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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260601T122233
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
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DTSTART;TZID=Europe/Paris:20231213T140000
DTEND;TZID=Europe/Paris:20231213T140000
DTSTAMP:20260601T122233
CREATED:20231106T143126Z
LAST-MODIFIED:20231206T213809Z
UID:164085-1702476000-1702476000@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Adrien Joly
DESCRIPTION:Venue : CGFB \nThesis defense in english \n\nAdrien Joly\nIINS\nTeam : Spatio-temporal and mechanical control of motile structures\nThèse dirigée par : Olivier Rossier\n \n\nTitle\nDeciphering the molecular links between actomyosin force\, integrin regulation and ECM properties through an in vitro reconstitution \nAbstract\nIn cancer\, 90% of deaths are due to the formation of metastases in which migration is deregulated. Among the motile structures affected are focal adhesions (FAs)\, which enable cells to grasp and probe their microenvironment. These mechanosensitive structures are highly complex in terms of composition and three-dimensional organization. The aim of my thesis is to identify the force-dependent and force-independent elementary events that govern the formation and maturation of FAs. To this end\, I have developed an experimental strategy to reconstitute FAs from a minimal set of proteins in order to control molecular composition and determine the key steps in FA function. This work has enabled us to highlight the mechanosensitivity of certain fundamental events. Ultimately\, it will provide a better understanding of FAs and how they are deregulated in cancer cells. \nKey words\nIntegrin adhesion sites\, biomimetic reconstitution\, mechanosensibility\, integrin activation\, super-resolution microscopy\, single particle tracking \nPublications\n\n– Orré T\, Joly A\, Karatas Z\, Kastberger B\, Cabriel C\, Böttcher RT\, Lévêque-Fort S\, Sibarita JB\, Fässler R\, Wehrle-Haller B\, Rossier O\, Giannone G. Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions. Nat Commun. 2021 May 25;12(1):3104. doi: 10.1038/s41467-021-23372-w. PMID: 34035280; PMCID: PMC8149821. \n– Pernier J\, Cardoso Dos Santos M\, Souissi M\, Joly A\, Narassimprakash H\, Rossier O\, Giannone G\, Helfer E\, Sengupta K\, Le Clainche C. Talin and kindlin cooperate to control the density of integrin clusters. J Cell Sci. 2023 Apr 15;136(8):jcs260746. doi: 10.1242/jcs.260746. Epub 2023 Apr 21. PMID: 37083041.\nJury\n\nMme. ROYOU\, Anne – Directrice de recherche (CNRS)\, IECB – Présidente\nM. GOULT\, Ben – Professeur\, University of Kent – Rapporteur\nMme. ALBIGES-RIZO\, Corinne – Directrice de recherche (CNRS)\, IAB – Rapporteure\nM. POINCLOUX Renaud – Ingénieur de recherche (CNRS)\, IPBS – Examinateur\nM. ROSSIER Olivier – Chargé de recherche (INSERM)\, IINS – Directeur de thèse\n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-adrien-joly/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20231213T140000
DTEND;TZID=Europe/Paris:20231213T140000
DTSTAMP:20260601T122233
CREATED:20231107T135413Z
LAST-MODIFIED:20231107T140003Z
UID:164142-1702476000-1702476000@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Mohamed-Lyès Kaci
DESCRIPTION:Venue : Centre Broca  \nThesis defense in french \n\nMohamed-Lyès Kaci\nNeurocentre Magendie\nTeam : Neurogenesis and pathophysiology\nThesis directed by Muriel Koehl \n\nTitle\nInvolvement of adult hippocampal neurogenesis and prenatal stress in vulnerability to develop memory disturbances associated with post-traumatic stress disorder in a mouse model \nAbstract\nPost-Traumatic Stress Disorder (PTSD) is a neuropsychiatric condition that can develop after a traumatic experience. While PTSD is classically associated with an excessive intensification of the traumatic memory\, patients actually exhibit a unique memory profile where both an emotional hypermnesia for salient sensory cues and a declarative amnesia for the context surrounding the event coexist. This memory profile appears central to the pathology\, and recent studies suggest that the contextual amnesia might be at the core of traumatic memory. However\, the neurobiological mechanisms underlying this traumatic memory remain largely unexplored. \nNeurons generated throughout adulthood in the hippocampus (Adult Hippocampal Neurogenesis\, AHN) play a crucial role in contextual memory\, pattern separation\, and stress resilience. These functions suggest a potential role for these neurons in PTSD-like memory. Therefore\, we tested the hypothesis according to which the activity of these adult-born neurons is involved in the formation of traumatic memory. Using optogenetics combined with a mouse model that differentiates the development of normal adaptive fear memory from that of pathological PTSD-like fear memory\, we demonstrated that activating or inhibiting these neurons prevented or induced PTSD-like memory development\, respectively. \nIn humans\, not all individuals exposed to traumatic events develop PTSD\, highlighting the existence of risk factors. Early life experiences\, including those encountered in utero\, have a lasting impact on brain development and functions. Notably\, it has been suggested that early life stress might increase vulnerability to different neuropsychiatric disorders\, but again the underlying mechanisms remain poorly known. Interestingly\, exposure to prenatal stress reduces AHN in mice. Taken together with our findings on the role of AHN in traumatic memory\, that led us to postulate on one hand that prenatal stress could heighten susceptibility to traumatic memory\, and on the other hand that disturbances of AHN could be involved in such a vulnerability. We first validated the presence of behavioral changes linked to functions underpinned by AHN in mice subjected to prenatal stress using two pattern separation behavioral tasks. Subsequently\, using our PTSD-like memory model\, we found that these mice exhibited a mnemonic profile typical of PTSD\, and that optogenetic activation of hippocampal adult-born neurons could prevent the development of this profile in favor of a normal and adaptive fear memory. \nIn conclusion\, this thesis work highlights the pivotal role of hippocampal neurons generated in adulthood in PTSD-like memory and suggests that they are a core neurobiological mechanism that could explain the increased vulnerability to PTSD induced by prenatal stress\, thereby opening new preventive and therapeutic targets for PTSD. \nKey words\nAdult neurogenesis\, PTSD\, fear memory\, prenatal stress\, hippocampus\, behavior \nJury\nPatricia Gaspar\,\nRené Hen\,\nCatherine Belzung\,\nGuillaume Ferreira\,\nPierre Gagnepain\,\nMuriel Koehl (thesis director)\nAline Desmedt (invited)\nNora Abrous (invited) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-mohamed-lyes-kaci/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20231213T140000
DTEND;TZID=Europe/Paris:20231213T140000
DTSTAMP:20260601T122233
CREATED:20231204T121207Z
LAST-MODIFIED:20231204T121646Z
UID:165388-1702476000-1702476000@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Federica Quici
DESCRIPTION:Venue: Module 1.2\, Bâtiment CROUS\, 1er étage.\nZoom link https://u-bordeaux-fr.zoom.us/j/81586413997?pwd=akJzajlWTitOcjhsUnV4Q3NHRGtpZz09 \nTitle\nSuper-resolution analysis of the nano-anatomical determinants of the synaptic function of hippocampal neurons \nAbstract\nSynapses are the core of neuronal communication in the mammalian brain\, mediating rapid and flexible transmission of electrical signals. Excitatory synaptic transmission is conveyed from presynaptic terminals to postsynaptic spines\, small protrusions stemming from dendrites\, possessing a unique morphology. In the hippocampus\, the function and regulation of excitatory synapses play central roles in higher brain functions such as learning and memory. These synapses are finely tuned by activity-dependent changes that are intricately linked to the morphology of dendritic spines. Therefore\, elucidating the relationship between the morphology and the function of dendritic spines is crucial for understanding how neurons process and store information. In particular\, the size and length of the spine neck can significantly impact the electrical properties of the synapse. A longer\, narrower spine neck could act as an electrical barrier\, limiting the spread of voltage and current from the spine head to the dendrite and ultimately to the soma. \nHowever\, the exact mechanism by which spine neck morphology acts as an electrical modifier for the synapse remains only partially understood\, because of considerable technical challenges involved in investigating the biophysical\, morphological\, and functional properties of dynamic and small dendritic spines. To investigate the complex relationship between the morphology and the function of spines\, it is crucial to develop an experimental setup capable of simultaneous observation and perturbation of the morphology and function of synapses. \nTo tackle these challenges a custom experimental setup was modified to incorporate time-lapse STED microscopy\, functional imaging\, 2-photon glutamate uncaging\, and patch-clamp electrophysiology on a single microscope platform. Specifically\, I implemented a system based on an inverted home-made 3D-STED microscope with a second laser scanner enabling simultaneous control of two laser spots within the sample. I validated that this system allowed to perform precise targeting of a 2-photon laser spot for glutamate uncaging near specific spine synapses while concurrently visualizing their morphology through STED or recording functional calcium events. Using super-resolution microscopy analysis\, I reported a diversity of spine morphologies and biophysical properties (such as neck widths\, lengths and resistances) in hippocampal organotypic slices. To directly link morphologies and functional properties\, I activated pairs of STED-resolved spines with opposite neck morphologies (long and thin\, wide and short) using single spine 2-photon glutamate uncaging while simultaneously recording patch-clamp somatic uncaging excitatory postsynaptic potentials (uEPSPs) and currents (uEPSCs). \nThis methodology has the potential to be a valuable tool for investigating the intricate structure-function relationship at the nanoscale during synaptic plasticity. \n  \nKeywords: dendritic spines\, hippocampal organotypic slices\, STED microscopy\, 2-photon glutamate uncaging\, electrophysiology\, dual scanner system \nPublication\nArizono M\, Idziak A\, Quici F\, Nägerl UV.\nGetting sharper: the brain under the spotlight of super-resolution microscopy.\nTrends Cell Biol.\n2023 Feb;33(2):148-161. doi: 10.1016/j.tcb.2022.06.011. Epub 2022 Jul 26. PMID: 35906123. \nJury\nDr. Jérôme Baufreton\nProf. Martin Fuhrmann\nDr. Judit Makara\nDr. Agnès Nadjar \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-federica-quici/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20231213T143000
DTEND;TZID=Europe/Paris:20231213T143000
DTSTAMP:20260601T122233
CREATED:20231108T150434Z
LAST-MODIFIED:20231108T151136Z
UID:164209-1702477800-1702477800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Valentine Chirokoff
DESCRIPTION:Venue : BBS Amphitheater \nThesis defense in french \n\nValentine Chirokoff\nINCIA\nTeam : Motor control and cognition\nThesis directed by Joel Swendsen and Sandra Chanraud \n\nTitle\nCognitive processes in Addiction: from Brain to Daily-Life \nAbstract\nAddiction is a major public health issue characterised by a high relapse rate\, potentially sustained by the intensity of the urge to use a substance (craving)\, and deficits in high- order cognitive functioning. In this thesis\, I have used smartphones-based Ecological Momentary Assessment (EMA) to provide repeated measures of inhibition performance\, craving\, and substance use in patients with different addiction to different substances (alcohol\, nicotine\, cannabis) and in healthy controls. In parallel\, we acquired multimodal brain imaging data of the same patients. The first objective was to quantify the influence of craving dynamics and of momentary inhibition performance on substance use in daily life. A second objective was to determine the association of these variables with underlying anatomofunctional brain connectivity. Using prospective modelling analyses\, we first demonstrated that patients exhibit highly unstable craving symptoms whose fluctuations predicted substance use beyond mean intensity. The more unstable the patient’s craving was\, the more participants tended to use substances; this relationship was also related to functional connectivity between interoceptive\, limbic\, and executive brain areas. To further elucidate the factors influencing substances use\, our second study aimed to examine the interplay between inhibition performance\, craving\, and substance use at the momentary level. We highlighted a vicious circle in which substance use at a one-time point predicted higher probabilities of using again later. However\, the level of inhibition performance concurrently assessed permitted both 1) to predict a lower use probability at the following time assessment and 2) to break this vicious circle by mediating the link between use and future use. Real-time inhibition performance was also linked to functional connectivity within a fronto-occipito-cerebellar network\, itself predicting lower probability of use. Whereas this study did not reveal either an interplay between inhibition and craving or an overlap of their cerebral bases\, it emphasised the direct protective effect against use of inhibition and underlying cerebral markers. Finally\, we aimed at searching for cerebral markers that could be related to both the cognitive and functional factors highlighted previously. In the last study\, we demonstrated that impairments in inhibition was linked to poorer brain integrity in major white matter pathways connecting the frontal cortex to the rest of the brain ; anatomical connectivity was also linked to the measured functional connectivity in fronto-occipito-cerebellar network. Furthermore\, white matter integrity in the same network was moderating the effect of inhibition on use\, whereby better inhibition was predictive of a lower probability of use in patients with higher white matter integrity indexes. Here\, for the first time\, psychological data were directly linked to the brain integrity and functioning markers\, enabling a multi-level prediction of use which incorporates the strong psychological and biological interaction well characterised in addiction. Moving forward into a clinical perspective\, these markers could allow to identify patients at high-risk of use in real-time. \nKey words\nAddiction ; EMA ; Executive Functions ; craving\, cerebral markers \nPublications\n\nChirokoff\, V.\, Di Scala\, G.\, Swendsen\, J.\, Dilharregui B.\, Berthoz S.\, Chanraud\, S. (2022). Impact of metacognitive and psychological factors in learning-induced plasticity of resting state networks. Biology.\n\nChirokoff\, V.\, Abdallah\, M.\, Serre\, F.\, Auriacombe\, M.\, Fatseas\, M.\, Dupuy\, M.\, Berthoz\, S.\, Chanraud\, S. & Swendsen\, J. (2022). Craving Dynamics and its functional substrates in substance use disorders. Under review at Addiction Neurosciences.\n\nChirokoff\, V.\, Berthoz\, S. Fatseas\, M.\, Misdrahi\, D.\, Dupuy\, M.\, Abdallah\, M.\, Serre\, F.\, Auriacombe\, M.\, S.\, Sulivan\, E.\, Pfeffeurbaum\, A.\, Chanraud\, S. (2023). Identifying the role of (dis)inhibition in the vicious cycle of substance use through Ecological Momentary Assessment and resting-state fMRI . – Under review at Translational Psychiatry.\n\nChirokoff\, V.\, Pohl\, K.\, Dupuy\, M.\, Abdallah\, M.\, Misdrahi\, D.\, Serre\, F.\, Auriacombe\, M.\, Fatseas\, M.\, Berthoz\, S.\, Swendsen\, J.\, Pfefferbaum\, A.\, Sullivan\, E. & Chanraud\, S. (2023). Multi-level prediction of substance use: interaction of white matter integrity\, resting-state connectivity\, and inhibitory control measured repeatedly in every-day life. – Under review at Addiction Biology.\n\n\n\nSoussi C\, Berthoz S\, Chirokoff V\, Chanraud S. Interindividual Brain and Behavior Differences in Adaptation to Unexpected Uncertainty. Biology. 2023; 12(10):1323.\n\nIoannucci\, S.\, Chirokoff\, V.\, Dilharreguy\, B.\, Ozenne\, V.\, Chanraud\, S.\, & Zénon\, A. (2023). Neural fatigue by passive induction: repeated stimulus exposure results in cognitive fatigue and altered representations in task-relevant networks. Communications Biology\, 6(1)\, 142.\n\nMorawetz\, C.\, Berboth\, S.\, Chirokoff\, V.\, Chanraud\, S.\, Misdrahi\, D.\, Serre\, F.\, … & Swendsen\, J. (2022). Mood Variability Craving and Substance Use Disorders: From Intrinsic Brain Network Connectivity to Daily Life Experience. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.\n\nJakubiec\, L.\, Chirokoff\, V.\, Abdallah\, M.\, Sanz-Arigita\, E.\, Dupuy\, M.\, Swendsen\, J.\, … & Fatseas\, M. (2022). The executive functioning paradox in substance use disorders. Biomedicines\,\n\nAbdallah\, M.\, Farrugia\, N.\, Chirokoff\, V.\, & Chanraud\, S. (2020). Static and dynamic aspects of cerebro-cerebellar functional connectivity are associated with self-reported measures of impulsivity: A resting-state fMRI study. Network Neuroscience\, 4(3)\, 891-909.\n\n\nJury\nPr Stacey Callahan (Rapporteur)\,\nPr Fabien Gierski (Examinateur)\,\nPr Jean Philippe Ranjeva (Examinateur)\nDr Anne Lise Pitel (Rapporteur)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-valentine-chirokoff/
CATEGORIES:Thesis
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