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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20210315
DTEND;VALUE=DATE:20210326
DTSTAMP:20260503T181241
CREATED:20201216T215428Z
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UID:131400-1615766400-1616716799@www.bordeaux-neurocampus.fr
SUMMARY:Semaine du cerveau 2021
DESCRIPTION:A l’occasion de la semaine du Cerveau\, plusieurs événements en ligne sont proposés par des chercheurs de Bordeaux Neurocampus. \nConférences organisées par l’université et Bordeaux Neurocampus\nA voir sur la chaîne YouTube de Bordeaux Neurocampus. \nLe sommeil\, un mécanisme à toute épreuve ?\nLundi 15 mars / 18:00 – 19:30\nDans le cadre des Rencards du savoir (Service Culture de l’université de Bordeaux) \nLorsque notre corps nous emprisonne : la sclérose latérale amyotrophique\nMercredi 17 mars / 18:30\nAvec Eric Boué-Grabot (IMN) et Sandrine Bertrand (INCIA) \nTraiter la mémoire traumatique par la contextualisation du trauma\nJeudi 18 mars / 18:30 \nAvec Aline Desmedt (Neurocentre Magendie) \nRepos\, rêverie\, méditation : ce que nous apprend l’imagerie du cerveau\nJeudi 25 mars / 18:30\n Avec Emmanuel Mellet (IMN) \nNos chercheurs invités\nOù se loge l’anxiété dans notre cerveau\, à gauche ou à droite ?\nMercredi 17 mars / 19:00\nAvec Christel Glangetas (IMN)\nLauréate du Prix Jeune Chercheur 2020 de la Fondation Thérèse et René Planiol pour l’étude du Cerveau\, Christelle Glangetas recevra son Prix à l’issue de la conférence. \nOrganisé par l’université de Tours \nExposition\nImages scientifiques de l’IINS. \nwww.iins.u-bordeaux.fr  \nProchaine exposition à Cap Sciences\nPlusieurs chercheurs de Bordeaux Neurocampus ont collaboré avec Cap Sciences pour leur prochaine exposition\, qui aurait dû ouvrir à l’occasion de la Semaine du cerveau. Plus d’informations prochainement ! \n\nA propos\nOrganisée chaque année au mois de mars depuis 1999\, la Semaine du Cerveau est coordonnée en France par la Société des Neurosciences. \nCette manifestation internationale\, organisée simultanément dans une centaine de pays et plus de 120 villes en France\, a pour but de sensibiliser le grand public à l’importance de la recherche sur le cerveau. C’est l’occasion pour de nombreux chercheurs\, médecins et étudiants bénévoles de rencontrer le public et de partager avec lui les avancées obtenues dans les laboratoires de recherche en neurosciences\, d’en présenter les enjeux pour la connaissance du cerveau et les implications pour notre société. \nCoordinateur local : Abdelhamid Benazzouz \nTout le programme : \nhttps://www.semaineducerveau.fr \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/semaine-du-cerveau-2021/
CATEGORIES:Events for all
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DTSTART;TZID=Europe/Paris:20210317T140000
DTEND;TZID=Europe/Paris:20210317T140000
DTSTAMP:20260503T181241
CREATED:20210121T100147Z
LAST-MODIFIED:20210216T082544Z
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SUMMARY:Thesis defense - Adeline Cathala
DESCRIPTION:\n	\n		\n			Title: Role of central serotonin2B receptors in the regulation of ascending dopaminergic pathways: implication in the effects of cocaine. \nThesis supervisor: Umberto Spampinato \nDefense in french \nAbstract\nThis thesis work focuses on the study of the functional role of the central serotonin2B receptor (5-HT2BR) in the regulation of ascending dopaminergic (DA) pathways. Recent results obtained in the laboratory have shown that 5-HT2BRs differentially modulate ascending dopaminergic (DA) pathways. Indeed\, 5-HT2BR antagonist reduces DA release in the nucleus accumbens (NAc)\, increases DA release in the medial prefrontal cortex (mPFC)\, and had no effect on striatal DA release. This differential control on the DA system involves an interaction between 5-HT2BR in the dorsal raphe nucleus (DRN) and 5-HT1AR expressed in the mPFC\, and results from an activation of DRN 5-HT neurons projecting to the mPFC. These results point out the DRN as the major site of action of 5-HT2BRs to the control of 5-HT and DA activity. In addition\, it has been shown that 5-HT2BRs blockade control the neurochemical and behavioral responses induced by psychostimulants as amphetamine\, 3\,4-methylenedioxymethamphetamine and cocaine\, one of the most worldwide abused drugs. Indeed\, 5-HT2BR blockade suppresses cocaine-induced hyperlocomotion. This effect\, which occurs independently of DA release in the NAc and striatum\, where DA activity is tightly related to cocaine-induced behavioral reponses\, likely involves post-synaptic interaction in subcortical DA brain regions. Nevertheless\, (1) the involvement of mPFC DA release in this interaction remained to be determined\, as this brain region is known for its anatomical and functional relationships with the NAc and striatum\, and its involvement in cocaine-induced behavioral responses. (2) In addition\, the cellular localization of 5-HT2BR within the DRN and the cellular mechanisms underlying their interactions between DA and 5-HT networks are unknown at the beginning of this study. Thus\, the objective of this thesis is to answer the two points mentioned above. To this purpose\, we assessed the effects of two potent and selective 5-HT2BR antagonists (RS 127445 and LY 266097) on 5-HT and DA activity\, by using neurochemical\, cellular and behavioral approaches in rats. \nIn a first group of experiments\, we provided anatomo-functional evidences showing that 5-HT2BR exert a GABA-mediated tonic inhibitory control on DRN 5-HT neurons innervating mPFC. This 5-HT control is a first step of a complex poly-synaptic regulation leading to differential control of DA mesocorticolimbic pathways. A second group of experiments shown that 5-HT2BR blockade inhibits cocaine-induced hyperlocomotion by acting at the level of DA neurotransmission in NAc\, this effect resulting from the potentiation of cocaine-induced mPFC DA release. \nTo conclude\, the work accomplished over the past three years provides substantial information with regards to the functional role of 5-HT2BRs in the regulation of the activity of ascending DA pathways. Moreover\, while improving the understanding of the interaction between DA and 5-HT systems\, the present findings altogether highlight the therapeutic potential of 5-HT2BR antagonists for the treatment of cocaine addiction. \nKeywords: Serotonin\, serotonin2B receptors\, dopamine\, cocaine\, rat \n  \nJury\nSgambato Véronique : Chargé de recherche (Lyon) – Rapporteur \nMaroteaux Luc: Directeur de recherche (Paris) – Rapporteur \nCota Daniela : Directrice de recherche (Bordeaux) – Examinateur \nVoisin Daniel: Professeur d’université (Bordeaux) – Examinateur \nArtigas Francesc: Professeur d’université (Barcelone) – Invité \nSpampinato Umberto : Professeur d’université (Bordeaux) – Directeur de thèse \n\n		\n	\n\n	\n		\n			Aline Cathala\nTeam Revest\nNeurocentre Magendie \n\n		\n	\n\n	\n		\n			Publications\nCathala A.\, Devroye C.\, Vallée M.\, Revest J.M.\, Spampinato U. 2020. Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways.  DOI: 10.1016/j.neuropharm.2020.108309. \nSpampinato U. Cathala A.\, Devroye C. 2020. The serotonin2B receptor and neurochemical regulation in the brain. Handbook of the behavioural Neurobiology of serotonin\, Second edition; 147-156. \nCathala A.\, Spampinato U. 2020. Serotonin2B receptor interactions with dopamine network: implications for therapeutics in schizophrenia. Chapitre\, sous presse \nCathala A.\, Devroye C.\, Drutel G.\, Revest J.M.\, Artigas F.\, Spampinato U. 2019. Serotonin2B receptors in the rat dorsal raphe nucleus exert a GABA-mediated tonic inhibitory control on serotonin neurons. Exp Neurol. 311\, 57-66. \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-adeline-cathala/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20210317T150000
DTEND;TZID=Europe/Paris:20210317T150000
DTSTAMP:20260503T181241
CREATED:20210129T140302Z
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SUMMARY:Thesis defense - William Fyke
DESCRIPTION:\n	\n		\n			Defense is held behind closed doors \n\n		\n	\n\n	\n		\n			Title: Identifying Therapeutic Targets for the Treatment of Fragile X Syndrome: Implications for Autism Spectrum Disorder \nThesis supervisors: Susanna Pietropaolo (INCIA) and Juan Marcos Alarcon (SUNY Downstate Medical Center\, Ney York) \n\nAbstract: Fragile X syndrome (FXS) is a neurodevelopmental disorder due to an X-linked mutation in the FMR1 gene that results in intellectual disability (ID)\, autism spectrum disorder (ASD)\, anxiety\, attention deficit hyperactivity disorder (ADHD) and sensory processing deficits. There is substantial overlap between FXS and ASD as approximately 30 to 50% of individuals diagnosed with FXS also meet the diagnostic criteria for ASD. Furthermore FXS-ASD patients represent approximately 5% of all cases of ASD. Since there is currently no targeted therapeutic approach\, novel pharmacological agents addressing the neurobiological underpinnings of these disorders are crucially needed. Due to the overlap between the two conditions\, systems which are disrupted in FXS and ASD patients may provide targets for treating the ASD symptoms observed in FXS-ASD patients and some non-syndromic ASD patients. FMRP\, the protein lost by the FMR1 mutation\, is a potent regulator of the endocannabinoid system (ECS) and BKCa channels. These function to regulate presynaptic excitability. Dysfunction in these systems is found in FXS patients and some ASD patients. The presynaptic role of these agents conceptualizes the “presynaptic hypothesis of FXS-ASD”. This project used genetic and pharmacological approaches which target FMRP\, the ECS or BKCa channels in combination with an extensive behavioral characterization of FXS and ASD-relevant phenotypes\, in order to assess the therapeutic value of these targets. This work demonstrates that the ECS and BKCa channels contribute to behavioral domains affected in neurodevelopmental disorders and offer several targets for therapeutics which should be explored. \n  \nKeywords: neurodevelopmental disorders\, animal models\, fragile x syndrome\, autism spectrum disorder \nAccepted Manuscripts\nFyke\, W.\, Alarcon\, J.M.\, Velinov\, M.\, & Chadman\, K.K. (2021) Pharmacological inhibition of BKCa channels induces a specific social deficit in adult C57BL6/J mice [Behavioral Neuroscience] \nManuscripts in review\nFyke\, W.\, Alarcon\, J.M.\, Velinov\, M.\, & Chadman\, K.K. (2021) Pharmacological inhibition of the primary endocannabinoid producing enzyme\, DGL-α\, induces ASD-like and co-morbid phenotypes in adult C57BL/J mice. [Autism Research] \nMendoza\, R*. Fyke\, W*.\, Daniel\, D.\, Gabutan\, E.\, Ballabh\, D.\, Easy\, M.\, Vasileva\, A.\, Colbourn\, R.\, Alawad\, M.\, Dehghani\, A.\, Lin\, B.\, Emechebe\, D.\, Patel\, P.\, Jabbar\, M.\, Nikolov\, D. B.\, Giovaniello\, D.\, Kang\, S.\, Tatem\, L.\, Bromberg\, K.\, Augenbraun\, M.\, Premsrirut\, P.\, Libien\, J.\, & Norin\, A.J. (2021) Administration of high titer convalescent anti-SARS-CoV-2 plasma: association with improved survival of hospitalized Covid-19 patients. [Human Immunology]  \n Mendoza\, R. Saha\, N. Momeni\, A. Gabutan\, E\, Alawad\, M. Dehghani\, A. Diks\, J. Lin\, B. Wang\, D. Alshal\, M.\, Fyke\, W.\, Alshal\, M.\, Wang\, B.\, Himanen\, J.\, Premsrirut\, P.\, & Nikolov\, D.B. (2021) Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19 [Cell Reports]  \nManuscripts in preparation\nFyke\, W.\, Premoli\, M.\, Middei\, S.\, Lemaire-Mayo\, V.\, Wohr\, M.\, Crusio\, W.E.\, Marsicano\, G.\, & Pietropaolo\, S. (2021) Communication during post-natal development and adulthood in the CB1 mouse: Implications for Autism Spectrum Disorder. Target journal: Autism Research \nPremoli\, M*\, Fyke W*\, Lemaire-Mayo\, V.\, Belloochio\, L.\, Lecorf\, K.\, Wooley-Roberts\, M.\, Crusio\, W.E.\, & Pietropaolo\, S. (2020) Evaluation of the neurobehavioral effects of CBDV administration in the Fmr1-KO mouse model of Fragile X Syndrome: the relevance of early treatments. Target journal: Neuropsychopharmacology \nCrusio\, W. E. Lemaire-Mayo\, V. Fyke\, W. Premoli\, M.\, Subashi\, E.\, Delprato\, A.\, & Pietropaolo\, S. Effects of prenatal stress on the behavior of Fmr1 knock-out mice. Target journal: Behavioral Brain Research \n*Co-first author \n\n		\n	\n\n	\n		\n			 \nWilliam Fyke \nAffiliations : \nInstitut de Neurosciences Cognitives et Intégratives d’Aquitaine\,\nCNRS UMR 5287 \nSUNY Downstate Health Sciences Center\nSchool of Graduate Studies – Neural and Behavioral Science\n450 Clarkson Ave\nBrooklyn\, NY 11203 \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-william-fyke/
CATEGORIES:Thesis
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