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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20220327T010000
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DTSTART;TZID=Europe/Paris:20221019T143000
DTEND;TZID=Europe/Paris:20221019T143000
DTSTAMP:20260415T175159
CREATED:20220921T093303Z
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UID:151059-1666189800-1666189800@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Marina Casiraghi
DESCRIPTION:Marina Casiraghi\nVenue : Salle Pyramide (Centre Broca Nouvelle-Aquitaine) \n\nMarina Casiraghi\nDepartment of Molecular and Cellular Physiology\, Stanford University School of Medicine\, 279 CampusDrive\, Stanford\, CA 94305\, USA \nInvited by Daniel Choquet \nTitle\nInvestigation of G–protein specificity and biased agonism at the beta–2 adrenergic receptor (β 2AR) \nAbstract\nThe beta–2–adrenergic receptor (β2AR) is a prototypical G–protein coupled receptor (GPCR). In cardiomyocytes\, β2AR couples to the G–protein subtypes Gs and Gi to regulate cardiac function. We used this system to investigate the molecular determinants of biased agonism and G–protein specificity. We developed a Gi–biased agonist\, LM189\, that we used to obtainthe cryo–EM structure of the β2AR–Gi complex. Spectroscopic investigations show that distinct intermediate states\, differentially stabilized by balanced and biased ligands\, contribute to G–protein specificity. Understanding the basis of specificity and bias is important to design safer drugs that target GPCRs with reduced side effects. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-marina-casiraghi/
CATEGORIES:For scientists,home-event,Impromptu seminar
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