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PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
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DTSTART:20251026T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20250922
DTEND;VALUE=DATE:20251011
DTSTAMP:20260526T193924
CREATED:20250221T135021Z
LAST-MODIFIED:20251009T092733Z
UID:181026-1758499200-1760140799@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: "Cancer and Neuroscience"
DESCRIPTION:Venue : CARF \nOrganized by the Bordeaux School of Neuroscience. \nLectures are open to everyone. \n\n\n\nProgramme\n\n\n\n\nMonday 22 September – 11:00am\nAnna Golebiewska (Luxembourg Institute of Health\, Luxembourg)\nHeterogeneity and plasticity of the brain tumor ecosystem: What can we learn from advanced patient-derived models? \nTuesday 23 September – 9:00am\nSimona Parrinello (University College London\, UK)\nInjury programmes shape gliomagenesis. \nTuesday 23 September – 11:00am\nHenrik Heiland (Dep. of Neurosurgery\, University Clinic Erlangen\, Germany)\nTBA\n \nThursday 25 September – 9:00am\n Hélène Castel (Cancer and Brain Genomics\, Inserm\, University of Rouen\, France)\nNeurosciences in Oncology: When Cancer Thinks Out of the Box. \nThursday 25 September – 11:00am \nThomas Daubon (CNRS\, University of Bordeaux\, France)\nLactate Shuttle between Glioblastoma Cells and Neurons: a Cancer Neuroscience Case. \nMonday 29 September – 9:00am\nFranck Winkler (University of Heidelberg\, Germany)\nCancer Neuroscience of Brain Tumors. \nMonday 29 September – 11:00am \nVidhya M. Ravi (Medical Centre University Clinic of Freiburg\, Germany)\nTumor–Host Interdependence: Decoding the Microenvironmental Dialogue. \nThursday 2 October – 9:00am \nHrvoye Miletic (University of Bergen\, Norway)\nCell communication and mitochondria transfer in brain tumors. \nThursday 2 October – 11:00am\nManuel Valiente (Spanish National Cancer Research Centre\, Spain)\nThe Evolving Landscape of Brain Metastases. \nFriday 3 October – 9:00am\nLeila Akkari (Netherlands Cancer Institute\, The Netherlands)\nMacrophages: Jack of all Trades in the Brain Ecosystem? \nMonday 6 October – 9:00am\nVarun Venkataramani (German Cancer Research Center\, Germany)\nTBA \nOctober 6 – 11:00am\nAurélie Tchoghandjian (Institute of Neurophysiopathology\, Marseille\, France)\nGlioblastoma stemness and immunosuppression: breaking the lethal cycle. \nOctober 9 – 9:00am\nAntonio Pagano Zottola (Bordeaux Institute of Oncology\, University of Bordeaux\, France)\nMitoDREADD: a new mitochondria-specific chemogenetic tool. \n\n\n\nCourse Directors \n\nAnna Golebiewska – Luxembourg Institute of Health\, Luxembourg\nAntonio C. Pagano Zottola – Bordeaux Institute of Oncology – Inserm\, France\nVarun Venkataramani – Universität Heidelberg\, Germany\n\n\nMore details about the course \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-cancer-and-neuroscience/
CATEGORIES:Cajal Lectures,For scientists
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20251006
DTEND;VALUE=DATE:20251011
DTSTAMP:20260526T193924
CREATED:20250425T164326Z
LAST-MODIFIED:20251001T092950Z
UID:183450-1759708800-1760140799@www.bordeaux-neurocampus.fr
SUMMARY:Neuroscience Alliance Workshop
DESCRIPTION:Venue: Bordeaux \n\nEmergent Properties of the Connected Brain \nMore details \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/neuroscience-alliance-workshop/
CATEGORIES:For scientists,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251010T100000
DTEND;TZID=Europe/Paris:20251010T100000
DTSTAMP:20260526T193924
CREATED:20250922T184757Z
LAST-MODIFIED:20251003T183515Z
UID:188162-1760090400-1760090400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Elise Grevet
DESCRIPTION:Venue: BBS \nAnd on zoom : https://u-bordeaux-fr.zoom.us/j/7838516638?omn=89044241474 \n\nElise Grevet\nTeam Mococo – Incia \nTitle\nImproving the acceptability to enhance the efficiency of stroke rehabilitation procedures based on brain-computer interfaces \nSummary\nOver the past thirty years\, the global incidence of stroke has risen by 70%\, making post-stroke motor rehabilitation a pressing public health priority. In this context\, motor imagery (MI)\, the mental simulation of movement\, combined with sensory feedback (e.g.\, limb mobilisation) is frequently employed in rehabilitation to “close the sensorimotor loop.” Its therapeutic value lies in the activation of neural circuits that closely overlap with those involved in actual movement execution\, thereby fostering neuroplasticity and promoting functional recovery. However\, a major limitation of current approaches is the lack of synchronisation between the MI generated by the patient and the physical mobilisation delivered by the therapist. Brain-computer interfaces (BCIs)\, which analyse brain activity in real time to detect MI\, allow for precise temporal coupling with sensory feedback. As such\, they represent a promising technology to address this limitation. Yet despite their recognised potential\, BCIs remain marginal in clinical use\, largely due to limited ergonomic development. Even a technically optimal BCI is of little value if patients and clinicians are unable or unwilling to use it\, in other words\, if it is not accepted. We hypothesise\, first\, that personalising BCI protocols based on individual acceptability factors could reduce patient anxiety\, enhance engagement\, facilitate learning\, and ultimately improve motor recovery. Second\, the patient’s social environment\, including the attitudes\, perceptions\, and behaviours of relatives and health professionals\, may also influence acceptability\, and by extension\, the clinical efficacy of BCIs. To test these hypotheses\, our research is structured around three main objectives: \n\nTo model the determinants of BCI acceptability across patients\, health professionals\, and the general public;\nTo personalise BCI rehabilitation protocols for patients\, and to evaluate this personalisation in terms of (i) acceptability and (ii) motor recovery outcomes;\nTo develop awareness-raising initiatives aimed at improving BCI acceptability among the general public and health professionals\, and by extension\, among all stakeholders likely to encounter these technologies.\n\nUnder Objective 1\, we developed the first theoretical model of BCI acceptability in post-stroke rehabilitation\, along with an associated questionnaire\, both made publicly available (https://bci-acceptability-tool.cnrs.fr/). The questionnaire was administered to the general public (N = 753) and to post-stroke patients (N = 140). In parallel\, semi-structured interviews were conducted with 12 patients and 12 health professionals. These data informed: (i) the levers for personalising BCI protocols (Objective 2); and (ii) the priority content areas for communication materials (Objective 3). Clustering methods combined with regression analyses were used to identify distinct patient profiles based on acceptability factors (Objective 2). These findings led to the development of automatised personalisation strategies\, embedded in a “Plug & Play” software solution designed for ease of clinical deployment. This system enabled the launch of a multicentre randomised controlled trial\, currently underway\, involving 52 subacute patients (across the Toulouse\, Bordeaux\, and Montauban university hospitals)\, each undergoing 15 training sessions. The aim is to compare the efficacy and acceptability of personalised versus standard BCI protocols. Finally\, in support of objective 3\, a digital exhibition is being developed in partnership with the “Science with and for Society” programme at the University of Bordeaux. This initiative seeks to demystify BCIs and foster their acceptability among the general public\, patients\, their families\, and healthcare providers. \nKeywords: Neurofeedback; Brain-computer interface; Acceptability; Motor rehabilitation; Electroencephalography \nPublications\nGrevet\, E.\, Forge\, K.\, Tadiello\, S.\, Izac\, M.\, Amadieu\, F.\, Brunel\, L.\, Pillette\, L.\, Py\, J.\, Gasq\, D.\, & Jeunet-Kelway\, C. (2023). Modeling the acceptability of BCIs for motor rehabilitation after stroke: A large scale study on the general public. Frontiers in Neuroergonomics\, 3. https://www.frontiersin.org/articles/10.3389/fnrgo.2022.1082901</span \nGrevet\, E.\, Izac\, M.\, Amadieu\, F.\, Py\, J.\, Gasq\, D.\, & Jeunet-Kelway\, C. (2024). Which factors affect the acceptability of bcis for functional rehabilitation after stroke among patients? In 9th Graz Brain-Computer Interface Conference 2024. Verlag der Technischen Universität Graz. https://doi.org/10.3217/978-3-99161-014-4-032 \nJury\n\nMme Camille JEUNET-KELWAY\, Docteure\, Université de Bordeaux\, Directrice de thèse\nM. François CABESTAING\, Professeur des universités\, Université de Lille (Villeneuve d’Ascq)\, Rapporteur\nM. Ricardo CHAVARRIAGA\, Chargé de recherche\, Centre for Artificial Intelligence\, School of Engineering\, Zurich University of Applied Sciences ZHAW (Winterthur\, SUISSE)\,  Rapporteur \nMme Andrea KÜBLER \, Professeure des universités\, Julius-Maximilians-Universität Würzburg (ALLEMAGNE)\, Rapporteure\nMme Julie LEMARIÉ\, Professeure des universités\, Université de Toulouse (Toulouse)\, Examinatrice\nM. Athanasios VOURVOPOULOS\, Assistant professor\, Instituto Superior Técnico (IST)\, Universidade de Lisboa (PORTUGAL)\, Examinateur \nMme Stefanie ENRIQUEZ-GEPPERT\, Assistant professor\, Université  de Groningen\, Co-encadrante et Membre invitée\nM. Igor SIBON\, PU-PH\, Université  de Bordeaux\, Membre invité\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-elise-grevet/
CATEGORIES:Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251010T113000
DTEND;TZID=Europe/Paris:20251010T130000
DTSTAMP:20260526T193924
CREATED:20250624T072051Z
LAST-MODIFIED:20251006T164739Z
UID:185501-1760095800-1760101200@www.bordeaux-neurocampus.fr
SUMMARY:PhD Seminar - Katlin Silm
DESCRIPTION:Venue: Centre Broca \n\nKatlin Silm. Photo credit: Dominique Trinh\nDr. Katlin Silm \nCedars-Sinai Health Sciences University\,\nL.A.\, USA \nInvited by Audrey Dufau (IINS) \nTitle\nSynaptic vesicles that store monoamines and glutamate differ in protein composition and functional properties \nAbstract\nNeuromodulators like monoamines assure essential brain functions but many open questions remain about their mechanism of release. While recent work has advanced our knowledge of active zones in dopamine axons\, release machinery within the synaptic vesicle (SV) remains poorly understood. In our recent work\, we addressed differences between the release of monoamines and classical synaptic transmitters by comparing the composition of SVs that contain the vesicular monoamine transporter 2 (VMAT2) versus vesicular glutamate transporter 2 (VGLUT2). Complementing previous work showing that these SV populations differ in frequency dependence\, recycling kinetics and biogenesis\, we now find differences in abundance and isoform expression of many SV protein families. Validation in primary neurons and brain tissue confirms these findings. Functional analysis shows that loss of differentially expressed proteins has a distinct impact on the recycling of VGLUT2 versus VMAT2 vesicles even within the same neuronal population. These findings provide insights into the molecular diversity of SVs and mechanisms of dopamine release. \nSelected publications\nhttps://pubmed.ncbi.nlm.nih.gov/40661501/ \nhttps://pubmed.ncbi.nlm.nih.gov/31003725/ \nhttps://pubmed.ncbi.nlm.nih.gov/37812725/ \nhttps://pubmed.ncbi.nlm.nih.gov/39034608/ \n\nMeet the speaker!\nYou are a research staff ? Write to Julia Goncalves who will organize the schedule. \nYou are a PhD student? You can register to share some pizza after the talk. Registration opens 3 weeks before. \n\nPhD seminars are organized by the NBA\, Bordeaux Neurocampus\, and the Bordeaux Neurocampus Graduate Program.  \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-katlin-silm/
CATEGORIES:For scientists,home-event,Monthly conferences
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251010T140000
DTEND;TZID=Europe/Paris:20251010T140000
DTSTAMP:20260526T193924
CREATED:20250704T100432Z
LAST-MODIFIED:20250923T120046Z
UID:185855-1760104800-1760104800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Hadrien Plat
DESCRIPTION:Venue: BBS \nDefense in french \n\nHadrien Plat\nTeam: DECAD\nINCIA \nSupervisor: Etienne Coutureau \nTitle\nApprendre à décider: une perspective neurocognitive chez le Rat. Le rôle de la noradrénaline préfrontale chez le rat dans le comportement adaptatif \nLearning to decide: a neurocognitive perspective in rats. The role of rat prefrontal noradrenaline in adaptive behavior \nSummary\nEvery day\, organisms adapt their choices to a changing environment\, relying on the ability to learn which actions lead to valuable outcomes and to revise these predictions when circumstances shift. Such adaptive decision-making is central to survival and is thought to depend on prefrontal circuits and their modulation by neuromodulators such as dopamine\, noradrenaline or serotonin. Yet\, the precise role of noradrenergic transmission in prefrontal subregions remains unclear. This thesis combines behavioural paradigms\, circuit manipulations\, fiber photometry recordings\, and computational modelling to investigate how noradrenergic inputs to the medial prefrontal cortex (mPFC) and the orbitofrontal cortex (OFC) shape flexible learning. In the first set of experiments\, we used a Pavlovian contingency degradation paradigm to probe stimulus–outcome updating. We show that noradrenergic transmission in the mPFC is necessary for adapting to changes in predictive contingencies\, complementing its well-established involvement in instrumental contingency degradation that underpins goal-directed behaviour. In a second line of work\, we used a reversal learning paradigm\, where outdated associations must be abandoned and replaced with new ones. Here\, we demonstrate that stronger noradrenaline responses in the OFC predict better individual performance\, and we confirmed the causal role of this signal by showing that chemogenetic and optogenetic silencing of LC→OFC projections slowed reversal learning. Finally\, using a probabilistic reversal learning task\, we combined computational modeling\, photometry recordings\, and chemogenetic manipulations. We show that rat behavior is best explained by a metareinforcement learning model with volatility-dependent learning rates\, that orbitofrontal noradrenaline seems to track these volatility estimates\, and that silencing LC→OFC projections selectively slows adaptive adjustments\, mimicking model lesions of volatility signaling. Taken together\, these findings provide converging evidence that noradrenaline contributes in anatomically specific ways to flexible behavior. While NA in the mPFC is required for detecting and adapting to changes in the causal relationship between stimuli and their outcomes\, NA in the OFC enables reversal and volatility-dependent adjustments of learning. This work highlights the complementary functions of prefrontal noradrenaline in ensuring that behavior remains both stable and adaptable in uncertain environments. \nJury\nMme DOYERE Valérie DR\, CNRS\, Université Paris-Saclay Rapporteure\nM. GIRARD Benoit DR\, CNRS\, Université de la Sorbonne Rapporteur\nMme KOEHL Muriel DR\, CNRS\, Université de Bordeaux Examinatrice\nM. PROCYK Emmanuel DR\, CNRS\, Université de Lyon Examinateur\nM. COUTUREAU Etienne DR\, CNRS\, Université de Bordeaux Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-hadrien-plat/
CATEGORIES:Thesis
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