BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260601T072416
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231116
DTEND;VALUE=DATE:20231120
DTSTAMP:20260601T072416
CREATED:20231004T075059Z
LAST-MODIFIED:20231110T090846Z
UID:163131-1700092800-1700438399@www.bordeaux-neurocampus.fr
SUMMARY:FACTS 2023 «Intuition(s)»
DESCRIPTION:Retrouvez les créations des artistes et des chercheurs ainsi que toute la programmation bientôt sur le site de l’événement et les réseaux sociaux. \nAu programme : dispositif immersif\, mise en voix\, performances\, exposition\, jeux\, soirée DJ set\, cinéma\, visites guidées\, rencontres\, … \nVous pourrez retrouver tous ces événements dans les lieux partenaires du festival : \n\nHalle des Douves Bordeaux\nHall de l’atrium Victoire\nChapelle du Crous Bordeaux\nJardin botanique campus Talence\n\nPlus d’information : https://www.u-bordeaux.fr/evenements/facts-2023 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/facts-2023-intuitions/
CATEGORIES:Société
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231117T113000
DTEND;TZID=Europe/Paris:20231117T113000
DTSTAMP:20260601T072416
CREATED:20230321T135509Z
LAST-MODIFIED:20231108T171945Z
UID:157505-1700220600-1700220600@www.bordeaux-neurocampus.fr
SUMMARY:Friday Seminar - Ludovic Telley
DESCRIPTION:Venue : Centre Broca \n\nLudovic Telley\nUniversité de Lausanne\nhttps://wwwfbm.unil.ch/dnf/group/molecular-mechanisms-of-cerebellar-development/member/telley-ludovic-telley\n\nInvited by Matthieu Letellier\n\nTitle\nThe molecular logic of cerebellar diversity and assembly\nAbstract\nThe lab of Ludovic Telley is interested in understanding the molecular programs that control neuron differentiation\, interactions and assembly thus leading to functional circuits required as the bases for its many functions. His lab combines single-cells technologies\, bioinformatic tools and in vitro/in vivo gain and loss of function strategies. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-17-november-2023/
CATEGORIES:For scientists,home-event,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231117T113000
DTEND;TZID=Europe/Paris:20231117T113000
DTSTAMP:20260601T072416
CREATED:20231109T142250Z
LAST-MODIFIED:20231113T170314Z
UID:164248-1700220600-1700220600@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Liangyi Chen
DESCRIPTION:Venue: CGFB \n\nLiangy Chen\nSchool of Future Technology\nPeking University \nInvited by Daniel Choquet \nTitle\nQuantitative and holistic superresolution live-cell imaging: from structured illumination microscopy to the sparse deconvolution algorithm \nAbstract\nHere we present an overview of our recent works in live-cell superresolution (SR) microscopy. Over the past five years\, we have developed several innovative techniques to improve the resolution and accuracy of live-cell imaging. \nOur first breakthrough was the development of a structured illumination microscopy technique based on the continuity of biological structures embedded in Hessian matrices (Hessian-SIM). Hessian-SIM significantly reduces the photon dosage required for SR microscopy while suppressing reconstruction artifacts induced by random noise. Additionally\, we demonstrated that the high sensitivity of this method allows for the use of sub-millisecond excitation pulses followed by dark recovery times\, reducing photobleaching and enabling hour-long time-lapse SR imaging with common fluorescent probes in live cells (Nat. Biotechnol. 2018). \nTo enable holistic SR imaging\, we developed a dual-mode microscopy technique that combines SIM with label-free three-dimensional optical diffraction tomography (ODT). By providing a holistic view of organelles and simultaneously highlighting molecules\, this method is ideal for studying organelle interactomes. We demonstrated that the ODT module can resolve mitochondria\, lipid droplets\, the nuclear membrane\, chromosomes\, the tubular endoplasmic reticulum\, and lysosomes (Light Sci Appl. 2020). \nTo further push the resolution limit of live-cell SR imaging\, we developed a two-step iterative deconvolution algorithm based on continuity and sparsity of fluorescence signals (Sparse deconvolution)\, which extends resolutions beyond the physical limits of optical systems. Sparse-SIM achieving ~60 nm resolution at a 564 Hz frame rate\, resolving dynamics of ring-shaped nuclear pores over an hour in live cells. The algorithm can also be used to improve resolutions of other fluorescence microscopes\, such as confocal\, STED\, and lightsheet microscopes. Thus this mathematical path to improve microscopic resolution may have broad implications (Nat. Biotechnol. 2022). \nFinally\, for live-cell SR imaging to be quantitative\, the completeness of delicate structures and the linearity of fluorescence signals are required in addition to resolution. To make live-cell SIM microscopy more quantitative\, we proposed a physical model-based background removal method (BF-SIM). BF-SIM preserves intricate and weak structures down to sub-70 nm resolution while maintaining signal linearity\, enabling us to discover novel\, dynamic actin structures in live cells (Nat. Commun. 2023). \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-liangy-chen/
CATEGORIES:For scientists,home-event,Impromptu seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231117T140000
DTEND;TZID=Europe/Paris:20231117T140000
DTSTAMP:20260601T072416
CREATED:20231002T141155Z
LAST-MODIFIED:20231018T123402Z
UID:162778-1700229600-1700229600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Margaux Lebouc
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine  \nDefense in french \n\nMargaux Lebouc\nIMN\nTeam : Dopamine and neuronal assemblies\nThesis directed by Jérôme Baufreton\n \n\nTitle\nDevelopmental defect of the striatal circuit in mice models of Huntington’s disease \nAbstrat\nHuntington’s disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene encoding the Huntingtin protein (Htt). While symptoms\, primarily characterized by progressive deterioration of the striatum and motor and cognitive functions\, typically manifest in adulthood\, recent studies have also highlighted developmental deficits in HD. Indeed\, alterations in cortical and striatal development have been observed in individuals carrying the mutation as early as in embryonic stages. Furthermore\, the fact that selective expression of mHtt during development is sufficient to trigger symptom onset in adulthood suggests the existence of a developmental period during which physiological changes could render the brain vulnerable to HD pathogenesis. It is therefore crucial to better understand this neurodevelopmental aspect of the disease. However\, despite the striatum being one of the most affected regions in HD\, few studies have investigated potential developmental alterations in this structure\, especially in the early weeks after birth. This postnatal period is critical as it determines the establishment of morphological and electrophysiological properties of striatal neurons and the formation of their connections with the rest of the brain. All these maturation processes are finely coordinated\, implying that disruption of any of these mechanisms could significantly impact the formation of a functional striatal network. \n  \nTo address this question\, we longitudinally compared striatal development between wild-type (WT) mice and two murine models of HD\, R6/1 and CAG140 mice. These mouse lines were crossed with D1-GFP or D2-GFP mice to distinguish the two main subpopulations of striatal neurons (MSNs)\, those in the direct pathway (expressing the D1 receptor) and those in the indirect pathway (expressing the D2 receptor). First\, using immunohistochemistry approaches\, we demonstrated that the distribution of MSN-D1 and MSN-D2 within the striatum is not altered in HD mice during the first two postnatal weeks. Subsequently\, through ex vivo electrophysiology\, we observed that the maturation of electrical properties was specifically disrupted in MSN D2 neurons of HD mice\, with a decrease in their excitability. By reconstructing the dendritic arborization of these neurons\, we also observed alterations in their morphology\, characterized by increased dendritic complexity. When studying the establishment of striatal afferents\, we observed that glutamatergic transmission\, especially cortico-striatal transmission\, was specifically reduced in MSN-D2 neurons during the second postnatal week. Finally\, we found that projections from MSN-D2 neurons to their target structure\, the external Globus Pallidus (GPe)\, were reduced during the early postnatal days\, suggesting axonal growth defects. All these alterations were transient\, occurring during the early postnatal days\, before the circuit normalized on its own after the second postnatal week. These anatomical and electrophysiological data highlight the significant impact of the Htt mutation on numerous striatal development processes during the postnatal period. Interestingly\, we observed that these alterations specifically affect MSNs in the indirect pathway. This preferential vulnerability aligns with the early death of these neurons in adulthood\, suggesting that early treatment of these alterations could potentially modify the disease’s progression. \nKey words\nStriatum\, Huntington’s disease\, Electrophysiology\, Development\, Neuronal excitability\, Morphology\, Glutamatergic transmission \nJury\nDr. Sandrine Humbert\, Directrice de recherche\, Sorbonne Université\, Rapportrice\nDr. Nathalie Dehorter\, Prof Associate\, Université de Brisbane\, Rapportrice\nDr. Emilie Pacary\, Chargée de recherche\, Université de Bordeaux\, Examinatrice\nDr. Laurent Juvin\, Maître de conférences des universités\, Université de Bordeaux\, Examinateur\nDr. Wokciech Krezel\, Directeur de recherche\, Université de Strasbourg\, Examinateur\nDr. Jérôme Baufreton\, Directeur de recherche\, Université de Bordeaux\, Directeur de thèse\nDr. Maurice Garret\, Directeur de recherche\, Université de Bordeaux\, Invité \nPublications\nLebouc M\, Richard Q\, Garret M\, Baufreton J (2020) Striatal circuit development and its alterations in Huntington’s disease. Neurobiol Dis 145:105076.\nLebouc M\, Bonamy L\, Richard Q\, Scharnholz J\, Garret M\, Baufreton J\, Selective developmental alterations of striatal indirect-pathway neurons in mice models of Huntington’s disease. (en préparation)\nFois G*\, Lebouc M*\, Fioramonti S\, Morales M\, Baufreton J\, Barrot M\, Georges F\, GABAergic neurons in the tail of the VTA control dopaminergic neurons projecting to the globus pallidus. (en préparation)\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-margaux-lebouc/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR