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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20210519
DTEND;VALUE=DATE:20211115
DTSTAMP:20260504T045334
CREATED:20210510T093453Z
LAST-MODIFIED:20210616T200839Z
UID:135231-1621382400-1636934399@www.bordeaux-neurocampus.fr
SUMMARY:Exhibition "Critical Thinking\, think again !"
DESCRIPTION:Bordeaux Neurocampus is a partner of the exhibition. Several researchers from our community have participated in the design of “Défi curieux”\, one of the animations. \nSpecific events are also planned during the exhibition. More information on these events will be available soon. \n\nAt Cap Sciences – Bordeaux \nWelcome to the exhibition “Critical thinking\, think again! “Rumours\, fake news\, preconceived ideas… Who can you trust? How do you know if information is reliable?Sharpening our critical thinking skills means becoming aware of what can make us vulnerable: our prejudices\, our habits of thought\, our emotions and sometimes… our unjustified mistrust! It is also about finding support to see things clearly. Sometimes it means admitting that we don’t know… In short\, it’s learning to adjust your level of trust.Enter the experience of this exhibition\, play at verifying information\, explore tricky situations\, unmask preconceived ideas. \nThis travelling exhibition “ESPRIT CRITIQUE\, Détrompez–vous! “is part of the off–site activities of the Palais de la découverte (Paris)\, during its temporary closure for renovation. The exercise of critical thinking has been encouraged by the Palais since its creation in 1937. Cap Sciences in Bordeaux and the Quai des Savoirs in Toulouse are convinced of the relevance of this approach and have joined forces with Universcience to co–produce this exhibition\, which is aimed at everyone aged 10 and over. \nAverage duration of the visit : 1h30All public / from 10 years old \nExhibition in four languages: French/English/Spanish/LSF \nOn social networks\, comment and share on the exhibition with : @capsciences #ExpoEspritCritique #EspritCritique \n\nMore details\nCap Sciences\nHangar 20\, Quai de Bacalan\n33300 Bordeaux\nTél. 05 56 01 07 07 \nhttps://www.cap-sciences.net/au-programme/exposition/esprit-critique.html \n\n\n  \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-esprit-critique/
CATEGORIES:Events for all,not-calendar
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20210612
DTEND;VALUE=DATE:20220103
DTSTAMP:20260504T045335
CREATED:20210609T121801Z
LAST-MODIFIED:20211118T204807Z
UID:135804-1623456000-1641167999@www.bordeaux-neurocampus.fr
SUMMARY:Exhibition "Disgusting Food Museum"
DESCRIPTION:Cap Sciences \nWith the partnership of Bordeaux Neurocampus / University of Bordeaux \n\nYuck ! What seems disgusting to some is not necessarily so to others ! Who will have the guts to smell that stinky cheese or taste a fermented shark or a cricket ? Disgusting food Museum presents 85 of the world’s most disgusting foods. The opportunity for adventurous visitors to wander from table to table between turtle soup\, insects or hundred–year–old eggs… Everyone puts their disgust to the test\, a beautiful way to change our preconceived ideas\, to question what seems edible or not and to open up to other food practices. This exhibition illustrates the cultural dimension of food and our propensity to change it. Curious” foods from exotic cultures have always fascinated us. In addition to the pleasure of curiosity and discovery\, everyone will be able to put into perspective one of the six fundamental human emotions\, which is disgust. The visit is completed by a tasting at the bar where visitors can test several products from a selection. An exhibition of the Disgusting Food Museum (Malmö Sweden) and with the kind collaboration of the Alimentarium (Vevey Switzerland). Average length of visit: 1 hour All public / from 6 years old On social media\, comment and share about the exhibition with: @capsciences #DisgustingFoodMuseum \n  \nMore details\nhttps://www.cap-sciences.net \n
URL:https://www.bordeaux-neurocampus.fr/en/event/disgusting-food-museum/
CATEGORIES:Events for all,not-calendar
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DTSTART;TZID=Europe/Paris:20210916T143000
DTEND;TZID=Europe/Paris:20210916T143000
DTSTAMP:20260504T045335
CREATED:20210901T153359Z
LAST-MODIFIED:20210910T065631Z
UID:137681-1631802600-1631802600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Caroline Bonnet
DESCRIPTION:\n	\n		\n			Venue: Centre Broca Nouvelle-Aquitaine \nDefense in french \n\nTitle\nIntracellular transport of AMPA receptors and regulation by their associated proteins \nAbstract\nLearning and memory rely on synaptic plasticity events during which the neuron modulates the efficiency of synaptic transmission. These events require a strict spatial and temporal control of the number of alpha-amino-3-hydroxy-5-méthyl-4-isoxazolepropionate receptors (AMPAR) at the post-synaptic plasma membrane (PM)\, and more importantly at the synapse. This control is a challenge for neurons in which the synapse can be localized hundreds of micrometers away from the cell body and the nucleus where the genes are transcribed. The traffic and localization of AMPAR is ensured by a complex cooperation between different mechanisms: intracellular transport (IT) of neosynthetized receptors to the PM\, their diffusion at the PM and stabilization at the post-synapse or their recycling during which receptors are endocytosed and degraded or inserted again at the PM. The IT of neosynthetized receptors is a major contributor in the increase of AMPAR observed at the synapse during long term potentiation (LTP). The receptors mature in the different compartments of the secretory pathway and are transported in vesicles to the PM. The IT is difficult to image as it is composed of fast small vesicles of low contrast and that are impossible to distinguish from those containing recycled receptors. Thanks to a molecular tool allowing the retention of AMPAR in the endoplasmic reticulum combined with video-microscopy\, our lab showed that the IT of GluA1 has stable characteristics in basal conditions. This IT is regulated by the Ca2+ concentration that varies after LTP induction\, like in the late phase during which the number of vesicles and their speed are increased. It is also modulated by point-mutations of phosphorylation sites of AMPAR C-terminal domain (CTD). \nOur objective was to provide insight in the molecular mechanisms that govern this regulation. AMPAR have many interactors\, including auxiliary proteins\, membrane proteins that modulate their properties and trafficking. Gamma8\, the most abundant auxiliary protein of the hippocampus\, has a major role for LTP expression. The IT we observed in Gamma8-KO mice neurons is decreased compared to the WT\, both in terms of number of vesicles and speed\, while the time they spent in pause is increased. Our data suggest that Gamma8 participates in GluA1 IT. \nAMPAR also interact with cytosolic proteins via their CTD. GluA1 has two known cytosolic interactors: 4.1N and SAP97. The interaction with 4.1N is governed by two phosphorylations. 4.1N is involved in the exocytosis of the receptor especially during LTP. SAP97 is involved in the exit of the Golgi apparatus and is associated with the molecular motor MyoVI. In addition of its role in exocytosis\, our data suggest that 4.1N regulates GluA1 IT during LTP but not in basal conditions. Indeed\, after LTP induction\, the vesicles containing the S816A S818A mutant that doesn’t bind 4.1N show decreased speeds. Conversely\, SAP97 regulates the IT in basal conditions by controlling the number of vesicles budding from the Golgi apparatus and by modulating their speed\, a regulation that could be maintained after LTP induction. \nThe most abundant AMPAR are GluA1/GluA2 heteromers. We characterized the IT of the GluA2 subunit and found that it exhibits the same characteristics as GluA1. GluA2 binds other proteins that might regulate the IT during activity\, but their effect need to be determined. We propose that the IT of AMPAR is strongly modulated by its auxiliary proteins and cytosolic interactors of its CTD. \nKeywords : AMPA receptors\, synaptic plasticity\, video-microscopy\, intracellular transport \nJury\nNathalie SANS (Présidente)\,\nCyril Hanus (Rapporteur)\,\nJulie Perroy (Rapportrice)\,\nEric Boué-Grabot (Invité)\,\nFrançoise Coussen (Directrice de thèse). \n\n		\n	\n\n	\n		\n			 \nCaroline Bonnet \nTeam Choquet\nIINS \nThesis supervisor: Françoise Coussen \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-caroline-bonnet/
CATEGORIES:Thesis
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