BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220211
DTEND;VALUE=DATE:20230103
DTSTAMP:20260422T204840
CREATED:20220209T143152Z
LAST-MODIFIED:20220209T143152Z
UID:144934-1644537600-1672703999@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : "Cell Immersion"
DESCRIPTION:Les Bassins des Lumières – Imp. Brown de Colstoun\, Bordeaux \n\nCell Immersion vous convie à un voyage Art & Science dans un monde microscopique méconnu : l’humain. \nL’œuvre est la première brique d’un projet d’envergure\, nommé Cell Worlds\, qui amène les images de microscopie là où elles ne sont jamais allées. Loin des laboratoires et des disques durs des scientifiques et au plus près des cellules humaines. Ici\, tout est bien réel\, et surtout vivant. Chaque visuel de l’exposition se compose de véritables cellules : de l’électrisant neurone au fragile embryon en passant par les mélancoliques flux sanguins du cerveau. Découvrez un univers aux couleurs chatoyantes et d’une diversité incroyable. \nCell Immersion est une première mondiale scientifique\, mettant en scène le vivant microscopique dans des proportions jamais tentées. C’est également un des plus grands showcases de la recherche scientifique\, regroupant de nombreuses équipes\, laboratoires et instituts du monde entier. Une preuve que la science et l’art n’ont pas de frontières. \nÀ travers l’émerveillement\, ce voyage saura éveiller votre curiosité scientifique. Au-delà du simple divertissement\, Cell Immersion vous invite à vous reconnecter avec le monde vivant microscopique qui est aujourd’hui trop inconnu\, trop peu contemplé et parfois trop mystifié. \n  \n\nRéalisation : Terence Saulnier et Renaud Pourpre \nComposition de la bande originale : Youenn Lerb \n\nCet événement est organisé dans le cadre de la Semaine du Cerveau. \nPour plus d’informations : https://www.bassins-lumieres.com/fr/cell-immersion \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cell-immersion/
LOCATION:Les Bassins des Lumières\, Imp. Brown de Colstoun\, Bordeaux\, 33000\, France
CATEGORIES:not-calendar,Semaine du cerveau 2022
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20221107T140000
DTEND;TZID=Europe/Paris:20221107T140000
DTSTAMP:20260422T204840
CREATED:20220823T080518Z
LAST-MODIFIED:20221018T140443Z
UID:150253-1667829600-1667829600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Camille Miermon
DESCRIPTION:Camille Miermon\nVenue:  Centre broca \nDefense in english \nThesis supervisor: Lisa Roux (IINS) \n\nTitle\nImpact of oxytocin in the anterior piriform cortex and link with respiration \nAbstract\nBreathing is a highly dynamic process that varies in frequency and intensity. These variations are related to the emotional and cognitive state of the animal but also to the recruitment of its olfactory system for the detection of odorant molecules\, as it is the case during social interactions between individuals. In addition\, a growing body of evidence shows that breathing influences brain neuronal rhythms. In this context\, having an accurate and reliable tool of respiratory activity in freely moving animals that is also compatible with neuronal recordings seems more relevant than ever. We have developed a technique to record nasal pressure in freely moving mice and have characterized this signal according to the state of vigilance of the animal (awake – non-REM sleep – REM sleep). Our research shows that each state is associated with a specific combination of parameters characterizing the respiratory signal. Moreover\, the precision of this technique allowed us to highlight the presence of pauses in this signal (i.e. transient absence of airflow). These pauses are not insignificant since they dictate the frequency of breathing\, the other components of the respiratory cycle (inhalation and exhalation) forming units of relatively fixed duration. Finally\, based on this signal\, we built an artificial neural network from annotated data\, capable of predicting the vigilance state of a mouse based on recordings its nasal pressure. \nIn a second part of this thesis\, we focused on the role of oxytocin in the piriform cortex during social behaviors. Oxytocin has been widely described as a pro-social neuropeptide that promotes interactions and social memory. In rodents\, olfaction is the main sensory modality\, of which the piriform olfactory cortex represents a major neural substrate. The piriform has an anatomy similar to that of the hippocampus and is involved in olfactory memory processes. Because the piriform cortex expresses a high density of oxytocin receptors and because it receives oxytocinergic afferents\, we tested the hypothesis that oxytocin in the piriform cortex modulates sociability and social memory. With a pharmacological approach targeted on this cortex\, we showed that oxytocin induces subtle but surprising effects. Indeed\, blocking its receptor leads to a selective increase in certain types of social interactions and seems to increase the attraction towards olfactory social stimuli. However\, no effect on social memory was observed under our conditions. \nFinally\, in a third part we started to dissect the mechanisms of action of oxytocin on the physiology of the piriform cortex. We show that the oxytocin receptor agonist leads to a decrease in the burstiness of a subtype of excitatory neurons\, both in vitro and in vivo. We further show that oxytocin decreases the entrainment of piriform cortex neurons by respiration. \nKey words = oxytocin\, respiration\, sociability\, social memory\, piriform \nPublications\nNasal pressure dynamics reveal state-specific features of respiratory cycles in freely moving mice (En cours de soumission) \nJury\n– Lisa Roux – Université de Bordeaux (Directrice de thèse) \n– Stéphane Oliet – Université de Bordeaux (Président) \n– Claire Martin – Université Paris Diderot (Rapportice) \n– Alexandre Charlet – Université de Starsbourg (Rapporteur) \n– Anne-Marie Mouly – Université de Lyon (Examinatrice) \n– Guillaume Ferreira – Université de Bordeaux (Examintateur) \n– Francoise Muscatelli-Bossy – Université de Marseille (Examinatrice) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-camille-miermon/
CATEGORIES:Thesis
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20221107T150000
DTEND;TZID=Europe/Paris:20221107T150000
DTSTAMP:20260422T204840
CREATED:20221018T101257Z
LAST-MODIFIED:20221018T102245Z
UID:151494-1667833200-1667833200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Agata Idziak
DESCRIPTION:CGFB and on zoom (https://u-bordeaux-fr.zoom.us/j/6325485773) \nDefense in english \n\nThesis Supervisor : Valentin Nägerl (IINS) \nTitre\nInvestigating the structure and function of brain extracellular space using super-resolution microscopy \nAbstract\nEvery cell in the brain is embedded in a fluid called the extracellular space (ECS). Its structural complexity with intercellular gaps as narrow as ten nanometers\, presents a challenge of visualizing the ECS in living brain tissue. Our recently established SUSHI technique overpasses this issue enabling to image the ECS with a nanoscale resolution. During my PhD training\, I unveiled new structural information about ECS\, as well as characterized novel tools to study it. My PhD work was divided into three projects\, all aiming at investigating the structure and function of brain ECS.\n(1) Using the SUSHI approach\, I studied the heterogeneity of ECS structure across hippocampal layers\, which are known to have a very distinct cellular organization. My results show that ECS varies in volume and width across hippocampus\, raising a question whether region-based differences in ECS structure in the hippocampus could support the unique anatomical as well as functional properties of each layer.\n(2) Chemical fixation leads to drastic shrinkage of ECS\, yet it was only investigated in a context of electron microscopy. With help of SUSHI\, I performed a systematic analysis of the impact of chemical fixation on brain tissue morphology. The results revealed only minor structural alteration\, meaning that chemical fixation alone is not the reason for such dramatic effects.\n(3) Studying calcium signals in the ECS was a challenge since all available biosensors were not designed to measure ion concentrations with a millimolar affinity. Here\, I characterized a novel tool\, GreenT\, to capture extracellular calcium dynamics. By imaging GreenT signals during electrophysiological stimulations\, I was able to measure calcium fluctuations in the ECS upon neuronal activation. This is the beginning of applying this tool for physiology studies aiming at understanding the role of extracellular calcium. \nKeywords: super-resolution STED microscopy\, SUSHI\, ECS\, chemical fixation\, extracellular calcium\, GreenT \nPublications\nDembitskaya Y\, Boyce A\, Idziak A\, (…)\, Nägerl V.U. Shadow imaging as a versatile method for panoptic visualization of living brain tissue. In preparation. \nGrassi D\, Idziak A\, Lee A\, Calaresu I\, Sibarita JB\, Cognet L\, Nägerl V.U.\, Groc L. Nanoscale and functional heterogeneity of the hippocampal extracellular space. Under revision. \nIdziak A\, Inavalli Krishna VVG\, Bancelin S\, Arizono M\, Nägerl V.U. Super-resolution analysis of the effects of chemical fixation on the cellular microarchitechture of organotypic mouse brain slices. In preparation. \nArizono M\, Idziak A\, Quici F\, Nägerl V.U. Getting sharper: the brain under the spotlight of super-resolution microscopy (2022). Trends in Cell Biology. 1851:1-14. \nArizono M\, (…)\, Idziak A\, (…)\, Nägerl V.U. Nanoscale imaging of the functional anatomy of the brain (2021). De Gruyter. https://doi.org/10.1515/nf-2021-0004. \nArizono M\, Idziak A\, Nägerl V.U. Il faut être trois pour danser le tango Illuminer les signaux Ca2+ des synapses tripartites (2021). Med Sci. 37: 127–129. \nAntoniou A\, Khudayberdiev S\, Idziak A\, Jacob R\, Bicker S\, Schratt G. The dynamic membrane recruitment of miRNA processing complexes in neurons controls dendritogenesis (2017). EMBO Reports. e44853. \nJury\nMARSICANO Giovanni\, directeur de Recherche\, INSERM (president)\nTØNNESEN Jan\, Associate Professor\, Achurraco Bilbao (reviewer)\nIMIG Cordelia\, Associate Professor\, University of Copenhagen (reviewer)\nHRABĚTOVÁ Sabina\, Associate Professor\, SUNY\, (examiner) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-agata-idziak/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR