BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20210326T140000
DTEND;TZID=Europe/Paris:20210326T140000
DTSTAMP:20260525T204436
CREATED:20210225T182337Z
LAST-MODIFIED:20210303T183319Z
UID:131623-1616767200-1616767200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Ana Dorrego-Rivas
DESCRIPTION:\n	\n		\n			Venue: Centre Broca (restricted) and onzoom (link on request) \n\nTitle: Revisiting neuronal polarity in the context of PCP\n\nDefense in english \nThesis surpervisor: Jérôme Ezan \nAbstract\nThe axonal initial segment (AIS) is a neuronal subdomain that coordinates the axo-dendritic polarity establishment and maintenance and constitutes the site for action potential tuning. The AIS structure relies on a highly organized cytoskeleton and associated molecules like Ankyrin-G (AnkG) and βIV spectrin. AnkG is the AIS master organizer\, since it arrives to the proximal axon and recruits all the AIS components. The early steps of AIS assembly are still unknown\, notably because of few identified AnkG partners. \nPlanar cell polarity (PCP) signaling controls tissue morphogenesis and cell polarity by modulating the cytoskeleton. It has important functions during nervous system development but its specific role in neurons remains unexplored. We found that some PCP proteins accumulate at the AIS in early and late stages of neuronal development\, and colocalize with the main AIS members\, specially AnkG\, and identified new AIS protein complexes. The disruption of PCP signaling impaired AIS formation by altering the distribution and levels of the main AIS markers and disrupted the periodic actin cytoskeleton organization. \nOur data identifies new players in AIS formation and composition and reveals novel mechanisms in neuronal polarity and function. \nKey words: neuronal polarity\, planar cell polarity\, axon initial segment \nPublication\nLubiana T\, Weber S\, Andrade Paranhos B\, Araujo D\, Dorrego-Rivas A\, Franzen D\, Nogueira Vicosa G\, Ghosh A and Hojas Garcia-Plaza I. ANN: a platform to annotate text with wikidata IDs (2020\, preprinted). \nJury\nFrançois George\, University of Bordeaux\, Président \nMonica Sousa\, University of Porto\, Rapporteur \nMatthew Grubb\, King’s College London\, Rapporteur \nMaren Engelhardt\, University of Heidelberg\, Examinateur \nMireille Montcouquiol\, University of Bordeaux\, Invitée \n\n		\n	\n\n	\n		\n			 \nAna Dorrego-Rivas\nTeam Montcouquiol-Sans\nNeurocentre Magendie \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defenseana-dorrego-rivas/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR