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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
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TZOFFSETFROM:+0200
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TZNAME:CET
DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190909T090000
DTEND;TZID=Europe/Paris:20190926T130000
DTSTAMP:20260504T115149
CREATED:20190208T093515Z
LAST-MODIFIED:20191030T154754Z
UID:103130-1568019600-1569502800@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures : Whole brain imaging
DESCRIPTION:Lecture program\nFree access / Venue: CGFB \nAu CGFB\, entrée libre \n\nWednesday\, September 11th – 9:00\nJean-Michel FRANCONI\nMR image formation \nThursday\, September 12th – 9:00\nRuss POLDRACK\nTask-related fMRI \nFriday\, September 13th – 9:00\nTim DYRBY\nWhite matter architecture \nMonday\, September 16th – 9:00\nFabrice CRIVELLO\nStructural brain MRI \nWednesday\, September 18th – 9:00\nUrs RIBARY\nEEG-MEG connectivity dynamics \nWednesday\, September 18th – 11:00\nMickaël TANTER\nFunctional ultrasound \nThursday\, September 19th – 9:00\nArno VILLRINGER\nInfrared imaging \nMonday\, September 23rd – 9:00\nGitte KNUDSEN\nNeuroPET \nTuesday\, September 24th – 9:00\nSven CICHON\nNeuroimaging and omics \nTuesday\, September 24th – 11:45\nChristophe TZOURIO\nImaging markers for neuro-epidemiology \nWednesday September 25th – 9:00\nRoundtable :\nKatrin AMUNTS\, Gwenaëlle DOUAUD & Arthur TOGA\nDatabasing\, sharing and meta-analysing \nThursday\, September 26th – 9:00\nLaura HARSAN\nPreclinical imaging \nThursday\, September 26th – 11:00\nRoundtable :\nStéphanie DEBETTE & Kathinka EVERS\nBrain imaging ethics \n  \n  \nAbout the course\nThe CAJAL course in Whole Brain Imaging is an intensive three-week course that will carry participants through the theory and practice of advanced methods for investigating brain structure-function relationships at the organ level. The course will balance lectures from world-acknowledged neuroimaging experts to experimental demonstrations and hands-on laboratory work in small groups. Participants will be introduced to a wide spectrum of techniques\, from microscopic post-mortem brain cyto- and myelo-architectony to macroscopic in vivo 3D-imaging using magnetic resonance\, functional ultrasound\, near-infrared spectroscopy\, electromagnetic waves\, and gamma-ray emission tomography. Issues associated with whole brain neuroimaging multimodality and data-sharing will also be addressed. During the course\, each participant will be given the opportunity to acquire and analyze whole-brain neuroimaging data in both preclinical and clinical environments. \nCourse director \nKatrin Amunts\nJülich Research Centre\nGermany \n  \n  \nCo-directors \nBernard Mazoyer\nCNRS\nNeurodegeneratives Diseases Institute\nUMR 5293\nUniversity of Bordeaux\nFrance \n  \nSylvain Miraux\nCNRS – RMSB\nUMR 5536\nUniversity of Bordeaux\nFrance \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-whole-brain-imaging/
CATEGORIES:home-event,Seminars,Trainings
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190917
DTEND;VALUE=DATE:20190918
DTSTAMP:20260504T115149
CREATED:20190503T140705Z
LAST-MODIFIED:20191030T154834Z
UID:109374-1568678400-1568764799@www.bordeaux-neurocampus.fr
SUMMARY:Synapse Day
DESCRIPTION:Organized by:\nMaurice Garret – maurice.garret@u-bordeaux.fr\nNathalie Sans – nathalie.sans@u-bordeaux.fr\nMathieu Letellier – mathieu.letellier@u-bordeaux.fr \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/synapse-day/
CATEGORIES:home-event,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190917T140000
DTEND;TZID=Europe/Paris:20190917T170000
DTSTAMP:20260504T115149
CREATED:20190902T093719Z
LAST-MODIFIED:20190916T130443Z
UID:110714-1568728800-1568739600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Nan Jiang
DESCRIPTION:Venue: Neurocentre Magendie – conference room\n \n\nNan Jiang\nTeam Mulle\nThesis supervisor: Thierry Amédée \nAbstract\nAzheimer’s disease (AD) is a neurodegenerative disease that is linked in its early stage to synaptic dysfunction and loss of synapses. Numerous clinical data obtained from patients but also experimental data obtained on mouse models of AD show that there is a sexual dimorphism evidenced by a higher amyloid plaque deposition and an early onset of memory disorders in female mice compared to male mice. \nIn this work\, we investigated the molecular and cellular alterations of AD as well as the associated cognitive deficits in female APP/PS1 mice\, a double transgenic murine model of AD. In parallel we studied the alterations of hippocampal synaptic transmission and plasticity in the stratum moleculare\, a layer in the vicinity of the dentate gyrus (DG) which specifically displayed a high density of amyloid plaques.  We showed the presence of numerous amyloid plaques in the DG in a larger amount in 6 month old females compared to age-matched males as well as a strong activation of astrocyte and microglia glial cells. These molecular and cellular alterations are accompanied by hippocampo-dependent memory deficits (contextual fear conditioning and novel object place recognition task) from the age of 4 months in females whereas males have no deficit until the age of 12 months.  We then studied the electrical properties of DG neurons\, the transmission and the plasticity of the perforant pathway – DG neurons (PP-DG synapse) in the 6 month old female mouse by comparing the two genotypes APP/PS1 vs wild type (WT). \nIn both genotypes\, DG neurons displayed two distinct populations in terms of input resistance and action potential discharge pattern (APs). In contrast\, the resting membrane potential\, the input resistance\, the activation threshold and the amplitude PAs were not modified in APP/PS1 vs WT. The frequency of discharge of APs was increased in APP/PS1 without shift of E-S curve which relates EPSP-slopes to the associated AP firing probability. \nBasal transmission at the PP-DG synapse was altered in the APP/PS1 mouse vs WT without alterations in the AMPA/NMDA ratio or the AMPA rectification index. The frequency of the NMDA miniature currents was increased in APP/PS1 DG neurons vs WT which suggests the unmasking of silent synapses that express almost no AMPA receptors. The long term potentiation (LTP) of population spike amplitude was decreased by approximately 50% in APP/PS1 mice. The decrease in LTP observed in APP/PS1 was partly related to alterations in the intrinsic properties of DG neurons as evidenced by LTP-induced shifts of E-S curves\, which reflects an increased excitability for APP/PS1 mice. \nIn conclusion our results show a prominent sexual dimorphism with much earlier amyloid plaque deposition\, neuroinflammatory glial activation in female vs male APP/PS1. In parallel\, significant deficits in hippocampal-dependent memory are observed as well as alterations of synaptic transmission and plasticity at the PP-DG synapse\, a key synapse of the integration of mnesic informations originated from the entorhinal cortex. \nPublications\nNan Jiang\, Junjun Wu\, Tiandong Leng\,Tao Yang\, Yufan Zhou\, Qian Jiang\, Bin Wang\, Youjia Hu\, Yong-hua Ji\, Roger P Simon\, Xiang-ping Chu\, Zhi-Gang Xiong and Xiang-ming Zha: Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury\, J Cereb Blood Flow Metab\, 2017\n\nYan Huang\, Nan Jiang\, Jun Li\, Yong-hua Ji\, Zhi-gang Xiong\, Xiang-ming Zha: Two Aspects of ASIC Function: Synaptic Plasticity and Neuronal Injury. Neuropharmacology\, 2015\n\nMaingret V\, Barthet G\, Deforges S\, Jiang N\, Mulle C\, Amédée T: PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer’s disease\, Neurobiol Aging\, 2017\n\nHongyan Zhu\, Yuxiao Zhao\, Hao Wu\, Nan Jiang\, Ziyi Wang\, Weide Lin\, Jiahui Jin\, Yonghua Ji: Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis\, Scientific Reports\, 2016\nJury\nMme Valérie Fénelon\, Université de Bordeaux Présidente\nMme Claire Rampon\, Directrice de Recherche CNRS Rapporteure\nMme Corinne Beurrier \,Chargée de Recherche CNRS Rapporteure\nMr Thierry Amédée\, Directeur de Recherche CNRS Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-defense-nan-jiang/
CATEGORIES:Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190917T143000
DTEND;TZID=Europe/Paris:20190917T143000
DTSTAMP:20260504T115149
CREATED:20190906T125025Z
LAST-MODIFIED:20190906T130044Z
UID:110944-1568730600-1568730600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Ismail Koubiyr
DESCRIPTION:\n	\n		\n			Venue: Salle module 2.6\n \n\nTeam : Glia-neuron interactions\nNeurocentre Magendie \nThesis supervisor: Pr. Bruno Brochet \n\n		\n	\nRésumé\n\n	\n		\n			Cognitive impairment is frequent in multiple sclerosis (MS) but its underlying mechanisms are still poorly understood. MRI techniques have been a valuable tool to investigate the biological substrates of cognitive processes. The objective of this thesis was to better understand the pathophysiological mechanisms of cognitive functioning at the early stage of MS. We followed clinically isolated syndrome (CIS) patients for one year\, using neuropsychological tests\, conventional and more advanced MRI techniques. We first demonstrated a differential gray matter vulnerability at the beginning of MS with a pathological spread from the hippocampus towards the cortex. We showed that the first microstructural alterations taking place within the hippocampus were able to predict its future volume loss. After that\, we were interested in the potential brain functional reorganization at this stage of the disease. Using resting-state functional MRI\, we were able to demonstrate very early regional brain functional reorganization starting from the disease onset and becoming more pronounced after one year of evolution. We also noticed a preservation of cognitive performances in CIS patients\, which we found was associated to more functional reorganization. These results suggested then a compensation mechanism at the first year after a CIS. However\, the relationship between these functional changes and the underlying anatomy was still missing. Thus\, we combined resting-state functional MRI and diffusion tensor imaging to represent both functional and structural connectivity. Using the structural-functional coupling parameter\, representing the association between structural and functional connections\, we showed a decoupling one year after the disease onset in three major networks (salience\, visual and somatomotor networks). This decoupling was noticed while cognitive performances were preserved and functional reorganization present. These last results led us to suggest that the functional reorganization at this stage\, acting as a compensation mechanism\, occurs along indirect anatomical pathways. In order to confirm these results and further follow-up brain networks topology and its impact on cognition\, we are currently calling back our CIS patients for their 5-year visit. \nKeywords: Multiple sclerosis\, MRI\, clinically isolated syndrome\, connectivity\, functional MRI\, diffusion tensor imaging. \n\n		\n	\nPublications\n\n	\n		\n			1. Koubiyr I\, Besson P\, Deloire M\, Charré-Morin J\, Saubusse A\, Tourdias T\, Brochet B and Ruet A (2019) Dynamic modular-level alterations of structural-functional coupling in clinically isolated syndrome. Brain. doi: 10.1093/brain/awz270 \n2. Koubiyr I\, Deloire M\, Besson P\, Coupé P\, Dulau C\, Pelletier J\, Tourdias T\, Brochet B\, Ranjeva JP and Ruet A (2018) Longitudinal Study of Functional Brain Network Reorganization in Clinically Isolated Syndrome. Mult Scler. 1–13. doi: 10.1177/135245851881310814 \n3. Koubiyr I\, Deloire M\, Coupé P\, Dulau C\, Besson P\, Moroso A\, Planche V\, Tourdias T\, Brochet B and Ruet A (2018) Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome. Front. Neurol. 9:824. doi: 10.3389/fneur.2018.00824 \n4. Planche V\, Koubiyr I\, Romero J.E\, Manjon J.V\, Coupé P\, Deloire M\, Dousset V\, Brochet B\, Ruet A and Tourdias T (2018) Regional hippocampal vulnerability in early multiple sclerosis: dynamic pathological spreading from dentate gyrus to CA1. Human Brain Mapping. doi: 10.1002/hbm.23970 \n\n		\n	\nJury\n\n	\n		\n			Pr. Iris-Katharina Penner\, Heinrich Heine University\, Düsseldorf. Rapporteur\nDr. Menno M. Schoonheim\, VU University Medical Center\, Amsterdam. Rapporteur\nPr. Charles R.G. Guttmann\, Harvard University\, Boston. Examinateur\nDr Céline Louapre\, Université Paris-Sorbonne. Examinatrice\nDr. Gwenaëlle Catheline\, Université de Bordeaux. Examinatrice\nDr. Lucina Q. Uddin\, University of Miami\, Miami. Examinatrice invitée \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-ismail-koubiyr/
CATEGORIES:Thesis
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