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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20210304
DTEND;VALUE=DATE:20210305
DTSTAMP:20260503T181324
CREATED:20210126T115402Z
LAST-MODIFIED:20210224T095726Z
UID:130533-1614816000-1614902399@www.bordeaux-neurocampus.fr
SUMMARY:Microbiology Day
DESCRIPTION:Exclusively by video conference. \nClimate change\, population dynamics in association with limited resources and an increasing threat of worldwide pandemics are immense challenges that govern the world of today and tomorrow. The microbiology field has the potential to play a key role in confronting these challenges by providing innovative and sustainable solutions for the health\, agricultural\, industry and environmental sectors. \nIn this context the microbiology community in Bordeaux and the Nouvelle Aquitaine region covers a wide ranging spectrum of disciplines including basic research on microbial pathogens (“green” and “red”) as well as clinical\, epidemiological\, agricultural\, environmental\, technical and social aspects of microbiology. This combined expertise places our community into an ideal position to respond at the regional level\, as we could show during  the Covid-19 crisis. \nFollowing the success of the first edition of the Microbiology Day in 2020\, the second “Microbiology Day” will take place in 2021. This meeting will be a chance to further reunite the community and will present an opportunity to establish an annual common forum for scientific exchange and to highlight the diversity of the microbiology field present here in Bordeaux and the region. \nThis scientific meeting is a great opportunity to present your most recent data and meet the microbiology community. \nRegistration\n\n(Mandatory) \nhttps://www.tbmcore.u-bordeaux.fr/microbiology-day/ \n\nOrganized by the Département Sciences et Biologie Médicale \n
URL:https://www.bordeaux-neurocampus.fr/en/event/microbiology-day/
CATEGORIES:For scientists,Other events
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DTSTART;TZID=Europe/Paris:20210304T140000
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UID:129481-1614866400-1614866400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Marine Persillet
DESCRIPTION:\n	\n		\n			Etude des altérations  des cycles éveil/sommeil dans des modèles de la maladie de Parkinson et de l’atrophie multisystématisée \n(Study of sleep/wake alterations in mouse models of Parkinson’s disease et Multiple System Atrophy) \n\nDefense in french \nThesis supervisor : Erwan Bézard \nAbstract\nParkinson’s disease (PD) and Multiple System Atrophy are both synucleinopathies. These diseases are characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) and the presence of cytoplasmic inclusions. These inclusions are named Lewy Bodies (LB) in PD and glial cytoplasmic inclusions (GCI) in MSA and contain notably misfolded alpha-synuclein (a‑syn). In addition to movement disorders\, PD and MSA patients exhibit a myriad of non-motor symptoms including sleep/wake alterations that may occur early in the course of the diseases and that are even considered as predictors of synucleinopathies. The aim of my thesis is thus to investigate the likelihood of a relationship between the progression of neurodegeneration\, the progression of the a‑syn pathology\, and the occurrence of sleep/wake issues. \nFirst\, as the loss of DA neurons is a characteristic of synucleinopathies\, we studied the impact of dopamine depletion on sleep. This study tends to show that dopamine has a role in the maintenance of arousal phases. \nWe then used a mouse model of PD which consists of the intracerebral injection of LB fractions containing pathological a-syn to study possible alterations of the wake/sleep cycles. A few months after the injection of these fractions\, several sleep parameters appear altered\, including the total time spent awake or asleep. This model\, therefore\, appears adequate for the subsequent study of the impact of alterations in the wake/sleep cycle on the development of the pathology. In contrast\, no alteration was observed in the AMS model studied\, namely the PLP-syn mice. More studies are therefore needed on other models of the disease. \nFinally\, since sleep has a known role in protein elimination\, we have studied its impact on the pathology associated with a-syn. \nThe work carried out is particularly relevant because understanding whether alterations in the wake/sleep cycles can be used at the experimental level as a marker of the progression of the pathology could allow early detection and lead to new therapeutic strategies to slow down its progression. This work is of particular relevance as understanding if sleep disorders may serve experimentally as a surrogate marker of neurodegeneration or pathology progression could provide an early way detection and lead to new therapeutic strategies to slow down its progression. \nKeywords: sleep; animal modeling; synuclein; human pathology \nPublications\nYu X.°\, Persillet M.°\, Zhang L.\, Zhang Y.\, Xiuping S.\, Li X.\, Ran G.\, S. Breger L.S.\, Dovero S.\, Porras G.\, Dehay D.\, Bezard E.\, Qin C. (2021)\, Evaluation of blood flow as a route for propagation in experimental Synucleinopathy\, Neurobiology of disease \nDecoeur F.\, Benmamar-Badel A.\, Leyrolle Q.\, Persillet M.\, Layé S.\, Nadjar A. (2020) Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice\, Brain\, Behavior\, and Immunity \nJury\n– Pierre-Hervé LUPPI – Directeur de recherche\, CNRS\n– Véronique FABRE – Chargée de recherche\, INSERM\n– Ana MARQUES – Praticien hospitalier\, CHU de Clermont-Ferrand\n– Agnès NADJAR – Professeure des Universités\, Université de Bordeaux\n– Erwan BEZARD – Directeur de recherche\, INSERM \n\n		\n	\n\n	\n		\n			Marine Persillet\nTeam Pathophysiology of parkinsonian syndromes\nIMN \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-marine-persillet/
CATEGORIES:Thesis
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