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DTSTART;TZID=Europe/Paris:20251001T133000
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SUMMARY: Thesis defense -  Juliette Montet
DESCRIPTION:Venue : BBS conference room \nThesis defended in French \n\nJuliette Montet \nNutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)\nNutrineuro \nTitle\nRole of early-life adversity in inflammation-related neuropsychiatric comorbidities in obesity:  Implication of GTP-CH1 enzymatic pathway and dopamine metabolism \nAbstract\nNeuropsychiatric comorbidities are common in obesity\, and numerous studies highlight the involvement of adiposity-related chronic low-grade inflammation in this effect. Cytokines alter dopamine metabolism by modulating the activity of the enzyme GTP cyclohydrolase 1 (GTP-CH1). This mechanism could contribute to the onset of several key symptoms\, such as fatigue\, decreased motivation\, anhedonia\, and psychomotor slowing in vulnerable individuals. Various data suggest that early life adversity (ELA) is an important factor in vulnerability to the neuropsychiatric effects of inflammation. Interestingly\, ELA\, like inflammation\, can disrupt the activity of the GTP-CH1 pathway. The objective of this thesis is i) to evaluate the combined effect of ELA and obesity-related inflammation in neuropsychiatric comorbidities associated with obesity\, and ii) to determine whether this effect is based on modulation of dopaminergic metabolism. The methodology used combines neuropsychiatric assessments\, peripheral measurements of GTP-CH1 activity and inflammation\, and [18F]DOPA PET brain imaging in a cohort of obese subjects. This work could contribute to the definition of new treatment perspectives for neuropsychiatric symptoms occurring in inflammatory contexts\, which are known for their frequent resistance to conventional antidepressants. \nKeywords\nObesity\, inflammation\, neuropsychiatric symptoms\, early life adversity\, dopamine \nSelected publication\nMontet J\, Dexpert S\, Darnaudéry M\, Beau C\, Forestier D\, Ledaguenel P\, Magne E\, Aouizerate B\, Capuron L. Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity. Brain Behav Immun. 2025 Aug;128:612-619. doi: 10.1016/j.bbi.2025.04.039. Epub 2025 Apr 30. PMID: 40316033. \nJury\n\nPr Philippe Fossati\, PU-PH\, APHP\, Sorbonne Université\, Rapporteur\nPr Christine Poitou-Bernert\, PU-PH\, APHP\, Sorbonne Université\, Rapportrice\nDr Raphaële Castagné\, Chargée de recherche\, Université Toulouse III Paul Sabatier\, Examinatrice\nDr Lucile Capuron\, Directrice de recherche\, Université de Bordeaux\, Directrice de Thèse\nPr Bruno Aouizerate\, PU-PH\, CH Charles Perrens\, Univerité de Bordeaux\, Examinateur invité\nDr Eric Magne\, Chirurgien\, Clinique Tivoli\, Bordeaux\, Examinateur invité\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-juliette-montet/
CATEGORIES:Thesis
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