies led to the characterization of new animal species with ATP13A2 protein deficiency\, in both rats and non-human primates\, displaying a parkinsonian phenotype and a significant impairment of the autophagic pathway. Furthermore\, these models support the activation of compensatory neuroprotective mechanisms in ATP13A2 knockout animals induced at the embryonic stage. In addition\, modelling of Parkinson’s and Alzheimer’s diseases through intracerebral injection of pathological protein extracts from patients into non-human primates validated the prion-like hypothesis proposed for these diseases. Moreover\, the characterization of different pathophysiological dynamics was revealed depending on the type of aggregates inoculated. Finally\, to restore autophagic function\, particularly lysosomal activity\, the team previously attempted to reacidify the lysosomal lumen using poly(lactic-co-glycolic acid) nanoparticles or trehalose\, a natural disaccharide known to enhance the biogenesis of autophagic vacuoles. In this project\, the goal was to produce and test a polymersome-based nanocarrier capable of crossing the blood–brain barrier and specifically targeting dopaminergic neurons through the conjugation of glucose and DCP (a dopamine agonist) groups on its corona\, enabling the co-delivery of two active molecules. The results showed that the polymersomes were able to enter dopaminergic neurons of the substantia nigra following intracerebral\, intranasal\, and retro-orbital injections\, and to reach the lysosomes. Moreover\, we demonstrated both in vitro and in vivo that polymersome treatment led to a physiological reacidification of the lysosomal lumen. Finally\, an increase in autophagic flux induced by the release of trehalose encapsulated within the polymersome was observed. These findings position this acidic polymersome-based therapy encapsulating trehalose as a promising treatment for Parkinson’s disease\, as well as for other neurodegenerative diseases\, owing to the versatility and tunability of its components. \nKey words\nPolymersome\, lysosome\, therapy\, animal model \nPublications\n\nKinet R*\, Bourdenx M*\, et al. Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates. Science Advances. 2025;11-25 doi: 10.1126/sciadv.adu6050\nDarricau M*\, Dou C*\, Kinet R\, et al. Tau seeds from Alzheimer’s disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation. Alzheimers Dement. 2024;20(3):1894-1912. doi:10.1002/alz.13604\nBrouillard M\, Kinet R\, Joyeux M\, Dehay B\, Crauste-Manciet S\, Desvergnes V. Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives. Bioconjug Chem. 2023;34(3):572-580. doi:10.1021/acs.bioconjchem.3c00041\nKinet R\, Dehay B. Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease. Cells. 2023;12(4):621. Published 2023 Feb 15. doi:10.3390/cells12040621\nMarie A\, Kinet R\, Helbling JC\, et al. Impact of dietary vitamin A on striatal function in adult rats. FASEB J. 2023;37(8):e23037. doi:10.1096/fj.202300133R\nSikora J*\, Dovero S*\, Kinet R\, et al. Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates. NPJ Parkinsons Dis. 2024;10(1):141. Published 2024 Aug 1. doi:10.1038/s41531-024-00757-4\n* co-premier auteur\n\nJury\nDr. MURA Simona\, Université Paris-Saclay\, Rapporteuse\nDr. MOLLEREAU Bertrand\, École Normale Supérieure de Lyon\, Rapporteur\nDr. BOMONT Pascale\, Université de Lyon\, Examinatrice\nDr. FRISCOURT Frédéric\, Institut Européen de Chimie et Biologie\, Examinateur\nDr. DEHAY Benjamin\, Université de Bordeaux\, Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-remi-kinet/
CATEGORIES:IMN,Thesis
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