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DTSTART;TZID=Europe/Paris:20251128T143000
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SUMMARY:Thsesis defense - Simon Lecomte
DESCRIPTION:Venue: BBS \n\nSimon Lecomte\nTeam: Synapses et circuits neuronaux \nThesis supervisor: Christophe Mulle \nTitle\n“Impact of FMRP deletion on presynaptic mechanisms at mf-CA3 synapse” \nAbstract\nFragile X syndrome (FXS)\, the most common inherited form of intellectual disability and a major cause of autism spectrum disorder\, results from silencing of the Fmr1 gene encoding the RNA-binding protein\, FMRP. While most research has focused on dendritic and postsynaptic mechanisms\, emerging evidence suggests a presynaptic role of FMRP\, particularly through cAMP-dependent signaling pathways. This project investigates how loss of FMRP affects presynaptic mechanisms in the CA3 region of the hippocampus\, with a specific emphasis on cAMP–protein kinase A (PKA) signaling. Using patch-clamp electrophysiology and imaging in acute and fixed mouse hippocampal slices with targeted genetic mutations in dentate gyrus cells\, I show that presynaptic loss of FMRP disrupts mossy fiber–CA3 synaptic transmission. My results indicate a deregulation of cAMP–PKA signaling and altered presynaptic calcium-dependent mechanisms\, providing new insights into the presynaptic contribution of FMRP to synaptic function in FXS. \nKeywords: FMRP\, hippocampus\, mossy fiber\, presynapse\, patch-clamp \nPublication\nMarneffe\, C.\, Moreira-de-Sá\, A.\, Lecomte\, S.\, Erhardt\, A.\, & Mulle\, C. (2025). Short term plasticity at hippocampal mossy fiber synapses. Neuroscience\, 578\, 105-117. (ainsi que diverses publications dans le journal étudiant brainstorm\, et podcast “Thèse et vous”)\nJury\n\nAndreas Frick (Neurocentre Magendie\, Bordeaux\, président du jury\, examinateur)\nIngrid Bureau (INMED\, Marseille\, rapportrice)\nPierre Vincent (IGF\, Montpellier\, rapporteur)\nJoana Lourenço (ICM\, Paris\, examinatrice)\nYann Humeau (FMI\, Bâle\, invité)\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thsesis-defense-simon-lecomte/
CATEGORIES:Thesis
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