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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20231029T010000
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DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260531T110512
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20231024
DTEND;VALUE=DATE:20231110
DTSTAMP:20260531T110512
CREATED:20221122T113608Z
LAST-MODIFIED:20231109T141649Z
UID:152946-1698105600-1699574399@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: Advanced techniques for synapse biology
DESCRIPTION:Venue: CGFB \nFree access \n\nOctober 24 – 9:00am \nCécile Charrier (Institute of Biology\, École Normale Supérieure\, France)\nMolecular mechanisms of synaptic development: insights from a human-specific gene. \nOctober 24 – 11:00am \nBrian Mac Cabe (EPFL\, Lausanne\, Swiss)\nUnknown knowns of Drosophila synapses. \nOctober 26 – 9:00am\n Noa Lipstein (LeibnizFMP\, Germany)\nSynaptic transmission in health and disease. \nOctober 26 – 11:00am\n Julie Perroy (IGF\, University of Montpellier\, France)\nMolecular dynamics at glutamatergic synapses and beyond. \nOctober 28 – 9:00am \nJosef Kittler (University College London\, UK)\nMolecular mechanism of inhibitory synapse formation and plasticity. \nOctober 30 – 9:00am \nDaniel Choquet (CNRS/University of Bordeaux\, France)\nNanoscale synapse organization and function. \nNovember 2 – 9:00am \nMarina Mikhaylova (Humboldt University \, Germany)\nCalcium and synaptic heterogeneity. \nNovember 3 – 9:00am\nRosa Paolicelli (University of Lausanne\, Swiss)\nMicroglia: key players in synapse remodeling in the healthy and diseased brain. \nNovember 3 – 11:00am \nAlfredo Kirkwood (Johns Hopkins University\, USA)\nPrinciples of Hebbian\, Pavlovian and Homeostatic synaptic plasticity. \nNovember 6 – 9:00am \nJuan Burrone (King’s College London\, UK)\nThe emergence and plasticity of inhibitory synapses: from dendrites to the axon initial segment. \nNovember 6 – 11:00am \nAxion BioSystems : Presentation \nNovember 7 – 9:00am \nNael Nadif Kasri (Radboud University Medical Center\, Netherlands)\nLeveraging spontaneous activity in human neuronal stem cell-derived neurons to model neurodevelopmental disorders. \nNovember 9 – 9:00am \nChristian Lohmann (Netherlands Institute for Neuroscience\, Netherlands)\nImaging synapse development. \nNovember 9 – 11:00am \nJulijana Gjorgjieva (Max Planck Institute for Brain Research\, Germany)\nEmergence of organization and computations at the subcellular and cellular scales. \nCourse directors\nAna Luisa Carvalho – Coimbra University\, Portugal \nMathieu Letellier – Bordeaux University\, France \nHey-Kyoung Lee – John Hopkins University.\, US \nAbout the course\nAdvanced techniques for synapse biology – CAJAL (cajal-training.org) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/advanced-techniques-for-synapse-biology/
CATEGORIES:Cajal Lectures,For scientists
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DTSTART;TZID=Europe/Paris:20231102T140000
DTEND;TZID=Europe/Paris:20231102T140000
DTSTAMP:20260531T110512
CREATED:20230828T132907Z
LAST-MODIFIED:20230829T095217Z
UID:161796-1698933600-1698933600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Morgane Darricau
DESCRIPTION:Venue : Centre Broca \nDefense in French \n\nMorgane Darricau\nIMN\nTeam: Pathophysiology of proteinopathies (Bezard)\nThesis directed by PLANCHE Vincent \n\nTitle\nPathophysiology of tauopathies and modeling in non-human primate \nAbstract\nMy PhD project was dedicated to the study of tauopathies. Tauopathies are a group of neurodegenerative diseases characterized by the accumulation and aggregation of pathological misfolded tau proteins. Alzheimer’s disease (AD)\, progressive supranuclear palsy (PSP)\, cortico-basal degeneration (CBD) and some frontotemporal lobar degenerations (FTLD) are part of the large family of tauopathies. These pathologies differ both clinically and anatomically\, with a distinct anatomical distribution of typical lesions. \nHowever\, the mechanisms of initiation and progression of tauopathies remain poorly understood for these pathologies. Recent studies have suggested that the development of tauopathies is based on “prion-like” features\, where a single tau proteopathic seed would have the ability to transmit pathogenic information\, to “contaminate” non-pathological soluble tau proteins leading to neurotoxicité. Tau aggregates would be transmitted from cell to cell\, thus explaining the spreading of tauopathy in different connected brain regions. However\, this hypothesis is based only on in vitro and vivo rodents experiments. These experimental models offer many advantages for the study of tauopathies\, but they do not fully reproduce human pathologies. In order to develop relevant pre-clinical studies of these pathologies\, it seems necessary today to work on experimental models as close as possible to human models. \nThus\, in my PhD project\, we proposed to model tauopathies in rhesus macaques (Macaca mulatta)\, an animal phylogenetically closest to humans. We focused on two tauopathies: PSP and Alzheimer’s disease. \nThe main aim of my PhD was to demonstrate the “prion-like” propagation of these two tauopathies in non-human primates. We focused on two tauopathies : PSP and Alzheimer’s disease. \nUsing intracerebral injections of tau proetopathic seeds extracted and purified from PSP and Alzheimer’s disease patients\, we induced the pathologies. Indeed\, we were able to observe in these primates the presence of lesions typical of these two tauopathies\, inclusions of hyperphosphorylated tau protein in neurons and glial cells for PSP\, and lesions of NFTs and neuropils threads for Alzheimer’s disease. The observation of these lesions around injection sites and within connected structures suggests the “prion-like” feature of tau protein\, where the simple injection of pathogenic material allows the formation of new aggregates progressing from cell to cell. \nThese various projects have enabled us to better understand the pathophysiology and mechanisms involved in the cognitive and motor disorders of these tauopathies. Furthermore\, the development of an animal model close to humans pave the way to new therapies. \nKeywords\nTauopathies\, “Prion-like”\, PSP\, Alzheimer’s disease\, non-human primates\, pathophysiology \nJury\nDr. Luc BUÉE\, Directeur de Recherche\, CNRS – Président\nDr. Marie-Claude POTIER\, Directeur de Recherche\, CNRS – Rapporteur\nDr. Philippe HANTRAYE\, Directeur de Recherche\, CNRS – Rapporteur\nDr. Vincent PLANCHE\, MCU-PH\, Univ. Bordeaux – Directeur de thèse \nPublications\nDarricau\, M.\, Canron\, M.-H.\, Bosc\, M.\, Arotçarena\, M.-L.\, Quang\, M.L.\, Dehay\, B.\, Bezard\, E.\, Planche\, V.\, 2021. Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment. Neurobiology of Aging 107\, 53–56. https://doi.org/10.1016/j.neurobiolaging.2021.07.009 \nDarricau\, M.\, Katsinelos\, T.\, Raschella\, F.\, Milekovic\, T.\, Crochemore\, L.\, Li\, Q.\, Courtine\, G.\, McEwan\, W.A.\, Dehay\, B.\, Bezard\, E.\, Planche\, V.\, 2023 Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates. Brain 1;146(6):2524-2534. https://doi.org/10.1093/brain/awac428 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-morgane-darricau/
CATEGORIES:Thesis
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