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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20210328T010000
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DTSTART:20211031T010000
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DTSTART;TZID=Europe/Paris:20210326T113000
DTEND;TZID=Europe/Paris:20210326T123000
DTSTAMP:20260603T080058
CREATED:20210119T130457Z
LAST-MODIFIED:20210312T095532Z
UID:130317-1616758200-1616761800@www.bordeaux-neurocampus.fr
SUMMARY:Webinar - Giulio Pergola
DESCRIPTION:\n	\n		\n			On Zoom: https://bit.ly/38yWu9T \n\n		\n	\n\n	\n		\n			\nPolygenic risk for psychiatric disorders and postmortem co-expression provide different perspectives on the relationship between genetic variation and cognition.\n\n		\n	\n\n	\n		\n			Abstract\nThe talk will give a general perspective on polygenic risk and use the publication A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing as a case study. \nGenome-Wide-Association studies have involved miR-137 in schizophrenia. However\, the biology underlying this statistical evidence is unclear. Statistical polygenic risk for schizophrenia is associated with working memory\, while other biological evidence involves miR-137 in emotion processing. We investigated the function of miR-137 target schizophrenia risk genes in humans. \nWe identified a prefrontal co-expression pathway of schizophrenia-associated miR-137 targets and validated the association with miR-137 expression in neuroblastoma cells. Alleles predicting greater co-expression of this pathway were associated with greater prefrontal activation during emotion processing in two independent cohorts of healthy volunteers (N1=222; N2=136). Statistical polygenic risk for schizophrenia was instead associated with prefrontal activation during working memory. \nA co-expression pathway links miR-137 and its target genes to emotion processing and risk for schizophrenia. Low prefrontal miR-137 expression may be related with SCZ risk via increased expression of target risk genes\, itself associated with increased prefrontal activation during emotion processing. \n\n		\n	\n\n	\n		\n			 \nGiulio Pergola\, PhD\nAssistant Professor in Biological Psychology\nScientific Director – Group of Psychiatric Neuroscience\nDepartment of Basic Medical Science\, Neuroscience and Sense Organs\nUniversity of Bari Aldo Moro – Italy \nMarie Curie Visiting Scientist\nLieber Institute for Brain Development – Baltimore\, MD \nhttps://bit.ly/2EctXJW \n  \n\nInvited by Susanna Pietropaolo (INCIA) \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/webinar-giulio-pergola/
CATEGORIES:For scientists,home-event,Seminars
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DTSTART;TZID=Europe/Paris:20210326T140000
DTEND;TZID=Europe/Paris:20210326T140000
DTSTAMP:20260603T080058
CREATED:20210225T182337Z
LAST-MODIFIED:20210303T183319Z
UID:131623-1616767200-1616767200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Ana Dorrego-Rivas
DESCRIPTION:\n	\n		\n			Venue: Centre Broca (restricted) and onzoom (link on request) \n\nTitle: Revisiting neuronal polarity in the context of PCP\n\nDefense in english \nThesis surpervisor: Jérôme Ezan \nAbstract\nThe axonal initial segment (AIS) is a neuronal subdomain that coordinates the axo-dendritic polarity establishment and maintenance and constitutes the site for action potential tuning. The AIS structure relies on a highly organized cytoskeleton and associated molecules like Ankyrin-G (AnkG) and βIV spectrin. AnkG is the AIS master organizer\, since it arrives to the proximal axon and recruits all the AIS components. The early steps of AIS assembly are still unknown\, notably because of few identified AnkG partners. \nPlanar cell polarity (PCP) signaling controls tissue morphogenesis and cell polarity by modulating the cytoskeleton. It has important functions during nervous system development but its specific role in neurons remains unexplored. We found that some PCP proteins accumulate at the AIS in early and late stages of neuronal development\, and colocalize with the main AIS members\, specially AnkG\, and identified new AIS protein complexes. The disruption of PCP signaling impaired AIS formation by altering the distribution and levels of the main AIS markers and disrupted the periodic actin cytoskeleton organization. \nOur data identifies new players in AIS formation and composition and reveals novel mechanisms in neuronal polarity and function. \nKey words: neuronal polarity\, planar cell polarity\, axon initial segment \nPublication\nLubiana T\, Weber S\, Andrade Paranhos B\, Araujo D\, Dorrego-Rivas A\, Franzen D\, Nogueira Vicosa G\, Ghosh A and Hojas Garcia-Plaza I. ANN: a platform to annotate text with wikidata IDs (2020\, preprinted). \nJury\nFrançois George\, University of Bordeaux\, Président \nMonica Sousa\, University of Porto\, Rapporteur \nMatthew Grubb\, King’s College London\, Rapporteur \nMaren Engelhardt\, University of Heidelberg\, Examinateur \nMireille Montcouquiol\, University of Bordeaux\, Invitée \n\n		\n	\n\n	\n		\n			 \nAna Dorrego-Rivas\nTeam Montcouquiol-Sans\nNeurocentre Magendie \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defenseana-dorrego-rivas/
CATEGORIES:Thesis
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