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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190329T113000
DTEND;TZID=Europe/Paris:20190329T113000
DTSTAMP:20260504T230155
CREATED:20190103T175745Z
LAST-MODIFIED:20191030T154805Z
UID:101387-1553859000-1553859000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Claire Meissirel
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine / Conference hall\n \n\nClaire Messirel\nChargée de recherche INSERM in the research team entitled “Synaptopathies and autoantibodies” headed by Jérôme Honnorat. NeuroMyogene Institute. Lyon. \nInvited by: Véronique Deroche-Gamonet\, Neurocentre Magendie \n\n\nScientific focus\nIncreasing evidence indicate that the vascular endothelial growth factor (VEGF) and its receptor VEGFR2 mediate key neurobiological processes including among others\, adult neurogenesis\, hippocampal-dependent synaptic plasticity and cognition. Our recent work demonstrates that the impact of VEGF on adult synaptic plasticity and memory involving the hippocampus requires the neuronal expression of VEGFR2. Moreover\, we documented a new crosstalk between VEGFR2 and NMDAR that increases NMDAR synaptic responses in hippocampal neurons and triggers the formation of new synapses.\nOur current interest is to determine whether the VEGF/VEGFR2 signaling is impaired in neurological disorders in which glutamatergic transmission mediated by NMDA receptors is altered\, such as Alzheimer Disease and Depression. \nSelected publications\nDe Rossi P\, Harde E\, Dupuis JP\, Martin L\, Chounlamountri N\, Bardin M\, Watrin C\, Benetollo C\, Pernet-Gallay K\, Luhmann HJ\, Honnorat J\, Malleret G\, Groc L\, Acker-Palmer A\, Salin PA\, Meissirel C. A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior. Mol Psychiatry. 2016\, 21(12):1768-1780. \nMeissirel C\, Ruiz de Almodovar C\, Knevels E\, Coulon C\, Chounlamountri N\, Segura I\, de Rossi P\, Vinckier S\, Anthonis K\, Deléglise B\, de Mol M\, Ali C\, Dassonville K\, Loyens E\, Honnorat J\, Michotte Y\, Rogemond V\, Smolders I\, Voets T\, Vivien D\, Vanden Berghe P\, Van den Bosch L\, Robberecht W\, Chédotal A\, Oliviero S\, Dewerchin M\, Schmucker D\, Thomasset N\, Salin P\, Carmeliet P. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A. 2011\, 108(33):13782-7. \nRuiz de Almodovar C\, Coulon C\, Salin PA\, Knevels E\, Chounlamountri N\, Poesen K\, Hermans K\, Lambrechts D\, Van Geyte K\, Dhondt J\, Dresselaers T\, Renaud J\, Aragones J\, Zacchigna S\, Geudens I\, Gall D\, Stroobants S\, Mutin M\, Dassonville K\, Storkebaum E\, Jordan BF\, Eriksson U\, Moons L\, D’Hooge R\, Haigh JJ\, Belin MF\, Schiffmann S\, Van Hecke P\, Gallez B\, Vinckier S\, Chédotal A\, Honnorat J\, Thomasset N\, Carmeliet P\, Meissirel C. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010\, 30(45):15052-66. \n\n\n  \n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-claire-meissirel/
LOCATION:Centre Broca Nouvelle-Aquitaine\, 38 Rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:home-event,Seminars
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