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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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DTSTART:20200329T010000
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DTSTART;VALUE=DATE:20201005
DTEND;VALUE=DATE:20201010
DTSTAMP:20260427T170225
CREATED:20200730T105623Z
LAST-MODIFIED:20201005T155346Z
UID:124127-1601856000-1602287999@www.bordeaux-neurocampus.fr
SUMMARY:Fête de la science
DESCRIPTION:\n\nEn 2020 : un circuit scientifique bordelais “hors les murs” \nChaque année\, le Circuit scientifique bordelais est organisé dans le cadre de la Fête de la science. Face à la crise sanitaire liée à l’épidémie de Covid-19\, l’édition 2020 sera organisée exceptionnellement “hors les murs”. \nAinsi les chercheurs partiront à la rencontre des élèves de plusieurs établissements\, sélectionnés par le rectorat de Bordeaux en Gironde\, Lot-et-Garonne et Dordogne du lundi 5 au vendredi 9 octobre. \nPlusieurs chercheurs de Bordeaux Neurocampus se rendront au collège Georges Lapierre de Lormont vendredi 9 octobre : Jacques Taillard (Sanpsy)\, avec un atelier sur le sommeil sous forme de quizz\, Alexandra Gros et Arthur Leblois (IMN) qui parleront de leur métier via un objet mystère. \nEn savoir plus\nhttps://www.u-bordeaux.fr/Actualites/De-la-recherche/L-universite-fete-la-science2 \n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/fete-de-la-science/
CATEGORIES:Events for all,home-event
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DTSTART;TZID=Europe/Paris:20201009T113000
DTEND;TZID=Europe/Paris:20201009T123000
DTSTAMP:20260427T170225
CREATED:20201006T165629Z
LAST-MODIFIED:20201006T183100Z
UID:123016-1602243000-1602246600@www.bordeaux-neurocampus.fr
SUMMARY:Monthly conference (PhD seminar series) : Johannes Kohl
DESCRIPTION:Online. More details soon about the way to watch the conference. \n\nJohannes Kohl\nFrancis Crick Institute – London\, UK\nhttps://www.kohl-lab.org/ \nTitle : Deconstructing instinctive behaviours \n\nAbstract  \nParenting is essential for the survival and wellbeing of offspring in many species\, but we lack a circuit-level understanding of how this behaviour is orchestrated. Using viral tracing\, in vivo imaging\, optogenetic manipulations and behavioural profiling in mice\, we recently discovered that a genetically specified class of hypothalamic neurons forms projection-defined subpopulations\, each controlling specific aspects of parenting. This functional organization provides a new model for how discrete elements of a social behaviour are generated at the circuit level. Our current goal is to understand how physiological states (such as pregnancy\, hunger and sleep) alter the form and function of this and other circuits for instinctive behaviours. \nSelected publications \n\nKohl J. Parenting – a paradigm for investigating the neural circuit basis of behavior. (2020). Curr Op. Neurobiol. 60:84-91.\nAutry AE\, Wu Z\, Kohl J\, Bambah-Mukku D\, Rubinstein ND\, Marin-Rodriguez B\, Carta I\, Sedwick V and Dulac C. Perifornical area Urocortin-3 neurons promote infant-directed neglect and aggression. (2019). bioRxiv doi: https://doi.org/10.1101/697334\nKohl J\, Babayan BM\, Rubinstein ND\, Autry AE\, Marin-Rodriguez B\, Kapoor V\, Miyamichi K\, Zweifel LS\, Luo L and Dulac C. Functional circuit architecture underlying parental behaviour. (2018). Nature 556(7701):326-331.\nKohl J\, Ng J\, Cachero S\, Ciabatti E\, Dolan MJ\, Sutcliffe B\, Tozer A\, Ruehle S\, Krueger D\, Frechter S\, Branco T\, Tripodi M\, Jefferis GSXE. Ultrafast tissue staining with chemical tags. (2014). PNAS 111(36): E3805-14.\nKohl J\, Ostrovsky AD\, Frechter S and Je­fferis GSXE. A bidirectional circuit switch reroutes pheromone signals in male and female brains. (2013). Cell 155(7): 1610-23.\n\n\nInvité par Bordeaux Neurocampus et la NBA \n
URL:https://www.bordeaux-neurocampus.fr/en/event/conference-mensuelle-octobre-2020/
CATEGORIES:For scientists,home-event,Monthly conferences
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DTSTART;TZID=Europe/Paris:20201009T140000
DTEND;TZID=Europe/Paris:20201009T170000
DTSTAMP:20260427T170225
CREATED:20200921T071755Z
LAST-MODIFIED:20200921T083549Z
UID:125309-1602252000-1602262800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Tiffen Clément
DESCRIPTION:\nAmphithéâtre Louis de l’ISPED // Accès restreint en raison des restrictions sanitaires.\n\nDefense in english\n\nThesis supervisor: Jérôme Badaut\, INCIA.\n\n\n\n\nAstrocytes contribution in brain vulnerability after juvenile mild traumatic brain injury\n\n\n\n\nAstrocytes are crucial for various physiological functions in the brain such as homeostasis\, metabolism\, neurovascular coupling or neurotransmission regulation. In injuries\, astrocytes become reactive and have a crucial role in the neuroinflammatory response. This reactivity is heterogeneous and depends on many parameters such as the type and severity of insult\, astrocyte proximity to insult\, or state of brain maturity. However\, the specific response of astrocytes to mild traumatic brain injury (TBI) in the developmental context has never been studied yet. Mild TBI is the leading cause of emergency department visits in the pediatric population. A significant proportion of mild TBI pediatric patients will suffer of long-lasting cognitive and emotional impairments but the underlying cellular and molecular mechanisms are still poorly understood. Astrocytes might take part to this vulnerability and be partly responsible for the long-term consequences. \nWe investigated astrocyte response to juvenile mild TBI and hypothesized that: (1) astrocytes display a specific pattern of reactivity evolving over time and brain development; and that (2) astrocytes reactivity differs when the TBI is preceded by an early systemic inflammation inducing a priming of astrocytes\, with a different neuroinflammatory and vascular response to juvenile mild TBI\, impacting the brain vulnerability and long-term outcome. \nWe have shown that: \n\n\n\n\n\n\n(1)  Reactive astrocytes express a specific spatiotemporal reactivity pattern even at distance from the injury site\, in terms of intermediate filaments expression and morphological evolution\, and that structural alterations are observed in brain imaging on the long-term after juvenile mild TBI. \n(2)  When the juvenile mild TBI is preceded by perinatal systemic inflammation\, astrocytes express a different reactivity phenotype considered as a state of transition towards scar-forming astrocytes\, with increased metabolism and extracellular matrix-related gene changes\, associated to morphological alterations sustaining over time and delayed over-expression of VEGF\, resulting in the absence of vascular alterations induced by TBI alone. \nThis work brings new insights in the specificities of astrocyte reactivity and in the pathophysiology of vulnerability after juvenile mild TBI\, opening possibilities for novel targets for therapeutics. \nKeywords: Astrocyte\, traumatic brain injury\, neuroinflammation\, vulnerability \n\n\n\n\n\n\n\n\n\nPublications\n\n\n\n\n• Clement\, T.\, Delahaye-Duriez\, A.\, Van Steenwinckel J.\, Fournier\, M.L.\, Aussudre\, J.\, Blugeon\, C.\, Lemoine\, S.\, Faivre\, V.\, Boccazzi\, M.\, Ogier\, M.\, Canini\, F.\, Konsman\, J.P.\, Gressens\, P.\, Badaut\, J. (2021). Transition states towards scar-forming astrocytes and neurovascular remodeling after juvenile TBI in perinatal systemic inflammation sensitized brain. In preparation. \n• Fournier\, M.L.\, Clement\, T.\, Aussudre\, J.\, Plesnila\, N.\, Obenaus\, A.\, Badaut.\, J. (2021). Contusion rodent model of traumatic brain injury: controlled cortical impact. Methods Mol Biol. 2021;2193:49-65. doi: 10.1007/978-1-0716-0845-6_6 \n• Clement\, T.\, Lee\, J.B.\, Ichkova\, A.\, Rodriguez-Grande\, B.\, Fournier\, M.L.\, Aussudre\, J.\, Ogier\, M.\, Haddad\, E.\, Canini\, F.\, Koehl\, M.\, Abrous\, D.N.\, Obenaus\, A.\, Badaut\, J. (2020). Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses. Glia. 2020;68(3):528-542. doi:10.1002/glia.23736 \n• Clement\, T.\, Rodriguez-Grande\, B.\, & Badaut\, J. (2018). Aquaporins in brain edema. J Neurosci Res. 2020;98(1):9-18. doi:10.1002/jnr.24354 \n• Blochet\, C.\, Buscemi\, L.\, Clement\, T.\, Gehri\, S.\, Badaut\, J.\, & Hirt\, L. (2018). Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis. J Cereb Blood Flow Metab. 2020;40(1):163-176. doi:10.1177/0271678X18806893 \nJury\n\n\n\n\nM. TOURDIAS\, Thomas  Professeur\, Université de Bordeaux Président \nMme ESCARTIN\, Carole  Directeur de recherche\, Université Paris-Saclay Rapporteur \nMme SOHRABJI\, Farida  Professeur\, Texas A&M University Rapporteur \nM. GRESSENS\, Pierre  Professeur\, Université Paris Diderot  Examinateur \nM. CANINI\, Frédéric Professeur\, IRBA Invité \nM. OGIER\, Michaël Chargé de recherche\, IRBA Invité \n\n\n\n\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-tiffen-clement/
CATEGORIES:Thesis
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