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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20221219
DTEND;VALUE=DATE:20230619
DTSTAMP:20260502T232209
CREATED:20221215T174158Z
LAST-MODIFIED:20230214T143012Z
UID:153788-1671408000-1687132799@www.bordeaux-neurocampus.fr
SUMMARY:Exposition: Illusions
DESCRIPTION:Lieu : Cap Siences \n\n\n\nEt si le cerveau était un véritable terrain de jeu… Qu’est-ce qu’une illusion ? Comment et pourquoi sommes-nous trompés ? \n\n\n\n\nSi l’illusion naît de nos sens\, elle s’élabore dans le cerveau. Nous voyons\, entendons\, touchons « avec notre cerveau ». Une perception est rarement uni-sensorielle. Plusieurs sens se combinent pour produire une interprétation du monde qui nous entoure : c’est le rôle du cerveau de produire du sens. Il utilise le passé pour s’adapter au présent et dans de nombreux cas compenser le manque d’informations dont il dispose. \nLe cerveau Il tient compte de ce qu’il “sent”\, mais aussi de ce qu’il sait déjà\, de ce que nous avons vécu\, mémorisé. Ce qui nous rend bien des services au quotidien pour prendre des décisions et réagir rapidement ! Mais aussi sophistiqué soit-il\, cet outil peut cependant être trompé par certaines situations… \nCette exposition\, propose une approche interactive à la découverte de nos sens et de nos perceptions. Les manipulations\, des plus simples aux plus impressionnantes troublent les perceptions dans une expérience déroutante. \n\n\n\n\nLe cerveau devient alors un terrain de jeu : Alors\, prêts pour une nouvelle expérience de la réalité ? \n  \n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-illusions/
CATEGORIES:Events for all,not-calendar,Semaine du cerveau 2023
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DTSTART;TZID=Europe/Paris:20230203T113000
DTEND;TZID=Europe/Paris:20230203T113000
DTSTAMP:20260502T232209
CREATED:20220917T121409Z
LAST-MODIFIED:20230131T140200Z
UID:150959-1675423800-1675423800@www.bordeaux-neurocampus.fr
SUMMARY:Monthly conference (PhD seminar) - Andreas Lüthi
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nAndreas LÜTHI\n(Friedrich Miescher Institute for Biomedical Research\, Basel – CH) \nInvited by Cloé Lheraux (PhD student\, Cyril Herry’s team) \nTitle\nBrain mechanisms for emotional states \nAbstract\nAnimal behavior is dictated by internal variables\, such as the need to feed\, drink\, survive or reproduce. Together with external stimuli and past experiences\, these variables define an animal’s state\, or emotional state\, that determines a repertoire of appropriate behaviors given the specific circumstances. Although it is understood that the emotional state of an animal is a function of the ongoing brain network configuration\, it remains largely unknown how the corresponding brain-wide configurations are generated and how they define emotional states and behavior. Key to understanding of the neurobiological principles underlying emotional states is a distributed brain system\, historically termed the “limbic system”\, that processes emotional\, metabolic and social stimuli. One of the key hubs of the “limbic system” is the amygdala\, a set of subcortical nuclei highly interconnected with many brain areas and classically implicated in associative conditioning. \nIn my talk\, I will discuss the general neurobiological principles underlying the generation of emotional states across different behavioral paradigms by focusing on the mouse amygdala. I will present recent experiments longitudinally imaging neural calcium dynamics across different environments in freely moving mice engaged in exploratory or learned instrumental behaviors demonstrating that changes in the activity of major\, non-overlapping populations of amygdala principal neurons predict switches between behavioral states and that these state signals are tightly correlated with an animal’s learned expectations. The amygdala broadcasts state information via several output pathways to larger brain networks\, and sensory responses in BA occur independently of behavioral state encoding. Thus\, the brain processes external stimuli and internal states orthogonally\, which may facilitate rapid and flexible selection of appropriate\, state-dependent behavioral responses. \nBiosketch\nAndreas Lüthi obtained his PhD in Neurobiology at the University of Basel\, Switzerland. After postdoctoral stays in Bristol\, UK and in Zurich\, Switzerland\, he established his own research group in 2000\, initially at the Biozentrum of the University of Basel and then at the Friedrich Miescher Institute for Biomedical Research. His lab addresses how neuronal circuits can generate behavior with a particular emphasis on synaptic\, cellular and circuit mechanisms underlying learning and memory using classical conditioning as a model system. Recently\, his lab became interested in the neuronal network mechanisms underlying the generation of emotional states. \nKey publications\n\nCourtin J\, Bitterman Y\, Müller S\, Hinz J\, Hagihara KM\, Müller C\, Lüthi A. (2022) A neuronal mechanism for motivational control of behavior. Science 375: eabg7277.\nFustinana MS\, Eichlisberger T\, Bouwmeester T\, Bitterman Y\, Lüthi A (2021) State-dependent encoding of exploratory behavior in the amygdala. Nature 592: 267-271.\nHagihara KM\, Bukalo O\, Zeller M\, Aksoy-Aksel A\, Karalis N\, Limoges A\, Rigg T\, Campbell T\, Mendez A\, Weinhotz C\, Mahn M\, Zweifel LS\, Palmiter RD\, Ehrlich I\, Lüthi A\, Holmes A (2021) Competition between intercalated amygdala clusters orchestrates a switch in fear state. Nature 594: 403-407.\nGründemann J\, Bitterman Y\, Lu T\, Krabbe S\, Grewe BF\, Schnitzer MJ\, Lüthi A (2019) Amygdala ensembles encode behavioral states. Science: eaav8736.\nGrewe BF\, Gründemann J\, Kitch LJ\, Lecoq JA\, Parker J\, Marshall JD\, Larkin MC\, Jercog P\, Grenier F\, Li JZ\, Lüthi A\, Schnitzer MJ (2017) Neural ensemble dynamics underlying long-term associative memory. Nature 543: 670-675.\n\n  \n  \n\nPhD seminars are organized by the NBA\, Bordeaux Neurocampus\, and the Bordeaux Neurocampus Graduate Program \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-andreas-luthi/
CATEGORIES:For scientists,home-event,Monthly conferences
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DTSTART;TZID=Europe/Paris:20230203T140000
DTEND;TZID=Europe/Paris:20230203T140000
DTSTAMP:20260502T232209
CREATED:20221213T171111Z
LAST-MODIFIED:20230123T135510Z
UID:153711-1675432800-1675432800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Valentin Plateau
DESCRIPTION:Venue: Centre Broca \nDefense in english \n\nValentin Plateau\nValentin Plateau\nIMN\nTeam: Baufreton / Georges\nThesis supervisor: Morgane Le Bon-Jégo \nTitre\nElectrophysiological characterization and functional importance of midbrain dopaminergic neurons projecting to the primary motor cortex \nAbstract\nThe primary motor cortex (M1) plays a key role in motor learning processes. Learning sophisticated motor sequences\, such as skill-reaching behavior\, relies on dopamine (DA)-dependent structural and synaptic plasticity in M1. Although the architecture of the dopaminergic system within M1 has been well characterized anatomically\, the electrophysiological characterization and functional importance of these midbrain dopaminergic neurons projecting to M1 remains poorly understood. Thus\, the objectives of this thesis were\, on the one hand\, to identify and characterize the intrinsic properties of the dopaminergic neurons of the midbrain projecting to M1\, and then to study their activity during motor learning; and on the other hand\, to study the functional importance of this dopaminergic innervation at the level of M1 neurons. Firstly\, retrograde tracing experiments demonstrated in mice a rostro-ventrolateral localization of midbrain dopaminergic neurons projecting to M1. Ex vivo electrophysiological recordings of the activity of these neurons showed that they have an electrophysiological signature similar to that of dopaminergic neurons of the nigrostriatal pathway. It has then been demonstrated that their excitability increases during the learning of a new fine motor task (single pellet reaching task)\, and that this increase in excitability was correlated with the greatest increase in learning in mice. Moreover\, this increase in excitability was no longer observable when the motor task was learned. DA release in M1 was then demonstrated by ex vivo imaging using GRABDA1m\, a genetically encoded dopaminergic sensor. Then\, optogenetic activation of dopaminergic fibers from midbrain neurons revealed glutamate and/or GABA corelease in rare experiments in some M1 pyramidal cells. To measure the functional importance of these dopaminergic afferents on pyramidal neurons\, a pharmacological approach was used. In order to study the role of the D1 receptor in M1\, experiments were performed in young and adult mice to test if age-dependent differences are observed as it has been shown in the prefrontal cortex. First\, a mapping of D1 receptors in M1 was performed\, indicating no real age-dependent difference in D1 receptor localization. Ex vivo electrophysiological recordings then showed that D1 receptor activation induces an increase in the excitability of M1 pyramidal neurons in young and adult mice\, whereas D1 receptor blockade induces a decrease in the excitability of these neurons in young mice\, but an increase in adult mice. Thus\, the modulation of M1 pyramidal neurons by D1 receptors is age dependent. This project has led to a better understanding and knowledge of the origins and implications at the cellular and behavioral levels of dopamine in M1. \nJury\n– Denis COMBES – Université de Bordeaux – Professeur des universités – Président du jury\n– Ingrid BUREAU – Aix-Marseille Université – Chargée de recherche – Rapporteur\n– Jacques BARIK – Université Côte d’Azur – Maître de conférence universitaire – Rapporteur\n– Catherine LE MOINE – Université de Bordeaux – Directrice de recherche – Examinateur\n– Emmanuel VALJENT – Université de Montpellier – Directeur de recherche – Examinateur\n– Morgane LE BON-JÉGO – Université de Bordeaux – Maître de conférence universitaire – Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-valentin-plateau/
CATEGORIES:Thesis
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