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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20210328T010000
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DTSTART;VALUE=DATE:20210519
DTEND;VALUE=DATE:20211115
DTSTAMP:20260504T010156
CREATED:20210510T093453Z
LAST-MODIFIED:20210616T200839Z
UID:135231-1621382400-1636934399@www.bordeaux-neurocampus.fr
SUMMARY:Exhibition "Critical Thinking\, think again !"
DESCRIPTION:Bordeaux Neurocampus is a partner of the exhibition. Several researchers from our community have participated in the design of “Défi curieux”\, one of the animations. \nSpecific events are also planned during the exhibition. More information on these events will be available soon. \n\nAt Cap Sciences – Bordeaux \nWelcome to the exhibition “Critical thinking\, think again! “Rumours\, fake news\, preconceived ideas… Who can you trust? How do you know if information is reliable?Sharpening our critical thinking skills means becoming aware of what can make us vulnerable: our prejudices\, our habits of thought\, our emotions and sometimes… our unjustified mistrust! It is also about finding support to see things clearly. Sometimes it means admitting that we don’t know… In short\, it’s learning to adjust your level of trust.Enter the experience of this exhibition\, play at verifying information\, explore tricky situations\, unmask preconceived ideas. \nThis travelling exhibition “ESPRIT CRITIQUE\, Détrompez–vous! “is part of the off–site activities of the Palais de la découverte (Paris)\, during its temporary closure for renovation. The exercise of critical thinking has been encouraged by the Palais since its creation in 1937. Cap Sciences in Bordeaux and the Quai des Savoirs in Toulouse are convinced of the relevance of this approach and have joined forces with Universcience to co–produce this exhibition\, which is aimed at everyone aged 10 and over. \nAverage duration of the visit : 1h30All public / from 10 years old \nExhibition in four languages: French/English/Spanish/LSF \nOn social networks\, comment and share on the exhibition with : @capsciences #ExpoEspritCritique #EspritCritique \n\nMore details\nCap Sciences\nHangar 20\, Quai de Bacalan\n33300 Bordeaux\nTél. 05 56 01 07 07 \nhttps://www.cap-sciences.net/au-programme/exposition/esprit-critique.html \n\n\n  \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/exposition-esprit-critique/
CATEGORIES:Events for all,not-calendar
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20210612
DTEND;VALUE=DATE:20220103
DTSTAMP:20260504T010156
CREATED:20210609T121801Z
LAST-MODIFIED:20211118T204807Z
UID:135804-1623456000-1641167999@www.bordeaux-neurocampus.fr
SUMMARY:Exhibition "Disgusting Food Museum"
DESCRIPTION:Cap Sciences \nWith the partnership of Bordeaux Neurocampus / University of Bordeaux \n\nYuck ! What seems disgusting to some is not necessarily so to others ! Who will have the guts to smell that stinky cheese or taste a fermented shark or a cricket ? Disgusting food Museum presents 85 of the world’s most disgusting foods. The opportunity for adventurous visitors to wander from table to table between turtle soup\, insects or hundred–year–old eggs… Everyone puts their disgust to the test\, a beautiful way to change our preconceived ideas\, to question what seems edible or not and to open up to other food practices. This exhibition illustrates the cultural dimension of food and our propensity to change it. Curious” foods from exotic cultures have always fascinated us. In addition to the pleasure of curiosity and discovery\, everyone will be able to put into perspective one of the six fundamental human emotions\, which is disgust. The visit is completed by a tasting at the bar where visitors can test several products from a selection. An exhibition of the Disgusting Food Museum (Malmö Sweden) and with the kind collaboration of the Alimentarium (Vevey Switzerland). Average length of visit: 1 hour All public / from 6 years old On social media\, comment and share about the exhibition with: @capsciences #DisgustingFoodMuseum \n  \nMore details\nhttps://www.cap-sciences.net \n
URL:https://www.bordeaux-neurocampus.fr/en/event/disgusting-food-museum/
CATEGORIES:Events for all,not-calendar
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20210719
DTEND;VALUE=DATE:20210730
DTSTAMP:20260504T010156
CREATED:20210721T092530Z
LAST-MODIFIED:20210722T151825Z
UID:137091-1626652800-1627603199@www.bordeaux-neurocampus.fr
SUMMARY:Lectures "Introduction to Experimental Neuroscience"
DESCRIPTION:Venue: CGFB. \n\nThese lectures are organized in the frame of the Workshop “Introduction to Experimental Neuroscience” but are open. \nTuesday 20 July – 9:00-9:45 : Sofia Cussotto (NutriNeuro)\nTuesday 20 July – 9:45-10:00 : Sandra Chanraud (INCIA) \nThursday 22 July – 9:00-9:45 : Marc Landry (IMN)\nThursday 22 July – 9:45-10:00 : David Perrais (IINS) \nTuesday 27 July – 9:00-9:45 : Arthur Leblois (IMN)\nTuesday 27 July – 9:45-10:00 : Xavier Fioramonti (NutriNeuro) \nThursday 29 July – 9:00-9:45 : Gwenaelle Catheline (INCIA)\nThursday 29 July – 9:45-10:00 : Christophe Mulle (IINS) \nMore details about the lectures \nneurocampus.graduateprogram@u-bordeaux.fr \nFollow the School’s Twitter account \nAbout theworkshop \nhttp://www.bordeaux-school-of-neuroscience.eu/trainings/workshops/workshop-eur/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/lectures-introduction-to-experimental-neuroscience/
CATEGORIES:Cajal Lectures,For scientists,home-event
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DTSTART;TZID=Europe/Paris:20210723T100000
DTEND;TZID=Europe/Paris:20210723T100000
DTSTAMP:20260504T010156
CREATED:20210614T175002Z
LAST-MODIFIED:20210615T082943Z
UID:136015-1627034400-1627034400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Nadia di Franco
DESCRIPTION:\n	\n		\n			Closed-door defense\n \n\nDefense in english \nTitle\nDevelopment and characterization of a new therapeutic approach of the Down Syndrome\, systeme endocannabinoid \nAbstract\nDown syndrome (DS) is the most common genetic cause of intellectual disability (ID) triggered by the complete or partial triplication of human chromosome 21 (HSA21). While researches advancements improved life conditions of patients\, the ID impedes them to lead a normal life. Up to now\, although several preclinical and clinical studies are ongoing\, no pharmacological curative solutions that improve ID are available for patients with DS. The associated memory deficits are due to a reduction in the volume of the hippocampus (HPC) and in particular dysfunctions in GABAergic and glutamatergic transmissions. The preclinical trial failure and the lack of effective treatments for ID in DS reflect the urgent need to fine-tune a valid translational test and the primary necessity of new therapeutic targets.\nThe endocannabinoid system (ECS) was shown to be involved in memory and learning functions both in physiological and pathological processes. Recently\, it has been suggested that the alteration of the ECS and notably the type-1 cannabinoid receptor (CB1) overexpression and hyperactivation could play a major role for ID in DS mouse models. It has been discovered that Ts65Dn aged mice expressed high levels of the endocannabinoid 2-AG in the brain and CB1 increased expression was found in Ts65Dn and TgDyrk1A mice. Giving strength to the hypothesis\, the CB1 antagonist rimonabant improved memory deficits in Ts65Dn and TgDyrk1A mice. Hence\, these data on DS mouse models suggesting ECS involvement in DS cognitive deficits encourage further exploration of CB1 activity deregulation.\nIn the team\, we have recently discovered an endogenous modulatory system involving the neurosteroid pregnenolone (Preg) that counteracts the CB1 signaling activity by binding to an allosteric CB1 site\, thereby blocking the toxic and addictive effects of the exogenous CB1 agonist\, delta9-tetrahydrocannabinol (THC)\, in several animal models\, thus providing a new therapeutic target for CB1-related pathologies. Although Preg has a suitable therapeutic pharmacological profile\, it cannot be used as a medication\, mainly due to its downstream steroid metabolism. For this reason\, non-metabolized synthetic Preg analogs\, named AEF compounds\, were developed in collaboration with the biotech Aelis Farma and protected by patents (n° WO2019162328A1 and WO2020127468A1). AEF compounds maintain the pharmacological properties of Preg against CB1 but with an upgraded and further strengthened therapeutic profile. Indeed\, AEF compounds have an increase half-life\, are not metabolized in steroid hormones and have a very good bioavailability after oral administration. In the thesis work\, the AEF0217 compound was studied as a leader candidate for the treatment of ID in DS.\nThe general objectives of this thesis were:\n1) Investigation of the neurobiological bases underlying the ID in DS;\n2) Validation of a translational test for the evaluation of ID in DS patients and trisomic Ts65Dn mice;\n3) Proposition of a therapeutic solution for ID in DS.\nThe current work confirmed that the ECS played a key role in ID in Ts65Dn mice. 1) Key elements highlighted an overexpression of CB1 in specific region and cell populations of the dorsal HPC and decreased levels of Preg and Preg synthesis encoding enzyme gene Cyp11a1. Preg rescued synaptic plasticity and memory deficits. Furthermore\, inhibition of CB1-induced Erk1/2MAPK activity restored memory impairment in Ts65Dn mice. 2) We then validated the Radial-maze procedure as a suitable translational test for the assessment of ID in DS providing the basis for a novel therapeutic approach with preclinical and clinical significance. 3) Finally\, the Preg-like compound AEF0217 also rescued cognitive deficits in several cognitive tests\, including the translational Radial-maze test in Ts65Dn mice. In conclusion\, the therapeutic profile of AEF0217 associated with the translational test constitutes promising assets towards a clinical application. \nJury\nSilvia-Gines Padros\, Professor; Neuroscience Institute\, University of Barcelona\, SP – Reviewer \nMarie-Claude Poitier\, PharmD\, PhD; Institut du cerveau of Paris\, FR – Reviewer \nYann Herault\, PhD; IGBMC Institute\, Strasbourg\, FR – Examiner \nFilippo Caraci\, Professor\, MD\, PhD; Neuroscience Institute\, University of Catania\, IT – Examiner \nMonique Vallée\, PhD; Neurocentre Magendie\, Bordeaux\, FR – Guest \nJean-Michel Revest\, PhD; Neurocentre Magendie\, Bordeaux\, FR – Supervisor \n\n		\n	\n\n	\n		\n			Nadia di Franco\nTeam Revest\nNeurocentre Magendie \nThesis supervisor: Jean-Michel Revest \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-nadia-di-franco/
CATEGORIES:Thesis
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