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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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DTSTART:20240331T010000
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DTSTART:20241027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260530T040759
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183442Z
UID:162245-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le “cognitilab”\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cervorama/
CATEGORIES:Events for all,not-calendar,pour tous homepage,Semaine du cerveau 2024
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231011
DTEND;VALUE=DATE:20231012
DTSTAMP:20260530T040759
CREATED:20231002T194721Z
LAST-MODIFIED:20231010T153111Z
UID:162797-1696982400-1697068799@www.bordeaux-neurocampus.fr
SUMMARY:FKNE Symposium: Cellular & Circuit Dynamics in Learning & Memory
DESCRIPTION:Venue: Centre Broca \n\nOrganized by the FENS KAVLI Network of Excellence  \nLocal organizer : Anna Beyeler \nFree access \nProgram\n09:50 – 10:00\nIntroduction of the FENS-Kavli Network & day overview \n10:00 – 11:00 / Keynote speaker – Chair: Anna Beyeler\, FKNE\, Magendie Center\, INSERM\, FR\nSheena Josselyn (Hospital for Sick Children\, Canada)\nMaking memories in mice \n11:30 – 13:00 / Session 1 – Chair: Abhishek Banerjee\, FKNE\, Newcastle University\, UK \nBianca Silva\, FKNE\, Humanitas Research Hospital\, CNR\, IT\nBrain circuits for fear attenuation \nSami El Boustani\, FKNE\, University of Geneva\, CH\nCortical circuits for cross-modal transfer learning \nDorothy Tse\, FKNE\, Edge Hill University\, UK\nThe determinants of memory \nLisa Genzel\, FKNE\, Radboud University\, NL\nSemantic-like memories in rodents \nLisa Roux\, Institut interdisciplinaire de Neuroscience (IINS)\, CNRS\, FR\nPopulation bursts in archicortices: from hippocampal ripples to piriform cortex \n14:00 – 15:30 / Session 2 – Chair: Alex Cayco Gajic\, FKNE\, ENS – PSL University\, FR \nJulijana Gjorgjieva\, FKNE\, Technical University of Munich\, DE\nLearning nonlinear neuronal computations  \nMartin Dresler\, FKNE\, Donders Institute\, NL\nhy and how we sleep? \nNikolaos Kontantidines\, FKNE\, Institut Jaques Monod\, CNRS\, FR\nEvolution and development of neuronal diversity \nEmilie Pacary\, Neurocentre Magendie\, INSERM\, FR\nDevelopmental and adult neurogenesis in the dentate gyrus: Do they generate similar neurons? \nArthur Leblois\, Institut des Maladies Neurodégénératives (IMN)\, CNRS\, FR\nBehavioral variability and basal ganglia-dependent motor learning: Lessons from songbirds \n16:00 – 17:30 / Session 3 – Chair: Michaela Fenckova\, FKNE\, Univ. of South Bohemia\, CZ \nYoav Livneh\, FKNE\, Weizmann Institute\, IL\nBrain-body interactions: Sensations and predictions in the insular cortex \nNora Raschle\, FKNE\, University of Zurich\, CH\nPerspectives on emotion regulatory brain correlates from childhood to adolescence \nTaro Kitazawa\, FKNE\, DANDRITE\, Nordic-EMBL\, DK\nRecording cellular memory to unveil the mechanisms of brain memory \nAgnès Nadjar\, Neurocentre Magendie\, INSERM\, FR\nEffect of nutrient sensing by microglia on mouse behavior \nDavid Dupret\, FKNE Alumni\, Oxford\, UK\nOrganizing the coactivity structure of the hippocampus from robust to flexible memory \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/fkne-symposium-cellular-circuit-dynamics-in-learning-memory/
CATEGORIES:For scientists,home-event,Other events,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231011T093000
DTEND;TZID=Europe/Paris:20231011T123000
DTSTAMP:20260530T040759
CREATED:20230927T082048Z
LAST-MODIFIED:20231004T093255Z
UID:162634-1697016600-1697027400@www.bordeaux-neurocampus.fr
SUMMARY:Mini-symposium "Synaptic Health and Dysfunction: Implications for Brain Disorders"
DESCRIPTION:\nVenue : CGFB \n3D render of a medical background with virus cells on brain highlighted\n\n\nProgramme\n09:30 – 10:15\nProfessor Ana Luisa Carvalho\nDepartment of Life Sciences\, The University of Coimbra\n\n10:15 – 11:00\nProfessor David Wyllie\nCentre for Discovery Brain Sciences\, The University of Edinburgh \n\n11:00 – 11:45\nProfessor Dimitri Kullmann\nQueen Square Institute of Neurology\, University College London \n\n  \nOrganized by Daniel Hunter (IINS) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/synaptic-health-and-dysfunction-implications-for-brain-disorders/
CATEGORIES:For scientists,home-event,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231011T120000
DTEND;TZID=Europe/Paris:20231011T173000
DTSTAMP:20260530T040759
CREATED:20230922T083710Z
LAST-MODIFIED:20230922T171955Z
UID:162595-1697025600-1697045400@www.bordeaux-neurocampus.fr
SUMMARY:2ème journée de Rencontres et d’Échanges autour des techniques d'imagerie biomédicale
DESCRIPTION:Lieu : CGFB – Salle de conférence \n\nCette 2ème journée de rencontre Chimie-Biologie fait suite à celle que nous avions organisée le 16 décembre dernier autour des “petites molécules thérapeutiques”. \nCette fois-ci\, la journée\, qui sera en fait une grosse demi-journée\, aura pour thème l’imagerie biomédicale. Elle aura lieu dans l’amphithéâtre du Centre de Génomique Fonctionnelle de Bordeaux\, sur le Campus de Carreire. Les présentations seront entrecoupées de temps pour pouvoir discuter et échanger . \nL’idée de la journée est toujours de faire rencontrer la chimie et la biologie de Bordeaux autour de thèmes balayant les différentes activités de recherche des laboratoires bordelais. \nPour plus d’informations : https://sts.u-bordeaux.fr/evenements/rencontre-imagerie-biomedicale  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/2eme-journee-de-rencontres-et-dechanges-autour-des-techniques-dimagerie-biomedicale/
CATEGORIES:For scientists,home-event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231011T140000
DTEND;TZID=Europe/Paris:20231011T140000
DTSTAMP:20260530T040759
CREATED:20231002T134950Z
LAST-MODIFIED:20231004T100422Z
UID:162770-1697032800-1697032800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Daniel Hunter
DESCRIPTION:Venue : Conference room – Neurocentre Magendie \nDefense in english \n\nDaniel Hunter\nIINS\nTeam : Development and adaptation of neuronal circuits\nThesis directed by Laurent Groc \n\nTitle\nA Characterisation of Hippocampal Pathophysiology in Autoimmune Encephalitis: From Synapse to Circuit \nAbstract\nNMDAR and GABAAR encephalitides are immune-mediated neurological syndromes\, in which the expression of pathogenic autoantibodies (Abs)\, directed against either NMDARs or GABAARs respectively\, results in complex disease presenting with seizures and neuropsychiatric complications. Molecular investigations have delineated the actions of patient-derived Abs on their target antigens\, whereby NMDAR and GABAAR Abs ultimately drive respective hypofunctions of major excitatory or inhibitory ion channels. Paradoxically however\, despite this converse action of disease-causing Abs\, preclinical investigations have demonstrated that both NMDAR and GABAAR Abs induce hyperexcitation of neuronal networks. As such\, we aimed to characterise a broader-scale functional impact of autoantibody actions\, at synaptic\, cellular and circuit-levels\, to finely elucidate the mechanisms by which both NMDAR and GABAAR Abs elicit a hyper-excitable seizure phenotype in clinical settings. \nWe observed that 24-hour autoantibody exposure\, irrespective of the target antigen\, reduced the amplitude of both spontaneous excitatory and inhibitory postsynaptic currents. Intriguingly\, the magnitude of reduction in inhibition was consistently greater\, suggesting that the synaptic input onto pyramidal cells becomes unbalanced in favour of hyperexcitation. Examination of spontaneous current kinetics\, and immunocytochemistry experiments further suggest these alterations are underpinned by a displacement of both AMPARs and GABAARs from their respective postsynaptic compartments. Further\, imaging and multiplicity analysis revealed that both pathogenic Abs drive a selective depletion of inhibitory synaptic scaffolding protein\, gephyrin\, in a phosphorylation-associated manner. However\, the excitatory synaptic scaffold\, homer-1c\, remained intact after exposure to Abs\, further supporting a shift towards synaptic hyperexcitation\, despite overall depression of synaptic inputs. \nTo understand how these aberrant synaptic inputs are functionally integrated into hippocampal network activity we subsequently characterised a range of intrinsic cellular properties of excitatory and inhibitory hippocampal populations. We observed that GABAAR Abs uniquely disrupt the excitatory cell populations\, driving an increase in the resting membrane potential and an increased action potential output in response to current injection. Further investigations suggested this increase in excitability may be underpinned by the loss of tonic GABAergic inhibition and/or modulation of axonal GABAAR channel conductance. Additionally\, we uncovered a unique impact of NMDAR Abs on the inhibitory cell populations\, whereby intrinsic excitability is significantly reduced. In this case\, exposure to NMDAR Abs results in hyperpolarisation of interneuron resting potentials and reduced action potential output. This is in line with a classical disinhibitory model\, in which potent inhibitory control over hippocampal networks is abolished\, leading to destabilised hyperfunction of the local excitatory cell population. Cell-attached recordings and calcium imaging experiments further provided support of these findings\, in which we observed hyperactivation of excitatory cell populations\, after exposure to either pathogenic Ab\, and a unique hypersynchronous state after NMDAR Ab exposure. \nTaken together\, these findings are indicative of two discrete disease models whereby synaptic inputs are similarly dysregulated but differentially gated by shifts in intrinsic cellular properties\, resulting in an overall similar hyperexcitable phenotype at the scale of hippocampal network function. Ultimately\, our work has expanded on the current knowledge of pathological mechanisms involved in two autoimmune encephalitic diseases and helps to identify key nodes of convergence and divergence in these two conditions\, lending some explanation towards the similar phenotypic presentations observed at the clinical scale. \nJury\nProfessor Dimitri KULLMANN – Queen Square Institute of Neurology\, University College London\nProfessor David WYLLIE – Centre for Discovery Brain Sciences\, The University of Edinburgh\nProfessor Ana Luisa CARVALHO – Department of Life Sciences\, The University of Coimbra \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-daniel-hunter/
CATEGORIES:Thesis
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