BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20220128T113000
DTEND;TZID=Europe/Paris:20220128T123000
DTSTAMP:20260430T212936
CREATED:20200225T113900Z
LAST-MODIFIED:20220121T110930Z
UID:117025-1643369400-1643373000@www.bordeaux-neurocampus.fr
SUMMARY:Webinar - Sébastien Carnicella
DESCRIPTION:\n \nSébastien Carnicella\nGrenoble Institut Neurosciences \nWebpage  https://neurosciences.univ-grenoble-alpes.fr/ \nInvited by Clémentine Bosch-Bouju (Nutrineuro) \n\nOn Zoom\n \nTitle\nImplication of hypodopaminergic state of the nigrostriatal pathway in compulsive alcohol-related behaviors \n\nAbstract\nNeurobiological mechanisms underlying compulsive alcohol use\, a cardinal problem of addiction\, remain elusive. Dopamine (DA)\, key modulator of motivational processes\, is suspected to play an important role in this pathology\, but its exact implication remains to be determined. Here\, we found that rats expressing a compulsive alcohol-related behavior presented a decrease of DA levels restricted to the dorsolateral-striatum\, a main output structure of the DA nigrostriatal pathway. Using chemogenetic\, we induced a selective hypodopaminergia of nigrostriatal pathway. This alteration led to motivational impairments reminiscent of alcohol withdrawal and to the emergence of compulsive-alcohol related behavior in rats that do not initially express this phenotype. These results identify and demonstrate a major implication of tonic hypodopaminergic state in alcohol addiction and provide new insights to understand neurobiological mechanism underlying compulsive alcohol use. \nSelected publications\nGoutaudier R\, Coizet V\, Carcenac C\, Carnicella S. Compound 21\, a two-edged sword with both DREADD-selective and off-target outcomes in rats. PLoS One\, 2020 15(9): e0238156 \nGoutaudier R\, Coizet V\, Carcenac C\, Carnicella S. DREADDs: The Power of the Lock\, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. eNeuro\, 2019 6(5): ENEURO.0171-19.2019 \nDrui G*\, Carnicella S*\, Carcenac C\, Favier M\, Bertrand A\, Boulet S\, Savasta M. Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease. Mol Psychiatry\, 2014 19(3): 358-67 \nBarak S*\, Carnicella S*\, Yowell QV\, Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J Neurosci\, 2011 31(27):9885-94 \nCarnicella S\, Kharazia V\, Jeanblanc J\, Janak PH\, Ron D. GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A\, 2008 105(23):8114-9 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/webinar-sebastien-carnicella/
CATEGORIES:For scientists,home-event,Seminars
END:VEVENT
END:VCALENDAR