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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190510T113000
DTEND;TZID=Europe/Paris:20190510T123000
DTSTAMP:20260416T113355
CREATED:20190128T180155Z
LAST-MODIFIED:20191030T154802Z
UID:102573-1557487800-1557491400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Stéphanie Trouche
DESCRIPTION:Stéphanie Trouche\nStéphanie Trouche\nCR INSERM\, IGF\, Montpellier \nInvited by Catherine Le Moine\nDirecteur de Recherche CNRS\nINCIA / CNRS UMR 5287 Université de Bordeaux \n\nAbstract\nAnimals must retrieve memories of food-predicting environments and direct their spatial behaviour to ensure their survival. In mammals\, pyramidal cells of the dorsal hippocampus provide a map-like representation of space. How these representations influence the behavioural expression of spatial appetitive memory is still unknown. Our latest work addresses this question by monitoring and manipulating neuronal ensembles from the dorsal hippocampus and the nucleus accumbens in behaving mice. I will present recent evidence showing a functional dissociation between the neuronal reinstatement of a memory and its behavioural manifestation\, often assumed to be the same process. We found that hippocampal representations of space are indeed necessary\, but not sufficient\, to act on appetitive memory retrieval. I will also present mechanistic evidence showing the importance of a tripartite neuronal motif in the dorsal hippocampus-accumbens pathway for successful place-reward behavior. \nSelected publications\nTrouche\, S.\, Koren\, V.\, Doig\, N. M.\, Ellender\, T. J.\, El-Gaby\, M.\, Lopes-Dos-Santos\, V.\, Reeve\, H. M.\, Perestenko\, P. V.\, Garas\, F. N.\, Magill\, P. J.\, Sharott\, A.\, & Dupret\, D. (2019). A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space. Cell\, 176\, 1393-1406 e1316. \nvan de Ven\, G. M.\, Trouche\, S.\, McNamara\, C. G.\, Allen\, K.\, & Dupret\, D. (2016). Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples. Neuron\, 92\, 968-974. \nTrouche\, S.\, Perestenko\, P. V.\, van de Ven\, G. M.\, Bratley\, C. T.\, McNamara\, C. G.\, Campo-Urriza\, N.\, Black\, S. L.\, Reijmers\, L. G.\, & Dupret\, D. (2016). Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nat Neurosci\, 19\, 564-567. \nTrouche\, S.\, Sasaki\, J. M.\, Tu\, T.\, & Reijmers\, L. G. (2013). Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron\, 80\, 1054-1065. \nTrouche\, S.\, Bontempi\, B.\, Roullet\, P.\, & Rampon\, C. (2009). Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc Natl Acad Sci U S A\, 106\, 5919-5924. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-stephanie-trouche/
CATEGORIES:home-event,Seminars
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