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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
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TZOFFSETFROM:+0200
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190405T090000
DTEND;TZID=Europe/Paris:20190405T110000
DTSTAMP:20260504T210416
CREATED:20190315T174752Z
LAST-MODIFIED:20191030T154838Z
UID:104882-1554454800-1554462000@www.bordeaux-neurocampus.fr
SUMMARY:Mini-symposium - “When Chemistry and Structural Biology meet Neuroscience”
DESCRIPTION:Centre Broca Nouvelle-Aquitaine \nOrganizer: Matthieu Sainlos\, IINS \nSpeakers : \nArnaud Gautier\nENS Paris\n“Spying on cells with glowing chemical-genetic hybrids” \nNicolas Wolff\nInstitut Pasteur\, Paris\n“PDZ-mediated interactome in the auditory sensory cells” \nAlexandre Specht\nLaboratoire de Conception et Application de Molécules Bioactives\, Illkirch\n“Light-controlled chemical reactions and their applications in chemical and biological systems” \n
URL:https://www.bordeaux-neurocampus.fr/en/event/mini-symposium-when-chemistry-and-structural-biology-meet-neuroscience/
CATEGORIES:home-event,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190405T113000
DTEND;TZID=Europe/Paris:20190405T113000
DTSTAMP:20260504T210416
CREATED:20180619T090702Z
LAST-MODIFIED:20190304T115919Z
UID:101926-1554463800-1554463800@www.bordeaux-neurocampus.fr
SUMMARY:Monthly PhD seminar - Markus Heilig
DESCRIPTION:Lieu : Centre Broca Nouvelle-Aquitaine \nMarkus Heilig\nMarkus Heilig\nProfessor of Neuro Psychiatry\nDepartment of Clinical and Experimental Medicine (IKE)\nCenter for Social and Affective Neuroscience (CSAN) \nInvité par la NBA et Bordeaux Neurocampus dans le cadre des PhD seminars \n\nAbstract\nAlcohol use is an ongoing public health crisis\, and effective treatments are largely lacking. Neurobiological research has grown exponentially in the past two decades\, and has become increasingly sophisticated in its ability to identify neural circuits behind alcohol seeking and taking in animal models. To date\, however\, these advances have not translated into novel clinical treatments. \nThis talk will discuss potential limitations of drug discovery strategies that use animal models where drug seeking is studied in isolation\, using conventional self-administration in groups of animals. It will introduce the critical importance of phenomena that are key to clinical alcohol addiction: individual variation in vulnerability\, choice of alcohol over natural rewards\, and continued use of alcohol despite adverse consequences. These concepts will be discussed in the context of our recent discoveries implicating GABA-transmission in central amygdala as a key process to target with novel medications. \nRecent key references\n1. Augier E\, Barbier E\, Dulman RS\, Licheri V\, Augier G\, Domi E\, Barchiesi R\, Farris S\, Natt D\, Mayfield RD\, Adermark L\, Heilig M. 2018. A molecular mechanism for choosing alcohol over an alternative reward. Science 360: 1321-6 \n2. Grodin EN\, Sussman L\, Sundby K\, Brennan GM\, Diazgranados N\, Heilig M\, Momenan R. 2018. Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers. Biol Psychiatry Cogn Neurosci Neuroimaging 3: 1022-31 \n3. Barbier E\, Johnstone AL\, Khomtchouk BB\, Tapocik JD\, Pitcairn C\, Rehman F\, Augier E\, Borich A\, Schank JR\, Rienas CA\, Van Booven DJ\, Sun H\, Natt D\, Wahlestedt C\, Heilig M. 2017. Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Molecular Psychiatry 22: 1746-58 \n4. Barbier E\, Tapocik JD\, Juergens N\, Pitcairn C\, Borich A\, Schank JR\, Sun H\, Schuebel K\, Zhou Z\, Yuan Q\, Vendruscolo LF\, Goldman D\, Heilig M. 2015. DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. J Neurosci 35: 6153-64 \n5. Heilig M\, Epstein DH\, Nader MA\, Shaham Y. 2016. Time to connect: bringing social context into addiction neuroscience. Nat Rev Neurosci 17: 592-9 \n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/monthly-phd-seminar-markus-heilig/
CATEGORIES:For scientists,home-event,Monthly conferences
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DTSTART;TZID=Europe/Paris:20190405T143000
DTEND;TZID=Europe/Paris:20190405T143000
DTSTAMP:20260504T210416
CREATED:20190309T140613Z
LAST-MODIFIED:20191004T143958Z
UID:104048-1554474600-1554474600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Aleksandra Ichkova
DESCRIPTION:\n	\n		\n			Venue: Centre Broca Nouvelle-Aquitaine / Salle de conférence \n\nAleksandra Ichkova\nCNRS UMR5287\, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA)\, University of Bordeaux \nPhD supervisor:\nJérôme Badaut\nDirecteur de recherche CNRS\nTeam leader “Brain molecular Imaging” / INCIA \n\n		\n	\nAbstract\n\n	\n		\n			Traumatic brain injury (TBI) is the first cause for emergency department visits in the pediatric population. Regardless of the severity of TBI\, pediatric patients suffer long-term cognitive and emotional impairments but the underlying cellular and molecular mechanisms are still poorly understood and there are no effective treatments available. The neurovascular unit is composed by blood vessels\, neurons and astrocytes. Astrocytes are crucial for various physiological functions of this unit such as brain homeostasis and neurovascular coupling. In injuries astrocytes become “reactive”\, and this “astrocytopathy” can impact their physiological roles and worsen the outcome after injury. \nWe investigated the astrocytopathy in juvenile TBI and hypothesized that: (1) reactive astrocytes contribute to spread of edema through connexin gap junctions after juvenile moderate TBI; (2) astrocytopathy also develops after juvenile mild TBI with calcium changes that could contribute to (3) impaired vascular reactivity\, all of which impacts the behavioral outcome after injury. \nWe showed that: \n\nReducing astrocytopathy by downregulating connexin 43 improved behavioral outcome after juvenile moderate TBI\, but did not impact the spread of edema.\nAstrocytes became reactive and underwent morphological changes after juvenile mild TBI with disturbances in purinergic-calcium signaling related to expression changes of the water channel aquaporin 4 (AQP4).\nMajor vascular dysfunction developed after juvenile mild TBI with functional and morphological changes of the intraparenchymal vessels that paralleled behavioral impairments and preceded axonal damage after injury.\n\nThis work brings new insights in the pathophysiology of juvenile TBI and opens prospects for developing therapeutics targeting astrocytopathy after injury. \nKey words: traumatic brain injury\, astrocytes\, calcium\, aquaporin 4\, connexin 43\, blood vessels \n\n		\n	\nList of publications\n\n	\n		\n			\nIchkova A.\, Rodriguez-Grande B.\, Aussudre J.\, Fournier\, ML.\, Obenaus A.\, Badaut J.\, Juvenile mild traumatic injury impacts “invisible” intracortical blood vessels properties beyond blood-brain barrier dysfunction (in preparation)\nIchkova A.\, Fukuda\, A. M.\, Nishiyama\, N.\, Paris G.\, Badaut J. (2019) Small interference RNA targetting connexin-43 improves motor function and limits astrogliosis. ASN Neuro\, under revision\nClément\, T.\, Lee J.\, Ichkova\, A.\, Rodriguez-Grande\, B.\, Fournier\, ML.\, Aussudre\, J.\, Ogier\, M.\, Haddad\, E.\, Canini F.\, Koehl\, M.\, Abrous\, N.\, Obenaus\, A.\, Badaut\, J. (2019) Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses\, Glia\, under revision\nRodriguez-Grande\, B.\, Obenaus\, A.\, Ichkova\, A.\, Aussudre\, J.\, Bessy\, T.\, Barse\, E.\, Hiba B.\, Catheline\, G.\, Barriere\, G.\, Badaut\, J. (2018). Gliovascular changes precede white matter damage and long-term disorders in juvenile mild closed head injury. Glia. doi:10.1002/glia.23336\nJullienne\, A.\, Fukuda\, A. M.\, Ichkova\, A.\, Nishiyama\, N.\, Aussudre\, J.\, Obenaus\, A.\, & Badaut\, J. (2018). Modulating the water channel AQP4 alters miRNA expression\, astrocyte connectivity and water diffusion in the rodent brain. Sci Rep\, 8(1)\, 4186. doi:10.1038/s41598-018-22268-y\nIchkova\, A.\, Badaut J. (2017) New biomarker stars for traumatic brain injury. J Cereb Blood Flow Metab\, 37(10)\, 3276-3277. doi:10.1177/0271678X17724683\nRodriguez-Grande B.\, Ichkova A.\, Lemarchant. S.\, Badaut J.\, (2017) Early to long-term alterations of CNS barriers after traumatic brain injury: considerations for drug development. AAPS\, 19(6):1615-1625. doi: 10.1208/s12248-017-0123-3\nIchkova\, A.\, Rodriguez-Grande\, B.\, Bar\, C.\, Villega\, F.\, Konsman\, J. P.\, & Badaut\, J. (2017). Vascular impairment as a pathological mechanism underlying long-lasting cognitive dysfunction after pediatric traumatic brain injury. Neurochem Int. doi:10.1016/j.neuint.2017.03.022\nJullienne\, A.\, Obenaus\, A.\, Ichkova\, A.\, Savona-Baron\, C.\, Pearce\, W. J.\, & Badaut\, J. (2016). Chronic cerebrovascular dysfunction after traumatic brain injury. J Neurosci Res\, 94(7)\, 609-622. doi:10.1002/jnr.23732\n\n\n		\n	\nJury\n\n	\n		\n			  \n\nMme NADJAR Agnès\, Maître de Conférences\, Université de Bordeaux\nPrésident\nMme HEURTEAUX Catherine\, Directeur de recherche CNRS\, Université Côte d’Azur\nRapporteur\nMme ALI Carine\, Professeur des Universités\, Normandie Université\nRapporteur\nM NÄGERL U. Valentin\, Professeur\, Université de Bordeaux\nExaminateur\nM MARCHI Nicola\, Chargée de recherche CNRS\, Université de Montpellier\nExaminateur\nMme GUIBERT Christelle\, Chargée de recherche INSERM\, Université de Bordeaux\nInvité\n\n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-aleksandra-ichkova/
LOCATION:Centre Broca Nouvelle-Aquitaine\, 38 Rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:Thesis
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