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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20191122T140000
DTEND;TZID=Europe/Paris:20191122T160000
DTSTAMP:20260504T082953
CREATED:20191112T132110Z
LAST-MODIFIED:20191114T162202Z
UID:112741-1574431200-1574438400@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Céline Duffau
DESCRIPTION:Venue: CGFB \n(Thesis defense in french) \n\nImplication of the anatomo-functional connectivity of frontal cortex regions in the formation and consolidation of associative olfactory memory in the rodent \n\nCéline Duffau\nTeam Bruno Bontempi \nThesis supervisor : Olivier Nicole \nAbstract\nInitially encoded in the hippocampus\, new associative memories\, also referred to as memory engrams\, are thought to become progressively dependent on a broadly distributed cortical network as they mature and consolidate over time. While acting as permanent repository sites for remote memories\, converging findings point however to an earlier recruitment\, upon encoding\, of some cortical sites that participate actively to the generation of engram cells\, albeit in an immature form. One such region is the frontal cortex in which rapid functional and structural changes occur\, raising the possibility that subsequent maturation of cortical engrams requires a complex and time-dependent interplay between dedicated brain regions. Here\, by tracking the expression of the activity-dependent gene c-fos\, we sought to dissect the involvement of interconnected cortical regions: medial Prefrontal Cortex (mPFC)\, anterior (aCC) and posterior (pCC) parts of Cingulate Cortex\, Orbitofrontal Cortex (OFC)\, which may participate to the generation of functionally mature engrams. Recent or remote associative olfactory memory was probed in rats submitted to the social transmission of food preference paradigm. \nWe identified three key brain regions that were co-activated upon remote memory retrieval (mPFC\, aCC and OFC) suggesting that they act as critical “hub-like” nodes within the extended network of cortical regions supporting remote memory formation. By computing interregional correlations\, we found that neuronal activity within mPFC and OFC were highly correlated although their recruitment was dependent on the age of memory. This correlated neuronal activity may be the consequence of a direct anatomical connection between these two cortices. While OFC activation was delayed\, that of mPFC occurred at both recent and remote delays. Chemogenetic experiments aimed at examining causal relationships revealed a crucial role of mPFC in both encoding and retrieval phases of the memory process. Altogether\, these findings suggest that cortical engram maturation holds region-specificity but also involves complex cortical network connections and distinct kinetics of interactions that likely guide engram cells to their final maturation state to enable optimal remote memory storage and expression. \nA specific fragility inside this functional connectivity\, especially during aging could slow down the learning process. Building upon the analysis of a comprehensive set of observations derived from a large population of aged (22 month-old) mice submitted to spatial discrimination testing in an 8-arm radial maze\, we isolated two populations of aged mice\, one with a memory performance similar to that a group of young mice (normal learners) and another exhibiting a reduced speed of learning (categorized as slow learners). Future studies could help to examine to what extent brain functional connectivity is differentially altered in these two aged mouse populations and might be responsible for their specific memory profile and underlying cognitive strategies. \nKeywords: Associative olfactory memory\, Spatial memory\, Memory consolidation\, Frontal cortex\, Aging  \n  \nJury\nM. FRERET Thomas – Professeur – Université de Caen – Rapporteur\nM. MALLERET Gaël – CR – CNRS – Rapporteur\nM. MICHEAU Jacques – Professeur – Université de Bordeaux – Examinateur\nMme. POIRIER Roseline – MCU – Université de Paris Sud – Examinateur\nMme. Abrous Nora – DR – INSERM – Examinateur\nM. BONTEMPI Bruno – DR – CNRS – Invité\nM. NICOLE Olivier – CR – CNRS – Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-celine-duffau/
CATEGORIES:Thesis
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2019/11/duffau-vignette-DSC_4777.jpg
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DTSTART;TZID=Europe/Paris:20191122T150000
DTEND;TZID=Europe/Paris:20191122T160000
DTSTAMP:20260504T082953
CREATED:20190225T144615Z
LAST-MODIFIED:20191118T095451Z
UID:103646-1574434800-1574438400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Isabelle Mansuy
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \nThe epigenome as a vector of inheritance of acquired behaviors: Evidence in mammals involving the germline \n\nIsabelle Mansuy\nPhd\, Laboratory of Neuroepigenetics\, University and ETH Zürich\, Brain Research Institute\, Winterthurerstrasse 190\, Zürich\, Switzerland.\nEmail: mansuy@hifo.uzh.ch \nInvited by  Giovanni Marsicano\nNeurocentre Magendie \nAbstract\nBehavior and physiology in mammals are strongly influenced by the environment and living conditions\, particularly during early postnatal life. While positive factors can favor proper development and good mental and physical health in adulthood\, negative events such as traumatic experiences can increase the risk for psychiatric\, metabolic and psychosomatic diseases. Such disorders can affect directly exposed individuals but strikingly\, they can also impact their offspring. The biological mechanisms underlying the transmission of experience-induced symptoms from parent to offspring have recently started to be examined and are thought to involve epigenetic mechanisms. This talk will present an experimental model of postnatal trauma in mice recapitulating trauma-induced symptoms including depressive symptoms\, increased risk-taking\, altered social behaviors\, cognitive deficits\, and impaired blood and brain metabolism in adulthood. The symptoms are pronounced and persist throughout life\, and most of them are transmitted to the following offspring by both females and males in up to the 5th generation. They are associated with epigenetic alterations involving persistent changes in DNA methylation at the promoter-associated CpG island of several genes\, in the brain of the offspring and the germline of their father. Further to DNA methylation\, other epigenetic mechanisms involving RNA are also involved\, those with causal consequences. Initial translational analyses in humans exposed to early life trauma validate these results. Overall\, the findings suggest that epigenetic processes contribute to the impact of environmental exposure in postnatal life on adult behavior and physiology\, and to its inheritance across generations. \n  \n  \n\n  \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-isabelle-mansuy-2/
CATEGORIES:home-event,Seminars
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