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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20220211
DTEND;VALUE=DATE:20230103
DTSTAMP:20260426T014935
CREATED:20220209T143152Z
LAST-MODIFIED:20220209T143152Z
UID:144934-1644537600-1672703999@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : "Cell Immersion"
DESCRIPTION:Les Bassins des Lumières – Imp. Brown de Colstoun\, Bordeaux \n\nCell Immersion vous convie à un voyage Art & Science dans un monde microscopique méconnu : l’humain. \nL’œuvre est la première brique d’un projet d’envergure\, nommé Cell Worlds\, qui amène les images de microscopie là où elles ne sont jamais allées. Loin des laboratoires et des disques durs des scientifiques et au plus près des cellules humaines. Ici\, tout est bien réel\, et surtout vivant. Chaque visuel de l’exposition se compose de véritables cellules : de l’électrisant neurone au fragile embryon en passant par les mélancoliques flux sanguins du cerveau. Découvrez un univers aux couleurs chatoyantes et d’une diversité incroyable. \nCell Immersion est une première mondiale scientifique\, mettant en scène le vivant microscopique dans des proportions jamais tentées. C’est également un des plus grands showcases de la recherche scientifique\, regroupant de nombreuses équipes\, laboratoires et instituts du monde entier. Une preuve que la science et l’art n’ont pas de frontières. \nÀ travers l’émerveillement\, ce voyage saura éveiller votre curiosité scientifique. Au-delà du simple divertissement\, Cell Immersion vous invite à vous reconnecter avec le monde vivant microscopique qui est aujourd’hui trop inconnu\, trop peu contemplé et parfois trop mystifié. \n  \n\nRéalisation : Terence Saulnier et Renaud Pourpre \nComposition de la bande originale : Youenn Lerb \n\nCet événement est organisé dans le cadre de la Semaine du Cerveau. \nPour plus d’informations : https://www.bassins-lumieres.com/fr/cell-immersion \n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-cell-immersion/
LOCATION:Les Bassins des Lumières\, Imp. Brown de Colstoun\, Bordeaux\, 33000\, France
CATEGORIES:not-calendar,Semaine du cerveau 2022
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DTSTART;TZID=Europe/Paris:20220608T113000
DTEND;TZID=Europe/Paris:20220608T113000
DTSTAMP:20260426T014935
CREATED:20220531T134605Z
LAST-MODIFIED:20220601T194134Z
UID:148547-1654687800-1654687800@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Gerti Beliu
DESCRIPTION:\nDr. Gerti BeliuRudolf Virchow Center for Integrative and Translational Bioimaging \nUniversity of Wuerzburg \nGermany \n\nVenue: salle Pyramide – Centre Broca Nouvelle-Aquitaine \n\nTitle\n“Genetic Code Expansion and Click Chemistry for super-resolution imaging in living cells” \nAbstract\nOptical nanoscopy has contributed significantly to our understanding of biological structures. Although steadily emerging fluorescence techniques are constantly improving spatio-temporal resolution and thus enable visualization of biological processes in real time\, there are still a number of challenges to overcome [1].\nSince the density of fluorophores controls the achievable structural resolution\, efficient and specific labeling with fluorescent probes is a decisive factor in super-resolution microscopy techniques. Despite recent progress in the development of new fluorophores with superior photophysical properties\, specific and efficient labeling of the molecule of interest with minimal linkage error remains a significant challenge. As the field moves towards higher spatial resolution\, the effective size of the label will be the main limiting factor of super-resolution microscopy\, demanding the development of efficient labeling methods with small dyes\, which can be site-specifically and quantitatively attached to a protein of interest with low linkage error [2-3].\nSite-specific introduction of unnatural amino acids (uAA) into proteins of interest followed by bioorthogonal click chemistry with tetrazine-dyes represents a broadly useful possibility to overcome current limitations and enable high-end fluorescence imaging with organic dyes. A particularly promising type of uAA include strained alkenes\, such as trans-cyclooct-2-ene (TCO)\, that can react with a 1\,2\,4\,5-tetrazine in an ultrafast\, specific and bioorthogonal click reaction.\nAdditionally\, the tetrazine moiety can elicit substantial quenching of many fluorescent dyes (e.g. red-absorbing oxazines and rhodamine derivatives) and thus be utilized for improved live-cell labeling and quantitative super-resolution imaging experiments under physiological and wash-free conditions. Furthermore\, this powerful tool can be applied to improve protein-protein interaction (PPI) assays [4-5]\, making them faster\, more accurate and easier to implement. \nIn conclusion\, new labeling techniques will enable previously impossible experiments with unseen reactivity and specificity while preserving biological function. Advances of optical microscopy in biological science will depend crucially on advances in sample preparation and labeling. \n[1] L Lelek\, M.\, Gyparaki\, M.T.\, Beliu\, G. et al. Single-molecule localization microscopy. Nat Rev  Methods Primers 1\, 39 (2021). https://doi.org/10.1038/s43586-021-00038-x \n[2] Beliu\, G. et al. Bioorthogonal labeling with tetrazine-dyes for super-resolution microscopy. Commun Biol 2\, 261 (2019). https://doi.org/10.1038/s42003-019-0518-z \n[3] Neubert*\, F.\, Beliu*. G.\, et al. Bioorthogonal click chemistry enables site-specific fluorescence labeling of functional NMDA receptors for super-resolution imaging. Angew. Chem. Int. Ed. 57\, 16364–16369 (2018). https://doi.org/10.1002/anie.201808951 \n[4] Beliu G.\, Altrichter. S.\, Guixa-Gonzalez\, R. et al. Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Mol. Cell. 81: 905–921 (2021). https://doi.org/10.1016/j.molcel.2020.12.042 \n[5] Bessa-Neto*\, D.\, Beliu*\, G. et al.\, Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons. Nature Communications (2021) https://doi.org/10.1038/s41467-021-27025-w \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-gerti-beliu/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20220608T140000
DTEND;TZID=Europe/Paris:20220608T140000
DTSTAMP:20260426T014935
CREATED:20220406T091215Z
LAST-MODIFIED:20220603T160658Z
UID:147021-1654696800-1654696800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense -  Vincent Martin
DESCRIPTION:Venue: Amphithéâtre du laboratoire IMS à Talence\,\net sur Zoom à l’adresse :\nhttps://u-bordeaux-fr.zoom.us/j/8475497370?pwd=U0lHRWdMZnBXT0ZrV1kyZ3hueVpGZz09 \nDefense in french \n\nNew speech biomarkers for automatic sleepiness detection \nAbstract\nVoice is one of the most promising tools in digital medicine. In association with virtual medical companions\, the estimation of symptoms based on voice features will allow both home monitoring of patients suffering from chronic neuropsychiatric diseases and access to personalized lifestyle advice for the general population. Sleepiness\, occuring in many pathologies and being very prevalent both in patients suffering from chronic diseases and in the general population\, is a key symptom for this approach. \nThe objective of the work presented in this manuscript is thus to complete the information collected by virtual assistants during the interaction of the subjects with them\, by using vocal markers validated as being reliable markers of sleepiness. Our approach is the following. \nFirst\, we introduce the mechanisms of voice production and the different pathologies that can interfere with the involved muscular and neuro-muscular functions\, with a focus on the methodologies used for the recording and annotation of the corpora. \nThen\, we attempt to establish a consensual definition of sleepiness using three reference dictionaries of the French language; two text mining approaches; and finally through an umbrella review of tools designed to measure it. \nSubsequently\, we present our own corpus of patients with hypersomnia\, recorded at the sleep medicine center of the Bordeaux University Hospital on a reading aloud task\, annotated with both subjective (questionnaires) and objective (sleep latency to the Multiple Sleep Latency Test) measures of sleepiness validated by the physicians of the University Hospital. \nThis corpus is then compared with other state-of-the-art corpora on voice sleepiness detection\, from which we propose recommendations on the development of such corpora. Then\, using a perceptual study\, we validate the use of the MSLT database for the detection of sleepiness in speech. \nBased on this corpus\, we develop four categories of speech features\, measuring two dimensions of the impact of sleepiness on speech. On the one hand\, we study markers of acoustic voice quality; on the other hand\, we design markers of reading quality\, divided into three subcategories: reading errors made by patients\, their automation through errors made by automatic speech recognition systems\, and finally the durations and locations of reading pauses. \nThese features are validated on different forms of sleepiness (objective and subjective). \nFinally\, we present a methodology to train a classifier for the clinical use of these speech features for the detection of three symptoms related to sleepiness. We carry out a detailed analysis of the obtained results and of the descriptors used by the classifier. To go further\, we then propose to bring the classification problem closer to the reality of clinical reasoning by classifying two syndromes derived from the previous symptoms. \nFinally\, in this same direction\, we consider research perspectives around symptom networks\, in the framework of digital medicine research on sleepiness and\, in a more general way\, on digital psychiatry. \nJury\n– Pr. Corinne Fredouille\, Univ. d’Avignon\, Rapporteuse– Pr. Isabel Trancoso\, Univ. de Lisbonne\, Rapporteuse– Dr. Pierre-Alexis Geoffroy\, Univ. de Paris\, Rapporteur– Dr. Véronique Delvaux\, FNRS – Univ. de Mons\, Examinatrice– Dr. Guy Fagherazzi\, Luxembourg Institute of Health\, Examinateur\n– Dr. Jean-Arthur Micoulaud-Franchi\, Univ. de Bordeaux\, Invité – Dr. Jean-Luc Rouas\, CNRS – LaBRI\, Directeur– Pr. Pierre Philip\, Univ. de Bordeaux\, Co-directeur \nVincent MARTIN\nPhD Student – Sleepiness detection through voice – LaBRI / SANPSY\nENSEA Engineer – Multimedia signal processing\nhttps://www.researchgate.net/profile/Vincent_P_Martin \n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-vincent-martin/
CATEGORIES:Thesis
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