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SUMMARY:Thesis defense - Matéo NDiaye
DESCRIPTION:Venue: BBS \n\nMatéo NDiaye\nTeam FoodCircus – NutriNeuro \nThesis supervisor: Pauline Lafenêtre \nDefense in french \nTitle\nSexual differences in the effects of an obesogenic diet on memory\n \nAbstract\nObesity is an increasing global public health issue\, starting at an increasingly early age and affecting particularly teenagers. It is mainly due to overconsumption of foods rich in saturated fats and sugars\, which are highly palatable and easily accessible. In addition to comorbidities such as diabetes and cardiovascular disease\, obesity also impairs brain functioning and cognitive performances\, which are particularly worrying for teenagers. It has now been established in humans\, but also in animal models\, that exposure to an obesogenic diet\, high in fat and sugar (HFS)\, particularly during adolescence (adoHFS)\, induces hippocampus-dependent deficits in non-aversive long-term memory. Interestingly\, our laboratory has found that these memory impairments arise from hippocampal dysfunction\, induced by neuronal hyperactivity associated with overactivation of an important neuromodulatory system\, the endocannabinoid system. However\, this work has been carried out exclusively on male rodents. The aim of this PhD thesis is therefore to study these effects in females and to compare the neurobiological mechanisms involved in the memory alterations induced by the adoHFS diet in males and females. \nPublications\nN’Diaye M*\, Ducourneau EG*\, Bakogiannis I\, Potier M\, Lafenetre P\, Ferreira G. Sex and obesogenic diet effects on contextual fear memory and associated hippocampal activity in mice. À soumettre. *co-premiers auteurs \nN’Diaye M*\, Ducourneau EG*\, Potier M\, Décarie-Spain L\, Bakogiannis I\, Fermigier A\, Lafenetre P\, Bellocchio L\, Marsicano G° & Ferreira G°. Hippocampal and prefrontal CB1 receptors differentially mediate obesogenic diet-induced recognition memory deficits in males\nand females. À soumettre. *co-premiers auteurs; °co-derniers auteurs \nBakoyiannis I*\, Ducourneau EG*\, N’Diaye M\, Fermigier A\, Ducroix-Crepy C\, Fauré L\, Bosch-Bouju C\, Coutureau E\, Trifilieff P\, Ferreira G. Chemogenetic silencing of hippocampal projections to nucleus accumbens and medial prefrontal cortex prevents diet- induced\nrecognition and location memory deficits. Soumis à eLife *co-premiers auteurs \nDucourneau EG*\, Janthakhin Y*\, Oliveira da Cruz J\, Artinian J\, Bakoyiannis J\, Busquets-Garcia A\, N’Diaye M\, Fermigier A\, Helbling JC\, Mathias I\, Alfos S\, Bosch-Bouju C\, Trifilieff P\, Marsicano G°\, Ferreira G°. Hippocampal endocannabinoid system mediates diet-induced\nmemory consolidation deficits.\nÀ soumettre *co-premiers auteurs; °co-derniers \nJury\n\nAnne-Marie Mouly (Chargé de Recherche CNRS\, Lyon) rapportrice\nChristophe Magnan (Professeur Paris Cité) rapporteur\nGiuseppe Gangarosssa (Professeur Paris Cité) examinateur\nAline Marighetto (Directeur de Recherche CNRS\, Bordeaux)\, examinatrice\nGiovanni Marsicano (Directeur de Recherche INSERM\, Bordeaux)\, président\nPauline Lafenêtre (Maitre de Conférence INP\, Bordeaux)\, co-directrice de thèse\nGuillaume Ferreira (Directeur de Recherche INRAE\, Bordeaux)\, co-directeur de thèse\n\n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-mateo-ndiaye/
CATEGORIES:Thesis
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