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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20240930
DTEND;VALUE=DATE:20241019
DTSTAMP:20260531T230902
CREATED:20240123T170418Z
LAST-MODIFIED:20241018T082029Z
UID:167213-1727654400-1729295999@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures - Advanced imaging techniques for cellular and systems neuroscience
DESCRIPTION:Lectures are open to everyone. \nVenue: CARF \n\nProgram\nSeptember 30 – 11:00am Alexander Flügel (University Medical Center Göttingen\, Germany)\nIntravital 2-photon microscopy of CNS autoimmunity. \nOctober 1 – 9:00am Anna-Sophia Wahl (LMU Munich\, Germany)\nHigh-resolution 2photon imaging in-vivo to unveil key principles of neuronal repair. \nOctober 1 – 11:00am Dmitri Rusakov (University College\, UK)\nPrinciples and neuroscience applications of time-resolved fluorescence microscopy. \nOctober 2 – 9:00am Florian Engert (Havard University\, USA)\nDissection of a zebrafish integrator circuit through correlated light and electron microscopy. \nOctober 2 – 11:00am Moritz Helmstaedter (MPI for Brain Research\, Germany)\nCerebral Cortex Connectomics. \nOctober 5 – 11:00am Jan Huisken (Georg-August University Göttingen\, Germany)\nFlamingo: Fast and gentle volumetric imaging inside and outside the optics lab. \nOctober 10 – 9:00am Christophe Zimmer (Institut Pasteur\, France)\nDeep learning: principles and applications to biomedical imaging. \nOctober 12 – 9:00am Francesca Odoardi (Georg-August University Göttingen\, Germany)\nIntravital imaging in neuroimmunology: limitations and challenges. \nOctober 14 – 9:00am Johann Danzl (Institute of Science and Technology Austria\, Austria)\nReconstructing brain tissue with light microscopy. \nOctober 15 – 9:00am Laurent Groc (Bordeaux University\, France)\nUsing single molecule imaging to unveil membrane protein organization and extracellular space in the brain. \nOctober 15 – 11:00am Hans-Ulrich Dodt (Medical University of Vienna\, Austria)\nFrom mice to man – new results of ultramicroscopy of cleared sample. \nOctober 17 – 9:00am Valentin Närgel (Bordeaux University\, France)\nSTED imaging of living brain microstructures. \nMore details about the course\nWebsite : https://cajal-training.org/on-site/advanced-imaging-techniques-for-cellular-and-systems-neuroscience-2024/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-advanced-imaging-techniques-for-cellular-and-systems-neuroscience/
CATEGORIES:Cajal Lectures,For scientists
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DTSTART;TZID=Europe/Paris:20241002T140000
DTEND;TZID=Europe/Paris:20241002T140000
DTSTAMP:20260531T230902
CREATED:20240828T090517Z
LAST-MODIFIED:20240829T133509Z
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SUMMARY:Thesis defense - Alice Fermigier
DESCRIPTION:Venue: BBS \nDefense in french \n\nAlice Fermigier\nNutriNeuro\nThesis supervisor: Guillaume Ferreira \nTitle\nEffect of obesogenic food consumption on memory and social functions: implication of hippocampal area CA2 \nAbstract\nChildhood obesity is a concerning public health issue associated with cardiometabolic co- morbidities\, but also with cognitive deficits whose extent remains poorly understood. Due to increasing consumption of obesogenic foods\, the worldwide prevalence of overweight and obesity in children and adolescents aged 5 to 19 has risen considerably\, from 8% in 1990 to 20% in 2022\, hence the importance of knowing their cognitive consequences. Juvenile obesity be modeled with rodents fed a diet high in saturated fat and sugar (HFD) during adolescence. Our team has recently shown that HFD-induced deficits in spatial\, contextual and object recognition memory are associated with hippocampal hyperactivity and can be restored by chemogenetically decreasing the activity of hippocampal pyramidal neurons. In this thesis work\, we sought to decipher whether specific areas of the hippocampus might be responsible for alterations in social memory in particular. We focused on the CA2 area of the dorsal hippocampus\, known for its crucial role in social memory. \nEx vivo electrophysiological approaches carried out by the Chevaleyre-Piskorowski team revealed hyperexcitability of CA2 pyramidal cells\, associated with reduced oxytocinergic modulation in HFD-fed mice. In parallel\, we showed that chemogenetic inactivation restricted to CA2 pyramidal neurons and local injection of oxytocin in CA2 reversed social memory deficits in HFD-fed mice. \nStress also influences social interactions. So\, in a second study\, we assessed the impact of a HFD on this modulation of social orientations by stress\, and the role played by area CA2. Acute stress (electric shock or restraint) decreases the investigation of novel social targets\, leading to decreased preference for a novel conspecific and increased preference for familiar social odors\, and thus in control diet but not HFD-fed mice. This lack of stress-induced social neophobia in HFD-fed mice is associated with greater basal calcium activity in CA2 pyramidal neurons. Furthermore\, chemogenetic inactivation of these neurons or local injection of oxytocin into CA2 restored stress-induced social neophobia in HFD-fed mice. Altogether\, our results show that HFD feeding during adolescence disrupts social memory and stress-induced social neophobia by altering the activity and the oxytocinergic system in the CA2 area of the hippocampus. \nKeywords: obesity\, social memory\, social preferences\, stress\, adolescence\, CA2\, hippocampus\, oxytocin\, chemogenetics \nPublications\nFermigier A.\, Ferreira G. (2021). Neurobiologie des apprentissages alimentaires. La Lettre des Neurosciences 61 20-23 \nBakoyiannis I.\, Ducourneau E.G.\, N’Diaye M.\, Fermigier A.\, Ducroix-Crepy C.\, Fauré L.\, Bosch- Bouju C.\, Coutureau E.\, Trifilieff P.\, Ferreira G. (2024) Obesogenic diet induces circuit-specific memory deficits in mice. eLife 4:13:e80388. doi :10.7554/eLife.80388 \nFermigier A.\, Ducourneau E.G.\, Potier M.\, Helbling J.C.\, Bakoyiannis I.\, Chevaleyre V.\, Piskorowski R.A.\, Ferreira G. (in preparation) Obesogenic diet impairs social responses to stress through hippocampal CA2 dysfunction: emphasis on oxytocin signaling \nMuller M.\, Fermigier A.\, Ducourneau E.G.\, Potier M.\, Helbling J.C.\, Ferreira G.\, Piskorowski R.A.\, Chevaleyre V. (in preparation) A high-fat diet impairs social memory through aberrant hippocampal CA2 excitability and oxytocin signaling \nJury\n\nNadine RAVEL\, DR\, CNRS\, Université Lyon I – Rapportrice\nLaure VERRET\, Maître de Conférences\, CNRS\, Université Toulouse III – Rapportrice\nLisa ROUX\, DR\, CNRS\, INCIA (Bordeaux) – Examinatrice\nGiovanni MARSICANO\, DR\, INSERM\, Institut Magendie (Bordeaux) – Examinateur\nRebecca PISKOROWSKI\, DR\, INSERM\, Institut de Psychiatrie et de Neurosciences (Paris) – Examinatrice\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-alice-fermigier/
CATEGORIES:Thesis
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