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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Paris:20250424T110000
DTEND;TZID=Europe/Paris:20250424T110000
DTSTAMP:20260405T195511
CREATED:20250217T092319Z
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UID:180623-1745492400-1745492400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Mark Harnett
DESCRIPTION:Venue: Centre Broca \n\nMark Harnet\nMIT\nhttps://mcgovern.mit.edu/profile/mark-harnett/\nhttps://www.markharnett.org/ \nInvited by Naoya Takahashi (IINS) and Richard Naud \nTitle\nPatterns and Plasticity in Adult Cortex \nAbstract\nI will discuss my lab’s recent work on cortical burst firing\, plateau potentials\, and synaptic plasticity in adult mice. We have observed that burst firing is surprisingly common across cortical lamina and areas of awake cortex\, and\, in V1 L5 neurons\, is often mediated by large plateau potentials (similar to hippocampus). We further found that these cortical plateaus can drive Behavioral Time Scale Plasticity (BTSP)-like processes with distinct features. \nPublications\nA dendritic mechanism for balancing synaptic flexibility and stability. \nYaeger CE\, Vardalaki D\, Zhang Q\, Pham TLD\, Brown NJ\, Ji N\, Harnett MT. Cell Rep. 2024 Aug 27;43(8):114638. doi: 10.1016/j.celrep.2024.114638. Epub 2024 Aug 19. \nFilopodia are a structural substrate for silent synapses in adult neocortex. \nVardalaki D\, Chung K\, Harnett MT. Nature. 2022 Dec;612(7939):323-327. doi: 10.1038/s41586-022-05483-6. Epub 2022 Nov 30. PMID: 36450984 \nDifferential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio. \nLafourcade M\, van der Goes MH\, Vardalaki D\, Brown NJ\, Voigts J\, Yun DH\, Kim ME\, Ku T\, Harnett MT. Neuron. 2022 May 4;110(9):1532-1546.e4. doi: 10.1016/j.neuron.2022.01.025. Epub 2022 Feb 17. PMID: 35180389 \nAllometric rules for mammalian cortical layer 5 neuron biophysics. \nBeaulieu-Laroche L\, Brown NJ\, Hansen M\, Toloza EHS\, Sharma J\, Williams ZM\, Frosch MP\, Cosgrove GR\, Cash SS\, Harnett MT. Nature. 2021 Dec;600(7888):274-278. doi: 10.1038/s41586-021-04072-3. Epub 2021 Nov 10. PMID: 34759318 \nSomatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation. \nVoigts J\, Harnett MT. Neuron. 2020 Jan 22;105(2):237-245.e4. doi: 10.1016/j.neuron.2019.10.016. Epub 2019 Nov 20. PMID: 31759808 \nWidespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons. \nBeaulieu-Laroche L\, Toloza EHS\, Brown NJ\, Harnett MT. Neuron. 2019 Jul 17;103(2):235-241.e4. doi: 10.1016/j.neuron.2019.05.014. Epub 2019 Jun 6. PMID: 31178115 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-mark-harnett/
CATEGORIES:For scientists,home-event,IINS,Impromptu seminar
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