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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20191114T100000
DTEND;TZID=Europe/Paris:20191114T140000
DTSTAMP:20260415T134348
CREATED:20191112T180219Z
LAST-MODIFIED:20191112T180928Z
UID:112782-1573725600-1573740000@www.bordeaux-neurocampus.fr
SUMMARY:Stand commercial - Tebu-bio
DESCRIPTION: \n
URL:https://www.bordeaux-neurocampus.fr/en/event/stand-commercial-tebu-bio/
CATEGORIES:home-event,Industrial seminar or booth
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20191114T140000
DTEND;TZID=Europe/Paris:20191114T160000
DTSTAMP:20260415T134348
CREATED:20191003T151603Z
LAST-MODIFIED:20191007T152835Z
UID:111537-1573740000-1573747200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Ashley Castellanos Jankiewicz
DESCRIPTION:Venue: Neurocentre Magendie conference room \nBile acids signaling as a novel mechanism in the hypothalamic control of energy balance \nThesis supervisor:\nDaniela Cota\, MD\, HDR \nSummary: Bile acids (BA) are cholesterol-derived molecules mostly known for participating in the digestion of lipids. By activating the Takeda G protein coupled receptor 5 (TGR5) in peripheral organs\, BA can also act as signaling molecules to reduce body weight\, increase energy expenditure and improve glycaemia. These outcomes imply an anti-obesity function for TGR5. Since the major center of convergence of nutrient\, hormonal\, and environmental cues is the brain\, particularly the hypothalamus\, we hypothesized a role for TGR5 in this brain structure\, specifically under diet-induced obesity. \nOur results show that TGR5 and BAs transporters are expressed in the mediobasal hypothalamus (MBH)\, and that obese mice have decreased circulating and hypothalamic BA levels. Acute intracerebroventricular (ICV) or intra-MBH administration of TGR5 agonists reduced food intake and body weight in obese mice only\, and improved insulin sensitivity. Accordingly\, chronic ICV administration of the TGR5 agonist in obese mice reduced their body weight and adiposity\, while increasing energy expenditure and markers of sympathetic activity in the adipose tissue. Indeed\, experiments conducted at thermoneutrality (30°C) or chemical sympathectomy blunted these effects\, demonstrating that central TGR5 effects require the engagement of the sympathetic nervous system. Conversely\, by using genetic animal models\, we observed that the deletion of TGR5 in the MBH rapidly increased food intake\, body weight and adiposity\, while blunting the sympathetic response to a cold challenge (4h at 4°C)\, hence worsening obesity. \nOur work proves the existence of a functional hypothalamic BA – TGR5 receptor system. We show for the first time that the activation of TGR5 in the MBH decreases body weight and adiposity\, while increasing energy expenditure through recruitment of the sympathetic nervous system. These results expose a new mechanism of action for potential anti-obesity therapies. \nKeywords: Bile acids\, TGR5\, diet-induced obesity\, mediobasal hypothalamus\, energy balance\, sympathetic activity\, thermogenesis. \nSCIENTIFIC OUTPUT \nPublished research articles: \n\nAndré C\, Guzman-Quevedo O\, Rey C\, Rémus-Borel J\, Clark S\, Castellanos-Jankiewicz A\, Ladeveze E\, Leste-Lasserre T\, Nadjar A\, Abrous DN\, Laye S\, Cota D. Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation. Diabetes. 2017 Apr;66(4):908-919.\nRodríguez-Peredo SM\, Castellanos-Jankiewicz AK\, Imaz-Rosshandler I\, Espinoza-Camacho MA\, Rangel Escareño C\, Muñoz-Sánchez JL\, Melendez-Zajgla J\, Tejero ME\, Carbó R\, Maldonado V\, del Bosque-Plata L.   Modulation of the lung RNAome in a metabolic syndrome rat model. Int J Clin Exp Pathol 2017;10(5):5379-5392.\nCastellanos Jankiewicz AK\, Rodríguez Peredo SM\, Cardoso Saldaña G\, Díaz Díaz E\, Tejero Barrera ME\, del Bosque Plata L\, Carbó Zabala R. Adipose tissue redistribution caused by an early consumption of a high sucrose diet in a rat model. Nutr Hosp 2015;31(6):2546-53. doi: 10.3305/nh.2015.31.6.8935.\nCastellanos-Jankiewicz A\, Del Bosque-Plata L\, Tejero ME. Combined effect of plant sterols and dietary fiber for the treatment of hypercholesterolemia. Plant Foods Hum Nutr 2014;69(2):93-100. doi: 10.1007/s11130-014-0419-8.\nGuevara-Cruz M\, Torres N\, Tovar AR\, Tejero ME\, Castellanos-Jankiewicz A\, del Bosque-Plata L. A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio. Nutr Hosp 2014;30(3):671-677.\n\nArticles in progress: \n\nCastellanos-Jankiewicz A*\, Guzman-Quevedo O*\, Fenelon V\, Zizzari P\, Clark S\, Dupuy N\, Leste-Lasserre T\, Muhr-Tailleux A\, Staels B\, Shoonjans K\, Cota D. Brain bile acid-TGR5 signaling protects from obesity.\nPerino A\, Velazquez Villegas LA\, Castellanos-Jankiewicz A\, Guzman-Quevedo O\, Fenelon V\, Cota D\, Shoonjans K. Melanocortin-dependent effects determine the action of neuronal TGR5 signaling on feeding behavior.\nSoty M\, Vily J\, Castellanos-Jankiewicz A\, Guzman-Quevedo O\, Raffin M\, Clark S\, Vulin F\, Silva M\, Gautier-Stein A\, Cota D\, Mithieux G. Brain circuit by which glucose sensing in the portal vein controls energy homeostasis.\n\nBook chapters: \n\nGonzález-Franco L.R.\, Castellanos Jankiewicz A. (2019). Riesgos nutricionales y cuidado nutricional en el paciente con enfermedad de Parkinson (1st Ed.). In Entendiendo al paciente con enfermedad de Parkinson (pp. 219-228). México: Minaya Editorial. ISBN: 978-1-5323-9476-8.\n\nScience communication articles:  \n\nCastellanos Jankiewicz A.\, Guzmán Quevedo O.\, Cota D. El origen de la obesidad: ¿está todo en la cabeza? Revista Ciencia (ACM).\nhttps://www.revistaciencia.amc.edu.mx/index.php/ediciones-anteriores/articulos-fuera-de-los-volumenes-publicados-online/482-el-origen-de-la-obesidad-esta-todo-en-el-cerebro\nCastellanos Jankiewicz A. (2018 Octubre-Diciembre). Neurobiología del comportamiento alimentario. Revista Ciencia (ACM)\, vol. 69(4)\, pp. 56-61.\nhttps://www.revistaciencia.amc.edu.mx/index.php/ediciones-anteriores?id=282\n\nJury members:\n\nM. Guillaume Ferreira\, Directeur de Recherche\, INRA UMR 1286\, Université de Bordeaux\, France.  (Président)\nM. Luc Penicaud\, Directeur de Recherche\, CNRS Genopole Toulouse\, Université de Toulouse III\, Toulouse\, France.  (Rapporteur)\nM. Christophe Magnan\, Professeur des Universités\, Université Paris Diderot\, Paris\, France.  (Rapporteur)\nM. Gilles Mithieux\, Directeur de Recherche\, INSERM U1213\, Lyon\, France.  (Examinateur)\nMme. Daniela Cota\, Directrice de Recherche\, INSERM U1215\, Université de Bordeaux\, France. (Directrice de thèse\, examinatrice)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-ashely-castellanos-jankiewicz/
CATEGORIES:Thesis
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2019/10/catellanos-ashley-DSC_5367-vignette.jpg
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DTSTART;TZID=Europe/Paris:20191114T140000
DTEND;TZID=Europe/Paris:20191114T160000
DTSTAMP:20260415T134348
CREATED:20191022T093407Z
LAST-MODIFIED:20191024T155536Z
UID:112301-1573740000-1573747200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Miguel López Cuiña
DESCRIPTION:Miguel López Cuiña\nPhysiopathology and treatment of multiple system atrophy  \nThesis supervisor: Wassilios Meissner (IMN) \nAbstract\nMultiple system atrophy (MSA) is a rare\, rapidly progressive neurodegenerative disease that affects numerous regions of the central nervous system\, including the olivopontocerebellar and striatonigral systems as well as various autonomous nuclei of the brainstem. The pathological hallmark of MSA is the presence of oligodendroglial aggregates called glial cytoplasmic inclusions (GCI) whose main component is the protein α-synuclein. The neurodegenerative process leads to severe impairment of autonomic dysfunction\, together with a varying degree of parkinsonian and cerebellar syndromes. There is currently no disease modifying therapy available. This PhD work focused\, on the one hand\, on preclinical approaches aiming to reduce the accumulation of α-synuclein in an animal model of MSA\, and on the other hand\, on a neuropathological analysis in patients with a slowly progressive subtype of the disease. Throughout the three years of work\, we have assessed different therapeutic candidates in an animal model of MSA. Rapamycin\, a drug known to enhance autophagy and protein clearance\, showed only a partial neuroprotective effect against neural loss in our model. Nilotinib\, a drug that had shown neuroprotective properties in a Parkinson’s disease animal model\, failed to modify the disease course in our study. Finally\, we evaluated the combinations of two drugs that have already proven to reduce a-synuclein aggregation and protect neurons from degeneration\, to assess whether they have synergistic properties. \nKeywords: Synuclein\, Multiple system atrophy\, glial cytoplasmic inclusions\, post-mortem human brain study\, rodent\, translational approach\, c-terminal truncation\, phosphorylation\, autophagy\, protein aggregation \nPublications\nPresent and future of disease-modifying therapies in multiple system atrophy.\nLopez-Cuina M\, Foubert-Samier A\, Tison F\, Meissner WG.\nAuton Neurosci. 2018 May;211:31-38. doi: 10.1016/j.autneu.2017.12.008. Epub 2018 Jan 4 \nDeep brain stimulation does not enhance neuroinflammation in multiple system atrophy.\nLopez-Cuina M\, Fernagut PO\, Canron MH\, Vital A\, Lannes B\, De Paula AM\, Streichenberger N\, Guehl D\, Damier P\, Eusebio A\, Houeto JL\, Tison F\, Tranchant C\, Viallet F\, Witjas T\, Thobois S\, Meissner WG.\nNeurobiol Dis. 2018 Oct;118:155-160. doi: 10.1016/j.nbd.2018.07.016. Epub 2018 Jul 17. \nInhibition of c-Abl by nilotinib does not prevent alpha-synuclein aggregation and neurodegeneration in a mouse model of multiple system atrophy\nMiguel Lopez-Cuina\, MD\, Paul A. Guerin\, PhD\, Marie-Hélène Canron\, BS\, Anna Delamarre\, MD2\,3\, Benjamin Dehay\, PhD\, Erwan Bezard\, PhD\, Wassilios G. Meissner\, MD\, PhD\, Pierre-Olivier Fernagut\, PhD\nSubmitted to Movement Disorders Journal \nInhibition of the mammalian target of rapamycin alleviates alpha-synuclein aggregation and does partly protect dopamine neurons in a mouse model of multiple system atrophy\nMiguel Lopez-Cuina\, MD\, Paul A. Guerin\, PhD\, Marie-Laurre Arotçarena\, PhD\, Anna Delamarre\, MD\, Benjamin Dehay\, PhD\, Erwan Bezard\, PhD\, Wassilios G. Meissner\, MD\, PhD\, Pierre-Olivier Fernagut\, PhD\nSubmitted to Movement Disorders Journal \nJury\nM. JABER Mohamed ; Professeur Président ; Université de Poitiers\nM. SERGEANT Nicolas ; Directeur de recherche Rapporteur Université de Lille\nM. DERKINDEN Pascal ; PU-PH Rapporteur Université de Nantes\nM. FERNAGUT Pierre Olivier ; Directeur de recherche Invité Université de Poitiers\nM. MEISSNER Wassilios ; PU-PH Directeur de thèse ; Université de Bordeaux \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-miguel-lopez-cuina/
CATEGORIES:Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20191114T180000
DTEND;TZID=Europe/Paris:20191114T210000
DTSTAMP:20260415T134348
CREATED:20191112T144700Z
LAST-MODIFIED:20191112T145323Z
UID:112755-1573754400-1573765200@www.bordeaux-neurocampus.fr
SUMMARY:Projection-débat : « Télescope intérieur\, une œuvre spatiale d’Eduardo Kac »
DESCRIPTION:Cinéma UGC\, Allée du 7e Art\, Talence \n\nAvec la participation de\n– Virgile Novarina\, réalisateur du documentaire.\n– Jean-Luc Morel\, chercheur CNRS à l’IMN et président du groupe de travail exploration humaine de l’espace du CNES. \nÀ propos de l’événement\n\nDans le cadre des 80 ans du CNRS et du festival FACTS \n_ \nConçue pour exister en apesanteur par l’artiste Eduardo Kac\, et réalisée à bord de la Station Spatiale Internationale par l’astronaute français Thomas Pesquet\, l’œuvre « Télescope intérieur » pose le premier jalon d’une nouvelle forme de création artistique et poétique\, libérée des contraintes de la pesanteur. Le film Télescope intérieur\, une œuvre spatiale d’Eduardo Kac\, nous entraîne dans cette aventure artistique et scientifique\, depuis la conception de l’œuvre dans l’atelier d’Eduardo Kac à Chicago\, jusqu’à sa réalisation en orbite par Thomas Pesquet à 400 km de la Terre\, lors de la mission Proxima de l’ ESA – European Space Agency. \n– \nEn présence de Younis Hermès\, Délégué Régional du CNRS en Aquitaine et de Philippe Moretto\, Vice-Président Recherche de l’université de Bordeaux \n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/projection-debat-telescope-interieur-une-oeuvre-spatiale-deduardo-kac/
CATEGORIES:Events for all,home-event
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