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DTSTART;TZID=Europe/Paris:20240126T113000
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UID:162482-1706268600-1706268600@www.bordeaux-neurocampus.fr
SUMMARY:Friday Seminar - Salah El Mestikawy
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine  \n\nSalah El Mestikawy\nMcGill University\, Douglas Institute\, Montreal\, Canada\nCNRS\, Paris\nhttps://douglas.research.mcgill.ca/fr/salah-el-mestikawy-2/ \nInvited by Etienne Herzog (IINS) \nTitle\nA rare variant of VGLUT3 (p.T8I) involved in substance use disorders and eating disorders: Opening the door to a treatment of anorexia nervosa ? \nSummary\nCholinergic interneurons (Chis) are pivotal regulators of striatal functions. They have the particularity to express both the vesicular acetylcholine transporter (VAChT) and the atypical type 3 vesicular glutamate transporter (VGLUT3). Consequently\, they regulate the striatal network with both acetylcholine (ACh) and glutamate. We previously identified the missense polymorphism VGLUT3-p.T8I (threonine at position 8 changed to an isoleucine) in patients with substance use disorders (SUD) or eating disorders (ED). Using a rodent model (VGLUT3T8I/T8I mice)\, we found that the variant was causative in SUD and ED and identified an underlying mechanism. This led to a treatment that alleviate ED in mutant mice and potentially in humans. \nSelected publications\nEl Mestikawy S\, Wallen-Mackenzie A\, Fortin GM\, Descarries L\, Trudeau LE. From glutamate co-release to vesicular synergy: vesicular glutamate transporters. Nat Rev Neurosci 12\, 204-216 (2011). \nEveritt BJ\, Robbins TW. Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On. Annu Rev Psychol 67\, 23-50 (2016). \nFavier M\, et al. Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating. J Clin Invest 130\, 6616-6630 (2020). \nGodier LR\, Park RJ. Compulsivity in anorexia nervosa: a transdiagnostic concept. Front Psychol 5\, 778 (2014). \nSakae DY\, et al. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Mol Psychiatry 20\, 1448-1459 (2015). \nSteinglass JE\, Walsh BT. Neurobiological model of the persistence of anorexia nervosa. J Eat Disord 4\, 19 (2016). \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-salah-el-mestikawy/
CATEGORIES:For scientists,home-event,Seminars
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