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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20191015
DTEND;VALUE=DATE:20191031
DTSTAMP:20260422T000857
CREATED:20190208T093944Z
LAST-MODIFIED:20191030T154753Z
UID:103125-1571097600-1572479999@www.bordeaux-neurocampus.fr
SUMMARY:Cajal course : Advanced Techniques for Synapse Biology
DESCRIPTION:October 15 – 9:00\nInna SLUTSKY\nPlasticity-stability balance in hippocampal circuits: From basic principles to malfunctions \nOctober 17 – 9:00\nMonica DI LUCA\nSynapses dynamic in health and diseases \nOctober 18 – 9:00\nDaniel CHOQUET\nNanoscale imaging of synapse organization and function \nOctober 24 – 9:00\nDietmar SCHMUCKER\nMolecular Mechanisms of Neurite branching and CNS Synaptogenesis \nOctober 25 – 9:00\nBart DE STROOPER\nFrom biochemical to cellular phase in Alzheimer’s disease \nOctober 26 – 9:00\nReinhard JAHN\nSynaptic vesicles – key organelles in synaptic transmission \nOctober 28 – 9:00\nClaudia BAGNI\nBrain connectivity and molecular pathways in autism \nOctober 29 – 9:00 \nMatthijs VERHAGE\nUnique and shared principles in the secretion of different chemical signals from mammalian CNS neurons \nOctober 30 – 9:00\nStéphane OLIET\nContribution of astrocytes to synaptic transmission and plasticity \nAbout the course\nSynaptic contacts are critical for information transfer in the brain. They are specialized sites\, often far from the neuronal cell body\, and operate in part as independent units.  Synaptic contacts are very diverse and synaptic plasticity underlies memory formation and thought. Synaptic dysfunction is strongly associated with diseases of the brain and this is thought to be an early feature of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. The study of the molecular mechanisms of synaptic function and plasticity are the key to understanding how the brain works and what goes wrong in disease. Many of these processes are evolutionarily very well conserved and researchers study synaptic processes in a variety of species and in human neuron models.  The training of a new generation of neuroscientists with advanced techniques is crucial to make these studies a success in the coming decades. \nThe advanced course will allow students to integrate the basic techniques in molecular and cellular neurobiology with advanced state-of-the art molecular\, imaging and functional methodologies\, through direct hands-on experiments using a variety of models. \nCourse director\n \nPatrik Verstreken\nVIB-KULeuven\nBelgium \n  \n  \nCo-Directors \n \nNathalie Sans\nINSERM U8\nUniversity of Bordeaux\nFrance \n  \n  \n \nLaurent Groc\nCNRS – IINS\nUniversity of Bordeaux\nFrance \n  \n  \n\nThis course is organised in partnership with ERA-NET NEURON. \n \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-advanced-techniques-for-synapse-biology/
CATEGORIES:home-event,Seminars
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DTSTART;TZID=Europe/Paris:20191015T093000
DTEND;TZID=Europe/Paris:20191015T113000
DTSTAMP:20260422T000857
CREATED:20190930T141231Z
LAST-MODIFIED:20190930T143834Z
UID:111322-1571131800-1571139000@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Florelle Domart
DESCRIPTION:\n	\n		\n			Venue: Centre Broca Nouvelle-Aquitaine\n \n\nFlorelle Domart\nIINS \nThesis supervised by Dr. Richard Ortega (CENBG) and Dr. Daniel Choquet (IINS) \n\n		\n	\nAbstract\n\n	\n		\n			Abstract: Metallic chemical elements such as Fe\, Cu or Zn are present in minute quantities in the brain. The role of these trace metals in neuronal functions such as synaptic transmission and memory processes remains largely unclear. Moreover\, metal dyshomeostasis is found in many neuropathologies\, such as Alzheimer’s disease\, Parkinson’s or amyotrophic lateral sclerosis. The interaction mechanisms of trace metals at the neuronal level are difficult to describe because of the lack of analytical methods with appropriate resolution and sensitivity to determine metal distribution at the synaptic level. Synchrotron X-ray fluorescence spectrometry (SXRF) is a multielemental chemical analysis method for describing the quantitative distribution of these elements at the sub-cellular scale with a nanometric resolution (40 nm at ESRF beamline ID16A) and a very high sensitivity. In order to accurately interpret chemical imaging results\, we have developed a protocol to correlate nano-SXRF imaging with stimulated emission depletion super resolution microscopy (STED)\, allowing the correlation of metal distribution and that of target proteins in super resolution. We labeled microtubules and F-actin of primary rat hippocampal neurons and imaged the cytoskeleton by STED microscopy before determining the distributions of P\, S\, Fe\, Cu and Zn by SXRF spectrometry. We evidenced the colocalization of Zn and microtubules at the dendritic level and a localization of Cu mainly in the neck of dendritic spines rich in F-actin\, and a distribution of Fe in the form of very localized points in the dendrites. These results highlight the crucial role of Zn in cytoskeleton architecture of hippocampal neurons and the developed correlative imaging method opens new perspectives for the study of metal dyshomeostasis in neurodegenerative diseases. \nKeywords : analytical chemistry\, neurobiology\, trace metals\, synchrotron\, synapse\, correlative microscopy \n\n		\n	\nList of publications\n\n	\n		\n			 Correlative synchrotron nano X-ray fluorescence and STED super resolution imaging of metals and proteins in dendritic spines ; Florelle Domart\, Peter Cloetens\, Stéphane Roudeau\, Asuncion Carmona\, Emeline Verdier\, Daniel Choquet and Richard Ortega – submitted \nZinc and Copper Effects on Stability of Tubulin and Actin Networks in Dendrites and Spines of Hippocampal Neurons.Perrin L\, Roudeau S\, Carmona A\, Domart F\, Petersen JD\, Bohic S\, Yang Y6\, Cloetens P\, Ortega R ; ACS Chem Neurosci. 2017 Jul 19;8(7):1490-1499. \n\n		\n	\nJury\n\n	\n		\n			KUHN Alexander – Professeur\, ENSCPB\, Bordeaux\nExaminateur \nCARRIERE Marie – Chercheuse CEA\, HDR\, Grenoble\nRapporteuse \nBUISSON Alain – Professeur\, Université de Grenoble Alpes\nRapporteur \nISAURE Marie-Pierre – Maître de Conférences\, HDR\, IPREM Pau\nExaminatrice \nTHOUMINE Olivier – DR CNRS\, IINS\, Bordeaux\nExaminateur \nORTEGA Richard – DR CNRS\, CENBG\, Bordeaux-Gradignan\nDirecteur de thèse \nCHOQUET Daniel – DR CNRS\, IINS\, Bordeaux\nCo-directeur de thèse \nCLOETENS Peter – Chercheur ESRF\, Grenoble\nInvité \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-florelle-domart/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20191015T170000
DTEND;TZID=Europe/Paris:20191015T190000
DTSTAMP:20260422T000857
CREATED:20190919T180443Z
LAST-MODIFIED:20190927T093502Z
UID:111136-1571158800-1571166000@www.bordeaux-neurocampus.fr
SUMMARY:Honoris Causa ceremony - Monica di Luca
DESCRIPTION:Monica Di Luca\, professor at the University of Milano\, Italy and présidente du European Brain Council\, will receive the Honoris Causa insignia of the University of Bordeaux\, on October 15th\, 2019. \n\nThe ceremony will be in english\, from 5pm to 7pm\, at the Centre Broca Nouvelle-Aquitaine. \n\nOnline registration\n\n\nMonica Di Luca is an internationally recognized figure of neuroscience research both in its fundamental aspects and in its preclinical developments. Monica Di Luca holds a double PhD; in Pharmacy at the University of Milan\, and in Medical Science ar the University of Utrecht. Since 1995\, she is professor at the University of Milan\, where she progressively developed a lively and productive research laboratory focused on the pharmacology of neurodegeneration. She has fostered a vibrant Neuroscience community in Milan\, through the creation of the NeuroNest Center of Neuroscience. Monica Di Luca is the author of more than 180 articles published in peer reviewed journals. She is a member of the EMBO and has received major international distinctions and awards.Monica Di Luca’s primary research interest relates to neuronal plasticity both in physiological and pathological conditions. Her group has significantly contributed to understanding the molecular mechanisms regulating the molecular and structural dynamics of glutamatergic synapses. These findings open new avenues that help identifying novel molecules targeting early synaptic dysfunction for pharmacological interventions in the still unresolved need of neurodegenerative disease treatment .A preeminent trait of Monica Di Luca’s career is her deep and exigent involvement in establishing and steering collaborative networks of scientists and clinicians in connection with societal challenges. From 2010 to 2012 she was the Chair for Europe of International Brain research Organization (IBRO); from 2014 to 2016 she was President of Federation of European Neuroscience Societies (FENS); from 2014 to 2018 she served as Vice Rector of the University of Milan for International Affairs. At present\, Monica Di Luca is the President of the European Brain Council\, a non-profit organisation gathering scientific societies\, patient organisations\, professional societies and industry partners\, which main mission is to promote brain research\, in order to improve the lives of the estimated 179 million Europeans living with brain conditions. Altogether\, Monica Di Luca has shown an exceptional engagement in the European Brain research area. In Bordeaux\, we have been very fortunate to establish strong connections with Monica Di Luca since many years. There are many examples of participation of Bordeaux Neurocampus to consortia funded by different programs of the European Commission\, in which she was a leading figure. As president of FENS\, she supported the creation of the Bordeaux School of Neuroscience by making Bordeaux a major center for training activities of the prestigious CAJAL Training Programme. Students of Synapse courses organized in Bordeaux warmly praised the joyful atmosphere she puts in transmitting her wide knowledge during her keynote talks. \n\n\n\nDownload the program of the ceremony \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/ceremonie-honoris-causa-monica-di-luca/
CATEGORIES:Various
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