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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260530T221412
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20231024
DTEND;VALUE=DATE:20231110
DTSTAMP:20260530T221412
CREATED:20221122T113608Z
LAST-MODIFIED:20231109T141649Z
UID:152946-1698105600-1699574399@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures: Advanced techniques for synapse biology
DESCRIPTION:Venue: CGFB \nFree access \n\nOctober 24 – 9:00am \nCécile Charrier (Institute of Biology\, École Normale Supérieure\, France)\nMolecular mechanisms of synaptic development: insights from a human-specific gene. \nOctober 24 – 11:00am \nBrian Mac Cabe (EPFL\, Lausanne\, Swiss)\nUnknown knowns of Drosophila synapses. \nOctober 26 – 9:00am\n Noa Lipstein (LeibnizFMP\, Germany)\nSynaptic transmission in health and disease. \nOctober 26 – 11:00am\n Julie Perroy (IGF\, University of Montpellier\, France)\nMolecular dynamics at glutamatergic synapses and beyond. \nOctober 28 – 9:00am \nJosef Kittler (University College London\, UK)\nMolecular mechanism of inhibitory synapse formation and plasticity. \nOctober 30 – 9:00am \nDaniel Choquet (CNRS/University of Bordeaux\, France)\nNanoscale synapse organization and function. \nNovember 2 – 9:00am \nMarina Mikhaylova (Humboldt University \, Germany)\nCalcium and synaptic heterogeneity. \nNovember 3 – 9:00am\nRosa Paolicelli (University of Lausanne\, Swiss)\nMicroglia: key players in synapse remodeling in the healthy and diseased brain. \nNovember 3 – 11:00am \nAlfredo Kirkwood (Johns Hopkins University\, USA)\nPrinciples of Hebbian\, Pavlovian and Homeostatic synaptic plasticity. \nNovember 6 – 9:00am \nJuan Burrone (King’s College London\, UK)\nThe emergence and plasticity of inhibitory synapses: from dendrites to the axon initial segment. \nNovember 6 – 11:00am \nAxion BioSystems : Presentation \nNovember 7 – 9:00am \nNael Nadif Kasri (Radboud University Medical Center\, Netherlands)\nLeveraging spontaneous activity in human neuronal stem cell-derived neurons to model neurodevelopmental disorders. \nNovember 9 – 9:00am \nChristian Lohmann (Netherlands Institute for Neuroscience\, Netherlands)\nImaging synapse development. \nNovember 9 – 11:00am \nJulijana Gjorgjieva (Max Planck Institute for Brain Research\, Germany)\nEmergence of organization and computations at the subcellular and cellular scales. \nCourse directors\nAna Luisa Carvalho – Coimbra University\, Portugal \nMathieu Letellier – Bordeaux University\, France \nHey-Kyoung Lee – John Hopkins University.\, US \nAbout the course\nAdvanced techniques for synapse biology – CAJAL (cajal-training.org) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/advanced-techniques-for-synapse-biology/
CATEGORIES:Cajal Lectures,For scientists
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231026T103000
DTEND;TZID=Europe/Paris:20231026T103000
DTSTAMP:20260530T221412
CREATED:20231003T095003Z
LAST-MODIFIED:20231012T124149Z
UID:163046-1698316200-1698316200@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Franck Molina
DESCRIPTION:Venue: CGFB \n\n©Cyril FRESILLON / Sys2Diag / CNRS Photothèque\nFranck Molina\nSys2Diag UMR9005 CNRS / ALCEN\,\nMontpellier \nInvited by David Perrais (IINS) \nTitle\nSynthetic biology : Non-Living Biomachines design for next generation medical diagnostic \nAbstract\nCOVID-19 crisis showed us that research must adapt hit practices to face the pandemics challenges. EasyCOV rapid salivary covid test is an example of such public-private and inter-disciplinary cooperation. Current evolutions in medical practices induce a change of paradigm with the convergence of diagnosis and therapy\, going to precision medicine and “theranostics”. One can observe the new role of biomarkers in biomedical and therapeutic applications\, for instance in the development of molecular multiplex biosensors (nucleic acid\, proteins\, and metabolites). In addition\, there is an increasing interest for point-of-care (POC) and of home monitoring/testing technologies devoted to probe patient parameters in his direct environment. The obvious constraints for such a kind of new clinical practices are simplification\, drastic cost reduction while keeping high performances. Within this context\, synthetic biology provides new opportunities to develop a novel generation of biological biosensors able to perform multiplexed biomarkers detection\, simple computation and returning simplified relevant results 1) In order to design robust synthetic biological biosensor systems reliable in a clinical context and based on biochemical circuits\, we developed an original methodology ensuring biochemical implementation of logical tasks within nonliving vesicles so called “biomachines”. This methodology covers in silico design\, simulation\, microfluidics production and clinical validation on human samples 2). It ends up in very simple diagnostic assay like for instance the new insulin-resistance assay\, which is also quick and easy to run out of a laboratory and at very low cost. \nKey publications\n\n1. Courbet A\, Renard E\, Molina F. Bringing next-generation diagnostics to the clinic through synthetic biology. EMBO Mol Med. 2016;8(9):987-91. \n2. Courbet A\, Amar P\, Fages F\, Renard E\, Molina F. Computer-aided biochemical programming of synthetic microreactors as diagnostic devices. Mol Syst Biol. 2018;14(6):e8441. \n3. F Santos Schneider\, Amar P\, A Bahri\, J Espeut\, M Alali\, F. Fages\, F. Molina\,  Biomachines For Medical Diagnosis. Advanced Materials Letters\, VBRI Press\, 2020\, 11 (4)\, pp.1-5. ⟨10.5185/amlett.2020.041499⟩. ⟨hal-03059916⟩ DOI : 10.5185/amlett.2020.041499 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-franck-molina/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20231026T140000
DTEND;TZID=Europe/Paris:20231026T140000
DTSTAMP:20260530T221412
CREATED:20231006T125524Z
LAST-MODIFIED:20231011T150545Z
UID:163164-1698328800-1698328800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Anaëlle Braine
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine  \nThesis defense in english \n\nAnaelle Braine\nIMN\nTeam : Dopamine and neuronal assemblies\nThesis directed by François Georges \n\nTitle\nAnatomical and functional characterization of amygdala-striatal circuits \nAbstract\nChanges in emotional states are known to modify posture\, fine motor control\, and coordination. This suggests an overlap between neuronal circuits underlying emotions and motor control. We thus performed an extensive review of the anatomical projections between emotional-related and motor-related structures. Based on this analysis\, we focused the PhD on basolateral amygdala (BLA) projections to the dorsal striatum (DS) in mice. As the DS is functionally subdivided in dorsomedial (DMS) and dorsolateral (DLS) striatum\, we first defined the anatomical and electrophysiological properties of DMS- and DLS- projecting BLA neurons. To do so\, we used a palette of tracing tools combined with ex-vivo (patch-clamp). Anatomical and electrophysiological properties reveal two distinct DS-projecting BLA neuronal populations. We showed that the BLA topographically projects to the DS\, with main projections to the DMS and that DMS-projecting BLA neurons are more excitable than DLS-projecting BLA neurons. To understand how BLA inputs are integrated in the DS\, we determined the nature of DS neurons receiving BLA inputs using patch-clamp electrophysiological recordings in transgenic mouse lines following ChR2 expression in the BLA. BLA neurons preferentially excited medium spiny neurons (MSNs) and parvalbumin (PV) interneurons. This suggests that the BLA acts like a cortical input to the DMS. The function of BLA neuronal subpopulation is classically projection-defined. To shed light on the putative function of DMS-projecting BLA neurons\, we focused on deciphering the neural circuitry of DMS-projecting BLA neurons and performed a whole-brain mapping of the inputs and outputs of this pathway. To do so\, we used anterograde and retrograde viral cre-dependent strategies combined with semi-automatic mapping and counting analysis tools. We showed that DMS-projecting BLA neurons have extensive collaterals to olfactory and goal-directed circuits (olfactory tubercle and nucleus of the lateral olfactory tract)\, while receiving mainly limbic (ventral hippocampus\, insular cortex) and olfactory inputs (piriform cortex). Known outputs of BLA involved in fear- and anxiety-related behaviors such as the Bed Nucleus of the Stria Terminalis\, Central Amygdala and ventral Hippocampus were not innervated by DMS-projecting BLA neurons. \nThese anatomical results refined our hypothesis for the role of DMS-projecting BLA neurons in odor-guided behaviors. To test this hypothesis\, we set out to record the axonal activity of DMS-projecting BLA neurons in vivo. To do so\, we first carried out in vivo fiber photometry axonal imaging in the DMS of anesthetized mice and confirmed the functional connectivity of the main limbic inputs to DMS-projecting BLA neurons. We showed that both the insular cortex and the ventral hippocampus can send indirect disynaptic inputs to the DMS via the BLA. We then carried out in vivo fiber photometry in behaving mice in olfactory-related behavioral tasks such as the social interaction test and olfactory habituation-discrimination task. We show a phasic inhibition of the DMS-projection BLA axons\, time locked to the investigation/interaction to non-social and social odors. Future studies manipulating the activity of these neurons would help us determine whether they drive motor-related information such as orientation and locomotor or valence information for odor-driven approach or avoidance. \nKey Words\nAmygdala\, Striatum\, odor-guided behavior\, neuromodulator\, tracing\, Fiber photometry\, Emotion\, Anxiety \nJury\n– Emmanuel Valjent\n– Corrine Beurrier\n– Pierre Veinante\n– Anna Beyeler\n– Guillaume Ferreira\n– François Georges \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-anaelle-braine/
CATEGORIES:Thesis
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