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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260601T122157
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231205T110000
DTEND;TZID=Europe/Paris:20231205T110000
DTSTAMP:20260601T122157
CREATED:20230927T131706Z
LAST-MODIFIED:20231204T100342Z
UID:162718-1701774000-1701774000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Elena Martín-Garcia
DESCRIPTION:Venue: Neurocentre Magendie\, Conference room \n\nElena Martín-Garcia \n(https://orcid.org/0000-0002-4487-3028) \n\nLaboratory of Neuropharmacology-Neurophar\, Department of Medicine and Life Sciences\, Universitat Pompeu Fabra\, Barcelona\, Spain.\nDepartament de Psicobiologia i Metodologia de les Ciències de la Salut\, Universitat Autònoma de Barcelona\, Cerdanyola del Vallès\, 08193\, Barcelona\, Spain.\n\nInvited by Monique Vallée\, Neurocentre Magendie \nTitle\nEpigenetic and microbiota signatures in the vulnerability and resilience to food addiction \nSummary\nFood addiction is a multifactorial disorder characterized by a loss of control over food intake that may promote obesity\, alter gut microbiota composition\, and have an impact on epigenetic marks. We have investigated the potential involvement of the gut microbiota and the epigenetic marks in the mechanisms underlying food addiction. We used the YFAS 2.0 criteria to classify extreme food addiction mouse and human subpopulations to identify gut microbiota and epigenetic signatures associated with vulnerability to this disorder. Animal and human cohorts showed essential similarities in the gut microbiota signatures and the miRNAs linked to food addiction. Notably\, a decreased relative abundance of the species Blautia was observed in addicted humans and of Blautia genus in addicted mice. The administration of non-digestible carbohydrates\, known to favor Blautia growth\, led to an increased relative abundance of Blautia in mice feces in parallel to dramatic improvements in food addiction prevention. A similar improvement was revealed after the oral administration of Blautia as probiotics. We have also investigated the changes in miRNA expression promoted by food addiction in animals and humans. Sharp similitudes were found between the miRNA signatures in our animal cohort’s medial prefrontal cortex (mPFC) and the miRNAs circulating levels in our human cohort\, allowing us to identify several miRNAs of potential interest for developing this disorder. TuD inhibition of miRNA-29c-3p in the mouse mPFC promotes response persistence and enhances the vulnerability to develop food addiction\, whereas miRNA-665-3p inhibition promotes compulsive-like behavior and enhances food addiction vulnerability. Therefore\, miRNA-29c-3p and miRNA-665-3p could act as protective factors against food addiction. The elucidation of these novel mechanisms provides advances toward innovative biomarkers and possible future interventions for food addiction and related disorders. \nBiosketch\nElena Martín-García is a senior researcher at Universitat Pompeu Fabra (UPF) in Barcelona since 2012 and Associate professor of Psychobiology at Universitat Autònoma de Barcelona (UAB) since 2022. She has a BSc in Psychology\, an MSc in Neuroscience\, and a Ph.D. in Neuroscience from the UAB. She did her postdoctoral research at the Neuropharmacology lab from 2007 to 2010. She completed her postdoctoral period at the INSERM in Bordeaux between 2010 and 2011 before establishing herself as a senior researcher in the Neuropharmacology lab at the UPF in 2012. Currently\, her research interests include studying the neurobiological basis of addiction and related disorders\, including obesity\, focusing on developing novel behavioral models to investigate the nature and origins of individual differences in behavior with a particular emphasis on genetic and environmental influences. Her group uses cutting-edge techniques such as chemogenetics\, calcium imaging\, electrophysiology in vivo\, and transgenic and experimental animal models linked with translational research in humans. In addition\, she has 67 scientific publications (h-index 26) in peer-reviewed journals related to Neuroscience. She belongs to the World Association on Dual Disorders (WADD) scientific committee. Finally\, she has been granted national and international projects as a principal investigator\, such as the Plan Nacional sobre Drogas by the Spanish Ministry of Health or the European ERA-NET neuron agency. \nRelated publications with the topic\nDomingo-Rodriguez\, L.#\, Ruiz de Azua\, I.#\, Dominguez\, E.\, Senabre\, E.\, Serra\, I.\, Kummer\, S.\, Navandar\, M.\, Baddenhausen\, S.\, Hofmann\, C.\, Andero\, R.\, Gerber\, S.\, Navarrete\, M.\, Dierssen\, M.\, Lutz\, B.*\, Martín-García\, E.*\, Maldonado\, R.*\, 2020. A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat. Commun. 11\, 1–16. #equal contributions; *shared senior authorship. \nGarcía-Blanco\, A.#\, Domingo-Rodriguez\, L.#\, Cabana-Domínguez\, J.#\, Fernàndez-Castillo\, N.#\, Pineda-Cirera\, L.\, Mayneris-Perxachs\, J.\, Burokas\, A.\, Espinosa-Carrasco\, J.\, Arboleya\, S.\, Latorre\, J.\, Stanton\, C.\, Cormand\, B.\, Fernández-Real\, J.-M.*\, Martín-García\, E.*\, Maldonado\, R.*\, 2022. MicroRNAs signatures associated with vulnerability to food addiction in mice and humans. J. Clin. Invest. 16;132(10):e156281. #equal contributions; *shared senior authorship. \nSamulėnaitė S.#\, García-Blanco\, A.#\, Mayneris-Perxachs\, J.#\, Domingo-Rodriguez\, L.\, Cabana-Domínguez\, J.\, Fernàndez-Castillo\, N.\, Pineda-Cirera\, L.\, Burokas\, A.\, Espinosa-Carrasco\, J.\, Arboleya\, S.\, Latorre\, J.\, Stanton\, C.\, Hosomi\, K.\, Kunisawa\, J.\, Cormand\, B.\, Fernández-Real\, J.-M.*\, Maldonado\, R.*\, Martín-García\, E.*\, 2022. Gut microbiota signatures of vulnerability to food addiction in mice and humans. Gut. (In second revision). #equal contributions; *shared senior authorship. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-elena-martin-garcia/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20231205T143000
DTEND;TZID=Europe/Paris:20231205T143000
DTSTAMP:20260601T122157
CREATED:20231122T135531Z
LAST-MODIFIED:20231124T092117Z
UID:164662-1701786600-1701786600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis Defense - Emmanuelle Baillet
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine \nThesis defense in French \n\nEmmanuelle Baillet\nSanpsy\nTeam : Addiction\nThesis directed by Marc Auriacombe \n\nTitle\nCraving: an early and predictive marker of addiction? \nAbstract\nAddiction\, or substance use disorder (SUD)\, can be characterized by deregulation of control over the use of reinforcing substances\, resulting in persistent use despite negative consequences. Craving\, defined as an intense urge to use\, is both a diagnostic criterion among the 11 DSM-5 criteria and a fluctuating phenomenon whose daily variations in everyday life explored with the Ecological Momentary Assessment (EMA) method have been prospectively associated with use\, giving it a potential prognostic and etiological value. The presence of craving in subjects with mild addiction suggests that it could be an early marker. On the other hand\, while craving is a powerful predictor of use and relapse in the short and medium term (1 year)\, the long-term impact (5 years and more) of its fluctuations is unknown. The cue-reactivity paradigm would lead to both craving and changes in brain and autonomic activity\, suggesting that these changes could be the physiological expression of craving. The aim of this PhD project was to investigate the role of craving in the development of addiction\, its impact on long-term relapse and its physiological correlates. A total of 1\,528 subjects with addiction or use of different substances\, in or out of treatment\, were included in different protocols. Craving was assessed either as a diagnostic criterion (a trait\, presence or absence)\, or as a fluctuating phenomenon (a state\, of variable intensity). DSM-5 diagnostic criteria were used to establish a network of symptoms in patients requesting treatment\, and to explore the predictive role of craving on addiction in a longitudinal general population study. The EMA was used to collect craving data\, while a wearable sensor was used to collect physiological data over a 14-day period. Multilevel models examined craving fluctuations and their impact on severity and relapse; then machine learning algorithms enabled exploration of its physiological correlates. Our results show that\, for different substances\, craving was the most central criterion in the network analyses\, and that a dose-response relationship for craving and its persistence over 12 months was associated with the number of SUD diagnostic criteria present. Dynamically\, variations in craving intensity during the first 14 days of treatment showed a slower decline for people relapsing to addiction after 5 years or more. Finally\, we were able to establish a physiological pattern distinguishing craving from no-craving episodes. In this PhD project\, we confirm the major role of craving as a central criterion for the expression of addiction\, and document that it is an early and predictive criterion in the development and severity of addiction. We show that fluctuations in craving intensity at the start of treatment could be a predictive marker of long-term relapse\, i.e.\, long-term response to treatment\, and that a physiological pattern could distinguish craving from no-craving episodes in daily life. These results underline the potential of craving as a marker of addiction and pave the way for biomarkers of craving\, offering new insights into its underlying mechanisms and new methods of identification and treatment. \nKey words\nCraving; Addiction; Ecological Momentary Assessment (EMA); Biomarkers; Autonomous reactivity \nJury\nPr Anna-Rose Childress (rapportrice)\nPr George Brousse (rapporteur)\nDr Sandra Chanraud (Examinatrice)\nDr Leonie Koban (Examinatrice)\nDr Serge Ahmed (Examinateur)\nDr Charlotte Kervran (Invitée)\nDr Hakim Si-Mohammed (Invité) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-emmanuelle-baillet/
CATEGORIES:Thesis
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