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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20210225T093000
DTEND;TZID=Europe/Paris:20210225T093000
DTSTAMP:20260503T164608
CREATED:20210121T145941Z
LAST-MODIFIED:20210122T111345Z
UID:130383-1614245400-1614245400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Tomas Jordà-Siquier
DESCRIPTION:\n	\n		\n			Centre Broca Nouvelle-Aquitaine and via Zoom \nPhysiological and pathological roles of the amyloid precursor protein at the presynapse. \nThesis supervisor: Gaël Barthet \nAbstract\nAlzheimer’s disease (AD) is a progressive neurodegenerative disease which affects 47 million people worldwide\, being the most prominent type of dementia. The etiology of the disease is unknown but genetic evidence from the familial form of the disease indicates that the amyloid precursor protein (APP) plays a key role in the pathology. The aim of my thesis was to study the physiological and pathological functions of APP related to its location at the presynapse. I studied the consequences on presynaptic mechanisms of the genetic deletion of APP and presenilin\, the catalytic subunit of γ-secretase and intramembrane protease which cleaves APP. I then investigated possible alterations of APP\, other than the amyloid peptides in AD brain\, discovering that APP dramatically accumulates together with presynaptic proteins around dense-core amyloid plaques in human AD brain. Altogether\, the data I collected during my thesis supports a role of presynaptic APP in physiology and in AD pathology and highlights APP accumulations as a pathological site where presynaptic proteins are mis-distributed. \nPublications\nUnder review: APP accumulates around dense-core amyloid plaques with presynaptic proteins in Alzheimer’s disease brain\nTomàs Jordà-Siquier\, Melina Petrel\, Vladimir Kouskoff\, Fabrice Cordelières\, Susanne Frykman\, Ulrike Müller\, Christophe Mulle\, Gaël Barthet\ndoi: https://doi.org/10.1101/2020.10.16.342196 \nUnder review: Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer’s disease\nTomás Jordá-Siquier\, Hazal Haytural\, Bengt Winblad\, Christophe Mulle\, Lars O. Tjernberg\, Ann-Charlotte Granholm\, Susanne Frykman\, Gaël Barthet\ndoi: https://doi.org/10.1101/2020.10.06.327833 \nHaytural H\, Lundgren JL\, Köse TB\, Jordà-Siquier T\, Kalcheva M\, Seed Ahmed M\, Winblad B\, Sundström E\, Barthet G\, Tjernberg LO\, Frykman S. Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies. Front Aging Neurosci. 2019 Oct 9;11:273 \nPresenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity\nBarthet G\, Jordà-Siquier T\, Rumi-Masante J\, Bernadou F\, Müller U\, Mulle C. . Nat Commun. 2018 Nov 14;9(1):4780. \nJury\nFrederic Checler\nJochen Herms\nAntonia Gutierrez\nEniko Kovari \n\n		\n	\n\n	\n		\n			 \nTomas Jordà-Siquier\nTeam Mulle\nIINS \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-tomas-jorda-siquier/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20210225T100000
DTEND;TZID=Europe/Paris:20210225T110000
DTSTAMP:20260503T164608
CREATED:20210222T122047Z
LAST-MODIFIED:20210222T141510Z
UID:131365-1614247200-1614250800@www.bordeaux-neurocampus.fr
SUMMARY:CNSeminar - James M Shine
DESCRIPTION:\n	\n		\n			In the frame of Clinical Neuroanatomy Seminars\, organized by Stephanie Forkel and Michel Thiebault de Schotten (IMN) \nOnline on Zoom or Youtube: \nhttps://www.youtube.com/channel/UCnvtSm-FGHC9HLw4p5hhhPg \nTitle\nThe thalamus integrates the macro systems of the brain to facilitate complex adaptive brain dynamics \nAbstract\nThe human brain is a complex\, adaptive system comprised of billions of cells with trillions of connections. The interactions between the elements of the system oppose this seemingly limitless capacity by constraining the system’s dynamic repertoire\, enforcing distributed neural states that balance integration and differentiation. How this trade-off is mediated by the brain\, and how the emergent\, distributed neural patterns give rise to cognition and awareness\, remains poorly understood. Here\, I argue that the thalamus is well-placed to arbitrate the interactions between distributed neural assemblies in the cerebral cortex. Different classes of thalamocortical connections are hypothesized to promote either feed-forward or feedback processing modes in the cerebral cortex. This activity can be conceptualized as emerging dynamically from an evolving attractor landscape\, with the relative engagement of distinctly distributed circuits providing differing constraints over the manner in which brain state trajectories change over time. In addition\, inputs to the distinct thalamic populations from the cerebellum and basal ganglia\, respectively\, are proposed to differentially shape the attractor landscape\, and hence\, the temporal evolution of cortical assemblies. The coordinated engagement of these neural macrosystems is then shown to share key characteristics with prominent models of cognition\, attention and conscious awareness. In this way\, the crucial role of the thalamus in mediating the distributed\, multi-scale network organization of the central nervous system can be related to higher brain function. \n\nAbout CNSeminars\nwww.clinicalneuroanatomyseminars \n\n		\n	\n\n	\n		\n			 \nDr James M Shine\nUniversity of Sydney\nhttps://macshine.github.io/cv/\n@jmacshine \n\n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/cnseminar-james-m-shine/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20210225T160000
DTEND;TZID=Europe/Paris:20210225T180000
DTSTAMP:20260503T164608
CREATED:20210224T152212Z
LAST-MODIFIED:20210224T152212Z
UID:131586-1614268800-1614276000@www.bordeaux-neurocampus.fr
SUMMARY:PhilinBioMed seminar - Eva Jablonka
DESCRIPTION:Eva Jablonka\n(Cohn Instit. for History & Philosophy of Science\, Tel Aviv Univ.) \nNeural Transitions in Learning and Cognition\nEva Jablonka is professor emeritus at the Cohn Institute for the History and Philosophy of Science and Ideas\, Tel Aviv University. In 1981 she was awarded the Landau prize of Israel for outstanding Master of Science (M.Sc.) work and in 1988\, the Marcus prize for outstanding Ph.D. work. EvaJablonka publishes about evolutionary themes\, especially epigenetics. Her emphasis on non-genetic forms of evolution has received interest from those attempting to expand the scope of evolutionist thinking into other spheres. Jablonka has been described as being in the vanguard of an ongoing revolution within evolutionary biology\, and is a leading proponent of the extended evolutionary synthesis. \nAbstract “Neural Transitions in Learning and Cognition” \nA focus on learning as a marker of a cognitive system provides a unifying framework for experimental and theoretical studies of cognition in the living world. Focusing on neural learning\, Simona Ginsburg and I identified five major neural transitions\, the first two of which involve animals at the base of the phylogenetic tree: (i) the evolutionary transition from learning in non-neural animals to learning in the first neural animals; (ii) the transition to animals showing limited\, elemental associative learning\, entailing neural centralization and primary brain differentiation; (iii) the transition to animals capable of unlimited associative learning (UAL)\, which\, on our account\, constitutes sentience and entails hierarchical brain organization and dedicated memory and value networks\, and (iv) the transition to imaginative animals that can plan and learn through selection among virtual events; (v) the transition to human\, symbol-based cognition and cultural learning. \nThe talk will be given by Zoom:\n\nZoom link for the talk; everyone is welcome to join. \n\nOrganized by PhilInBioMed\nInstitute for Philosophy in Biology and Medecine\n \nhttps://www.philinbiomed.org/event/eva-jablonka \n
URL:https://www.bordeaux-neurocampus.fr/en/event/philinbiomedi-seminar-eva-jablonka/
CATEGORIES:For scientists,home-event,Other events
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