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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;TZID=Europe/Paris:20180713T113000
DTEND;TZID=Europe/Paris:20180713T113000
DTSTAMP:20260417T194345
CREATED:20180607T152631Z
LAST-MODIFIED:20191030T154813Z
UID:101925-1531481400-1531481400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Yasunori Hayashi
DESCRIPTION:Yasunori Hayashi\nPhD\, Department of Pharmacology\nKyoto University Graduate School of Medicine \nInvitant : Daniel Choquet\nDirecteur de L’IINS \nAbstract :\nLong-term synaptic plasticity requires a mechanism that converts short Ca2+ pulses into persistent biochemical signaling to support the changes in the function and structure of synapses over long period of time. Here\, we present a positive feedback loop\, formed by a “reciprocally activating kinase-effector complex” (RAKEC) in dendritic spines\, enabling the persistence and confinement of the molecular memory. We found that stimulation of a single spine causes the rapid formation of a RAKEC consists of a kinase CaMKII and its substrate a RacGEF TIAM1\, which can stably promote actin-polymerization through Rac1\, thereby maintaining the structure of the spine over a long period of time during LTP. This is achieved by a pseudo-autoinhibitory domain found within TIAM1\, homologous to the autoinhibitory domain of CaMKII. RAKEC can store biochemical information in small subcellular compartments\, thus potentially serving as a general mechanism for the production of prolonged and compartmentalized signaling. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-yasunori-hayashi/
CATEGORIES:home-event,Seminars
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