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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20220327T010000
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DTSTART:20221030T010000
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DTSTART;VALUE=DATE:20220211
DTEND;VALUE=DATE:20230103
DTSTAMP:20260409T095720
CREATED:20220209T143152Z
LAST-MODIFIED:20220209T143152Z
UID:144934-1644537600-1672703999@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : "Cell Immersion"
DESCRIPTION:Les Bassins des Lumières – Imp. Brown de Colstoun\, Bordeaux \n\nCell Immersion vous convie à un voyage Art & Science dans un monde microscopique méconnu : l’humain. \nL’œuvre est la première brique d’un projet d’envergure\, nommé Cell Worlds\, qui amène les images de microscopie là où elles ne sont jamais allées. Loin des laboratoires et des disques durs des scientifiques et au plus près des cellules humaines. Ici\, tout est bien réel\, et surtout vivant. Chaque visuel de l’exposition se compose de véritables cellules : de l’électrisant neurone au fragile embryon en passant par les mélancoliques flux sanguins du cerveau. Découvrez un univers aux couleurs chatoyantes et d’une diversité incroyable. \nCell Immersion est une première mondiale scientifique\, mettant en scène le vivant microscopique dans des proportions jamais tentées. C’est également un des plus grands showcases de la recherche scientifique\, regroupant de nombreuses équipes\, laboratoires et instituts du monde entier. Une preuve que la science et l’art n’ont pas de frontières. \nÀ travers l’émerveillement\, ce voyage saura éveiller votre curiosité scientifique. Au-delà du simple divertissement\, Cell Immersion vous invite à vous reconnecter avec le monde vivant microscopique qui est aujourd’hui trop inconnu\, trop peu contemplé et parfois trop mystifié. \n  \n\nRéalisation : Terence Saulnier et Renaud Pourpre \nComposition de la bande originale : Youenn Lerb \n\nCet événement est organisé dans le cadre de la Semaine du Cerveau. \nPour plus d’informations : https://www.bassins-lumieres.com/fr/cell-immersion \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cell-immersion/
LOCATION:Les Bassins des Lumières\, Imp. Brown de Colstoun\, Bordeaux\, 33000\, France
CATEGORIES:not-calendar,Semaine du cerveau 2022
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20221216T090000
DTEND;TZID=Europe/Paris:20221216T153000
DTSTAMP:20260409T095720
CREATED:20221209T135249Z
LAST-MODIFIED:20221215T180655Z
UID:153644-1671181200-1671204600@www.bordeaux-neurocampus.fr
SUMMARY:Centre hospitalier Charles Perrens : Journée de la recherche
DESCRIPTION:Centre hospitalier Charles Perrens \n\nSite web : \nhttps://www.ch-perrens.fr/actualites/semaine-de-la-recherche-de-la-prevention-et-de-linnovation \nInscriptions à toutes les manifestations \nhttps://forms.gle/DXMbEpBbBxtKTcbt9 \nInformations: \nsemaine-prevention-recherche@ch-perrens.fr \n\nTélécharger le Programme complet (pdf) \n  \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/centre-hospitalier-charles-perrens-semaine-de-la-recherche-de-la-prevention-et-de-linnovation/
CATEGORIES:Events for all,For scientists,home-event,Other events
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20221216T140000
DTEND;TZID=Europe/Paris:20221216T140000
DTSTAMP:20260409T095720
CREATED:20221103T142442Z
LAST-MODIFIED:20221208T152834Z
UID:151740-1671199200-1671199200@www.bordeaux-neurocampus.fr
SUMMARY:thesis defense - Lise Guilhemsang
DESCRIPTION:Venue: Centre Broca \n\nThesis supervisors: Thomas Boraud (IMN) etTeresa Morera Herreras (UPV/EHU) \n\nTeamNetwork dynamics for procedural learning (Leblois / Mallet)\nIMN \nTitle\nNetwork dynamic of Basal Ganglia circuits in normal and parkinsonian conditions \nAbstract\nBasal ganglia (BG) circuits are involved in different functions from movement control to cognitive/motivational processes. The loss of dopamine (DA) in these circuits triggers Parkinson’s disease (PD) characterised by devastating motor impairments known as akinesia and bradykinesia. In addition to DA depletion\, PD patients present an early serotonergic (5-HT) alteration at the level of the BG nuclei. \n5-HT modulates the activity of BG circuitry by acting on a large variety of 5-HT receptor subtypes. Among them\, the 5-HT2A receptor is expressed in both motor and associative/limbic territories of the BG nuclei being implicated in regulation of motor\, executive and cognitive functions\, as well as automatisms. In addition\, 5-HT2A receptors may also play a role in diseases linked to BG dysfunction\, such as PD. However\, the role of the 5-HT2A receptor in cortical-BG information processing is still not well understood. \nTherefore\, in the first part of my PhD\, we investigated the specific contribution of 5-HT2A receptors on the dynamic response of BG output nucleus to motor and medial prefrontal (mPF) cortical information. For that purpose\, in vivo single-unit extracellular recordings of lateral and medial substantia nigra pars reticulata (SNr) neurons along with simultaneous electrical stimulation of the motor and mPF cortex were used to assess the effect of 5-HT2A receptor activation/blockade. The results showed a topographical-dependent dissociation in the effects triggered by the 5-HT2A agonist TCB-2\, which specifically increased the medial SNr neuron activity and had preferential action on mPF cortical information processing through the striato-nigral direct pathway. These findings provide novel evidence about the specific signature of 5-HT2A receptors on the dynamic regulation of BG circuits. \nThe second part of my PhD was focused on the study of BG dynamics in pathological conditions. In PD\, dopaminergic therapy such as the administration of the precursor levodopa reduces the symptomatology and improves movement execution in the early stage of the disease\, but quickly triggers abnormal and involuntary movements known as levodopa-induced dyskinesia (LID). LID is very debilitating and refractory to any further drug treatment. Hence\, understanding the neuronal mechanism underlying LID is fundamental to develop new therapeutic strategies. Recent studies have shown that LID is caused by excessive neuronal activity in the striatum\, however\, how such striatal activity impacts BG downstream circuits such as the external globus pallidus (GPe) to generate LID is still unknown. In addition\, a subpopulation of GPe neurons called the arkypallidal (Arky-GPe) neurons\, directly form a negative feedback loop with the striatum to powerfully control action inhibition in normal conditions. Importantly\, the activity and contribution of this GPe action-suppressing pathway during LID is totally unknown. \nFor these reasons\, the objective of this project was to characterise the dynamic changes of activity present in Arky-GPe neurons across different disease states\, going from healthy condition to the pathophysiological states of PD and LID. In this work\, we used optical methods (I.e. fiber photometry and miniscope) to monitor in vivo the calcium activity of Arky-GPe neurons across different motor and disease states. Having characterised the abnormal changes of activity\, we then used optogenetic manipulation to test their causal contribution to LID generation. We found that optogenetic reactivation of Arky-GPe neurons during LID reduces hyperkinetic behaviour and promotes normal-like motor behaviour. These results pave the way to understand the complex mechanisms involved in the generation and maintenance of LID. \nKeywords: Basal ganglia circuits\, Parkinson’s disease\, levodopa-induced dyskinesia\, serotonin\, 5-HT2A receptor\, external globus pallidus\, arkypallidal neurons\, optogenetic manipulation \nPublication\nPreferential modulatory action of 5-HT2A receptors on the dynamic regulation of basal ganglia circuits\nGuilhemsang et al.\, 2022\, Journal of Neuroscience \nJury\nPhilippe De Deurwaerdere – président du jury (University of Bordeaux)\nPierre-Olivier fernagut – rapporteur (University of Poitier)\nLedia F.Hernandez – rapportrice (Complutense University)\nMarianne Amalric – examinatrice (Aix-Marseille University)\nMaria Torrecilla – examinatrice (University of the Ba \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-lise-guilhemsang-2/
CATEGORIES:Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20221216T140000
DTEND;TZID=Europe/Paris:20221216T140000
DTSTAMP:20260409T095720
CREATED:20221117T085357Z
LAST-MODIFIED:20221117T085705Z
UID:152817-1671199200-1671199200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Maud Martinat
DESCRIPTION:Venue: to be confirmed \nDefense in french \n\nThesis supervisor: Sophie Layé (NutriNeuro) \nTitle\nOméga 3 et troubles de l’humeur : mécanismes d’action neuroprotecteurs (Omega 3 and mood disorders\, study of neuroprotective actions mechanisms) \nRésumé\nThe brain is rich in polyunsaturated fatty acids (PUFA) whose long chains\, such as docosahexaenoic acid (DHA) and ecosapentaenoic acid (EPA) from omega 3 (n–3)\, accumulate during development. Their precursors are not synthesized de novo by mammals and must be provided by food. However\, it has been shown that an unbalanced and deficient maternal dietary intake of n–3 PUFAs induces cognitiveand electrophysiological alterations in infants and in mouse models of nutritional deficiency. \nWe are interested in the impact of a nutritional intervention during development and how a diet unbalanced in n–3 PUFA alters neural networks and cognition\, by studying the molecular mechanisms and taking into account the gender. To this end\, different models are used: 1) mice are deficient in PUFAs during development and then exposed to a diet rich in n–3 PUFAs at weaning; 2) to develop a local deficiency model by viral injection blocking the expression of the elongase ELOVL2 (involved in the synthesis of long–chain PUFAs) in astrocytes to assess the impact on the properties of the surrounding neurons. \nOur results suggest that a change in nutritional status from deficiency to a diet rich in n–3 PUFA at weaning restores 1) long–term synaptic plasticity in the hippocampus in males and females\, 2) cognition as well as fatty acid levels in the brain but in a differential manner between the two sexes. In the second part of the results\, a local variation of PUFA synthesis in the astrocyte modifies the excitability of neurons without modifying the levels of fatty acids in the brain structure while modifying some criteria of emotional behavior. \nKey words: PUFA\, developpment\, cognition\, neuroprotection \nJury\nPr Mélanie Plourde\, Professeure\, Université de Sherbrooke\, Québec\, Canada\, Rapportrice \nDr Pascale Chavis\, Directrice de Recherche\, Inmed\, Marseille\, France\,   Rapportice \nDr Niyazi Acar\, Directeur de Recherche\, INRAE\, Dijon\, France\, Examinateur \nPr Frédéric Calon\, Professeur\, Université de Laval\, Canada\, Président\, Examinateur \nPr Richard Bazinet\, Professeur Associé\, Université de Toronto\, Canada\, Co-directeur \nDr Sophie Layé\, Directrice de Recherche\, INRAE\, Bordeaux\, France\, Directrice    \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-maud-martinat/
CATEGORIES:Thesis
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