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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
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TZOFFSETFROM:+0200
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190909T090000
DTEND;TZID=Europe/Paris:20190926T130000
DTSTAMP:20260504T115145
CREATED:20190208T093515Z
LAST-MODIFIED:20191030T154754Z
UID:103130-1568019600-1569502800@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures : Whole brain imaging
DESCRIPTION:Lecture program\nFree access / Venue: CGFB \nAu CGFB\, entrée libre \n\nWednesday\, September 11th – 9:00\nJean-Michel FRANCONI\nMR image formation \nThursday\, September 12th – 9:00\nRuss POLDRACK\nTask-related fMRI \nFriday\, September 13th – 9:00\nTim DYRBY\nWhite matter architecture \nMonday\, September 16th – 9:00\nFabrice CRIVELLO\nStructural brain MRI \nWednesday\, September 18th – 9:00\nUrs RIBARY\nEEG-MEG connectivity dynamics \nWednesday\, September 18th – 11:00\nMickaël TANTER\nFunctional ultrasound \nThursday\, September 19th – 9:00\nArno VILLRINGER\nInfrared imaging \nMonday\, September 23rd – 9:00\nGitte KNUDSEN\nNeuroPET \nTuesday\, September 24th – 9:00\nSven CICHON\nNeuroimaging and omics \nTuesday\, September 24th – 11:45\nChristophe TZOURIO\nImaging markers for neuro-epidemiology \nWednesday September 25th – 9:00\nRoundtable :\nKatrin AMUNTS\, Gwenaëlle DOUAUD & Arthur TOGA\nDatabasing\, sharing and meta-analysing \nThursday\, September 26th – 9:00\nLaura HARSAN\nPreclinical imaging \nThursday\, September 26th – 11:00\nRoundtable :\nStéphanie DEBETTE & Kathinka EVERS\nBrain imaging ethics \n  \n  \nAbout the course\nThe CAJAL course in Whole Brain Imaging is an intensive three-week course that will carry participants through the theory and practice of advanced methods for investigating brain structure-function relationships at the organ level. The course will balance lectures from world-acknowledged neuroimaging experts to experimental demonstrations and hands-on laboratory work in small groups. Participants will be introduced to a wide spectrum of techniques\, from microscopic post-mortem brain cyto- and myelo-architectony to macroscopic in vivo 3D-imaging using magnetic resonance\, functional ultrasound\, near-infrared spectroscopy\, electromagnetic waves\, and gamma-ray emission tomography. Issues associated with whole brain neuroimaging multimodality and data-sharing will also be addressed. During the course\, each participant will be given the opportunity to acquire and analyze whole-brain neuroimaging data in both preclinical and clinical environments. \nCourse director \nKatrin Amunts\nJülich Research Centre\nGermany \n  \n  \nCo-directors \nBernard Mazoyer\nCNRS\nNeurodegeneratives Diseases Institute\nUMR 5293\nUniversity of Bordeaux\nFrance \n  \nSylvain Miraux\nCNRS – RMSB\nUMR 5536\nUniversity of Bordeaux\nFrance \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-whole-brain-imaging/
CATEGORIES:home-event,Seminars,Trainings
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DTSTART;TZID=Europe/Paris:20190920T100000
DTEND;TZID=Europe/Paris:20190920T110000
DTSTAMP:20260504T115145
CREATED:20190910T090708Z
LAST-MODIFIED:20191030T154724Z
UID:110972-1568973600-1568977200@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Eric Prager
DESCRIPTION:Eric Prager\nEditor-in-Chief\, Journal of Neuroscience Research \nAbstract \nThe most important skill a scientist needs\, after the skills needed to execute a study\, is the ability to report their scientific endeavors in the written form. The aim of this seminar is to inform on what happens to a paper once the ‘submit’ button is pressed. I will discuss what editors consider when deciding whether to review a paper\, including our focus on transparency\, rigor and the appropriate use of statistics. I will also discuss our expectations from reviewers and briefly describe the peer review process and how peer review is evolving. \nInvited by Sandra Chanraud and Jérôme Badaut (INCIA) \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-eric-prager/
CATEGORIES:For scientists,home-event,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20190920T113000
DTEND;TZID=Europe/Paris:20190920T123000
DTSTAMP:20260504T115145
CREATED:20190207T095740Z
LAST-MODIFIED:20191030T154754Z
UID:103100-1568979000-1568982600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Andrew Lawrence
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nAndrew J Lawrence\nFlorey Institute of Neuroscience and Mental Health\, Parkville\, Victoria\, Florey Department of Neuroscience and Mental Health\, University of Melbourne\, Parkville\, Victoria\, Australia\nhttps://www.lawrencelab.net/people\nContact: Andrew.Lawrence@florey.edu.au \nInvited by : Marc Landry \n\nAbstract\nBackground: Despite the large socioeconomic burden of alcohol use disorders (AUD)\, therapeutic treatment options are limited. There is a need to characterise the underlying neurochemistry driving alcohol seeking to identify and evaluate novel targets. AUDs are characterised by a transition to compulsive seeking\, which is hypothesized to involve a shift from ventral to dorsal striatum and a medial to lateral dorsal striatal shift in the transition from goal-directed to habitual alcohol-seeking behaviours. Muscarinic acetylcholine receptors (mAChRs) are a potential target for AUD; they are expressed within the mesocorticolimbic reward system\, including dense expression in the dorsal striatum\, where they modulate dopamine and glutamate release\, which may regulate reward processing. \nMethods: To assess the role of mAChRs in AUD\, we conducted genome-wide RNA sequencing in the caudate/putamen of 10 human alcoholics and 10 healthy controls and concurrently examined muscarinic receptor expression in the corresponding regions in rat (dorsolateral and dorsomedial striatum) following chronic alcohol consumption/withdrawal using qPCR. We also examined the role of select muscarinic and nicotinic receptor subtypes in alcohol consumption and seeking using selective allosteric modulators. \nResults: In human alcoholics M4 receptor expression was significantly decreased in the putamen. In line with this\, M4 receptor expression was decreased in the rat dorsolateral striatum. Further\, administration of VU154 (30 mg/kg\, p.o.) reduced alcohol self-administration and cue-induced relapse\, without effects on natural reward consumption or sedation. We also found that a centrally active and selective negative allosteric modulator (NAM) for the rat M5 muscarinic receptor (mAChR)\, ML375\, selectively decreases ethanol self-administration and attenuates cue-induced reinstatement of ethanol-seeking in iP rats. We further show that in iP rats with an extensive history of ethanol intake that intra-dorsolateral (DL)\, but not intra-dorsomedial (DM)\, striatal injections of ML375 reduced ethanol self-administration to a similar extent as the nicotinic acetylcholine receptor (nAChR) ligand varenicline\, which can reduce the reinforcing effects of ethanol in humans with AUD. \nConclusions: Collectively\, our data show that specific mAChRs are potential novel target pharmacotherapies for the treatment of AUD. These data also implicate the DL striatum as a locus for the effects of cholinergic-acting drugs on ethanol-seeking in rats with a history of long-term ethanol use. Accordingly\, we demonstrate in rats that selectively targeting mAChR’s can modulate both voluntary ethanol intake and cue-induced ethanol-seeking implicating mAChR’s as a potential novel target for pharmacotherapies aimed at treating alcohol use disorders. \nFunding: National Health & Medical Research Council of Australia\, grants 1116930 and 1120576. \nSelection of recent publications\nRyan PR\, Kastman HE\, Krstew EV\, Rosengren KJ\, Hossain MA\, Churilov L\, Wade JD\, Gundlach AL & Lawrence AJ (2013) Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc. Natl. Acad. Sci (USA)\, 110\, 20789-20794. \nChen NA\, Jupp B\, Sztainberg Y\, Lebow M\, Brown RM\, Kim JH\, Chen A & Lawrence AJ (2014) Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine-seeking in mice. J. Neurosci.\, 34\, 11560 –11570 (featured in “This week in the journal”). \nWalker LC\, Kastman HE\, Krstew EV\, Gundlach AL & Lawrence AJ (2017) Central amygdala relaxin-3/RXFP3 signalling modulates alcohol-seeking in rats. Br. J. Pharmacol.\, 174\, 3359–3369. \nBerizzi AE\, Perry CJ\, Shackleford DM\, Lindsley CW\, Jones CK\, Chen NA\, Sexton PM\, Christopoulos A\, Langmead CJ & Lawrence AJ (2018) Muscarinic M5 receptors modulate ethanol seeking in rats. Neuropsychopharmacology\, 43\, 1510-1517. \nGibson GD\, Prasad\, AA\, Jean-Richard-dit-Bressel P\, Yau JOY\, Millan EZ\, Liu Y\, Campbell EJ\, Lim J\, Marchant NJ\, Power JM\, Killcross S\, Lawrence AJ & McNally GP (2018) Distinct accumbens shell output pathways promote versus prevent relapse to alcohol seeking. Neuron\, 98\, 512-520. \nCampbell EJ\, Flanagan JPM\, Walker LC\, Hill MKRI\, Marchant NJ & Lawrence AJ (2019) Anterior insular cortex is critical for the propensity to relapse following punishment-imposed abstinence of alcohol seeking. J. Neurosci.\, 39\, 1077-1087. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-andrew-lawrence/
CATEGORIES:home-event,Seminars
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