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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20240331T010000
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DTSTART:20241027T010000
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DTSTART;TZID=Europe/Paris:20240919T110000
DTEND;TZID=Europe/Paris:20240919T110000
DTSTAMP:20260422T142219
CREATED:20240903T104131Z
LAST-MODIFIED:20240904T100006Z
UID:174872-1726743600-1726743600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Liana Fattore
DESCRIPTION:Venue: Centre Broca \n\nLiana Fattore\nIstituto di Neuroscienze – University of Cagliari\, Italy\nhttp://www.in.cnr.it/index.php/it/9-people/85-liana-fattore\nInvited by Marc Landry \nTitle\nPharmacology and toxicology of Novel Psychoactive Substances (NPS) \nAbstract\nIn the last decade\, the trend of drug consumption has completely changed\, and several new psychoactive substances (NPS) have appeared on the drug market as legal alternatives to common drugs of abuse. Designed to reproduce the effects of illegal substances like cannabis\, ecstasy\, cocaine\, or ketamine\, NPS are only in part controlled by UN conventions and represent an emerging threat to global public health. The effects of NPS greatly differ from drug to drug and relatively scarce information is available at present about their pharmacology and potential toxic effects. Yet\, compared to more traditional drugs\, more dangerous short- and long-term effects have been associated with their use\, and hospitalizations and fatal intoxications have also been reported after NPS use. After a general overview of this new phenomenon\, the talk will provide preclinical evidence of the effects that arylcyclohexylamine derivatives (i.e.\, methoxetamine)\, phenethylamines (i.e.\, 2-Cl-4\,5-MDMA)\, synthetic cannabinoids (i.e.\, JWH-018\, AKB-48) and cathinones (i.e.\, 3\,4-MDPHP) can induce on brain and behavior. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-liana-fattore/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20240919T140000
DTEND;TZID=Europe/Paris:20240919T140000
DTSTAMP:20260422T142219
CREATED:20240903T132331Z
LAST-MODIFIED:20240909T133331Z
UID:174881-1726754400-1726754400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Floriane Uyttersprot
DESCRIPTION:Venue: Centre Broca \n\nFloriane Uyttersprot\nTeam Groc – IINS\n \nThesis supervisor: Julien Dupuis \nTitle\nExploring the molecular determinants of behavioral changes induced by ketamine at the nanoscale \nAbstract\nNMDA glutamate receptors (NMDAR) are major actors of excitatory neurotransmission and synaptic plasticity. Their synaptic organization plays a key role in these processes and is tightly and dynamically regulated. Consequently\, pathological alterations of this organization have been associated with severe neuropsychiatric disorders. Thus\, NMDAR synaptic organization could represent a valuable therapeutic target. In this work\, we show that ketamine\, a non-competitive NMDAR antagonist\, enhances synaptic trapping of the receptors and thereby mitigates anxiety and depression symptoms caused by autoantibodies from patients with autoimmune encephalitis. Furthermore\, our results suggest that the antidepressant action of ketamine involves a rewiring or brain networks that could involve a subtype-dependent reorganization of synaptic NMDAR. Together\, these results open new therapeutic perspectives for the treatment of mental disorders associated with NMDAR hypofunction. \nKeywords: NMDA receptor\, ketamine\, nanoscale organization\, depression \nPublication\nVilléga\, F. et al.\n Ketamine alleviates NMDA receptor hypofunction through synaptic trapping.\nNeuron S0896627324004902 (2024)\ndoi:10.1016/j.neuron.2024.06.028. \nJury\n\nStéphane OLIET – Directeur de Recherche\, Université de Bordeaux – Président\nAna Luisa CARVALHO – Professeure\, Université de Coimbra – Rapportrice\nMme. Julie PERROY – Directrice de Recherche\, Université de Montpellier – Rapportrice\nThomas FRERET – Professeur\, Université de Caen – Examinateur\nJulien DUPUIS – Chargé de Recherche\, Université de Bordeaux – Directeur de thèse\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-floriane-uyttersprot/
CATEGORIES:Thesis
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