BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20170326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20171029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20171215
DTEND;VALUE=DATE:20171216
DTSTAMP:20260410T114150
CREATED:20171215T151047Z
LAST-MODIFIED:20201202T091454Z
UID:19399-1513296000-1513382399@www.bordeaux-neurocampus.fr
SUMMARY:Thèse de Mélissa Sourioux
DESCRIPTION:[FR] Étude des mécanismes de coordination des activités rythmiques locomotrice et sympathique au sein d’un réseau spinal activé par l’acétylcholine chez le rat nouveau-né. \nDefended on December 15\, 2017\n \nSupervisor: Jean-René Cazalets. INCIA\, CNRS UMR 5287.\nÉquipe Coordination et plasticité des générateurs spinaux (Sandrine Bertrand). \n\nLocomotion\, as any other forms of physical activity\, mobilizes the autonomic nervous system to match the increasing physiological demand. These autonomic responses mostly rely on the coupling between sympathetic and somatic motor activities. The propriospinal cholinergic system plays an important role in the control of locomotor networks\, and several lines of evidences suggest that it may also activate sympathetic preganglionic neurons from the intermediolateral nucleus (IMLs). \nThe aim of my doctoral thesis was to investigate the role of the cholinergic propriospinal system in the coordination between these two systems. Using the in vitro isolated spinal cord from new born rat\, we showed that application of acetylcholine synchronized the locomotor and sympathetic networks\, via the activation of muscarinic receptors. Indeed\, the non-selective agonist oxotremorine induced slow rhythmic activity blocked by muscarinic receptor antagonists. In addition\, oxotremorine revealed endogenous rhythmogenic capabilities of the thoracic segments. \nThis slow oscillatory activity propagated from thoracic ventral roots to lumbar ones\, but not the reverse. We observed that thoracic MNs were rhythmically activated during both locomotor-like activity and oxotremorine-induced rhythm. In contrast\, IMLs were rhythmically activated solely in the presence of oxotremorine. This study provides new light on the origin of the coupling between the somatic and the sympathetic systems. We propose that synchronizing mechanisms are achieved in part by an intraspinal network which may be activated under the control of the cholinergic propriospinal system. \nKeywords: spinal cord\, electrophysiology\, somatic system\, sympathetic system\, acetylcholine. \n  \n\nPublications:\n \n– Sourioux M*\, Bestaven E*\, Guillaud E\, Bertrand SS\, Cabanas M\, Milan L\, Mayo W\, Garret M & Cazalets JR. 3-D motion capture for long-term tracking of spontaneous locomotor behaviors and circadian sleep/wake rhythms in mouse. Journal of Neuroscience Methods (2017). In press. *contributed equally\n– Sourioux M\, Bertrand SS & Cazalets JR.  A cholinergic-activated thoracic spinal network for coupling of locomotor and sympathetic activities. Submitted.\n \nMélissa Sourioux\, PhD student Institut de Neurosciences Cognitives et Intégratives d’Aquitaine UMR CNRS 5287 Université de Bordeaux Bâtiment 2A – Bordeaux Cedex  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/these-de-melissa-sourioux/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR